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              <text>e925865</text>
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              <text>25</text>
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              <text>2329-0358 1425-9524 1425-9524</text>
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                <text>Transplant radical nephrectomy and transplant radical nephroureterectomy for renal cancer: Postoperative and survival outcomes.</text>
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                <text>Annals of Transplantation</text>
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                <text>Survival Analysis; Nephrectomy; Kidney Neoplasms</text>
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                <text>Nabavizadeh R;Noorali AA;Makhani SS;Hong G;Holzman S;Patil DH;Kim FY;Tso PL;Turgeon NA;Ogan K;Master Viraj A</text>
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                <text>BACKGROUND The treatment of complex tumors in non-functioning renal transplants  requiring surgical extirpation is challenging. Here, we report the largest series of  patients who underwent transplant radical nephrectomy for renal cell carcinoma (RCC)  and transplant radical nephroureterectomy for urothelial cell carcinoma (UCC) in  their transplanted kidneys. MATERIAL AND METHODS From 2004 to 2018, 10 patients  underwent transplant radical nephrectomy (7 patients) and nephroureterectomy (3  patients). Retrospective analyses, in terms of complications, oncological  recurrence, and survival, of peri-operative and long-term outcomes, were performed.  RESULTS Out of the 10 patients, 7 had RCC and 3 had UCC. No intraoperative mortality  occurred. Three patients presented with Clavien-Dindo grade IIIa or greater within  30 days of surgery. Two patients died within 60 days of surgery, both due to  vascular events: one due to myocardial infarction and one due to stroke. Two other  patients died: one after 2.9 years, due to myocardial infarction, and the other  after 6 years, due to unknown reasons. At the 7-year follow-up, there was a 60%  overall survival rate. For all patients, average survival post-nephrectomy was  approximately 4.5 years, including the 6 living patients and 4 deceased patients.  Importantly, there was no observed cancer recurrence. CONCLUSIONS This study reports  outcomes of the largest series of transplant radical nephrectomy and  nephroureterectomy for malignancies of renal allografts. In the optimized setting,  extirpative surgeries appear safe, with favorable long-term oncological and survival  outcomes.</text>
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                <text>&lt;a href="http://doi.org/10.12659/AOT.925865" target="_blank" rel="noreferrer noopener"&gt;10.12659/AOT.925865&lt;/a&gt;</text>
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