1
40
35
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
9272-9276
Issue
24
Volume
20
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Dublin Core
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Title
A name given to the resource
Role of voltage-dependent calcium channel long-term potentiation (LTP) and NMDA LTP in spatial memory
Publisher
An entity responsible for making the resource available
Journal of Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
2000-12
Subject
The topic of the resource
hippocampus; rat; learning; verapamil; Neurosciences & Neurology; expression; neurons; long-term potentiation; environment; NMDA; MK-801; 2 forms; voltage-dependent calcium channel; nmdaLTP; spatial memory; vdccLTP; antagonist mk-801; working
Creator
An entity primarily responsible for making the resource
Borroni A M; Fichtenholtz H; Woodside B L; Teyler T J
Description
An account of the resource
This experiment explores the role of two forms of long-term potentiation (LTP) in behavioral memory. NMDA and/or voltage-dependent calcium channels (VDCCs) were antagonized pharmacologically at levels that block nmdaLTP and vdccLTP, respectively, in rats learning an eight-arm radial maze task. Animals were trained twice a day for 11 d under the systemic influence of MK-801, verapamil, both drugs, or saline. During acquisition, the mixed drug group displayed significantly more working memory errors and reference memory errors than all other groups. The mixed drug group was markedly impaired on the first daily trial but improved dramatically on their second daily trial. After a 7 d delay, saline and MK-801 animals maintained their predelay level of performance. The performance of the verapamil groups declined significantly over the delay. These results demonstrate that: (1) vdccLTP is necessary for the retention of information over a 7 dperiod, (2) the blockade of both forms of LTP prevents the retention of information over a 21 hr period, and (3) blockade of both forms of LTP does not prevent the storing of information over a short period of time (3 hr).
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2 forms
2000
antagonist mk-801
Borroni A M
Environment
expression
Fichtenholtz H
Hippocampus
Journal Article or Conference Abstract Publication
Journal of Neuroscience
Learning
Long-Term Potentiation
MK-801
Neurons
Neurosciences & Neurology
NMDA
nmdaLTP
rat
spatial memory
Teyler T J
vdccLTP
verapamil
voltage-dependent calcium channel
Woodside B L
Working
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1249/00005768-199510000-00008" target="_blank" rel="noreferrer noopener">http://doi.org/10.1249/00005768-199510000-00008</a>
Pages
1399–1405
Issue
10
Volume
27
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Enhanced cardiopulmonary reflex inhibition of heart rate during exercise.
Publisher
An entity responsible for making the resource available
Medicine and science in sports and exercise
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-10
Subject
The topic of the resource
Animals; Rats; Analysis of Variance; Physical Stimulation; Blood Pressure/drug effects/physiology; Rest; Biguanides/pharmacology; Blood Volume; Bradycardia/physiopathology; Heart Rate/drug effects/*physiology; Heart/drug effects/*physiology; Hypoglycemic Agents/pharmacology; Lung/drug effects/*physiology; Physical Exertion/*physiology; Reflex/drug effects/*physiology; Sympathetic Nervous System/drug effects/physiology; Vagotomy; Vagus Nerve/drug effects/physiology; Neurons; Chemical; Stimulation; Afferent/drug effects/physiology
Creator
An entity primarily responsible for making the resource
Chen C Y; DiCarlo S E; Collins H L
Description
An account of the resource
We tested the hypothesis that the reflex inhibition of heart rate (HR) during mechanical (acute bolus injection of 0.5% and 2% of estimated blood volume) and chemical (phenylbiguanide, PBG, 2.5 and 5 micrograms.kg-1) stimulation of cardiopulmonary receptors would be enhanced during exercise. Rats were instrumented with arterial and venous catheters. The reflex response to mechanical (N = 7) and chemical (N = 8) stimulation of cardiopulmonary receptors was examined at rest and during exercise (6 m.min-1, 10% grade). A two-way analysis of covariance (ANCOVA) with repeated measures was used to test for differences in the reflex regulation of HR at rest vs exercise. HR was used as the covariate because exercise significantly increased baseline HR. There was no significant treatment effect (rest vs exercise) for the reflex inhibition of HR during mechanical stimulation. However, the two-way ANCOVA revealed a significant treatment effect (rest vs exercise) for the reflex inhibition of HR during chemical stimulation. The reflex decreases in HR were enhanced (-delta 23 +/- 8 vs -delta 133 +/- 47 and -delta 208 +/- 40 vs -delta 374 +/- 10 bpm at 2.5 and 5 micrograms.kg-1, respectively). These data suggest that factors associated with exercise enhanced the cardiopulmonary reflex inhibition of heart rate during chemical stimulation.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1249/00005768-199510000-00008" target="_blank" rel="noreferrer noopener">10.1249/00005768-199510000-00008</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1995
Afferent/drug effects/physiology
Analysis of Variance
Animals
Biguanides/pharmacology
Blood Pressure/drug effects/physiology
Blood Volume
Bradycardia/physiopathology
Chemical
Chen C Y
Collins H L
DiCarlo S E
Heart Rate/drug effects/*physiology
Heart/drug effects/*physiology
Hypoglycemic Agents/pharmacology
Lung/drug effects/*physiology
Medicine and science in sports and exercise
Neurons
Physical Exertion/*physiology
Physical Stimulation
Rats
Reflex/drug effects/*physiology
Rest
Stimulation
Sympathetic Nervous System/drug effects/physiology
Vagotomy
Vagus Nerve/drug effects/physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jappl.1993.75.1.114" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jappl.1993.75.1.114</a>
Pages
114–120
Issue
1
Volume
75
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Cardiac afferents attenuate the muscle metaboreflex in the rat.
Publisher
An entity responsible for making the resource available
Journal of applied physiology (Bethesda, Md. : 1985)
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-07
Subject
The topic of the resource
Afferent/drug effects/*physiology; Animals; Aorta/drug effects/physiology; Blood Pressure/drug effects/physiology; Blood Volume/drug effects/physiology; Heart Rate/drug effects/physiology; Heart/drug effects/*innervation/physiology; Muscles/drug effects/*metabolism; N-Methylscopolamine; Neurons; Parasympatholytics/pharmacology; Physical Exertion/physiology; Procainamide/pharmacology; Propranolol/pharmacology; Rats; Reflex/drug effects/*physiology; Scopolamine Derivatives/pharmacology; Specimen Handling
Creator
An entity primarily responsible for making the resource
Collins H L; DiCarlo S E
Description
An account of the resource
The influence of cardiac afferents on the muscle metaboreflex was examined in 16 rats instrumented with a Silastic-tipped catheter in the pericardial space and right atrium, Doppler ultrasonic flow probe and a pneumatic vascular occluder around the terminal aorta, and a Teflon catheter in the thoracic aorta. In protocol I (cardiac efferent and afferent blockade), the muscle metaboreflex was examined under three experimental conditions: 1) control, 2) cardiac autonomic efferent blockade [intrapericardial methylscopolamine (10 micrograms/kg) and propranolol (50 micrograms/kg)], and 3) combined cardiac autonomic efferent and afferent blockade (intrapericardial procainamide, 2%). In protocol II (blood volume expansion), the muscle metaboreflex was examined before and after 15% blood volume expansion. Mild treadmill exercise (9 m/min, 10% grade) increased heart rate (71 +/- 9.4 beats/min), mean arterial pressure (12 +/- 2.0 mmHg), and terminal aortic blood flow velocity (6 +/- 1.0 kHz). During exercise, a reduction of terminal aortic blood flow velocity (10.5 +/- 1.1%) reduced mixed venous PO2 18 +/- 6%. The gain of the muscle metaboreflex in the control condition was 14.6 +/- 2.9 mmHg/kHz. Efferent blockade reduced the gain 51 +/- 7%. However, combined cardiac efferent and afferent blockade increased the gain 207 +/- 64% above the efferent blocked condition and restored the gain to levels above those obtained in the control condition (18.3 +/- 4.6 mmHg/kHz). In addition, 15% blood volume expansion reduced the gain of the muscle metaboreflex regulation of mean arterial pressure and heart rate (44 +/- 9.5% and 41 +/- 12.0%, respectively). Thus cardiac afferents tonically inhibit the pressor response to a reduction in terminal aortic blood flow velocity during exercise.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jappl.1993.75.1.114" target="_blank" rel="noreferrer noopener">10.1152/jappl.1993.75.1.114</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1993
Afferent/drug effects/*physiology
Animals
Aorta/drug effects/physiology
Blood Pressure/drug effects/physiology
Blood Volume/drug effects/physiology
Collins H L
DiCarlo S E
Heart Rate/drug effects/physiology
Heart/drug effects/*innervation/physiology
Journal of applied physiology (Bethesda, Md. : 1985)
Muscles/drug effects/*metabolism
N-Methylscopolamine
Neurons
Parasympatholytics/pharmacology
Physical Exertion/physiology
Procainamide/pharmacology
Propranolol/pharmacology
Rats
Reflex/drug effects/*physiology
Scopolamine Derivatives/pharmacology
Specimen Handling
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0014-2999(91)90101-u" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0014-2999(91)90101-u</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
167-172
Issue
2
Volume
194
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The Local Monoaminergic Dependency Of Spinal Ketamine
Publisher
An entity responsible for making the resource available
European Journal of Pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-03
Subject
The topic of the resource
(intrathecal); 5-ht (5-hydroxytryptamine; analgesia; antinociception; cord; inhibition; ketamine; neurons; norepinephrine; opiate; opioid receptors; optical isomers; pharmacology; Pharmacology & Pharmacy; rat-brain; receptor; serotonin; tail-flick test
Creator
An entity primarily responsible for making the resource
Crisp T; Perrotti J M; Smith D L; Stafinsky J L; Smith D J
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0014-2999(91)90101-u" target="_blank" rel="noreferrer noopener">10.1016/0014-2999(91)90101-u</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
(intrathecal)
1991
5-ht (5-hydroxytryptamine
analgesia
antinociception
cord
Crisp T
European journal of pharmacology
inhibition
Ketamine
Neurons
Norepinephrine
opiate
opioid receptors
optical isomers
Perrotti J M
pharmacology
Pharmacology & Pharmacy
rat-brain
Receptor
serotonin
Smith D J
Smith D L
Stafinsky J L
tail-flick test
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
193-210
Issue
2
Volume
78
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Title
A name given to the resource
Kappa Agonist-induced Reduction In Dopamine Release - Site Of Action And Tolerance
Publisher
An entity responsible for making the resource available
Research Communications in Chemical Pathology and Pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-11
Subject
The topic of the resource
cortex; mu; neurons; opiate; opioid receptors; Pathology; Pharmacology & Pharmacy; rat-brain
Creator
An entity primarily responsible for making the resource
Donzanti B A; Althaus J S; Payson M M; Vonvoigtlander P F
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1992
Althaus J S
cortex
Donzanti B A
mu
Neurons
opiate
opioid receptors
Pathology
Payson M M
Pharmacology & Pharmacy
rat-brain
Research Communications in Chemical Pathology and Pharmacology
Vonvoigtlander P F
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0304-3940(89)90142-0" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0304-3940(89)90142-0</a>
Pages
75–79
Issue
1
Volume
97
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The re-expression of two myosin heavy chains in regenerated rat muscle spindles.
