Browse Items (47 total)
- Tags: Osteoarthritis
Imperatorin suppresses IL-1beta-induced iNOS expression via inhibiting
Tags: 2020, Ahmad Nashrah, Ansari Mohammad Y, Bano Shabana, Department of Anatomy & Neurobiology, Haqqi Tariq M, Imperatorin, Inflammation, iNOS, International Immunopharmacology, journalArticle, June 2020 Update II, NEOMED College of Medicine, Osteoarthritis, Oxidative-stress, Plant-derived-polyphenol
Role of iNOS in osteoarthritis: Pathological and therapeutic aspects.
Inhibition of cartilage degradation and suppression of PGE2 and MMPs expression by pomegranate fruit extract in a model of posttraumatic osteoarthritis.
Tags: *Phytotherapy, *Punicaceae, 2017, ACLT, Akhtar Nahid, Animal, Animals, Anterior Cruciate Ligament/drug effects/metabolism/pathology, Apoptosis, Ashruf Omer S, Cartilage/cytology/*drug effects/metabolism/pathology, Chondrocytes/drug effects/metabolism/pathology, Collagen Type II/genetics/metabolism, Department of Anatomy & Neurobiology, Dinoprostone/*metabolism, Disease Models, Disease Progression, Female, Fruit, Haqqi Tariq M, Interleukins/metabolism, Joints/cytology/*drug effects/metabolism/pathology, Khan Nazir M, Male, Messenger/metabolism, Metalloproteases/genetics/*metabolism, Mitogen-Activated Protein Kinases/metabolism, MMPs, NEOMED College of Medicine, NF-kappa B/metabolism, Nutrition (Burbank, Los Angeles County, Calif.), Osteoarthritis, Osteoarthritis/*drug therapy/etiology/metabolism/pathology, PGE(2), Plant Extracts/pharmacology/therapeutic use, Pomegranate, Rabbit, Rabbits, RNA, Synovial Fluid/metabolism
MicroRNA-602 and microRNA-608 regulate sonic hedgehog expression via target sites in the coding region in human chondrocytes.
Tags: 2015, Academic Medical Centers, Aged, Akhtar Nahid, Analysis of Variance, Animal, Animals, Anterior Cruciate Ligament/surgery, Arthritis & rheumatology (Hoboken, N.J.), Blotting, Cells, Chondrocytes – Physiology, Chondrocytes/drug effects/*metabolism/pathology, Cultured, Department of Anatomy & Neurobiology, Disease Models, Female, Funding Source, Gene Expression Regulation/genetics/*physiology, Haqqi Tariq M, Hedgehog Proteins/genetics/*metabolism, HEK293 Cells, Human, Humans, Immunohistochemistry, In Vitro Techniques, Interleukin-1beta/pharmacology, Knee/etiology/*metabolism/pathology, Makki Mohammad S, Male, Matrix Metalloproteinase 13/metabolism, MicroRNAs/genetics/*metabolism, Middle Age, Middle Aged, NEOMED College of Medicine, Ohio, Open Reading Frames/genetics/*physiology, Osteoarthritis, Osteoarthritis – Epidemiology, Osteoarthritis – Physiopathology, Polymerase Chain Reaction, Rabbits, Signal Transduction/genetics/physiology, T-Tests, Transfection, Up-Regulation/drug effects/genetics/physiology, Western
Parkin clearance of dysfunctional mitochondria regulates ROS levels and increases survival of human chondrocytes.
Mitochondrial dysfunction triggers catabolic response in chondrocytes via ROS mediated activation of JNK/AP1 pathway.
Lysosomal dysfunction in osteoarthritis and aged cartilage triggers apoptosis in chondrocytes through BAX mediated release of cytochrome c.
Tags: 2020, ageing, Ansari M Y, Apoptosis, Ball HC, Bax, Department of Anatomy & Neurobiology, Haqqi TM, journalArticle, Lysosomal dysfunction, Mitochondrial dysfunction, NEOMED College of Medicine, NEOMED Student Publications, Novak K, October 2020 List, Osteoarthritis, Osteoarthritis and cartilage, Wase SJ
Butein Activates Autophagy Through AMPK/TSC2/ULK1/mTOR Pathway to Inhibit IL-6 Expression in IL-1beta Stimulated Human Chondrocytes.
