Age-related Changes In Spinal Biogenic Amine Levels Following The Induction Of Peripheral Nerve Injury
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Lovell J A; Novak J C; Avers B; Stuesse S L; Cruce W L R; Crisp T
Faseb Journal
1999
1999-03
Journal Article or Conference Abstract Publication
n/a
Changes In Spinal Serotonin Turnover Mediate Age-related Differences In The Behavioral Manifestations Of Peripheral Nerve Injury
allodynia; Behavioral Sciences; brain; endorphin; hyperalgesia; monoamine oxidase; mononeuropathy; neuropathic pain; Neurosciences & Neurology; norepinephrine; oxidative stress; Pharmacology & Pharmacy; rat; sciatic nerve; serotonin; spinal cord; systems
Lovell J A; Novak J C; Stuesse S L; Cruce W L R; Crisp T
Pharmacology Biochemistry and Behavior
2000
2000-08
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1016/s0091-3057(00)00285-9" target="_blank" rel="noreferrer noopener">10.1016/s0091-3057(00)00285-9</a>
The effects of aging on peripheral nerve injury induced thermal hyperalgesia and tactile-evoked allodynia
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Novak J C; Lovell J A; Bailey C M; Stuesse S L; Cruce W L R; Crisp T
Faseb Journal
1999
1999-03
Journal Article
n/a
Aging and neuropathic pain.
Aging/*physiology; Animals; Hot Temperature; Hyperalgesia/*physiopathology; Ligation; Male; Nociceptors/physiology; Pain/*physiopathology; Peripheral Nervous System Diseases/physiopathology; Rats; Sciatic Nerve/injuries
Although chronic neuropathic pain disorders are more prevalent in the senescent population, little is known about how the aging process alters the thermal hyperalgesic sensitivity to peripheral nerve injury. In this study, neuropathic pain was induced in young, mature and aged FBNF1 hybrid rats via unilateral ligation of the left sciatic nerve. The extent to which the aging process affects the thermal hyperalgesic responsiveness of these animals was investigated. The results demonstrate that the aging process differentially alters nociceptive processing.
Novak J C; Lovell J A; Stuesse S L; Cruce W L; McBurney D L; Crisp T
Brain research
1999
1999-07
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1016/s0006-8993(99)01522-x" target="_blank" rel="noreferrer noopener">10.1016/s0006-8993(99)01522-x</a>