Publisher
An entity responsible for making the resource available
Neuroscience letters
Date
A point or period of time associated with an event in the lifecycle of the resource
1989
1989-02
Subject
The topic of the resource
Female; Animals; Immunohistochemistry; Rats; *Gene Expression Regulation; *Regeneration; Muscle Denervation; Myosins/*metabolism; Muscles/innervation/*metabolism; Neurons; Afferent/*physiology; Inbred F344
Creator
An entity primarily responsible for making the resource
Fei C; Walro J M
Description
An account of the resource
The vascular supply and tendons of the extensor digitorum longus (EDL) muscles of two adult rats were unilaterally severed and the muscles were allowed to regenerate for 40 days. Serial frozen sections of muscle grafts were cut and stained for enzymes that delineated fiber type, sensory endings and motor endings. MF30 and ALD58, two antibodies which react only to intrafusal fibers in normal rat muscle, were reacted against sections of nerve-intact muscle grafts. Data were compared to that from muscles of normal rats. Encapsulated fibers devoid of sensory innervation and some extrafusal fibers in muscle grafts had a weak to moderate reaction to MF30, but no reaction to ALD58. Regenerated, encapsulated fibers with sensory innervation bound both MF30 and ALD58. These data indicate that afferents which reinnervate regenerated spindles retain the capacity to induce expression of spindle-specific myosin isoforms in rats.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0304-3940(89)90142-0" target="_blank" rel="noreferrer noopener">10.1016/0304-3940(89)90142-0</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Gene Expression Regulation
*Regeneration
1989
Afferent/*physiology
Animals
Fei C
Female
Immunohistochemistry
Inbred F344
Muscle Denervation
Muscles/innervation/*metabolism
Myosins/*metabolism
Neurons
Neuroscience letters
Rats
Walro J M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0887-2333(92)90088-9" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0887-2333(92)90088-9</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
77-87
Issue
1
Volume
6
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The Invitro Hippocampal Slice Preparation As A Screen For Neurotoxicity
Publisher
An entity responsible for making the resource available
Toxicology in Vitro
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-01
Subject
The topic of the resource
area ca1; brain; long-term potentiation; memory; metabolite; mptp; neurons; pyramidal cells-invitro; synaptic transmission; Toxicology; trimethyltin
Creator
An entity primarily responsible for making the resource
Fountain S B; Ting Y L T; Teyler T J
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0887-2333(92)90088-9" target="_blank" rel="noreferrer noopener">10.1016/0887-2333(92)90088-9</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1992
area ca1
Brain
Fountain S B
Long-Term Potentiation
Memory
metabolite
MPTP
Neurons
pyramidal cells-invitro
Synaptic Transmission
Teyler T J
Ting Y L T
Toxicology
Toxicology in Vitro
Trimethyltin
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0051646" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0051646</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
18-18
Issue
12
Volume
7
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Processing Of Communication Calls In Guinea Pig Auditory Cortex
Publisher
An entity responsible for making the resource available
Plos One
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-12
Subject
The topic of the resource
Acoustic noise; Action potentials; Anesthesia; Auditory cortex; Brain research; Broadband; Communication; conspecific; Auditory cortex; Cortex (temporal); cortical discrimination; Councils; functional specialization; Guinea pigs; Localization; Macaque; Medical research; Monkeys; neural representation; Neurobiology; neurons; Neurosciences; Ohio; purr call; rhesus-monkey; Saimiri; Science & Technology - Other Topics; Sciences: Comprehensive Works; single neurons; social vocalizations; Sound; species-specific vocalizations; squirrel-monkeys; Stimuli; United Kingdom--UK; Urethane; Vocalization; vocalizations
Creator
An entity primarily responsible for making the resource
Grimsley J M S; Shanbhag S J; Palmer A R; Wallace M N
Description
An account of the resource
Vocal communication is an important aspect of guinea pig behaviour and a large contributor to their acoustic environment. We postulated that some cortical areas have distinctive roles in processing conspecific calls. In order to test this hypothesis we presented exemplars from all ten of their main adult vocalizations to urethane anesthetised animals while recording from each of the eight areas of the auditory cortex. We demonstrate that the primary area (AI) and three adjacent auditory belt areas contain many units that give isomorphic responses to vocalizations. These are the ventrorostral belt (VRB), the transitional belt area (T) that is ventral to AI and the small area (area S) that is rostral to AI. Area VRB has a denser representation of cells that are better at discriminating among calls by using either a rate code or a temporal code than any other area. Furthermore, 10% of VRB cells responded to communication calls but did not respond to stimuli such as clicks, broadband noise or pure tones. Area S has a sparse distribution of call responsive cells that showed excellent temporal locking, 31% of which selectively responded to a single call. AI responded well to all vocalizations and was much more responsive to vocalizations than the adjacent dorsocaudal core area. Areas VRB, AI and S contained units with the highest levels of mutual information about call stimuli. Area T also responded well to some calls but seems to be specialized for low sound levels. The two dorsal belt areas are comparatively unresponsive to vocalizations and contain little information about the calls. AI projects to areas S, VRB and T, so there may be both rostral and ventral pathways for processing vocalizations in the guinea pig.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0051646" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0051646</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2012
Acoustic noise
Action Potentials
Anesthesia
auditory cortex
Brain research
Broadband
Communication
conspecific
Cortex (temporal)
cortical discrimination
Councils
functional specialization
Grimsley J M S
Guinea Pigs
Journal Article or Conference Abstract Publication
localization
Macaque
MEDICAL research
monkeys
neural representation
Neurobiology
Neurons
Neurosciences
Ohio
Palmer A R
PloS one
purr call
rhesus-monkey
saimiri
Science & Technology - Other Topics
Sciences: Comprehensive Works
Shanbhag S J
single neurons
social vocalizations
Sound
species-specific vocalizations
squirrel-monkeys
Stimuli
United Kingdom--UK
Urethane
Vocalization
vocalizations
Wallace M N
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/syn.890150207" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/syn.890150207</a>
Pages
149–157
Issue
2
Volume
15
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Presynaptic mechanism for heterosynaptic, posttetanic depression in area CA1 of rat hippocampus.
Publisher
An entity responsible for making the resource available
Synapse (New York, N.Y.)
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-10
Subject
The topic of the resource
Afferent/drug effects; Animals; Electric Stimulation; Electrophysiology; Evoked Potentials/physiology; Glutamate/drug effects; Glutamates/pharmacology; Glutamic Acid; Hippocampus/drug effects/*physiology; In Vitro Techniques; Membrane Potentials/physiology; N-Methyl-D-Aspartate/antagonists & inhibitors; Neuronal Plasticity/drug effects/physiology; Neurons; Presynaptic/drug effects/*physiology; Pyramidal Cells/drug effects; Rats; Receptors; Synapses/drug effects/*physiology
Creator
An entity primarily responsible for making the resource
Grover L M; Teyler T J
Description
An account of the resource
Conditioning stimulation applied to afferent fibers in stratum radiatum or stratum oriens of hippocampal area CA1 produced heterosynaptic, posttetanic depression (PTD) of excitatory postsynaptic potentials (EPSPs). PTD amounted to a
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/syn.890150207" target="_blank" rel="noreferrer noopener">10.1002/syn.890150207</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1993
Afferent/drug effects
Animals
Electric Stimulation
Electrophysiology
Evoked Potentials/physiology
Glutamate/drug effects
Glutamates/pharmacology
Glutamic Acid
Grover L M
Hippocampus/drug effects/*physiology
In Vitro Techniques
Membrane Potentials/physiology
N-Methyl-D-Aspartate/antagonists & inhibitors
Neuronal Plasticity/drug effects/physiology
Neurons
Presynaptic/drug effects/*physiology
Pyramidal Cells/drug effects
Rats
Receptors
Synapse (New York, N.Y.)
Synapses/drug effects/*physiology
Teyler T J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0304-3940(93)90166-i" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0304-3940(93)90166-i</a>
Pages
39–42
Issue
1
Volume
154
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Role of adenosine in heterosynaptic, posttetanic depression in area CA1 of hippocampus.
