1
40
3
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jappl.1992.73.1.117" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jappl.1992.73.1.117</a>
Pages
117–122
Issue
1
Volume
73
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Circulating neuropeptide Y does not produce pulmonary hypertension during massive sympathetic activation.
Publisher
An entity responsible for making the resource available
Journal of applied physiology (Bethesda, Md. : 1985)
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-07
Subject
The topic of the resource
Adrenal Glands/drug effects/physiology; Adrenalectomy; Animals; Dogs; Hypertension; In Vitro Techniques; Neuropeptide Y/*physiology; Norepinephrine/pharmacology; Pulmonary Circulation/drug effects; Pulmonary/chemically induced/*physiopathology; Sympathetic Nervous System/*physiology; Veratrine/pharmacology
Creator
An entity primarily responsible for making the resource
Lang S A; Maron M B; Maender K C; Pilati C F
Description
An account of the resource
We tested the possibility that neuropeptide Y (NPY) may contribute to the pulmonary hypertension that occurs after massive sympathetic activation produced by intracisternal veratrine administration in the chloralose-anesthetized dog. In six dogs, veratrine caused arterial NPY-like immunoreactivity (NPY-LI) to rise from 873 +/- 150 (SE) pg/ml to peak values of 3,780 +/- 666 pg/ml by 60-120 min. (In 3 animals, adrenalectomy significantly reduced the increases in NPY-LI.) In five additional dogs, we infused porcine NPY for 30 min in doses that increased arterial NPY-LI to 8,354 +/- 1,514 pg/ml and observed only minor changes in pulmonary hemodynamics. In three isolated perfused canine left lower lung lobe (LLL) preparations, increasing doses of NPY were administered, producing levels of plasma NPY-LI, at the highest dose, that exceeded those observed after veratrine administration by three orders of magnitude. No changes in LLL arterial or double-occlusion capillary pressures were observed at any dose. Similarly, no changes in LLL hemodynamics were observed in three additional lobes when NPY was administered while norepinephrine was being infused. We conclude that it is unlikely that NPY plays a role as a circulating vasoactive agent in producing the pulmonary hypertension and edema that occur in this model.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jappl.1992.73.1.117" target="_blank" rel="noreferrer noopener">10.1152/jappl.1992.73.1.117</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1992
Adrenal Glands/drug effects/physiology
Adrenalectomy
Animals
Dogs
Hypertension
In Vitro Techniques
Journal of applied physiology (Bethesda, Md. : 1985)
Lang S A
Maender K C
Maron M B
Neuropeptide Y/*physiology
Norepinephrine/pharmacology
Pilati C F
Pulmonary Circulation/drug effects
Pulmonary/chemically induced/*physiopathology
Sympathetic Nervous System/*physiology
Veratrine/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jappl.1998.84.2.618" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jappl.1998.84.2.618</a>
Pages
618–623
Issue
2
Volume
84
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effect of neuropeptide Y on hemodynamics of the rabbit lung.
Publisher
An entity responsible for making the resource available
Journal of applied physiology (Bethesda, Md. : 1985)
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1998-02
Subject
The topic of the resource
Animals; Cisterna Magna; Hemodynamics/*physiology; In Vitro Techniques; Injections; Neuropeptide Y/blood/pharmacology/*physiology; Norepinephrine/pharmacology; Perfusion; Pulmonary Circulation/drug effects/*physiology; Rabbits; Sympathetic Nervous System/drug effects/physiology; Vascular Resistance/drug effects/physiology; Vasoconstriction/drug effects/physiology; Vasoconstrictor Agents/pharmacology; Veratrine/administration & dosage/pharmacology
Creator
An entity primarily responsible for making the resource
Lang S A; Maron M B
Description
An account of the resource
