1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajpheart.1994.266.2.H531" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajpheart.1994.266.2.H531</a>
Pages
H531–539
Issue
2
Volume
266
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Myocardial work load is a major determinant of norepinephrine-induced left ventricular dysfunction.
Publisher
An entity responsible for making the resource available
The American journal of physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-02
Subject
The topic of the resource
Anesthesia; Animals; Blood Pressure/*drug effects; Cardiovascular; Consciousness; Diastole/drug effects; Dose-Response Relationship; Drug; General; Heart Rate/*drug effects; Heart/drug effects/*physiology; Left/drug effects/*physiology; Models; Norepinephrine/*pharmacology; Pentobarbital; Rabbits; Systole/drug effects; Time Factors; Ventricular Function
Creator
An entity primarily responsible for making the resource
Bosso F J; Allman F D; Pilati C F
Description
An account of the resource
This study was conducted to determine whether increased myocardial energy demand plays a role in norepinephrine (NE)-induced left ventricular (LV) dysfunction. A range of arterial pressure-heart rate (P-R) products (myocardial energy demand) was produced in both conscious and pentobarbital sodium-anesthetized rabbits with the same dose of NE (10 micrograms priming bolus plus 2.5 micrograms.kg-1 x min-1 for 2.5 h). After NE treatment, LV function was evaluated in vitro and found to be markedly diminished in the rabbits that had an elevated P-R product. In contrast, LV function was not significantly affected when the P-R product was maintained near control levels during NE treatment. In separate experiments, rabbit hearts were isolated and exposed to NE (10,000 or 50,000 pg/ml) for 2.5 h under low P-R product conditions. These hearts exhibited a dose-dependent decrease in LV function that was modest compared with that observed in rabbits that had elevated P-R products during in vivo NE treatment. Our results suggest that high concentrations of NE may cause modest degrees of LV dysfunction independently of increases in myocardial energy demand, but the LV dysfunction is exacerbated when myocardial energy demand is elevated.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajpheart.1994.266.2.H531" target="_blank" rel="noreferrer noopener">10.1152/ajpheart.1994.266.2.H531</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1994
Allman F D
Anesthesia
Animals
Blood Pressure/*drug effects
Bosso F J
Cardiovascular
Consciousness
Diastole/drug effects
Dose-Response Relationship
Drug
General
Heart Rate/*drug effects
Heart/drug effects/*physiology
Left/drug effects/*physiology
Models
Norepinephrine/*pharmacology
Pentobarbital
Pilati C F
Rabbits
Systole/drug effects
The American journal of physiology
Time Factors
Ventricular Function
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
494–496
Issue
8
Volume
56
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The effect of renal range dopamine and norepinephrine infusions on the renal vasculature.
Publisher
An entity responsible for making the resource available
The American surgeon
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1990-08
Subject
The topic of the resource
Animals; Dogs; Cardiac Output; Norepinephrine/*pharmacology; Creatine/pharmacokinetics; Dopamine/*pharmacology; Kidney/*drug effects/metabolism; Renal Circulation/*drug effects
Creator
An entity primarily responsible for making the resource
Strigle T R; Petrinec D
Description
An account of the resource
Renal range dopamine's value was assessed in 15 hypotensive canines using an endotoxin shock model and concurrent pharmacological pressor support. The dogs were prospectively randomized into three treatment groups (fluid resuscitation, fluid and norepinephrine, and fluid, norepinephrine and renal range dopamine). The two groups treated with norepinephrine showed no statistical difference between their pulmonary capillary wedge pressure, systolic blood pressure, and systemic vascular resistance. Cardiac index was slightly increased in the dopamine group (P less than 0.001). Creatinine clearance and renal blood flow were found to have no differences with or without renal range dopamine infusing in either group (P = 0.39 and P = 0.45, respectively). These findings suggest that renal range dopamine is not efficacious with concurrent alpha sympathetic agents for augmentation of renal function or flow in the hypotensive experimental model.
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1990
Animals
Cardiac Output
Creatine/pharmacokinetics
Dogs
Dopamine/*pharmacology
Kidney/*drug effects/metabolism
Norepinephrine/*pharmacology
Petrinec D
Renal Circulation/*drug effects
Strigle T R
The American surgeon