Publisher
An entity responsible for making the resource available
Neuroscience letters
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-05
Subject
The topic of the resource
Adenosine/*physiology; Afferent/drug effects/physiology; Animals; Dendrites/drug effects/physiology; Electric Stimulation; Evoked Potentials/drug effects/physiology; Hippocampus/cytology/drug effects/*physiology; In Vitro Techniques; Neuronal Plasticity/drug effects/physiology; Neurons; Purinergic Antagonists; Rats; Synapses/drug effects/*physiology; Synaptic Transmission/drug effects/physiology; Theophylline/analogs & derivatives/pharmacology; Xanthines/pharmacology
Creator
An entity primarily responsible for making the resource
Grover L M; Teyler T J
Description
An account of the resource
Conditioning stimulation of afferent fibers in hippocampal area CA1 produced heterosynaptic, posttetanic depression (PTD) of responses evoked by stimulation of an independent set of afferent fibers. PTD was present within 5 s of conditioning stimulation, amounted to a 60-80% reduction of excitatory postsynaptic potentials (EPSPs), and required a period of 3-5 min for recovery. Antagonists of A1 adenosine receptors substantially reduced PTD. Adenosine released into, or formed in, the extracellular space during conditioning stimulation may diffuse within the slice to depress evoked release of glutamate.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0304-3940(93)90166-i" target="_blank" rel="noreferrer noopener">10.1016/0304-3940(93)90166-i</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1993
Adenosine/*physiology
Afferent/drug effects/physiology
Animals
Dendrites/drug effects/physiology
Electric Stimulation
Evoked Potentials/drug effects/physiology
Grover L M
Hippocampus/cytology/drug effects/*physiology
In Vitro Techniques
Neuronal Plasticity/drug effects/physiology
Neurons
Neuroscience letters
Purinergic Antagonists
Rats
Synapses/drug effects/*physiology
Synaptic Transmission/drug effects/physiology
Teyler T J
Theophylline/analogs & derivatives/pharmacology
Xanthines/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0006-8993(94)91421-4" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0006-8993(94)91421-4</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
37-48
Issue
1
Volume
635
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Laminar Pattern Of Synaptic Activity In Rat Primary Visual-cortex - Comparison Of In-vivo And In-vitro Studies Employing The Current Source Density Analysis
Publisher
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Brain Research
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-01
Subject
The topic of the resource
anuran cerebellum; area ca1; cerebral-cortex; connections; current source density; electrically evoked-potentials; electrophysiology; field; multiple unit-activity; neocortex; neurons; Neurosciences & Neurology; organization; potentials; rat; slice; striate cortex
Creator
An entity primarily responsible for making the resource
Kenanvaknin G; Teyler T J
Description
An account of the resource
In the present study we employed current source density analysis to study the major excitatory/inhibitory pathways in rat primary visual cortex in vivo and in vitro. A natural photic stimulus was used in vivo and served as a baseline for understanding the results obtained from in vivo and in vitro studies employing electrical stimulation of the white matter. The temporal pattern of synaptic activity in the cortex revealed an early excitation, characterized by sinks of short duration and high amplitude, that was followed by inhibition, characterized by long lasting, low amplitude active sources. The spatial pattern of this synaptic activity displayed early excitatory inputs to layer IV and lower layer III. Supragranular layers exhibited synaptic activity of longer latency at more superficial layers. The excitatory activity of the infragranular layers was delayed relative to that in layer IV. This spatial and temporal pattern of synaptic activity supports the model of sequential information processing in visual cortex. Based on the results of electrical and photic stimulations in vivo we conclude that electrical stimulation of white matter activate the thalamo-cortical input which results in a similar laminar pattern of postsynaptic activity evoked by photic stimulation. Electrical stimulation revealed additional antidromic and anti-orthodromic activity (collaterals of descending axons to white matter), resulting in the early fast components and the additional activity in layer VI. The major differences between in vivo and in vitro laminar pattern of synaptic activity (applying electrical stimulation) were reduced synaptic activity in layer IV and increased synaptic activity in the infragranular layers in the in vitro preparation. We concluded that the visual cortex slice preparation preserves the major pathways and electrophysiological function of this area. The technical advantages of the cortical slice preparation will facilitate studies and provide additional insight into this complex cortical network.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0006-8993(94)91421-4" target="_blank" rel="noreferrer noopener">10.1016/0006-8993(94)91421-4</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1994
anuran cerebellum
area ca1
Brain research
cerebral-cortex
connections
current source density
electrically evoked-potentials
Electrophysiology
field
Journal Article or Conference Abstract Publication
Kenanvaknin G
multiple unit-activity
neocortex
Neurons
Neurosciences & Neurology
organization
potentials
rat
slice
striate cortex
Teyler T J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.gene.2011.11.013" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.gene.2011.11.013</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
349-353
Issue
2
Volume
492
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Dublin Core
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Title
A name given to the resource
Evolutionary Changes Of The Importance Of Olfaction In Cetaceans Based On The Olfactory Marker Protein Gene
Publisher
An entity responsible for making the resource available
Gene
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-01
Subject
The topic of the resource
Aquatic adaptation; deletion causes; Echolocation; Eocene whale; Filter-feeder; Genetics & Heredity; india; marine mammals; neurons; nucleotide; OMP; sea; sequences; whales
Creator
An entity primarily responsible for making the resource
Kishida T; Thewissen J G M
Description
An account of the resource
Odontocetes and mysticetes are two extant suborders of cetaceans. It is reported that the former have no sense of olfaction, while the latter can smell in air. To explain the ecological reason why mysticetes still retain their sense of smell, two hypotheses have been proposed - the echolocation-priority hypothesis, which assumes that the acquisition of echolocation causes the reduction of the importance of olfaction, and the filter-feeder hypothesis, which assumes that olfactory ability is important for filter-feeders to locate their prey because clouds of plankton give off a peculiar odor. The olfactory marker protein (OMP) is almost exclusively expressed in vertebrate olfactory receptor neurons, and is considered to play important roles in olfactory systems. In this study, full-length open reading frames of OMP genes were identified in 6 cetacean species and we analyzed the nonsynonymous to synonymous substitution rate ratio based on the maximum likelihood method. The evolutionary changes of the selective pressures on OMP genes did fit better to the filter-feeder hypothesis than to the echolocation-priority hypothesis. In addition, no pseudogenization mutations are found in all five odontocetes OMP genes investigated in this study. It may suggest that OMP retains some function even in 'anosmic' odontocetes. (C) 2011 Elsevier B.V. All rights reserved.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.gene.2011.11.013" target="_blank" rel="noreferrer noopener">10.1016/j.gene.2011.11.013</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2012
Aquatic adaptation
deletion causes
Echolocation
Eocene whale
Filter-feeder
gene
Genetics & Heredity
India
Journal Article or Conference Abstract Publication
Kishida T
marine mammals
Neurons
nucleotide
OMP
SEA
sequences
Thewissen J G M
WHALES
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1097/00001756-199803300-00026" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/00001756-199803300-00026</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
905-909
Issue
5
Volume
9
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Dublin Core
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Title
A name given to the resource
Neurotrophin-3 And Trkc In Muscle Are Non-essential For The Development Of Mouse Muscle Spindles
Publisher
An entity responsible for making the resource available
Neuroreport
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1998-03
Subject
The topic of the resource
afferents; expression; growth factors; mice; muscle spindles; neonatal rats; neurons; Neurosciences & Neurology; neurotrophin-3; proprioception; transgenic mice; TrkC
Creator
An entity primarily responsible for making the resource
Kucera J; Fan G P; Walro J; Copray S; Tessarollo L; Jaenisch R
Description
An account of the resource
NEUROTROPHIN-3 (NT3) or TrkC null mutant mice were examined for the presence of muscle spindles. Muscles of mastication, but not limbs, contained spindles in newborn and adolescent mutants. The intramuscular distribution and morphological properties of spindles in mutant masticatory muscles were indistinguishable from those of wild-type spindles. Intrafusal fibers of NT3- or trkC-deficient spindles expressed the slow-tonic isoform of myosin heavy chains, characteristic of wild-type spindles. Sensory nerve endings were observed in spindles of mutants by electron microscopy. Thus, NT3 or trkC, which is expressed in wild-type spindles, may serve functions other than those related to spindle assembly. Presumably, proprioceptive neurons innervating jaw muscles are dependent on factors other than NT3 for survival and maintenance. (C) 1998 Rapid Science Ltd.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/00001756-199803300-00026" target="_blank" rel="noreferrer noopener">10.1097/00001756-199803300-00026</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1998
afferents
Copray S
expression
Fan G P
growth factors
Jaenisch R
Journal Article or Conference Abstract Publication
Kucera J
Mice
muscle spindles
neonatal rats
Neurons
Neuroreport
Neurosciences & Neurology
neurotrophin-3
proprioception
Tessarollo L
Transgenic mice
trkC
Walro J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/dvdy.20964" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/dvdy.20964</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
3039-3050
Issue
11
Volume
235
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Title
A name given to the resource
Neurotrophin-3 Ameliorates Sensory-motor Deficits In Er81-deficient Mice
Publisher
An entity responsible for making the resource available
Developmental Dynamics
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-11
Subject
The topic of the resource
afferents; Anatomy & Morphology; connections; Developmental Biology; differentiation; ER81; ETS; innervation; motor neurons; muscle spindles; muscle spindles; mutant mice; neurons; neurotrophins; NT3; rat; regeneration; sensory neurons; specification; spinal-cord; transcription factors
Creator
An entity primarily responsible for making the resource
Li L Y; Wang Z; Sedy J; Quazi R; Walro J M; Frank E; Kucera J
Description
An account of the resource
Two factors, the ETS transcription factor ER81 and skeletal muscle-derived neurotrophin-3 (NT3), are essential for the formation of muscle spindles and the function of spindle afferent-motoneuron synapses in the spinal cord. Spindles either degenerate completely or are abnormal, and spindle afferents fail to project to spinal motoneurons in Er81 null mice; however, the interactions between ER81 and NT3 during the processes of afferent neuron and muscle spindle development are poorly understood. To examine if overexpression of NT3 in muscle rescues spindles and afferent-motoneuron connectivity in the absence of ER81, we generated myoNT3;Er81(-/-) double-mutant mice that selectively overexpress NT3 in muscle in the absence of ER81. Spindle reflex arcs in myoNT3;Er81(-/-) mutants differed greatly from Er81 null mice. Muscle spindle densities were greater and more afferents projected into the ventral spinal cord in myoNT3;Er81(-/-) mice. Spindles of myoNT3,Er81(-/-) muscles responded normally to repetitive muscle taps, and the monosynaptic inputs from la afferents to motoneurons, grossly reduced in Er81(-/-) mutants, were restored to wild-type levels in myoNT3,Er81(-/-) mice. Thus, an excess of muscle-derived NT3 reverses deficits in spindle numbers and afferent function induced by the absence of ER81. We conclude that muscle-derived NT3 can modulate spindle density and afferent-motoneuron connectivity independently of ER81.
Identifier
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<a href="http://doi.org/10.1002/dvdy.20964" target="_blank" rel="noreferrer noopener">10.1002/dvdy.20964</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2006
afferents
Anatomy & Morphology
connections
Developmental Biology
Developmental Dynamics
differentiation
ER81
ETS
Frank E
innervation
Journal Article or Conference Abstract Publication
Kucera J
Li L Y
motor neurons
muscle spindles
mutant mice
Neurons
neurotrophins
NT3
Quazi R
rat
Regeneration
Sedy J
sensory neurons
specification
spinal-cord
Transcription Factors
Walro J M
Wang Z
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/jnr.490350207" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/jnr.490350207</a>
Pages
170–182
Issue
2
Volume
35
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Serotonin-activated alpha 2-macroglobulin inhibits neurite outgrowth and survival of embryonic sensory and cerebral cortical neurons.
