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Text
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<a href="http://doi.org/10.1016/j.joca.2020.04.014" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.joca.2020.04.014</a>
ISSN
1522-9653 1063-4584
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<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.1016/j.joca.2020.04.014" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1016/j.joca.2020.04.014</a>
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Update Year & Number
June 2020 Update II
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Anatomy & Neurobiology
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Title
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tRNA-derived fragments (tRFs) regulate post-transcriptional gene expression via
Publisher
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Osteoarthritis and Cartilage
Date
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2020
2020-05-12
Subject
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Chondrocyte; JAK3; Noncoding RNA; Osteoarthritis; Transfer RNA; tRNA-derived fragments
Creator
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Green J A; Ansari M Y; Ball H C; Haqqi Tariq M
Description
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OBJECTIVES: Recent studies have shown that tRNA-derived RNA fragments (tRFs) are novel regulators of post-transcriptional gene expression. However, the expression profiles and their role in post-transcriptional gene regulation in chondrocytes is unknown. Here, we determined tRFs expression profile and explored tRF-3003a role in post-transcriptional gene regulation in IL-1beta stimulated chondrocytes. METHODS: We used qPCR arrays to determine tRNAs and tRFs expression in age- and sex-matched primary human OA chondrocytes and TC28/I2 cells stimulated with
Identifier
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<a href="http://doi.org/10.1016/j.joca.2020.04.014" target="_blank" rel="noreferrer noopener">10.1016/j.joca.2020.04.014</a>
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journalArticle
2020
Ansari M Y
Ball H C
chondrocyte
Department of Anatomy & Neurobiology
Green J A
Haqqi Tariq M
JAK3
journalArticle
June 2020 Update II
NEOMED College of Medicine
NEOMED College of Medicine Postdoc
NEOMED Postdoc Publications
Noncoding RNA
Osteoarthritis
Osteoarthritis and cartilage
Transfer RNA
tRNA-derived fragments