1
40
2
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Text
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URL Address
<a href="http://doi.org/10.1529/biophysj.105.061762" target="_blank" rel="noreferrer noopener">http://doi.org/10.1529/biophysj.105.061762</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
315-320
Issue
1
Volume
89
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Lateral diffusion coefficients of separate lipid species in a ternary raft-forming bilayer: A Pfg-NMR multinuclear study
Publisher
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Biophysical Journal
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005-07
Subject
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atomic-force microscopy; Biophysics; cell-membranes; fluorescence correlation spectroscopy; insulin-receptor; least-squares analysis; model membranes; phase-equilibria; plasma-membrane; signal-transduction; spectral data sets
Creator
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Oradd G; Westerman P W; Lindblom G
Description
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By isotopical labeling lipid lateral diffusion coefficients for each of the membrane constituents, including cholesterol, have been measured by H-1, H-2, and F-19 pulsed field gradient NMR spectroscopy in macroscopically oriented lipid bilayers. This provides a means of obtaining detailed dynamic and compositional information in raft-forming lipid bilayers without introducing foreign molecules into the systems. The raft systems studied contained dioleoylphosphatidylcholine/dipalmitoylphosphatidylcholine (DPPC)/cholesterol at the molar ratios of 42.5: 42.5: 15 and 35: 35: 30 in excess water. At temperatures below 30 degrees C the raft system forms large (>1 mu m) domains of a liquid ordered (l(o)) phase, in which the lipid lateral diffusion was; 5 times slower than for the lipids in the surrounding liquid disordered (l(d)) phase. Within each domain all lipid species showed the same diffusion coefficient, despite the very different structures of cholesterol and phospholipids. DPPC partitions exclusively into the l(o) domains, whereas cholesterol and dioleoylphosphatidylcholine were distributed in both l(o) and l(d) phases. The cholesterol concentration was found to be 10-20 mol% in the l(d) domain and 30-40 mol% in the l(o) domain. Comparison of these results with data from sphingomyelin-containing systems suggests that DPPC interacts more weakly with cholesterol than does sphingomyelin.
Identifier
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<a href="http://doi.org/10.1529/biophysj.105.061762" target="_blank" rel="noreferrer noopener">10.1529/biophysj.105.061762</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2005
atomic-force microscopy
Biophysical Journal
Biophysics
cell-membranes
fluorescence correlation spectroscopy
insulin-receptor
Journal Article
least-squares analysis
Lindblom G
model membranes
Oradd G
phase-equilibria
plasma-membrane
signal-transduction
spectral data sets
Westerman P W
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0006-3495(02)75279-x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0006-3495(02)75279-x</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
2702-2704
Issue
5
Volume
83
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Lateral diffusion of cholesterol and dimyristoylphosphatidylcholine in a lipid bilayer measured by pulsed field gradient NMR spectroscopy
Publisher
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Biophysical Journal
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002-11
Subject
The topic of the resource
Biophysics; caveolae; insulin-receptor; membranes; nuclear magnetic-resonance
Creator
An entity primarily responsible for making the resource
Oradd G; Lindblom G; Westerman P W
Description
An account of the resource
The pulsed field gradient NMR method for measuring self-diffusion has been used for a direct determination of the lateral diffusion coefficient of cholesterol, fluorine labeled at the 6-position, for an oriented lamellar liquid-crystalline phase of dimyristoylphosphatidylcholine (DMPC)/cholesterol/water. It is found that the diffusion coefficients of DMPC and cholesterol are equal over a large temperature interval. The apparent energy of activation for the diffusion process (58 kJ/mol) is about the same as for a lamellar phase of DMPC/water, whereas the phospholipid lateral diffusion coefficient is approximately four times smaller in the presence of cholesterol.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0006-3495(02)75279-x" target="_blank" rel="noreferrer noopener">10.1016/s0006-3495(02)75279-x</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2002
Biophysical Journal
Biophysics
caveolae
insulin-receptor
Journal Article
Lindblom G
membranes
nuclear magnetic-resonance
Oradd G
Westerman P W