1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.4081/reumatismo.2003.195" target="_blank" rel="noreferrer noopener">http://doi.org/10.4081/reumatismo.2003.195</a>
Pages
195–201
Issue
3
Volume
55
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Thermodynamic resolution of periosteal reaction and taphonomic change.
Publisher
An entity responsible for making the resource available
Reumatismo
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
1905-6
Subject
The topic of the resource
Humans; Osteoarthritis/pathology; *Fossils; Bone Remodeling; Hot Temperature; *Thermodynamics; Entropy; Paleopathology/*methods; Periosteum/*pathology; Biological; Models
Creator
An entity primarily responsible for making the resource
Rothschild B M; Rothschild C
Description
An account of the resource
New bone formation (e.g., periosteal reaction) is one component of bone and joint disease diagnosis. Its application in the archeologic record has been compromised by lack of standardization. An objective technique for validating observations seems especially valuable when visual examination of a single data set results in widely disparate perspectives. Such discrepancies as to presence or absence of periosteal reaction are amenable to objective analysis. Bone, as any other form of matter, has a variety of properties. Some are characterized by weight or volume and are referred to as colligative. Some are related to its intrinsic nature, independent of mass. The latter are referred to as non-colligative. Non-colligative properties of matter provide an opportunity to assess structure, independent of quantity. Study of one such property, entropy, revealed that taphonomic changes can confidently be distinguished from bone surface reaction. Contrasted with the homogeneous entropy of normal bone, the loss of surface bone inherent in taphonomy results in reduced entropy. Contrasted with the homogenous patterns of normal bone, specific non-homogenous patterns allow periosteal reaction to be recognized, independent of variety of periosteal reaction or its origin. Thermographic approach allows observational techniques to be independently validated. Such validation allows for greater facility in interobserver archeologic site sample comparisons.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.4081/reumatismo.2003.195" target="_blank" rel="noreferrer noopener">10.4081/reumatismo.2003.195</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Fossils
*Thermodynamics
2003
Biological
Bone Remodeling
Entropy
Hot Temperature
Humans
Models
Osteoarthritis/pathology
Paleopathology/*methods
Periosteum/*pathology
Reumatismo
Rothschild B M
Rothschild C
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.4081/reumatismo.2002.272" target="_blank" rel="noreferrer noopener">http://doi.org/10.4081/reumatismo.2002.272</a>
Pages
272–284
Issue
3
Volume
54
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Contributions of paleorheumatology to understanding contemporary disease.
Publisher
An entity responsible for making the resource available
Reumatismo
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002-09
Subject
The topic of the resource
Humans; Animals; Immunohistochemistry; Body Temperature; Phylogeny; Osteoarthritis/pathology; Radiography; Fossils; Bone Remodeling; DNA; DNA/genetics/isolation & purification; *Paleopathology/instrumentation/methods; *Rheumatology; Bone and Bones/chemistry/diagnostic imaging/immunology; Bone Diseases/*pathology; Collagen/immunology/isolation & purification; Dinosaurs; Gout/pathology; Joint Diseases/*pathology; Mammals; Microscopy/methods; Rheumatic Diseases/pathology; Imaging; Arthritis; Three-Dimensional; Sequence Analysis; Infectious/pathology; Reactive/pathology
Creator
An entity primarily responsible for making the resource
Rothschild B
Description
An account of the resource