Publisher
An entity responsible for making the resource available
Journal of neuroscience research
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-06
Subject
The topic of the resource
Afferent/drug effects/ultrastructure; alpha-Macroglobulins/metabolism/*pharmacology; Animals; Bovine/pharmacology; Cell Survival/drug effects; Cells; Chick Embryo; Cultured; Frontal Lobe/*cytology/embryology; Ganglia; Humans; Nerve Growth Factors/*antagonists & inhibitors/pharmacology; Neurites/drug effects/ultrastructure; Neurons; Neurons/*drug effects/ultrastructure; Protein Binding; Rats; Serotonin/metabolism/*pharmacology; Serum Albumin; Spinal/*cytology/embryology
Creator
An entity primarily responsible for making the resource
Liebl D J; Koo P H
Description
An account of the resource
Methylamine-modified alpha-2-macroglobulin (MA-alpha 2M) has been recently shown to inhibit the biological activity of beta-nerve growth factor (NGF) in promoting neurite outgrowth by embryonic dorsal root ganglia in culture (Koo PH, Liebl DJ, J Neurosci Res 31:678-692, 1992). The objectives of this study are to determine whether alpha 2M can also be modified by larger aromatic biogenic amines such as
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/jnr.490350207" target="_blank" rel="noreferrer noopener">10.1002/jnr.490350207</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1993
Afferent/drug effects/ultrastructure
alpha-Macroglobulins/metabolism/*pharmacology
Animals
Bovine/pharmacology
Cell Survival/drug effects
Cells
Chick Embryo
Cultured
Frontal Lobe/*cytology/embryology
Ganglia
Humans
Journal of neuroscience research
Koo P H
Liebl D J
Nerve Growth Factors/*antagonists & inhibitors/pharmacology
Neurites/drug effects/ultrastructure
Neurons
Neurons/*drug effects/ultrastructure
Protein Binding
Rats
Serotonin/metabolism/*pharmacology
Serum Albumin
Spinal/*cytology/embryology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s11064-011-0591-2" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s11064-011-0591-2</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
134-142
Issue
1
Volume
37
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Differential Effect Of Nimodipine In Attenuating Iron-induced Toxicity In Brain- And Blood-brain Barrier-associated Cell Types
Publisher
An entity responsible for making the resource available
Neurochemical Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-01
Subject
The topic of the resource
Astrocytes; Biochemistry & Molecular Biology; central-nervous-system; cerebrospinal-fluid; cultured astrocytes; intracerebral hemorrhage; Iron in brain; Metal toxicity; Neurodegenerative diseases; neurodegenerative disorders; neurons; Neurosciences & Neurology; Nimodipine; oxidative; parkinsons-disease; redox-active iron; stress; substantia-nigra; transferrin receptor; Vascular endothelial cells
Creator
An entity primarily responsible for making the resource
Lockman J A; Geldenhuys W J; Bohn K A; DeSilva S F; Allen D D; Van der Schyf C J
Description
An account of the resource
Metal homeostasis is increasingly being evaluated as a therapeutic target in stroke and neurodegenerative diseases. Metal dysregulation has been shown to lead to protein aggregation, plaque formation and neuronal death. In 2007, we first reported that voltage-gated calcium channels act as a facile conduit for the entry of free ferrous (Fe2+) ions into neurons. Herein, we evaluate differential iron toxicity to central nervous system cells and assess the ability of the typical L-type voltage-gated calcium channel blocker nimodipine to attenuate iron-induced toxicity. The data demonstrate that iron sulfate induces a dose-dependent decrease in cell viability in rat brain endothelial cells (RBE4; LC50 = 150 mu M), neuronal cells (Neuro-2 alpha neuroblastoma; LC50 = 400 mu M), and in astrocytes (DI TNC1; LC50 = 1.1 mM). Pre-treatment with nimodipine prior to iron sulfate exposure provided a significant (P < 0.05) increase in viable cell numbers for RBE4 (2.5-fold), Neuro2-alpha (similar to 2-fold), and nearly abolished toxicity in primary neurons. Astrocytes were highly resistant to iron toxicity compared to the other cell types tested and nimodipine had no (P > 0.05) protective effect in these cells. The data demonstrate variable susceptibility to iron overload conditions in different cell types of the brain and suggest that typical L-type voltage-gated calcium channel blockers (here represented by nimodipine), may serve as protective agents in conditions involving iron overload, particularly in cell types highly susceptible to iron toxicity.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s11064-011-0591-2" target="_blank" rel="noreferrer noopener">10.1007/s11064-011-0591-2</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2012
Allen D D
Astrocytes
Biochemistry & Molecular Biology
Bohn K A
central-nervous-system
cerebrospinal-fluid
cultured astrocytes
DeSilva S F
Geldenhuys W J
intracerebral hemorrhage
Iron in brain
Journal Article or Conference Abstract Publication
Lockman J A
Metal toxicity
Neurochemical Research
Neurodegenerative Diseases
neurodegenerative disorders
Neurons
Neurosciences & Neurology
nimodipine
oxidative
parkinsons-disease
redox-active iron
Stress
substantia-nigra
transferrin receptor
Van der Schyf C J
Vascular endothelial cells
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0014-2999(92)90390-p" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0014-2999(92)90390-p</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
337-341
Issue
3
Volume
211
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The Actions Of 3-aminopropanephosphinic Acid At Gaba(b) Receptors In Rat Hippocampus
Publisher
An entity responsible for making the resource available
European Journal of Pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-02
Subject
The topic of the resource
2-hydroxy-saclofen; b receptors; baclofen; brain slices; ca3 pyramidal cells; excitatory transmission; gaba(b) receptors (postsynaptic); gaba(b) receptors (presynaptic); inhibitory transmission; in-vitro; neurons; patch; Pharmacology & Pharmacy; potent; slice recording; synapses; transmission
Creator
An entity primarily responsible for making the resource
Lovinger D M; Harrison N L; Lambert N A
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0014-2999(92)90390-p" target="_blank" rel="noreferrer noopener">10.1016/0014-2999(92)90390-p</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1992
2-hydroxy-saclofen
b receptors
baclofen
brain slices
ca3 pyramidal cells
European journal of pharmacology
excitatory transmission
gaba(b) receptors (postsynaptic)
gaba(b) receptors (presynaptic)
Harrison N L
in-vitro
inhibitory transmission
Lambert N A
Lovinger D M
Neurons
patch
Pharmacology & Pharmacy
potent
slice recording
synapses
Transmission
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1177/002215540405201001" target="_blank" rel="noreferrer noopener">http://doi.org/10.1177/002215540405201001</a>
Pages
1249–1258
Issue
10
Volume
52
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The role of sensory neurons in cervical ripening: effects of estrogen and neuropeptides.
Publisher
An entity responsible for making the resource available
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004-10
Subject
The topic of the resource
Afferent/metabolism/*physiology; Cervical Ripening/*physiology; Cervix Uteri/innervation; Estrogen/physiology; Estrogens/*physiology; Female; Ganglia; Humans; Neurons; Neuropeptides/biosynthesis/*physiology; Pregnancy; Receptors; Spinal/physiology
Creator
An entity primarily responsible for making the resource
Mowa C N; Papka R E
Description
An account of the resource
Central nervous system nuclei and circuits, such as the medial preoptic, ventromedial and paraventricular nuclei of the hypothalamus, play important roles in reproduction and parturition, and are influenced by estrogen. Peripheral autonomic and sensory neurons also play important roles in pregnancy and parturition. Moreover, the steroid hormone estrogen acts directly, not only on the reproductive tract organs (uterus and cervix), but also on the central and peripheral nerves by regulating expression of various neuronal genes. The peripheral primary afferent neurons innervating the uterine cervix relay mechanical and biochemical sensory information induced by local cervical events and by passage of fetuses, to the spinal cord and supraspinal centers. Consequently, the birth process in mammals is influenced by the combined action of neurons and hormones. Peripheral sensory stimuli, induced physiologically by fetal expulsion or mechanically by vaginocervical stimulation, alter behavior, as well as autonomic and neuroendocrine systems. Recent evidence indicates that primary afferent neurons innervating the cervix, in addition to their sensory effects, likely exert local "efferent" actions on the ripening cervix near term. These efferent effects may involve estrogen-regulated production of such neuropeptides as substance P and calcitonin gene-related peptide in lumbosacral dorsal root ganglia, and their release in the cervix. Collectively, these findings suggest an interrelationship among estrogen, cervix-related sensory neurons, and local cervical events near term.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1177/002215540405201001" target="_blank" rel="noreferrer noopener">10.1177/002215540405201001</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2004
Afferent/metabolism/*physiology
Cervical Ripening/*physiology
Cervix Uteri/innervation
Estrogen/physiology
Estrogens/*physiology
Female
Ganglia
Humans
Mowa C N
Neurons
Neuropeptides/biosynthesis/*physiology
Papka R E
Pregnancy
Receptors
Spinal/physiology
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0196-9781(03)00120-7" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0196-9781(03)00120-7</a>
Pages
761–771
Issue
5
Volume
24
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Substance P in the uterine cervix, dorsal root ganglia and spinal cord during pregnancy and the effect of estrogen on SP synthesis.
Publisher
An entity responsible for making the resource available
Peptides
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
2003-05
Subject
The topic of the resource
Afferent/metabolism; Animals; Cervix Uteri/cytology/*metabolism; Down-Regulation; Estradiol/*analogs & derivatives/pharmacology; Estrogen/antagonists & inhibitors; Estrogens/*pharmacology; Female; Fulvestrant; Ganglia; Immunohistochemistry; In Situ Hybridization; Messenger/genetics/metabolism; Neurons; Postpartum Period; Pregnancy/*metabolism; Radioimmunoassay; Rats; Receptors; Reverse Transcriptase Polymerase Chain Reaction; RNA; Spinal Cord/cytology/*metabolism; Spinal/cytology/*metabolism; Sprague-Dawley; Substance P/*biosynthesis/genetics/metabolism; Up-Regulation
Creator
An entity primarily responsible for making the resource
Mowa C N; Usip S; Storey-Workley M; Amann R; Papka R
Description
An account of the resource
Prior to parturition the non-pliable uterine cervix undergoes a ripening process ("softens" and dilates) to allow a timely passage of the fetus at term. The exact mechanism(s) triggering and involved in cervical ripening are unknown, though evidence for a role for sensory neurons and their contained neuropeptides is emerging. Moreover, an apparent increase in neuropeptide immunoreactive nerves occurs in the cervix during pregnancy, maternal serum estrogen levels rise at term and uterine cervix-related L6-S1 dorsal root ganglia (DRG) sensory neurons express estrogen receptor (ER) and neuropeptides. Thus, we sought to test the hypothesis that the neuropeptide substance P (SP) changes biosynthesis and release over pregnancy, that estrogen, acting via the ER pathway, increases synthesis of SP in DRG, and that SP is utilized in cervical ripening at late pregnancy. Using immunohistochemistry, in situ hybridization, reverse transcriptase-polymerase chain reaction (RT-PCR) and radioimmunoassay (RIA), we investigated coexpression of ER-alpha/beta and SP; differential expression of
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0196-9781(03)00120-7" target="_blank" rel="noreferrer noopener">10.1016/s0196-9781(03)00120-7</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2003
Afferent/metabolism
Amann R
Animals
Cervix Uteri/cytology/*metabolism
Department of Anatomy & Neurobiology
Down-Regulation
Estradiol/*analogs & derivatives/pharmacology
Estrogen/antagonists & inhibitors
Estrogens/*pharmacology
Female
Fulvestrant
Ganglia
Immunohistochemistry
In Situ Hybridization
Messenger/genetics/metabolism
Mowa C N
NEOMED College of Medicine
Neurons
Papka R
Peptides
Postpartum Period
Pregnancy/*metabolism
Radioimmunoassay
Rats
Receptors
Reverse Transcriptase Polymerase Chain Reaction
RNA
Spinal Cord/cytology/*metabolism
Spinal/cytology/*metabolism
Sprague-Dawley
Storey-Workley M
Substance P/*biosynthesis/genetics/metabolism
Up-Regulation
Usip S
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.01148.2005" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.01148.2005</a>
Pages
2179–2192
Issue
4
Volume
95
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Roles of inhibition in complex auditory responses in the inferior colliculus: inhibited combination-sensitive neurons.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-04
Subject
The topic of the resource
Acoustic Stimulation; Action Potentials/drug effects/physiology; Afferent/drug effects/*physiology; Animals; Auditory; Auditory Pathways/drug effects/*physiology; Bicuculline/pharmacology; Brain Stem/drug effects/*physiology; Chiroptera; Electrophysiology; Evoked Potentials; GABA-A Receptor Antagonists; GABA-A/physiology; Glycine/antagonists & inhibitors/physiology; Inferior Colliculi/*physiology; Neural Inhibition/drug effects/*physiology; Neurons; Receptors; Strychnine/pharmacology
Creator
An entity primarily responsible for making the resource
Nataraj Kiran; Wenstrup Jeffrey J
Description
An account of the resource
We studied the functional properties and underlying neural mechanisms associated with inhibitory combination-sensitive neurons in the mustached bat's inferior colliculus (IC). In these neurons, the excitatory response to best frequency tones was suppressed by lower frequency signals (usually in the range of 12-30 kHz) in a time-dependant manner. Of 143 inhibitory units, the majority (71%) were type I, in which low-frequency sounds evoked inhibition only. In the remainder, however, the low-frequency inhibitory signal also evoked excitation. Of these, excitation preceded the inhibition in type E/I units (16%), whereas in type I/E units (13%), excitation followed the inhibition. Type E/I and I/E units were distinct in the tuning and threshold sensitivity of low-frequency responses, whereas type I units overlapped the other types in these features. In 71 neurons, antagonists to receptors for glycine [strychnine (STRY)] or GABA [bicuculline (BIC)] were applied microiontophoretically. These antagonists failed to eliminate combination-sensitive inhibition in 92% (STRY), 93% (BIC), and 87% (BIC + STRY) of the type I units tested. However, inhibition was reduced in many neurons. Results were similar for type E/I and I/E inhibitory neurons. The results indicate that there are distinct populations of combination-sensitive inhibited neurons in the IC and that these populations are at least partly independent of glycine or GABAA receptors in the IC. We propose that these populations originate in different brain stem auditory nuclei, that they may be modified by interactions within the IC, and that they may perform different spectrotemporal analyses of vocal signals.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jn.01148.2005" target="_blank" rel="noreferrer noopener">10.1152/jn.01148.2005</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2006
Acoustic Stimulation
Action Potentials/drug effects/physiology
Afferent/drug effects/*physiology
Animals
Auditory
Auditory Pathways/drug effects/*physiology
Bicuculline/pharmacology
Brain Stem/drug effects/*physiology
Chiroptera
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Electrophysiology
Evoked Potentials
GABA-A Receptor Antagonists
GABA-A/physiology
Glycine/antagonists & inhibitors/physiology
Inferior Colliculi/*physiology
Journal of neurophysiology
Nataraj Kiran
NEOMED College of Medicine
Neural Inhibition/drug effects/*physiology
Neurons
Receptors
Strychnine/pharmacology
Wenstrup Jeffrey J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/jnr.10421" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/jnr.10421</a>
Pages
808–816
Issue
6
Volume
70
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Estrogen receptor-alpha and neural circuits to the spinal cord during pregnancy.
