1
40
4
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/nar/17.2.799" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/nar/17.2.799</a>
Pages
799–799
Issue
2
Volume
17
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The complete nucleotide sequence of bovine liver cytochrome b5 mRNA.
Publisher
An entity responsible for making the resource available
Nucleic acids research
Date
A point or period of time associated with an event in the lifecycle of the resource
1989
1989-01
Subject
The topic of the resource
Animals; Amino Acid Sequence; Base Sequence; Molecular Sequence Data; Liver/*enzymology; Cattle; Cytochromes b5; Cytochrome b Group/*genetics/isolation & purification; RNA; Messenger/*isolation & purification
Creator
An entity primarily responsible for making the resource
Cristiano R J; Steggles A W
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/nar/17.2.799" target="_blank" rel="noreferrer noopener">10.1093/nar/17.2.799</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1989
Amino Acid Sequence
Animals
Base Sequence
Cattle
Cristiano R J
Cytochrome b Group/*genetics/isolation & purification
Cytochromes b5
Liver/*enzymology
Messenger/*isolation & purification
Molecular Sequence Data
Nucleic acids research
RNA
Steggles A W
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/nar/27.10.2219" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/nar/27.10.2219</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
2219-2226
Issue
10
Volume
27
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Oxidative damage of DNA by chromium(V) complexes: relative importance of base versus sugar oxidation
Publisher
An entity responsible for making the resource available
Nucleic Acids Research
Date
A point or period of time associated with an event in the lifecycle of the resource
1999
1999-05
Subject
The topic of the resource
Biochemistry & Molecular Biology; in-vitro; nucleic-acids; abstraction; aqueous-solution; carcinogen chromium(vi); hydrogen; molecular-oxygen; radical formation; redox potentials; singlet oxygen; strand breaks
Creator
An entity primarily responsible for making the resource
Bose R N; Moghaddas S; Mazzer P A; Dudones L P; Joudah L; Stroup D
Description
An account of the resource
Chromium(V)-mediated oxidative damage of deoxyribonucleic acids was investigated at neutral pH in aqueous solution by utilizing bis(2-ethyl-2-hydroxybutanato)oxochromate(V) (I) and bis(hydroxyethyl)amino-tris(hydroxymethyl)methane)oxochromate(V) (II). Single-stranded and double-stranded (ds) calf thymus and human placenta DNA, as well as two oligomers, 5'-GATCTAGTAGGAGGACAAATAGTGTPTG-3' and 5'-GATCCAAGCAAACACTATTTGTCCTCCTACTA-3', were reacted with the chromium(V) complexes. Most products were separated and characterized by chromatographic and spectroscopic methods, Polyacrylamide gel electrophoresis experiments reveal more damage at G sites in comparison to other bases. Three primary oxidation products, 5-methylene-2-furanone (5-MF), furfural and 8-oxo-2'-deoxyguanosine, were characterized, A minor product, which appears to be thymine propenal, was also observed. The dsDNA produces more furfural than furanone, The formation of these two products resulted from hydrogen abstraction dr hydride transfer from C1' and C5' positions of the ribose to the oxo-chromium(V) center. Since no enhancements of these products (except propenal) were observed in the presence of oxygen, mechanisms pertaining to the participation of activated oxygen species may be ruled out. The oxidation of the G base is most likely associated with an oxygen atom transfer from the oxo-metallates to the double bond between C8 and N7 of the purine ring. The formation of the propenal may be associated with an oxygen-activated species, since a marginal enhancement of this product was observed in the presence of oxygen, The formation of furfural in higher abundance over 5-MF for dsDNA was attributed to the ease of hydrogen abstraction (or hydride transfer) from the C5' compared to C1' position of the ribose within a Cr(V)-DNA intermediate in which the metal center is bound to the phosphate diester moiety.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/nar/27.10.2219" target="_blank" rel="noreferrer noopener">10.1093/nar/27.10.2219</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1999
abstraction
aqueous-solution
Biochemistry & Molecular Biology
Bose R N
carcinogen chromium(vi)
Dudones L P
hydrogen
in-vitro
Joudah L
Journal Article or Conference Abstract Publication
Mazzer P A
Moghaddas S
molecular-oxygen
Nucleic acids research
nucleic-acids
radical formation
redox potentials
singlet oxygen
strand breaks
Stroup D
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/nar/gkq397" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/nar/gkq397</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
6007-6017
Issue
18
Volume
38
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Dublin Core
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Title
A name given to the resource
Genome-wide interrogation of hepatic FXR reveals an asymmetric IR-1 motif and synergy with LRH-1
Publisher
An entity responsible for making the resource available
Nucleic Acids Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
2010-10
Subject
The topic of the resource
liver; orphan nuclear receptor; Biochemistry & Molecular Biology; binding; farnesoid X receptor; bile-acid; dna; activated receptor; fatty-acid synthase; ppar-gamma-rxr; target genes
Creator
An entity primarily responsible for making the resource
Chong H K; Infante A M; Seo Y K; Jeon T I; Zhang Y Q; Edwards P A; Xie X H; Osborne T F
Description
An account of the resource
We used mouse hepatic chromatin enriched with an FXR antibody and chromatin immunoprecipitation-sequencing (ChIP-seq) to evaluate FXR binding on a genome-wide scale. This identified 1656 FXR-binding sites and 10% were located within 2 kb of a transcription start site which is much higher than predicted by random occurrence. A motif search uncovered a canonical nuclear receptor IR-1 site, consistent with in vitro DNA-binding studies reported previously. A separate nuclear receptor half-site for monomeric receptors such as LRH-1 was co-enriched and FXR activation of four newly identified promoters was significantly augmented by an LRH-1 expression vector in a co-transfection assay. There were 1038 genes located within 20 kb of a peak and a gene set enrichment analysis showed that genes identified by our ChIP-seq analysis are highly correlated with genes activated by an FXR-VP16 adenovirus in primary mouse hepatocytes providing functional relevance to the genome-wide binding study. Gene Ontology analysis showed FXR-binding sites close to many genes in lipid, fatty acid and steroid metabolism. Other broad gene clusters related to metabolism, transport, signaling and glycolysis were also significantly enriched. Thus, FXR may have a much wider role in cellular metabolism than previously appreciated.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/nar/gkq397" target="_blank" rel="noreferrer noopener">10.1093/nar/gkq397</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2010
activated receptor
bile-acid
Binding
Biochemistry & Molecular Biology
Chong H K
DNA
Edwards P A
Farnesoid X receptor
fatty-acid synthase
Infante A M
Jeon T I
Journal Article or Conference Abstract Publication
Liver
Nucleic acids research
orphan nuclear receptor
Osborne T F
ppar-gamma-rxr
Seo Y K
target genes
Xie X H
Zhang Y Q
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/nar/17.2.799" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/nar/17.2.799</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
799-799
Issue
2
Volume
17
Search for Full-text
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<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The Complete Nucleotide-sequence Of Bovine Liver Cytochrome-b5 Messenger-rna
Publisher
An entity responsible for making the resource available
Nucleic Acids Research
Date
A point or period of time associated with an event in the lifecycle of the resource
1989
1989-01
Subject
The topic of the resource
Biochemistry & Molecular Biology
Creator
An entity primarily responsible for making the resource
Cristiano R J; Steggles A W
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/nar/17.2.799" target="_blank" rel="noreferrer noopener">10.1093/nar/17.2.799</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1989
Biochemistry & Molecular Biology
Cristiano R J
Nucleic acids research
Steggles A W