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Text
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<a href="http://doi.org/10.1517/13543784.2012.693479" target="_blank" rel="noreferrer noopener">http://doi.org/10.1517/13543784.2012.693479</a>
Pages
1123–1140
Issue
8
Volume
21
Dublin Core
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Title
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Curcumin and neurodegenerative diseases: a perspective.
Publisher
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Expert opinion on investigational drugs
Date
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2012
2012-08
Subject
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Humans; Animals; Oxidative Stress/drug effects; Neurodegenerative Diseases/*drug therapy/metabolism; Curcumin/adverse effects/pharmacokinetics/*pharmacology/*therapeutic use; Neuroprotective Agents/adverse effects/pharmacokinetics/*pharmacology/*therapeutic use; Drug Evaluation; Preclinical
Creator
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Darvesh Altaf S; Carroll Richard T; Bishayee Anupam; Novotny Nicholas A; Geldenhuys Werner J; Van der Schyf Cornelis J
Description
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INTRODUCTION: Curcumin, a dietary polyphenol found in the curry spice turmeric, possesses potent antioxidant and anti-inflammatory properties and an ability to modulate multiple targets implicated in the pathogenesis of chronic illness. Curcumin has shown therapeutic potential for neurodegenerative diseases including Alzheimer's disease (AD) and Parkinson's disease (PD). AREAS COVERED: This article highlights the background and epidemiological evidence of curcumin's health benefits and its pharmacodynamic and pharmacokinetic profile. Curcumin's ability to counteract oxidative stress and inflammation and its capacity to modulate several molecular targets is reviewed. We highlight the neuroprotective properties of curcumin including pre-clinical evidence for its pharmacological effects in experimental models of AD and PD. The bioavailability and safety of curcumin, the development of semi-synthetic curcuminoids as well as novel formulations of curcumin are addressed. EXPERT OPINION: Curcumin possesses therapeutic potential in the amelioration of a host of neurodegenerative ailments as evidenced by its antioxidant, anti-inflammatory and anti-protein aggregation effects. However, issues such as limited bioavailability and a paucity of clinical studies examining its therapeutic effectiveness in illnesses such as AD and PD currently limit its therapeutic outreach. Considerable effort will be required to adapt curcumin as a neuroprotective agent to be used in the treatment of AD, PD and other neurodegenerative diseases.
Identifier
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<a href="http://doi.org/10.1517/13543784.2012.693479" target="_blank" rel="noreferrer noopener">10.1517/13543784.2012.693479</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2012
Animals
Bishayee Anupam
Carroll Richard T
Curcumin/adverse effects/pharmacokinetics/*pharmacology/*therapeutic use
Darvesh Altaf S
Department of Pharmaceutical Sciences
Drug Evaluation
Expert opinion on investigational drugs
Geldenhuys Werner J
Humans
NEOMED College of Pharmacy
Neurodegenerative Diseases/*drug therapy/metabolism
Neuroprotective Agents/adverse effects/pharmacokinetics/*pharmacology/*therapeutic use
Novotny Nicholas A
Oxidative Stress/drug effects
Preclinical
Van der Schyf Cornelis J