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Text
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<a href="http://doi.org/10.1016/s0304-3940(02)00412-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0304-3940(02)00412-3</a>
Pages
81–84
Issue
2
Volume
328
Dublin Core
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Title
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Castration increases nisoxetine-evoked norepinephrine levels in vivo within the olfactory bulb of male rats.
Publisher
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Neuroscience letters
Date
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2002
2002-08
Subject
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Animal/drug effects/physiology; Animals; Atomoxetine Hydrochloride; Extracellular Space/metabolism; Fluoxetine/*analogs & derivatives/*pharmacology; Male; Microdialysis; Norepinephrine Plasma Membrane Transport Proteins; Norepinephrine/*metabolism; Olfactory Bulb/drug effects/*metabolism; Orchiectomy/*adverse effects; Presynaptic Terminals/drug effects/metabolism; Propylamines/pharmacology; Rats; Reproduction/*physiology; Sexual Behavior; Smell/drug effects/physiology; Sprague-Dawley; Symporters/antagonists & inhibitors/*metabolism; Testosterone/*deficiency/metabolism; Up-Regulation/drug effects/physiology
Creator
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Shang Yili; Dluzen Dean E
Description
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In the present experiment we compared differences in extracellular norepinephrine levels in vivo within the olfactory bulb of intact and castrated male rats following infusion of the norepinephrine transport inhibitors, nisoxetine and tomoxetine. With this approach it was possible to assess whether dynamic changes in in vivo norepinephrine transporter function occur as a function of the gonadal state of the animal. Norepinephrine levels following infusion of nisoxetine were significantly increased in castrated compared with intact male rats. While a similar trend was present in response to tomoxetine infusion, these differences failed to achieve a statistically significant difference. These results demonstrate that castration of male rats alters norepinephrine transporter function within the olfactory bulbs. The increased extracellular levels of norepinephrine in response to agents which inhibit transporter function suggest that castration reduces transporter activity. Such effects have important implications not only with regard to processes involving the norepinephrine system in the olfactory bulb but also to the generalized sites and mechanisms by which gonadal steroid hormones modulate central nervous system functions.
Identifier
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<a href="http://doi.org/10.1016/s0304-3940(02)00412-3" target="_blank" rel="noreferrer noopener">10.1016/s0304-3940(02)00412-3</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2002
Animal/drug effects/physiology
Animals
Atomoxetine Hydrochloride
Dluzen Dean E
Extracellular Space/metabolism
Fluoxetine/*analogs & derivatives/*pharmacology
Male
Microdialysis
Neuroscience letters
Norepinephrine Plasma Membrane Transport Proteins
Norepinephrine/*metabolism
Olfactory Bulb/drug effects/*metabolism
Orchiectomy/*adverse effects
Presynaptic Terminals/drug effects/metabolism
Propylamines/pharmacology
Rats
Reproduction/*physiology
Sexual Behavior
Shang Yili
Smell/drug effects/physiology
Sprague-Dawley
Symporters/antagonists & inhibitors/*metabolism
Testosterone/*deficiency/metabolism
Up-Regulation/drug effects/physiology