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Text
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URL Address
<a href="http://doi.org/10.1016/j.jchromb.2014.05.048" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jchromb.2014.05.048</a>
Pages
83–89
Volume
963
Dublin Core
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Title
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Development and validation of an LC-MS/MS method for determination of the L-type voltage-gated calcium channel/NMDA receptor antagonist NGP1-01 in mouse serum.
Publisher
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
Date
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2014
2014-07
Subject
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Animals; Bridged-Ring Compounds/*blood; Calcium Channel Blockers/*blood; Chromatography; LC-MS/MS; Limit of Detection; Liquid/*methods; Mice; Mouse serum; Multifunctional drug; N-Methyl-D-Aspartate/*antagonists & inhibitors; Neuroprotective agent; NGP1-01; Pentacycloundecylamine; Receptors; Reproducibility of Results; Tandem Mass Spectrometry/*methods
Creator
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Jogiraju Harini; Zhou Xiang; Gobburi Ashta Lakshmi Prasad; Pedada Kiran K; Geldenhuys Werner J; Van der Schyf Cornelis J; Crish Samuel D; Anderson David J
Description
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NGP1-01 (8-benzylamino-8,11-oxapentacyclo[5.4.0.0(2,6).0(3,10).0(5,9)]undecane) is a heterocyclic cage compound with multifunctional calcium channel blocking activity that has been demonstrated to be neuroprotective in several neurodegenerative models. A sensitive internal standard LC-MS/MS method was developed and validated to quantify NGP1-01 in mouse serum. The internal standard (IS) was
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.jchromb.2014.05.048" target="_blank" rel="noreferrer noopener">10.1016/j.jchromb.2014.05.048</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2014
Anderson David J
Animals
Bridged-Ring Compounds/*blood
Calcium Channel Blockers/*blood
Chromatography
Crish Samuel D
Department of Pharmaceutical Sciences
Geldenhuys Werner J
Gobburi Ashta Lakshmi Prasad
Jogiraju Harini
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
LC-MS/MS
Limit of Detection
Liquid/*methods
Mice
Mouse serum
Multifunctional drug
N-Methyl-D-Aspartate/*antagonists & inhibitors
NEOMED College of Pharmacy
Neuroprotective agent
NGP1-01
Pedada Kiran K
Pentacycloundecylamine
Receptors
Reproducibility of Results
Tandem Mass Spectrometry/*methods
Van der Schyf Cornelis J
Zhou Xiang