Pseudogout following intraarticular injection of sodium hyaluronate.
Chondrocalcinosis/*chemically induced; Contraindications; Humans; Hyaluronic Acid/*adverse effects; Injections; Intra-Articular; Knee Joint/drug effects/physiopathology; Male; Middle Aged; Osteoarthritis/*drug therapy; Pain/drug therapy
Luzar M J; Altawil B
Arthritis and rheumatism
1998
1998-05
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1002/1529-0131(199805)41:5%3C939::AID-ART24%3E3.0.CO;2-D" target="_blank" rel="noreferrer noopener">10.1002/1529-0131(199805)41:5%3C939::AID-ART24%3E3.0.CO;2-D</a>
Histone Deacetylase Inhibitor Vorinostat (SAHA) Suppresses IL-1beta-Induced Matrix Metallopeptidase-13 Expression by Inhibiting IL-6 in Osteoarthritis Chondrocyte.
Aged; Articular/drug effects/metabolism; Blotting; Cartilage; Chondrocytes/drug effects; Collagen Type II/drug effects/metabolism; Down-Regulation/drug effects; Female; Gene Expression Regulation/*drug effects; Histone Deacetylase Inhibitors/*pharmacology; Humans; Hydroxamic Acids/*pharmacology; Interleukin-1beta/*antagonists & inhibitors/genetics/metabolism; Knee Joint/metabolism; Male; Matrix Metalloproteinase 13/*drug effects/metabolism; Middle Aged; Osteoarthritis/*drug therapy; Proteoglycans/metabolism; Tumor Necrosis Factor-alpha/drug effects/metabolism; Vorinostat; Western
Osteoarthritis (OA) is the most common whole-joint disease and is characterized by progressive loss of the cartilage matrix. Matrix metallopeptidase-13 (MMP-13) is a highly active and an abundantly expressed protease in OA cartilage and chondrocytes and degrades type II collagen and proteoglycans. We investigated the mechanism of MMP-13 suppression by histone deacetylase inhibitor vorinostat (SAHA). OA chondrocytes were obtained from knee cartilage after enzymatic digestion and treated with IL-1beta in the absence or presence of various histone deacetylase inhibitors. Gene expression was quantified using quantitative RT-PCR. Protein expression and chromatin modifications were determined by Western immunoblotting using specific antibodies. The effect of IL-6 on the expression of
Makki Mohammad Shahidul; Haqqi Tariq M
The American journal of pathology
2016
2016-10
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1016/j.ajpath.2016.06.010" target="_blank" rel="noreferrer noopener">10.1016/j.ajpath.2016.06.010</a>