1
40
1
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0278-5846(95)00030-y" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0278-5846(95)00030-y</a>
Pages
499–508
Issue
3
Volume
19
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Scopolamine-physostigmine combination does not substitute for nicotine.
Publisher
An entity responsible for making the resource available
Progress in neuro-psychopharmacology & biological psychiatry
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-05
Subject
The topic of the resource
Animals; Conditioning; Discrimination Learning/*drug effects; Dose-Response Relationship; Drug; Injections; Male; Nicotine/administration & dosage/*pharmacology; Nicotinic/drug effects; Operant/*drug effects; Physostigmine/administration & dosage/*pharmacology; Rats; Receptors; Scopolamine/administration & dosage/*pharmacology; Sprague-Dawley; Subcutaneous; Task Performance and Analysis
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
1. Male Sprague-Dawley rats were trained to discriminate 0.4 mg/kg nicotine subcutaneously administered from its saline vehicle in a food-motivated operant discrimination task. Once trained, the discriminative performance was observed to be dose-responsive with an ED50 = 0.11 mg/kg. 2. The co-administration of 0.1 or 0.2 mg/kg physostigmine with either 0.1, 0.15 or 0.2 mg/kg scopolamine produced intermediate discriminative effects, i.e., neither nicotine- nor saline-like responding. However, the physostigmine-scopolamine combination neither substituted for nor increased the discriminative effects of co-administered nicotine. 3. The theoretical/mechanistic possibility that a combination of a cholinesterase inhibitor to increase available acetylcholine plus a specific anti-muscarinic to allow that increased acetylcholine to stimulate nicotinic receptors was investigated. Results indicate that the combination does not produce nicotine-like discriminative effects and evidence the possibility that nicotine discrimination may involve non-cholinergic mechanisms.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0278-5846(95)00030-y" target="_blank" rel="noreferrer noopener">10.1016/0278-5846(95)00030-y</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1995
Animals
Conditioning
Discrimination Learning/*drug effects
Dose-Response Relationship
Drug
Injections
Male
Nicotine/administration & dosage/*pharmacology
Nicotinic/drug effects
Operant/*drug effects
Physostigmine/administration & dosage/*pharmacology
Progress in neuro-psychopharmacology & biological psychiatry
Rats
Receptors
Schechter M D
Scopolamine/administration & dosage/*pharmacology
Sprague-Dawley
Subcutaneous
Task Performance and Analysis