Publisher
An entity responsible for making the resource available
Journal of neuroscience research
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002-12
Subject
The topic of the resource
Afferent/*metabolism; Animal/*physiology; Animals; Autonomic/anatomy & histology/metabolism; Blotting; Estrogen Receptor alpha; Estrogen/*biosynthesis; Estrogens/*physiology; Female; Ganglia; Immunohistochemistry; Neurons; Parturition/physiology; Pregnancy; Proto-Oncogene Proteins c-fos/*biosynthesis; Rats; Receptors; Sensory/anatomy & histology/metabolism; Spinal Cord/anatomy & histology/metabolism; Sprague-Dawley; Time Factors; Uterus/innervation; Western
Creator
An entity primarily responsible for making the resource
Papka R E; Hafemeister J; Puder B A; Usip S; Storey-Workley M
Description
An account of the resource
Estrogen receptor immunoreactivity and mRNAs are present in spinal cord neurons in locations that are associated with sensory and autonomic innervation of female reproductive organs. The present study was undertaken to examine the expression of estrogen receptor-alpha in the spinal cord during different stages of pregnancy and to determine whether estrogen receptor-alpha-expressing neurons are related to uterine afferent nerves bringing information to the spinal cord at parturition. Immunohistochemistry showed estrogen receptor-alpha-immunoreactive neurons in the dorsal one-half of the spinal cord, i.e., dorsal horn, dorsal intermediate gray areas (dorsal commissural nucleus), and around the central canal and sacral parasympathetic autonomic nucleus of the lumbosacral spinal cord. Neurons in these areas corresponded topographically to the distribution of central processes of visceral primary afferent neurons (e.g., containing calcitonin gene-related peptide and substance P) that innervate and activate second-order spinal cord neurons (evidenced by their expression of Fos) at parturition. Western blots showed that estrogen receptor-alpha increases in the spinal cord, with a peak at day 20 of gestation, followed by a slight decrease by 2 days postpartum. These studies show that estrogen receptor-alpha is expressed by neurons in autonomic and sensory areas of the lumbosacral spinal cord that have connections with the female reproductive system and that the level of estrogen receptor-alpha changes over the course of pregnancy, which may follow profiles of steroid hormones. Many of these neurons may be involved in processing information related to reproductive organ function, changes during pregnancy, and relays to other CNS centers.
Identifier
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<a href="http://doi.org/10.1002/jnr.10421" target="_blank" rel="noreferrer noopener">10.1002/jnr.10421</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2002
Afferent/*metabolism
Animal/*physiology
Animals
Autonomic/anatomy & histology/metabolism
Blotting
Department of Anatomy & Neurobiology
Estrogen Receptor alpha
Estrogen/*biosynthesis
Estrogens/*physiology
Female
Ganglia
Hafemeister J
Immunohistochemistry
Journal of neuroscience research
NEOMED College of Medicine
Neurons
Papka R E
Parturition/physiology
Pregnancy
Proto-Oncogene Proteins c-fos/*biosynthesis
Puder B A
Rats
Receptors
Sensory/anatomy & histology/metabolism
Spinal Cord/anatomy & histology/metabolism
Sprague-Dawley
Storey-Workley M
Time Factors
Usip S
Uterus/innervation
Western
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
71–74
Issue
2
Volume
319
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Estrogen receptor-alpha and -beta coexist in a subpopulation of sensory neurons of female rat dorsal root ganglia.
Publisher
An entity responsible for making the resource available
Neuroscience letters
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002-02
Subject
The topic of the resource
Female; Animals; Rats; Cell Count; *Sex Characteristics; Fluorescent Antibody Technique; Estrous Cycle/*physiology; Estrogen Receptor alpha; Cell Nucleus/metabolism/ultrastructure; Estrogen Receptor beta; Estrogens/*metabolism; Ganglia; Neurons; Sprague-Dawley; Receptors; Spinal/cytology/*metabolism; Genitalia; Estrogen/*metabolism; Afferent/cytology/*metabolism; Female/innervation
Creator
An entity primarily responsible for making the resource
Papka Raymond E; Storey-Workley Megan
Description
An account of the resource
Immunoreactivities for estrogen receptor-alpha (ER-alpha) and ER-beta are expressed in sensory neurons of the dorsal root ganglia (DRG). It has not been established, however, if the two receptor subtypes coexist in the same neuron. Double-staining immunohistochemical techniques were used to determine if subpopulations of neurons in the lumbosacral DRG exist based on their content of ERs. Results indicate that some neurons (approximately 17%) of the L6-S1 DRG contain ER-alpha -, some (approximately 23%) contain ER-beta - immunoreactivity and some (approximately 5%) express immunoreactivity for both subtypes of the ER. These results suggest that many sensory neurons can respond to estrogens, but estrogens may produce different morphofunctional effects in different neurons based on their expression of ER subtypes.