We evaluated the effect of neuropeptide Y (NPY) on the hemodynamics of the isolated rabbit lung perfused at constant flow and outflow pressure. Doses of 10(-8) and 10(-7) M NPY increased pulmonary arterial pressure (Ppa) from 11.5 +/- 1.0 (SE) mmHg to, respectively, 16.4 +/- 1.5 and 26.0 +/- 3.8 mmHg (P \textless 0.05, n = 5 mmHg lungs), with 78 +/- 4% of the increase at 10(-7) M resulting from an increased arterial resistance. At the latter dose, pulmonary capillary pressure increased from 5.8 +/- 0.9 to 9.4 +/- 1.0 mmHg (P \textless 0.05). When administered in the presence of norepinephrine, 10(-8) and 10(-7) M NPY (n = 6) produced extreme increases in Ppa to 66.1 +/- 20.5 and 114.7 +/- 25.5 mmHg, respectively, that were due primarily to an increased arterial resistance. To determine the significance of circulating NPY as a pulmonary vasoactive agent, we measured plasma NPY-like immunoreactivity in anesthetized rabbits after massively activating the sympathetic nervous system with veratrine. NPY-like immunoreactivity increased from 74 +/- 10 to 111 +/- 10 (SE) pM (P \textless 0.05). Thus, although NPY is a potent vasoconstrictor in the rabbit lung, it is not likely that plasma NPY concentrations rise sufficiently, even after massive sympathetic nervous system activation, to produce pulmonary vasoconstriction in the intact rabbit.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jappl.1998.84.2.618" target="_blank" rel="noreferrer noopener">10.1152/jappl.1998.84.2.618</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1998
Animals
Cisterna Magna
Hemodynamics/*physiology
In Vitro Techniques
Injections
Journal of applied physiology (Bethesda, Md. : 1985)
Lang S A
Maron M B
Neuropeptide Y/blood/pharmacology/*physiology
Norepinephrine/pharmacology
Perfusion
Pulmonary Circulation/drug effects/*physiology
Rabbits
Sympathetic Nervous System/drug effects/physiology
Vascular Resistance/drug effects/physiology
Vasoconstriction/drug effects/physiology
Vasoconstrictor Agents/pharmacology
Veratrine/administration & dosage/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
760–766
Issue
2
Volume
12
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Oxytocin induces preservation of social recognition in male rats by activating alpha-adrenoceptors of the olfactory bulb.
Publisher
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The European journal of neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
2000-02
Subject
The topic of the resource
Male; Animals; *Social Behavior; Rats; Adrenergic beta-Antagonists/pharmacology; Adrenergic beta-Agonists/pharmacology; Microdialysis; Adrenergic alpha-Antagonists/pharmacology; Phentolamine/pharmacology; Isoproterenol/pharmacology; Clonidine/pharmacology; Norepinephrine/pharmacology; Social Dominance; Adrenergic alpha-Agonists/pharmacology; Memory/*drug effects/physiology; Olfactory Bulb/*drug effects/physiology; Oxytocin/*pharmacology; Timolol/pharmacology; Receptors; Adrenergic; Wistar; alpha/*drug effects/physiology; Oxytocin/drug effects/*physiology
Creator
An entity primarily responsible for making the resource
Dluzen D E; Muraoka S; Engelmann M; Ebner K; Landgraf R
Description
An account of the resource
In this report, a series of four experiments was performed to evaluate the relationship between the olfactory bulb norepinephrine system and intra-olfactory bulb infusion of oxytocin in the preservation of social memory responses. The present data indicate that oxytocin exerts this preservation of social recognition through a specific, receptor-mediated mechanism within the olfactory bulb (experiment 1). The involvement of the olfactory bulb norepinephrine system is revealed by the demonstration that retrodialysis of oxytocin into the olfactory bulb increases norepinephrine release (experiment 4). Our data suggest that the increased output of olfactory bulb norepinephrine resulting from oxytocin appears to activate alpha-adrenoceptors to produce this preservation in recognition because infusions of clonidine into the olfactory bulb preserve recognition responses in a manner similar to that observed with oxytocin (experiment 2). In addition, a co-infusion of oxytocin with phentolamine abolishes recognition responses (experiment 3). Accordingly, this model affords the opportunity to study neuropeptide-catecholamine interactions, link these interactions with a specific behavioural outcome and identify a novel function/site of action for oxytocin in the male.
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Social Behavior
2000
Adrenergic
Adrenergic alpha-Agonists/pharmacology
Adrenergic alpha-Antagonists/pharmacology
Adrenergic beta-Agonists/pharmacology
Adrenergic beta-Antagonists/pharmacology
alpha/*drug effects/physiology
Animals
Clonidine/pharmacology
Dluzen D E
Ebner K
Engelmann M
Isoproterenol/pharmacology
Landgraf R
Male
Memory/*drug effects/physiology
Microdialysis
Muraoka S
Norepinephrine/pharmacology
Olfactory Bulb/*drug effects/physiology
Oxytocin/*pharmacology
Oxytocin/drug effects/*physiology
Phentolamine/pharmacology
Rats
Receptors
Social Dominance
The European journal of neuroscience
Timolol/pharmacology
Wistar