1
40
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1161/01.hyp.26.4.676" target="_blank" rel="noreferrer noopener">http://doi.org/10.1161/01.hyp.26.4.676</a>
Pages
676–683
Issue
4
Volume
26
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Acute exercise attenuates cardiac autonomic regulation in hypertensive rats.
Publisher
An entity responsible for making the resource available
Hypertension (Dallas, Tex. : 1979)
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-10
Subject
The topic of the resource
*Physical Exertion; Adrenergic Agents/pharmacology; Animals; Autonomic Nervous System/*physiopathology; Blood Pressure/drug effects; Cholinergic Agents/pharmacology; Heart Conduction System/*physiopathology; Heart Rate/drug effects; Hypertension/*physiopathology; Inbred SHR; Male; Nitroglycerin/pharmacology; Parasympathetic Nervous System/physiopathology; Phenylephrine/pharmacology; Rats; Sympathetic Nervous System/physiopathology; Time Factors
Creator
An entity primarily responsible for making the resource
Chen Y; Chandler M P; DiCarlo S E
Description
An account of the resource
Dynamic exercise may be used as a safe, therapeutic approach to reduce sympathetic nerve activity at rest and thus may be beneficial for individuals with hypertension. Therefore, we tested the hypothesis that a single bout of mild to moderate dynamic exercise would decrease cardiac sympathetic tonus at rest. We designed two experimental protocols to test this hypothesis in male spontaneously hypertensive rats. In protocol 1 (n = 6) cardiac sympathetic tonus and parasympathetic tonus were determined before and after a single bout of dynamic exercise. We developed protocol 2 (n = 5) to determine the component of the autonomic nervous system responsible for the postexercise reduction in heart rate. Rats were instrumented with catheters inserted into the descending aorta for measurements of arterial pressure, mean arterial pressure, and heart rate and into the jugular vein for infusion of drugs. A single bout of mild to moderate dynamic treadmill exercise (12 m/min, 10% grade for 42 +/- 1 minutes, representing approximately 74% to 79% of maximal heart rate) resulted in a postexercise reduction in mean arterial pressure (163 +/- 7 to 149 +/- 5 mm Hg; P \textless .05). Associated with the postexercise hypotension was a reduction in sympathetic and parasympathetic tonus (47 +/- 12% and 71 +/- 12%, respectively). The reduction in heart rate during the early recovery phase was due to a withdrawal of sympathetic tonus, because beta 1-adrenergic receptor blockade significantly enhanced the postexercise reduction in heart rate, and muscarinic-cholinergic receptor blockade did not affect the postexercise decrease in heart rate until 20 minutes after exercise.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1161/01.hyp.26.4.676" target="_blank" rel="noreferrer noopener">10.1161/01.hyp.26.4.676</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Physical Exertion
1995
Adrenergic Agents/pharmacology
Animals
Autonomic Nervous System/*physiopathology
Blood Pressure/drug effects
Chandler M P
Chen Y
Cholinergic Agents/pharmacology
DiCarlo S E
Heart Conduction System/*physiopathology
Heart Rate/drug effects
Hypertension (Dallas, Tex. : 1979)
Hypertension/*physiopathology
Inbred SHR
Male
Nitroglycerin/pharmacology
Parasympathetic Nervous System/physiopathology
Phenylephrine/pharmacology
Rats
Sympathetic Nervous System/physiopathology
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajpheart.1997.272.3.H1412" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajpheart.1997.272.3.H1412</a>
Pages
H1412–1418
Issue
3
Volume
272
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Daily exercise and gender influence postexercise cardiac autonomic responses in hypertensive rats.
Publisher
An entity responsible for making the resource available
The American journal of physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1997-03
Subject
The topic of the resource
*Physical Conditioning; Animal; Animals; Atropine Derivatives/pharmacology; Autonomic Nervous System/drug effects/*physiopathology; Exercise Test; Female; Heart Rate/*drug effects; Heart/*innervation; Hypertension/genetics/*physiopathology; Inbred SHR; Male; Metoprolol/pharmacology; Nitroglycerin/pharmacology; Phenylephrine/pharmacology; Rats; Running; Sex Characteristics; Sympathetic Nervous System/drug effects/*physiopathology; Weight Loss
Creator
An entity primarily responsible for making the resource
Chen Y; Chandler M P; DiCarlo S E
Description
An account of the resource
The influence of daily spontaneous running (DSR) and gender on postexercise cardiac autonomic responses was examined in spontaneously hypertensive rats. Rats were weaned at 4-5 wk of age and were randomly assigned to a sedentary (7 males and 6 females) or DSR (7 males and 8 females) group. After 8 weeks of DSR or sedentary control, rats were chronically instrumented with arterial and venous catheters. After 5 days of recovery, cardiac sympathetic (ST) and parasympathetic tonus (PT) were determined (by the response of heart rate to receptor antagonists) on alternate days under two experimental conditions: no exercise and postexercise. After a single bout of dynamic treadmill exercise (12 m/min, 10% grade for 40 min) ST was reduced (P \textless 0.05) (male sedentary: no exercise 45 +/- 4 vs. postexercise 28 +/- 3 beats/min; female sedentary: no exercise 69 +/- 10 vs. postexercise 37 +/- 7 beats/ min). PT was also altered after exercise (male sedentary: no exercise -31 +/- 4 vs. postexercise -11 +/- 2 beats/min; female sedentary: no exercise -5 +/- 4 vs. postexercise 7 +/- 4 beats/min). After DSR, ST was reduced (male sedentary 45 +/- 4 vs. DSR 22 +/- 3 beats/min; female sedentary 69 +/- 10 vs. DSR 36 +/- 4 beats/min) (P \textless 0.05). Finally, male rats had a lower ST and higher PT than female rats. These results demonstrate that 1) ST was reduced after a single bout of dynamic exercise; 2) ST was reduced after DSR; 3) the autonomic response to acute exercise was attenuated after DSR; and 4) there was a gender influence on the cardiac autonomic function.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajpheart.1997.272.3.H1412" target="_blank" rel="noreferrer noopener">10.1152/ajpheart.1997.272.3.H1412</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Physical Conditioning
1997
Animal
Animals
Atropine Derivatives/pharmacology
Autonomic Nervous System/drug effects/*physiopathology
Chandler M P
Chen Y
DiCarlo S E
Exercise Test
Female
Heart Rate/*drug effects
Heart/*innervation
Hypertension/genetics/*physiopathology
Inbred SHR
Male
Metoprolol/pharmacology
Nitroglycerin/pharmacology
Phenylephrine/pharmacology
Rats
Running
Sex Characteristics
Sympathetic Nervous System/drug effects/*physiopathology
The American journal of physiology
Weight Loss