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Sex Characteristics
2002
Afferent/cytology/*metabolism
Animals
Cell Count
Cell Nucleus/metabolism/ultrastructure
Estrogen Receptor alpha
Estrogen Receptor beta
Estrogen/*metabolism
Estrogens/*metabolism
Estrous Cycle/*physiology
Female
Female/innervation
Fluorescent Antibody Technique
Ganglia
Genitalia
Neurons
Neuroscience letters
Papka Raymond E
Rats
Receptors
Spinal/cytology/*metabolism
Sprague-Dawley
Storey-Workley Megan
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.90390.2008" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.90390.2008</a>
Pages
629–645
Issue
2
Volume
100
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Intracellular recordings from combination-sensitive neurons in the inferior colliculus.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
2008-08
Subject
The topic of the resource
Acoustic Stimulation/methods; Afferent/classification/*physiology; Animals; Auditory/physiology; Biological; Chiroptera; Evoked Potentials; Inferior Colliculi/*cytology; Membrane Potentials/physiology/radiation effects; Models; Neural Inhibition/*physiology; Neural Pathways/physiology; Neurons; Psychophysics; Reaction Time; Wakefulness
Creator
An entity primarily responsible for making the resource
Peterson Diana Coomes; Voytenko Sergiy; Gans Donald; Galazyuk Alexander; Wenstrup Jeffrey
Description
An account of the resource
In vertebrate auditory systems, specialized combination-sensitive neurons analyze complex vocal signals by integrating information across multiple frequency bands. We studied combination-sensitive interactions in neurons of the inferior colliculus (IC) of awake mustached bats, using intracellular somatic recording with sharp electrodes. Facilitated combinatorial neurons are coincidence detectors, showing maximum facilitation when excitation from low- and high-frequency stimuli coincide. Previous work showed that facilitatory interactions originate in the IC, require both low and high frequency-tuned glycinergic inputs, and are independent of glutamatergic inputs. These results suggest that glycinergic inputs evoke facilitation through either postinhibitory rebound or direct depolarizing mechanisms. However, in 35 of 36 facilitated neurons, we observed no evidence of low frequency-evoked transient hyperpolarization or depolarization that was closely related to response facilitation. Furthermore, we observed no evidence of shunting inhibition that might conceal inhibitory inputs. Since these facilitatory interactions originate in IC neurons, the results suggest that inputs underlying facilitation are electrically segregated from the soma. We also recorded inhibitory combinatorial interactions, in which low frequency sounds suppress responses to higher frequency signals. In 43% of 118 neurons, we observed low frequency-evoked hyperpolarizations associated with combinatorial inhibition. For these neurons, we conclude that low frequency-tuned inhibitory inputs terminate on neurons primarily excited by high-frequency signals; these inhibitory inputs may create or enhance inhibitory combinatorial interactions. In the remainder of inhibited combinatorial neurons (57%), we observed no evidence of low frequency-evoked hyperpolarizations, consistent with observations that inhibitory combinatorial responses may originate in lateral lemniscal nuclei.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jn.90390.2008" target="_blank" rel="noreferrer noopener">10.1152/jn.90390.2008</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2008
Acoustic Stimulation/methods
Afferent/classification/*physiology
Animals
Auditory/physiology
Biological
Chiroptera
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Evoked Potentials
Galazyuk Alexander
Gans Donald
Inferior Colliculi/*cytology
Journal of neurophysiology
Membrane Potentials/physiology/radiation effects
Models
NEOMED College of Medicine
Neural Inhibition/*physiology
Neural Pathways/physiology
Neurons
Peterson Diana Coomes
Psychophysics
Reaction Time
Voytenko Sergiy
Wakefulness
Wenstrup Jeffrey
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neurobiolaging.2019.04.007" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neurobiolaging.2019.04.007</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
99-110
Volume
80
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
GABAergic and glutamatergic cells in the inferior colliculus dynamically express the GABA(A)R gamma(1) subunit during aging
Publisher
An entity responsible for making the resource available
Neurobiology of Aging
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-08
Subject
The topic of the resource
Age-related hearing loss; age-related-changes; amino-acids; auditory-cortex; binding; brain; fischer-344 rat; GABA(A) receptor; GABA(A)R gamma(1) subunit; GABAergic; Geriatrics & Gerontology; Glutamatergic; glutamic-acid decarboxylase; hearing-loss; Inferior colliculus; Neurons; Neurosciences & Neurology; primary; receptive-fields
Creator
An entity primarily responsible for making the resource
Robinson L C; Barat O; Mellott J G
Description
An account of the resource
Age-related hearing loss may result, in part, from declining levels of gamma-amino butyric acid (GABA) in the aging inferior colliculus (IC). An upregulation of the GABA(A)R gamma(1) subunit, which has been shown to increase sensitivity to GABA, occurs in the aging IC. We sought to determine whether the upregulation of the GABA(A)R gamma(1) subunit was specific to GABAergic or glutamatergic IC cells. We used immunohistochemistry for glutamic acid decarboxylase and the GABA(A)R gamma(1) subunit at 4 age groups in the IC of Fisher Brown Norway rats. The percentage of somas that expressed the gamma(1) subunit and the number of subunits on each soma were quantified. Our results show that GABAergic and glutamatergic IC cells increasingly expressed the gamma(1) subunit from young age until expression peaked during middle age. At old age (similar to 77% of life span), the number of GABA(A)R gamma(1) subunits per cell sharply decreased for both cell types. These results, along with previous studies, suggest inhibitory and excitatory IC circuits may express the GABA(A)R gamma(1) subunit in response to the age-related decline of available GABA. Published by Elsevier Inc.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.neurobiolaging.2019.04.007" target="_blank" rel="noreferrer noopener">10.1016/j.neurobiolaging.2019.04.007</a>
2019
Age-related hearing loss
age-related-changes
amino-acids
auditory-cortex
Barat O
Binding
Brain
Department of Anatomy & Neurobiology
fischer-344 rat
GABA(A) receptor
GABA(A)R gamma(1) subunit
GABAergic
Geriatrics & Gerontology
Glutamatergic
glutamic-acid decarboxylase
hearing-loss
inferior colliculus
Mellott J G
NEOMED College of Medicine
Neurobiology of aging
Neurons
Neurosciences & Neurology
primary
receptive-fields
Robinson L C
September 2019 Update
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0041514" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0041514</a>
Pages
e41514–e41514
Issue
7
Volume
7
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Diminished behavioral and neural sensitivity to sound modulation is associated with moderate developmental hearing loss.
Publisher
An entity responsible for making the resource available
PloS one
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
1905-7
Subject
The topic of the resource
Female; Male; Animals; Gerbillinae; *Attention; *Behavior; Neurons; Animal; Hearing Loss; Afferent/pathology; Conductive/pathology/*physiopathology
Creator
An entity primarily responsible for making the resource
Rosen Merri J; Sarro Emma C; Kelly Jack B; Sanes Dan H
Description
An account of the resource
The acoustic rearing environment can alter central auditory coding properties, yet altered neural coding is seldom linked with specific deficits to adult perceptual skills. To test whether developmental hearing loss resulted in comparable changes to perception and sensory coding, we examined behavioral and neural detection thresholds for sinusoidally amplitude modulated (sAM) stimuli. Behavioral sAM detection thresholds for slow (5 Hz) modulations were significantly worse for animals reared with bilateral conductive hearing loss (CHL), as compared to controls. This difference could not be attributed to hearing thresholds, proficiency at the task, or proxies for attention. Detection thresholds across the groups did not differ for fast (100 Hz) modulations, a result paralleling that seen in humans. Neural responses to sAM stimuli were recorded in single auditory cortex neurons from separate groups of awake animals. Neurometric analyses indicated equivalent thresholds for the most sensitive neurons, but a significantly poorer detection threshold for slow modulations across the population of CHL neurons as compared to controls. The magnitude of the neural deficit matched that of the behavioral differences, suggesting that a reduction of sensory information can account for limitations to perceptual skills.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0041514" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0041514</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Attention
*Behavior
2012
Afferent/pathology
Animal
Animals
Conductive/pathology/*physiopathology
Department of Anatomy & Neurobiology
Female
Gerbillinae
Hearing Loss
Kelly Jack B
Male
NEOMED College of Medicine
Neurons
PloS one
Rosen Merri J
Sanes Dan H
Sarro Emma C
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.heares.2006.01.004" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.heares.2006.01.004</a>
Pages
81–89
Volume
216-217
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Pathways from auditory cortex to the cochlear nucleus in guinea pigs.
Publisher
An entity responsible for making the resource available
Hearing research
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-07
Subject
The topic of the resource
Animals; Auditory Cortex/*anatomy & histology/physiology; Auditory Pathways/anatomy & histology/physiology; Axons/physiology/ultrastructure; Cochlear Nucleus/*anatomy & histology/physiology; Efferent Pathways/*anatomy & histology/physiology; Efferent/physiology; Fluorescence; Fluorescent Dyes; Guinea Pigs; Inferior Colliculi/*anatomy & histology/physiology; Microscopy; Neurons; Olivary Nucleus/*anatomy & histology/physiology
Creator
An entity primarily responsible for making the resource
Schofield Brett R; Coomes Diana L
Description
An account of the resource
The inferior colliculus (IC) and superior olivary complex (SOC) are important sources of descending pathways to the cochlear nucleus. The IC and SOC are also targets of direct projections from the auditory cortex but it is not known if cortical axons contact the cells that project to the cochlear nucleus. Multi-labeling techniques were used to address this question in guinea pigs. A fluorescent anterograde tracer was injected into temporal cortex to label corticofugal axons. Different fluorescent tracers were injected into one or both cochlear nuclei to label olivary and collicular cells. The brain was subsequently processed for fluorescence microscopy and the IC and SOC were examined for apparent contacts between cortical axons and retrogradely labeled cells. The results suggest that cortical axons contact cochlear nucleus-projecting cells in both IC and SOC. In both regions, contacts were more numerous on the side ipsilateral to the injected cortex. In the IC, the contacted cells projected ipsilaterally or contralaterally to the CN. In the SOC, the contacted cells projected ipsilaterally, contralaterally or bilaterally to the CN. We conclude that auditory cortex is in a position to modulate descending pathways from both the IC and SOC to the cochlear nucleus.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.heares.2006.01.004" target="_blank" rel="noreferrer noopener">10.1016/j.heares.2006.01.004</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2006
Animals
Auditory Cortex/*anatomy & histology/physiology
Auditory Pathways/anatomy & histology/physiology
Axons/physiology/ultrastructure
Cochlear Nucleus/*anatomy & histology/physiology
Coomes Diana L
Department of Anatomy & Neurobiology
Efferent Pathways/*anatomy & histology/physiology
Efferent/physiology
Fluorescence
Fluorescent Dyes
Guinea Pigs
Hearing research
Inferior Colliculi/*anatomy & histology/physiology
Microscopy
NEOMED College of Medicine
Neurons
Olivary Nucleus/*anatomy & histology/physiology
Schofield Brett R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0378-5955(01)00333-1" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0378-5955(01)00333-1</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
58-62
Issue
1
Volume
160
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Dublin Core
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Title
A name given to the resource
Frequency sensitivity range of the saccule to bone-conducted stimuli measured by vestibular evoked myogenic potentials
Publisher
An entity responsible for making the resource available
Hearing Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
2001-10
Subject
The topic of the resource
Audiology & Speech-Language Pathology; bone conduction; frequency sensitivity range; myogenic potential; nerve; neurons; Neurosciences & Neurology; Otorhinolaryngology; repetition rate; responses; saccule; sound; squirrel-monkey; vestibular; vestibular evoked myogenic potential; vibration
Creator
An entity primarily responsible for making the resource
Sheykholeslami K; Kermany M H; Kaga K
Description
An account of the resource
Vestibular evoked myogenic potentials (VEMPs) occurring in cervical muscles after intense sound stimulation conducted by air or bone are thought to be a polysynaptic response of otolith-vestibular nerve origin. We report the results of an experiment to investigate whether acoustic stimulation of the saccule by bone conduction produces VEMPs in which response amplitudes are somewhat sensitive to stimulus frequency, as appears, to be the case with air-conducted stimuli. Prior to this we investigated the effect of stimulation repetition rate on bone-conducted VEMPs (B-VEMPs) at stimulus frequencies of 200 and 400 Hz with five different repetition rates (5, 10, 20, 40, and 80 Hz). B-VEMPs were recorded from 12 normal hearing subjects in response to bone-conducted 70 dB (normal hearing level), 10-ms tone bursts (rise/fall time = 1 ms and plateau time = 8 ms) at frequencies of 100, 200, 400, 800, 1600 and 3200 Hz. Our study showed that B-VEMP amplitudes were highest at 10 Hz but decreased as the repetition rate increased. B-VEMP response amplitudes were found to be maximal for stimulus frequencies from 200 to 400 Hz. This response may contribute to the perception of loud sounds. (C) 2001 Elsevier Science B.V. All rights reserved.
