1
40
5
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.pbb.2009.10.002" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.pbb.2009.10.002</a>
Pages
410–415
Issue
3
Volume
94
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Acute nicotine and phencyclidine increase locomotor activity of the guinea pig with attenuated potencies relative to their effects on rat or mouse.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
2010-01
Subject
The topic of the resource
Animals; Dizocilpine Maleate/pharmacology; Excitatory Amino Acid Antagonists/pharmacology; Guinea Pigs; Locomotion/*drug effects; Mice; Nicotine/*pharmacology; Phencyclidine/*pharmacology; Rats
Creator
An entity primarily responsible for making the resource
Simmons Mark A; Werkheiser Jennifer L; Hudzik Thomas J
Description
An account of the resource
Behavioral assays of the responses to psychomotor stimulants can be used to model certain aspects of CNS pathologies such as psychosis and addiction. However, species-dependent differences in the effects of neuromodulators in these assays can confound the interpretation of the results. The goal of this study was to determine the utility of the guinea pig as a model for assessing the behavioral actions of nicotinic receptor agonists and NMDA receptor antagonists. In the present study, the locomotor activity of adult male guinea pigs was measured, prior to and following an acute injection of nicotine, MK-801 or phencyclidine. Each animal received a single dose of the drug. Nicotine produced a dose-dependent increase in activity with an ED(50) of 1.5mg/kg. Phencyclidine also increased activity, with an ED(50) of 3.4 mg/kg. Nicotine produced increases in locomotion in all individual subjects tested, whereas at the maximally-effective dose of phencyclidine, only a fraction of the animals had locomotor activation. There was no change in activity in response to a single dose of MK-801 (0.5mg/kg). Haloperidol had a significant inhibitory effect on locomotor activity independent of the stimulant administered. Thus, both phencyclidine and nicotine are psychomotor stimulants when given to guinea pigs, although the intensity of the response and the potencies of these drugs are lower than in mice or rats under otherwise similar conditions.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.pbb.2009.10.002" target="_blank" rel="noreferrer noopener">10.1016/j.pbb.2009.10.002</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2010
Animals
Dizocilpine Maleate/pharmacology
Excitatory Amino Acid Antagonists/pharmacology
Guinea Pigs
Hudzik Thomas J
Locomotion/*drug effects
Mice
Nicotine/*pharmacology
Pharmacology, biochemistry, and behavior
Phencyclidine/*pharmacology
Rats
Simmons Mark A
Werkheiser Jennifer L
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(93)90182-s" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(93)90182-s</a>
Pages
657–659
Issue
3
Volume
44
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Differential effects of nicotine but not cathinone on motor activity of P and NP rats.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-03
Subject
The topic of the resource
Alcohol Drinking/*psychology; Alkaloids/*pharmacology; Animals; Dextroamphetamine/pharmacology; Discrimination (Psychology)/drug effects; Genotype; Male; Motor Activity/*drug effects; Nicotine/*pharmacology; Psychotropic Drugs/*pharmacology; Rats
Creator
An entity primarily responsible for making the resource
Gordon T L; Meehan S M; Schechter M D
Description
An account of the resource
The locomotor stimulatory effects of nicotine (0.4 and 0.8 mg/kg) and cathinone (0.5 and 1.0 mg/kg) were assessed in alcohol-preferring (P) and -nonpreferring (NP) rats. Whereas P rats demonstrated enhanced (0.8 mg/kg) or no change (0.4 mg/kg) in spontaneous locomotor activity (SMA) to nicotine, NP animals showed no change (0.4 mg/kg) or depression of activity (0.8 mg/kg). However, following cathinone administration both P and NP rats exhibited an increase in SMA. The above results are discussed in light of the genotypic variations between P/NP rats and the potential mediation of differential neurotransmitter effects in the two lines.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(93)90182-s" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(93)90182-s</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1993
Alcohol Drinking/*psychology
Alkaloids/*pharmacology
Animals
Dextroamphetamine/pharmacology
Discrimination (Psychology)/drug effects
Genotype
Gordon T L
Male
Meehan S M
Motor Activity/*drug effects
Nicotine/*pharmacology
Pharmacology, biochemistry, and behavior
Psychotropic Drugs/*pharmacology
Rats
Schechter M D
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0304-3940(97)00487-4" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0304-3940(97)00487-4</a>
Pages
140–142
Issue
2
Volume
230
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Estrogen differentially modulates nicotine-evoked dopamine release from the striatum of male and female rats.
