1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1002/sctm.17-0172" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/sctm.17-0172</a> Pages 115–124 Issue 1 Volume 7 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Role of SDF-1:CXCR4 in Impaired Post-Myocardial Infarction Cardiac Repair in Diabetes. Publisher An entity responsible for making the resource available Stem cells translational medicine Date A point or period of time associated with an event in the lifecycle of the resource 2018 2018-01 Subject The topic of the resource Cardiac; Cell therapy; Diabetes; Stem cells; Stromal derived factor-1 Creator An entity primarily responsible for making the resource Mayorga Maritza E; Kiedrowski Matthew; McCallinhart Patricia; Forudi Farhad; Ockunzzi Jeremiah; Weber Kristal; Chilian William; Penn Marc S; Dong Feng Description An account of the resource Diabetes is a risk factor for worse outcomes following acute myocardial infarction (AMI). In this study, we tested the hypothesis that SDF-1:CXCR4 expression is compromised in post-AMI in diabetes, and that reversal of this defect can reverse the adverse effects of diabetes. Mesenchymal stem cells (MSC) isolated from green fluorescent protein (GFP) transgenic mice (control MSC) were induced to overexpress stromal cell-derived factor-1 (SDF-1). SDF-1 expression in control MSC and SDF-1-overexpressing MSC (SDF-1:MSC) were quantified using enzyme-linked immunosorbent assay (ELISA). AMI was induced on db/db and control mice. Mice were randomly selected to receive infusion of control MSC, SDF-1:MSC, or saline into the border zone after AMI. Serial echocardiography was used to assess cardiac function. SDF-1 and CXCR4 mRNA expression in the infarct zone of db/db mice and control mice were quantified. Compared to control mice, SDF-1 levels were decreased 82%, 91%, and 45% at baseline, 1 day and 3 days post-AMI in db/db mice, respectively. CXCR4 levels are increased 233% at baseline and 54% 5 days post-AMI in db/db mice. Administration of control MSC led to a significant improvement in ejection fraction (EF) in control mice but not in db/db mice 21 days after AMI. In contrast, administration of SDF-1:MSC produced a significant improvement in EF in both control mice and db/db mice 21 days after AMI. The Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1002/sctm.17-0172" target="_blank" rel="noreferrer noopener">10.1002/sctm.17-0172</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). 2018 Cardiac Cell therapy Chilian William Department of Integrative Medical Sciences Diabetes Dong Feng Forudi Farhad Kiedrowski Matthew Mayorga Maritza E McCallinhart Patricia NEOMED College of Medicine Ockunzzi Jeremiah Penn Marc S stem cells Stem cells translational medicine Stromal derived factor-1 Weber Kristal