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<a href="http://doi.org/10.1016/s0378-5955(01)00333-1" target="_blank" rel="noreferrer noopener">10.1016/s0378-5955(01)00333-1</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2001
Audiology & Speech-Language Pathology
Bone Conduction
frequency sensitivity range
Hearing research
Journal Article
Kaga K
Kermany M H
myogenic potential
nerve
Neurons
Neurosciences & Neurology
Otorhinolaryngology
repetition rate
responses
saccule
Sheykholeslami K
Sound
squirrel-monkey
vestibular
vestibular evoked myogenic potential
vibration
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s1566-0702(02)00176-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s1566-0702(02)00176-5</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
85-89
Issue
1
Volume
102
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Title
A name given to the resource
Denervation of vagal cardiopulmonary receptors by injection of kainic acid into the nodose ganglia in dogs
Publisher
An entity responsible for making the resource available
Autonomic Neuroscience-Basic & Clinical
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002-11
Subject
The topic of the resource
acetylstrophanthidin; afferents; baroreflexes; cardiac receptors; cardiac vagal afferents; carotid-sinus; chemosensitive; kainic acid; nerve activity; neurons; Neurosciences & Neurology; nodose ganglia
Creator
An entity primarily responsible for making the resource
Wallick D W; Dunlap M E; Stuesse S; Thames M D
Description
An account of the resource
We determined if kainic acid, a neuroexcitotoxin, could be used to denervate the cell bodies of cardiopulmonary vagal sensory neurons. Kainic acid (5 mug) was injected into the nodose ganglion of five dogs. Ten to fourteen days following this procedure, these kainic acid-injected dogs were anesthetized and tested for the extent of the deafferentation. Five additional dogs were used as the control group. Heart rate and mean arterial pressure were measured, and a Swan-Ganz catheter was advanced into a branch of the pulmonary artery to measure pulmonary capillary wedge pressure. We recorded renal sympathetic nerve activity from branches of the left renal nerves. Bilateral carotid occlusion increased heart rate and mean arterial pressure in only the denervated group, but sympathetic nerve activity increased significantly in both groups. This demonstrates that the carotid baroreflex is preserved after kainic acid is injected into the nodose ganglia. Volume expansion by use of warmed saline (15 ml kg(-1)) increased pulmonary capillary wedge pressure 5 mm Hg in control and 14 mm Hg in denervated dogs. In control dogs, sympathetic nerve activity decreased by 10% per mm Hg increase in pulmonary capillary wedge pressure while in denervated dogs, it decreased by 2% per mm Hg. This demonstrates that the vagal cardiopulmonary baroreflex is essentially abolished after injection of kainic acid into the nodose ganglia. After opening the chest, acetylstrophanthidin 100 mug was applied directly to the epicardial surface of the left ventricle to activate cardiac vagal afferents. Epicardial acetylstrophanthidin decreased sympathetic nerve activity by 28% in the control group, but resulted in no change in the kainic-acid-injected dogs. This demonstrates that vagal cardiac chemosensitive reflexes are abolished after bilateral injection of kainic acid into the nodose ganglia. At the end of these experiments, we removed the nodose ganglia for histological evaluation. The vast majority of cell bodies in the ganglia from the denervated group appeared injured compared to cell bodies in ganglia that had not been injected, suggesting that the destruction of cell bodies of vagal afferents was responsible for the functional denervation. Our findings are consistent with the interpretation that kainic acid treatment interrupts vagal afferents that meditate reflex responses to epicardial acetylstrophanthidin and to volume expansion. (C) 2002 Elsevier Science B.V. All rights reserved.
Identifier
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<a href="http://doi.org/10.1016/s1566-0702(02)00176-5" target="_blank" rel="noreferrer noopener">10.1016/s1566-0702(02)00176-5</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2002
acetylstrophanthidin
afferents
Autonomic Neuroscience-Basic & Clinical
baroreflexes
cardiac receptors
cardiac vagal afferents
carotid-sinus
chemosensitive
Dunlap M E
Journal Article
Kainic Acid
nerve activity
Neurons
Neurosciences & Neurology
nodose ganglia
Stuesse S
Thames M D
Wallick D W
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0006-8993(87)90514-2" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0006-8993(87)90514-2</a>
Pages
311–318
Issue
2
Volume
425
Dublin Core
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Title
A name given to the resource
Sharing of sensory terminals between the dynamic bag1 and static bag2 fibers in the rat muscle spindle.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1987
1987-11
Subject
The topic of the resource
Female; Animals; Rats; Axons/ultrastructure; Muscle Spindles/*ultrastructure; Nerve Fibers/*ultrastructure; Neurons; Inbred Strains; Afferent/*ultrastructure
Creator
An entity primarily responsible for making the resource
Walro J M; Kucera J
Description
An account of the resource
The nuclear bag1 intrafusal fiber mediates the dynamic (velocity) sensitivity, whereas the nuclear bag2 and nuclear chain fibers mediate the static (length) sensitivity of muscle spindles to stretch. The pattern of branching of primary and secondary afferents, the distribution of their terminals to the 3 types of intrafusal fibers, and the incidence of sensory cross-terminals were determined by reconstruction of 4 spindles from serial 1-micron and ultrathin transverse sections of rat extensor digitorum longus muscles. A single primary afferent supplied each spindle, and secondary afferents innervated intrafusal fibers in 3 spindles. Only static intrafusal fibers shared cross-terminals of the secondary afferents. In contrast, the dynamic bag1 and static bag2 fibers of each spindle shared at least one terminal of the primary afferent. Cross-terminals shared by the dynamic bag1 and static bag2 fiber parallel the presence of fusimotor (gamma) axons which coinnervate these types of intrafusal fibers in muscle spindles of rats. Consequently, the greater degree of overlap of elements comprising the dynamic and static systems of spindles of the rat relative to that of the cat reduces the probability of generating a purely dynamic or purely static response to an applied stretch.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0006-8993(87)90514-2" target="_blank" rel="noreferrer noopener">10.1016/0006-8993(87)90514-2</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1987
Afferent/*ultrastructure
Animals
Axons/ultrastructure
Brain research
Female
Inbred Strains
Kucera J
Muscle Spindles/*ultrastructure
Nerve Fibers/*ultrastructure
Neurons
Rats
Walro J M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/bf00495009" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/bf00495009</a>
Pages
1–13
Issue
1
Volume
92
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Innervation of regenerated spindles in muscle grafts of the rat.
Publisher
An entity responsible for making the resource available
Histochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
1989
1905-06
Subject
The topic of the resource
Female; Animals; Rats; Cell Differentiation; *Nerve Regeneration; Adenosine Triphosphatases/analysis; Graft Survival; Histocytochemistry; Motor Neurons/enzymology/metabolism/*physiology; Muscle Spindles/enzymology/*physiology; Muscles/transplantation; Nerve Fibers/enzymology/physiology; Neurons; Inbred Strains; Afferent/enzymology/metabolism/*physiology
Creator
An entity primarily responsible for making the resource
Walro J M; Kucera J; Cui F; Staffeld C G
Description
An account of the resource
Features of the nerve supply and the encapsulated fibers of muscle spindles were assessed in grafted and normal extensor digitorum longus (EDL) muscles of rats by analysis of serial 10-microns frozen transverse sections stained for enzymes which delineated motor and sensory endings, oxidative capacity and muscle fiber type. The number of fibers was significantly more variable, and branched fibers were more frequently observed in regenerated spindles than in control spindles. Forty-eight percent of regenerated spindles received sensory innervation. Spindles reinnervated by afferents had a larger periaxial space than did spindles which were not reinnervated by afferents. Regenerated fibers innervated by afferents had small cross-sectional areas, equatorial regions with myofibrils restricted to the periphery of fibers, unpredictable patterns of nonuniform and nonreversible staining along the length of the fiber for 'myofibrillar' adenosine triphosphatase (mATPase) after acid and alkaline preincubation. In contrast, regenerated fibers devoid of sensory innervation resembled extrafusal fibers in that they usually exhibited myofibrils throughout the length of the fiber, no central aggregations of myonuclei, uniform staining for mATPase and a reversal of staining for mATPase after preincubation in an acid or alkaline medium. Approximately thirty percent of encapsulated fibers devoid of sensory innervation stained analogous to a type I extrafusal fiber, a pattern of staining never observed in intrafusal fibers of normal spindles. Groups of encapsulated fibers all exhibiting this pattern of staining reflect that either these fibers may have been innervated by collaterals of skeletomotor axons that originally innervated type I extrafusal fibers or that fibers innervated by only fusimotor neurons express patterns of staining for mATPase similar to extrafusal fibers in the absence of sensory innervation. Sensory innervation may also influence the reestablishment of multiple sites of motor endings on regenerated intrafusal fibers. Those regenerated fibers innervated by afferents had more motor endings than did regenerated fibers devoid of sensory innervation. Differences in size, morphology, and patterns of staining for mATPase and numbers of motor endings between fibers innervated by afferents and fibers devoid of sensory innervation reflect that afferents can influence the differentiation of muscle cells and the reestablishment of motor innervation other than during the late prenatal/early postnatal period when muscle spindles form and differentiate in rats.
Identifier
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<a href="http://doi.org/10.1007/bf00495009" target="_blank" rel="noreferrer noopener">10.1007/bf00495009</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Nerve Regeneration
1989
Adenosine Triphosphatases/analysis
Afferent/enzymology/metabolism/*physiology
Animals
Cell Differentiation
Cui F
Female
Graft Survival
Histochemistry
Histocytochemistry
Inbred Strains
Kucera J
Motor Neurons/enzymology/metabolism/*physiology
Muscle Spindles/enzymology/*physiology
Muscles/transplantation
Nerve Fibers/enzymology/physiology
Neurons
Rats
Staffeld C G
Walro J M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0304-3940(91)90861-m" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0304-3940(91)90861-m</a>
Pages
213–217
Issue
2
Volume
122
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Non-neural and neural expression of myosin heavy chains by regenerated intrafusal fibers of rats.
Publisher
An entity responsible for making the resource available
Neuroscience letters
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-01
Subject
The topic of the resource
Female; Animals; Rats; Organ Specificity; *Muscle Denervation; *Nerve Regeneration; Motor Endplate/metabolism; Muscles/*metabolism/transplantation; Myosins/analysis/*biosynthesis; Neurons; Inbred Strains; Afferent/*metabolism
Creator
An entity primarily responsible for making the resource
Walro J M; Kucera J; Narvy R
Description
An account of the resource
Expression of myosin heavy chain (MHC) isoforms was studied in rat soleus (SOL) and extensor digitorum longus (EDL) muscles which regenerated in the presence or absence of innervation. Frozen sections of two 5 day denervated SOL and EDL grafts, two 40 day denervated SOL and EDL grafts, and two reinnervated 40 day SOL and EDL grafts were processed for demonstration of motor endplates, sensory endings, myosin adenosine triphosphatase (mATPase) and for expression of 4 MHCs. No qualitative differences in MHC expression were noted between 5 day or 40 day denervated grafts of the SOL and EDL muscles. All regenerated intrafusal and extrafusal myotubes or myofibers reacted to antibodies against neonatal and fast-twitch MHCs, but not to antibodies against slow-twitch and slow-tonic MHCs in these grafts. These data indicate that MHCs expressed by regenerated intrafusal myotubes do not parallel those expressed by myotubes which give rise to the three types of intrafusal fibers during development and that MHC expression by regenerated intrafusal myotubes parallels that of regenerated extrafusal myotubes prior to innervation. However, some regenerated intrafusal fibers in 40 day nerve-intact grafts bound antibodies to slow-twitch and slow-tonic MHCs, thus expressions of these two MHCs are nerve-dependent in regenerated muscle spindles.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0304-3940(91)90861-m" target="_blank" rel="noreferrer noopener">10.1016/0304-3940(91)90861-m</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Muscle Denervation
*Nerve Regeneration
1991
Afferent/*metabolism
Animals
Female
Inbred Strains
Kucera J
Motor Endplate/metabolism
Muscles/*metabolism/transplantation
Myosins/analysis/*biosynthesis
Narvy R
Neurons
Neuroscience letters
Organ Specificity
Rats
Walro J M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/(sici)1097-4598(199712)20:12%3C1549::aid-mus10%3E3.0.co;2-w" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/(sici)1097-4598(199712)20:12%3C1549::aid-mus10%3E3.0.co;2-w</a>
Pages
1549–1560
Issue
12
Volume
20
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Afferent-inherent regulation of myosin heavy chain isoforms in rat muscle spindles.