As paleopathology has evolved from observational speculation to analysis of testable hypotheses, so too has recognition of its contribution to vertebrate paleontology. In the presence of significant structural and density variation (between matrix and osseous structures), x-rays provide an additional perspective of osseous response to stress and disease. As film techniques are time and cost expensive, fluoroscopy has proven a valuable alternative. Radiologic techniques also allow non-invasive "sectioning" of specimens, illustrating significant internal detail. The object can be "split" on a plane and the two portions rotated to "open" the image. This three-dimensional approach now can be applied to other forms of sequential data to their facilitate 3-dimensional representation graphically or with solid representations. Antigen and microstructure may be well preserved in fossils. Molecular preservation with retention of helical structure and sensitivity to collagenase has been demonstrated in 10,000 year old collagen. Antigen has been extracted from 100 million year old bone and documented, in situ, in 11,000 year old bone. If the appropriate site in the tissue is assessed, if antigen is still present, and if the appropriate antisera is utilized, fixation of the antibody to the specimen can be detected. Minute amounts of DNA can be amplified and analyzed. Recovery of DNA from a 40,000 year old mammoth, 17,000 year old bison and from 25 million year old insects provides opportunity for cloning and independent assessment of relationships. Implications of available technology focuses direction for development of collaborative approaches.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.4081/reumatismo.2002.272" target="_blank" rel="noreferrer noopener">10.4081/reumatismo.2002.272</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Paleopathology/instrumentation/methods
*Rheumatology
2002
Animals
Arthritis
Body Temperature
Bone and Bones/chemistry/diagnostic imaging/immunology
Bone Diseases/*pathology
Bone Remodeling
Collagen/immunology/isolation & purification
Dinosaurs
DNA
DNA/genetics/isolation & purification
Fossils
Gout/pathology
Humans
Imaging
Immunohistochemistry
Infectious/pathology
Joint Diseases/*pathology
Mammals
Microscopy/methods
Osteoarthritis/pathology
Phylogeny
Radiography
Reactive/pathology
Reumatismo
Rheumatic Diseases/pathology
Rothschild B
Sequence Analysis
Three-Dimensional
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1038/srep43789" target="_blank" rel="noreferrer noopener">http://doi.org/10.1038/srep43789</a>
Pages
43789–43789
Volume
7
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A wogonin-rich-fraction of Scutellaria baicalensis root extract exerts chondroprotective effects by suppressing IL-1beta-induced activation of AP-1 in human OA chondrocytes.
Publisher
An entity responsible for making the resource available
Scientific reports
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-03
Subject
The topic of the resource
Cells; Chemical Fractionation/methods; Chondrocytes/*drug effects/metabolism; Cultured; Cyclooxygenase 2/genetics/metabolism; Flavanones/*pharmacology; Gene Expression Regulation/drug effects; Humans; Interleukin-1beta/pharmacology; Interleukin-6/genetics/metabolism; Osteoarthritis/pathology; Plant Extracts/*pharmacology; Plant Roots/*chemistry; Protective Agents/pharmacology; Reactive Oxygen Species/metabolism; Scutellaria baicalensis/*chemistry; Transcription Factor AP-1/genetics/*metabolism
Creator
An entity primarily responsible for making the resource
Khan Nazir M; Haseeb Abdul; Ansari Mohammad Y; Haqqi Tariq M
Description
An account of the resource
Osteoarthritis (OA) is a common joint disorder with varying degrees of inflammation and sustained oxidative stress. The root extract of Scutellaria baicalensis (SBE) has been used for the treatment of inflammatory and other diseases. Here, we performed activity-guided HPLC-fractionation of SBE, identified the active ingredient(s) and investigated its chondroprotective potential. We found that the Wogonin containing fraction-4 (F4) was the most potent fraction based on its ability to inhibit ROS production and the suppression of catabolic markers including IL-6, COX-2, iNOS, MMP-3, MMP-9,
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1038/srep43789" target="_blank" rel="noreferrer noopener">10.1038/srep43789</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2017
Ansari Mohammad Y
Cells
Chemical Fractionation/methods
Chondrocytes/*drug effects/metabolism
Cultured
Cyclooxygenase 2/genetics/metabolism
Department of Anatomy & Neurobiology
Flavanones/*pharmacology
Gene Expression Regulation/drug effects
Haqqi Tariq M
Haseeb Abdul
Humans
Interleukin-1beta/pharmacology
Interleukin-6/genetics/metabolism
Khan Nazir M
NEOMED College of Medicine
Osteoarthritis/pathology
Plant Extracts/*pharmacology
Plant Roots/*chemistry
Protective Agents/pharmacology
Reactive Oxygen Species/metabolism
Scientific reports
Scutellaria baicalensis/*chemistry
Transcription Factor AP-1/genetics/*metabolism