Publisher
An entity responsible for making the resource available
Neuroscience letters
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1997-07
Subject
The topic of the resource
Animals; Corpus Striatum/drug effects/*metabolism; Dopamine/*metabolism; Estradiol/*pharmacology; Female; In Vitro Techniques; Kinetics; Male; Nicotine/*pharmacology; Orchiectomy; Ovariectomy; Rats; Sex Characteristics; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Dluzen D E; Anderson L I
Description
An account of the resource
In the present experiment we examined the effects of an in vitro infusion of nicotine (10 microM) upon dopamine release from superfused striatum of castrated male and female rats treated or not treated with estrogen. Estrogen exerted bidirectional effects on nicotine-evoked dopamine release as a function of the sex of the animal. Nicotine-evoked dopamine release was increased in estrogen treated females and decreased in estrogen treated males. Peak nicotine-evoked dopamine output from estrogen treated females was significantly greater than that of estrogen treated males. These results may be related to the gender differences in response to nicotine and smoking behavior.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0304-3940(97)00487-4" target="_blank" rel="noreferrer noopener">10.1016/s0304-3940(97)00487-4</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1997
Anderson L I
Animals
Corpus Striatum/drug effects/*metabolism
Dluzen D E
Dopamine/*metabolism
Estradiol/*pharmacology
Female
In Vitro Techniques
Kinetics
Male
Neuroscience letters
Nicotine/*pharmacology
Orchiectomy
Ovariectomy
Rats
Sex Characteristics
Sprague-Dawley
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0014-2999(95)00139-c" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0014-2999(95)00139-c</a>
Pages
59–64
Issue
1
Volume
279
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Genetic selection for nicotine activity in mice correlates with conditioned place preference.
Publisher
An entity responsible for making the resource available
European journal of pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-06
Subject
The topic of the resource
*Conditioning; Analysis of Variance; Animals; Female; Inbred Strains; Male; Mice; Movement/*drug effects; Nicotine/*pharmacology; Operant
Creator
An entity primarily responsible for making the resource
Schechter M D; Meehan S M; Schechter J B
Description
An account of the resource
Genetically heterogenous stock (HS) mice are being used to develop lines which have differential locomotor response to subcutaneously administered (0.75 mg/kg) nicotine. These groups of nicotine-depressed, nicotine-activated or randomly bred control mice were tested as to conditioned place preference using the same dose of nicotine employed to determine their locomotor performance in activity tests. Results indicate that the nicotine-activated mice showed a significantly greater preference to nicotine when compared to the nicotine-depressed mice; this effect was seen in the first generation and continued in the more recently tested third generation. Evidence is offered to support the hypothesis that it is the stimulatory effects of drugs (of abuse) that can be directly correlatable with the strength of their reinforcing effect upon behavior.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0014-2999(95)00139-c" target="_blank" rel="noreferrer noopener">10.1016/0014-2999(95)00139-c</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Conditioning
1995
Analysis of Variance
Animals
European journal of pharmacology
Female
Inbred Strains
Male
Meehan S M
Mice
Movement/*drug effects
Nicotine/*pharmacology
Operant
Schechter J B
Schechter M D
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0278-5846(94)90108-2" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0278-5846(94)90108-2</a>
Pages
925–933
Issue
5
Volume
18
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Nicotine place preference using the biased method of conditioning.
Publisher
An entity responsible for making the resource available
Progress in neuro-psychopharmacology & biological psychiatry
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-09
Subject
The topic of the resource
Animals; Conditioning; Cues; Injections; Male; Motor Activity/drug effects; Nicotine/*pharmacology; Operant/*drug effects; Rats; Sprague-Dawley; Subcutaneous
Creator
An entity primarily responsible for making the resource
Calcagnetti D J; Schechter M D
Description
An account of the resource
1. The objective of the experimentation was to determine whether nicotine (NIC, 0.8 mg/kg subcutaneously administered) would produce a conditioned place preference (CPP) in rats confined for thirty min to their less-preferred side in a three compartment apparatus, or an aversion when another group of rats were confined to their more preferred side. 2. On the non-drugged test day following eight conditioning trials, the rats spent more time in the compartment paired with NIC that was initially less-preferred, whereas animals that were conditioned with NIC in their preferred compartment had no significant change in time spent in that side. 3. Subsequently, locomotor activity was measured during a 30 min test session following the injection of NIC at the dose tested in CPP (0.8 mg/kg). A possible common mechanism on NIC-induced CPP and locomotor stimulation, as they may be regulated by mesolimbic dopamine neurons is discussed.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0278-5846(94)90108-2" target="_blank" rel="noreferrer noopener">10.1016/0278-5846(94)90108-2</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1994
Animals
Calcagnetti D J
Conditioning
Cues
Injections
Male
Motor Activity/drug effects
Nicotine/*pharmacology
Operant/*drug effects
Progress in neuro-psychopharmacology & biological psychiatry
Rats
Schechter M D
Sprague-Dawley
Subcutaneous