Publisher
An entity responsible for making the resource available
Muscle & nerve
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1997-12
Subject
The topic of the resource
Afferent Pathways/physiology; Afferent/*physiology; Animals; Denervation; Female; Ganglia; Ganglionectomy; Isomerism; Muscle Spindles/*metabolism; Myosin Heavy Chains/*metabolism; Neurons; Rats; Spinal Cord/physiology; Spinal/physiology; Sprague-Dawley; Toes/innervation
Creator
An entity primarily responsible for making the resource
Walro J M; Wang J; Story G M
Description
An account of the resource
Whether afferents exert their morphogenetic influence on spindles through release of trophic factors at intrafusal fiber junctions or via participation in proprioceptive pathways which modulate the motor activity to muscles was investigated by comparing myosin heavy chain (MHC) expression in intrafusal fibers after ablation of afferents (deafferentation, or DA) to the extensor digitorum longus (EDL) of adult rats or after ablation of the corresponding central processes of afferents to the spinal cord (central-process ablation, or CPA). DA and CPA elicited an exaggerated pedal plantarflexion, and hypertrophy of the EDL concomitant with atrophy of the soleus in the affected hindlimb. Frequencies and patterns of expression of seven MHCs expressed by intrafusal fibers in CPA muscles were indistinguishable from normal rats. However, frequencies and patterns of expression of several MHCs were abnormal following DA. Thus factors transported anterogradely from afferents to intrafusal fibers may regulate MHC expression in intrafusal fibers.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/(sici)1097-4598(199712)20:12%3C1549::aid-mus10%3E3.0.co;2-w" target="_blank" rel="noreferrer noopener">10.1002/(sici)1097-4598(199712)20:12%3C1549::aid-mus10%3E3.0.co;2-w</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1997
Afferent Pathways/physiology
Afferent/*physiology
Animals
Denervation
Female
Ganglia
Ganglionectomy
Isomerism
Muscle & nerve
Muscle Spindles/*metabolism
Myosin Heavy Chains/*metabolism
Neurons
Rats
Spinal Cord/physiology
Spinal/physiology
Sprague-Dawley
Story G M
Toes/innervation
Walro J M
Wang J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/(sici)1097-0185(199709)249:1%3C32::aid-ar5%3E3.0.co;2-h" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/(sici)1097-0185(199709)249:1%3C32::aid-ar5%3E3.0.co;2-h</a>
Pages
32–43
Issue
1
Volume
249
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Stability of myosin heavy chain isoforms in selectively denervated adult rat muscle spindles.
Publisher
An entity responsible for making the resource available
The Anatomical record
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1997-09
Subject
The topic of the resource
Afferent/physiology; Animals; Efferent/physiology; Female; Ganglia; Muscle; Muscle Denervation; Muscle Fibers; Muscle Spindles/*enzymology; Myosin Heavy Chains/analysis/chemistry/*metabolism; Myosins/*metabolism; Neurons; Rats; Skeletal/*enzymology/ultrastructure; Skeletal/cytology/enzymology/innervation; Spinal/surgery; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Wang J; McWhorter D L; Walro J M
Description
An account of the resource
BACKGROUND: Rat intrafusal fibers consist of multiple isoforms of myosin heavy chains (MHCs) whose expression involves complex interactions among motor neurons, sensory neurons, and muscle cells during spindle development. Little is known about the roles of sensory and motor innervation in regulating and maintaining expression of MHC isoforms in adult rat muscle spindles. METHODS: MHC expression was investigated in deafferented or deefferented adult rat muscle spindles by reacting transverse sections of spindles with a panel of monoclonal antibodies specific for different MHC isoforms. RESULTS: Deefferentation or deafferentation did not alter the number of intrafusal fibers expressing most MHC isoforms. However, the numbers of fibers expressing two MHC isoforms were altered in deefferented muscle spindles. Nuclear bag1 fibers ceased to express alpha-cardiac MHC and upregulated embryonic MHC after ablation of motor innervation. Likewise, bag2 and chain fibers downregulated avian neonatal/fast MHC following deafferentation, but chain fibers upregulated type 2A MHC and became more extrafusal-like in their pattern of MHC expression. CONCLUSIONS: These data indicate that (1) perturbations in spindle sensory and motor nerve supplies produce less severe alterations in MHC expression in mature intrafusal fibers than do similar lesions in developing intrafusal fibers and (2) MHC expression in intrafusal fibers reflects a combination of inductive and suppressive effects of motor and sensory neurons.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/(sici)1097-0185(199709)249:1%3C32::aid-ar5%3E3.0.co;2-h" target="_blank" rel="noreferrer noopener">10.1002/(sici)1097-0185(199709)249:1%3C32::aid-ar5%3E3.0.co;2-h</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1997
Afferent/physiology
Animals
Efferent/physiology
Female
Ganglia
McWhorter D L
Muscle
Muscle Denervation
Muscle Fibers
Muscle Spindles/*enzymology
Myosin Heavy Chains/analysis/chemistry/*metabolism
Myosins/*metabolism
Neurons
Rats
Skeletal/*enzymology/ultrastructure
Skeletal/cytology/enzymology/innervation
Spinal/surgery
Sprague-Dawley
The Anatomical record
Walro J M
Wang J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1111/j.1471-4159.2004.02834.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/j.1471-4159.2004.02834.x</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
59-71
Issue
1
Volume
92
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
RNAi knockdown of Par-4 inhibits neurosynaptic degeneration in ALS-linked mice
Publisher
An entity responsible for making the resource available
Journal of Neurochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005-01
Subject
The topic of the resource
amyotrophic lateral sclerosis; amyotrophic lateral sclerosis; anterior horn; antisense oligonucleotides; apoptosis; apoptosis response-4; Biochemistry & Molecular Biology; cells; Cu/Zn superoxide dismutase; motor-neuron degeneration; neurons; Neurosciences & Neurology; prostate; protein; RNA interference; sod1; spinal motor neurons; synapse; synapses; transgenic mouse model
Creator
An entity primarily responsible for making the resource
Xie J; Awad K S; Guo Q
Description
An account of the resource
Evidence from human amyotrophic lateral sclerosis (ALS) patients and ALS-linked Cu/Zn superoxide dismutase (Cu/Zn-SOD) transgenic mice bearing the mutation of glycine to alanine at position 93 (G93A) suggests that the pro-apoptotic protein prostate apoptosis response-4 (Par-4) might be a critical link in the chain of events leading to motor neuron degeneration. We now report that Par-4 is enriched in synaptosomes and post-synaptic density from the ventral horn of the spinal cord. Levels of Par-4 in synaptic compartments increased significantly during rapid and slow declining stages of muscle strength in hSOD1 G93A mutant mice. In the pre-muscle weakness stage, hSOD1 G93A mutation sensitized synaptosomes from the ventral horn of the spinal cord to increased levels of Par-4 expression following excitotoxic and apoptotic insults. In ventral spinal synaptosomes, Par-4-mediated production of pro-apoptotic cytosolic factor(s) was significantly enhanced by the hSOD1 G93A mutation. RNA interference (RNAi) knockdown of Par-4 inhibited mitochondrial dysfunction and caspase-3 activation induced by G93A mutation in synaptosomes from the ventral horn of the spinal cord, and protected spinal motor neurons from apoptosis. These results identify the synapse as a crucial cellular site for the cell death promoting actions of Par-4 in motor neurons, and suggest that targeted inhibition of Par-4 by RNAi may prove to be a neuroprotective strategy for motor neuron degeneration.
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<a href="http://doi.org/10.1111/j.1471-4159.2004.02834.x" target="_blank" rel="noreferrer noopener">10.1111/j.1471-4159.2004.02834.x</a>
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Journal Article
2005
amyotrophic lateral sclerosis
anterior horn
antisense oligonucleotides
Apoptosis
apoptosis response-4
Awad K S
Biochemistry & Molecular Biology
Cells
Cu/Zn superoxide dismutase
Guo Q
Journal Article
Journal of neurochemistry
motor-neuron degeneration
Neurons
Neurosciences & Neurology
Prostate
Protein
RNA Interference
sod1
spinal motor neurons
synapse
synapses
transgenic mouse model
Xie J
-
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<a href="http://doi.org/10.1097/opx.0000000000000441" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/opx.0000000000000441</a>
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Pages
107-114
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1
Volume
92
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Title
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Effect of Artificial Scotomas on Open-Loop Disparity Vergence Eye Movements
Publisher
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Optometry and Vision Science
Date
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2015
2015-01
Subject
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binocular disparity; convergence; depth-perception; disparity; dynamic asymmetries; eye movements; fusional; neurons; nystagmus; ocular motor control; Ophthalmology; responses; saccades; single-unit activity; V1; vergence; version
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Yang D S; Hertle R W; Zhu M X; Tai Z; Hald E; Kauffman M
Description
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Purpose. To investigate the effect of an artificial scotoma on open-loop disparity vergence responses (DVRs) and vergence control mechanisms, we examined open-loop DVRs to disparity stimuli using monocular artificial scotomas in normal subjects. Methods. Using a mirror haploscope with two computer monitors, we delivered disparity stimuli on a pair of random dot patterns subtending 40 by 30 degrees at 47 cm from each eye. The scotomas were black circles located in the center of a random dot pattern for the left eye. Eye movements of both eyes were recorded with a magnetic search coil system. Results. We first found that the amplitudes of DVRs were gradually decreased and the latency of DVRs was moderately increased as the size of the scotomas was increased. Second, monocular responses from each eye were symmetrical although the stimuli to each eye were asymmetrical. Conclusions. The results suggest that the monocular eye movements in disparity vergence are controlled by a binocular central mechanism, not driven separately by monocular inputs in the open-loop window.
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<a href="http://doi.org/10.1097/opx.0000000000000441" target="_blank" rel="noreferrer noopener">10.1097/opx.0000000000000441</a>
Format
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Journal Article
2015
binocular disparity
Convergence
depth-perception
Disparity
dynamic asymmetries
Eye Movements
fusional
Hald E
Hertle R W
Journal Article
Kauffman M
Neurons
Nystagmus
ocular motor control
Ophthalmology
Optometry and Vision Science
responses
saccades
single-unit activity
Tai Z
V1
vergence
version
Yang D S
Zhu M X