Tags: 2018, Ahmad Nashrah, AMP-Activated Protein Kinases/metabolism, AMPK, Ansari Mohammad Y, Articular/cytology/pathology, Autophagy, Autophagy-Related Protein 5/antagonists & inhibitors/genetics/metabolism, Autophagy-Related Protein-1 Homolog/metabolism, Autophagy/*drug effects, Butein, Cartilage, Cell Survival/drug effects, Cells, Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Chalcones/*pharmacology, Chondrocytes/cytology/drug effects/metabolism, Cultured, Department of Anatomy & Neurobiology, Haqqi Tariq M, Humans, Inflammation, Interleukin-1beta/*pharmacology, Interleukin-6/genetics/*metabolism, Intracellular Signaling Peptides and Proteins/metabolism, mTOR, NEOMED College of Medicine, Osteoarthritis, Osteoarthritis/metabolism/pathology, Phosphorylation/drug effects, Reactive Oxygen Species/metabolism, RNA, RNA Interference, Signal Transduction/*drug effects, Small Interfering/metabolism, TOR Serine-Threonine Kinases/metabolism, TSC2, Tuberous Sclerosis Complex 2 Protein, Tumor Suppressor Proteins/metabolism, ULK1
Genetic Inactivation of ZCCHC6 Suppresses Interleukin‐6 Expression and Reduces the Severity of Experimental Osteoarthritis in Mice.
Tags: 2019, Ahmad Nashrah, ANIMAL experimentation, Ansari Mohammad Y, Arthritis & Rheumatology, Cartilage, CARTILAGE cells, Dactinomycin, Department of Anatomy & Neurobiology, DNA-Binding Proteins, Gene Expression, GENETIC aspects, Green Jonathan, Haqqi Tariq M, In Vivo Studies, Interleukins, June 2019 Update, Khan Nazir M, Mice, MicroRNA, NEOMED College of Medicine, Novak Kimberly, Osteoarthritis, Prevention, Sequence Analysis, Severity of Illness Index, SYNOVITIS, Transcription Factors
A standardized extract of Butea monosperma (Lam.) flowers suppresses the
Tags: *Butea, 2017, Aged, Ansari Mohammad Y, Autophagy, Autophagy/drug effects/physiology, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, Butea monosperma (Lam.), Chondrocytes/drug effects/*metabolism, Department of Anatomy & Neurobiology, Dose-Response Relationship, Drug, Flowers, Gene Expression, Haqqi Tariq M, Humans, Interleukin-1beta/*pharmacology, Interleukin-6/*biosynthesis/genetics, Khan Nazir M, Matrix Metalloproteinase 13/biosynthesis/genetics, Matrix Metalloproteinase 3/biosynthesis/genetics, Matrix Metalloproteinase 9/biosynthesis/genetics, Matrix Metalloproteinases/*biosynthesis/genetics, Middle Aged, mTOR, NEOMED College of Medicine, Nutraceuticals, Osteoarthritis, Osteoarthritis/*metabolism, Plant Extracts/isolation & purification/pharmacology
Oxidative stress and inflammation in osteoarthritis pathogenesis: Role of polyphenols.
Assessing chondrocyte status by immunofluorescence-mediated localization of parkin relative to mitochondria.
Tags: 2021, Ansari MY, Autophagy, CCCP, Chondrocytes, Confocal microscopy, Department of Anatomy & Neurobiology, Haqqi TM, IL-1β, immunofluorescence, Inflammation, January 2021 List, journalArticle, Methods in Molecular Biology, Mitochondria, Mitochondrial dysfunction, mitophagy, MitoTracker Deep Red, NEOMED College of Medicine, Osteoarthritis, Oxidative Stress, Parkin, PINK1
Associations between biomarkers of joint metabolism, hand osteoarthritis, and hand pain and function: the Johnston County Osteoarthritis Project.
Tags: 2014, Adult, Aged, Arthralgia – Metabolism, Arthralgia – Physiopathology, Arthralgia – Radiography, Arthralgia/*diagnostic imaging/*metabolism/physiopathology, Aslam Imran, Biological Markers – Blood, Biomarkers, Biomarkers/blood, Carpometacarpal Joints – Metabolism, Carpometacarpal Joints – Physiopathology, Carpometacarpal Joints – Radiography, Carpometacarpal Joints/diagnostic imaging/metabolism/physiopathology, Cross Sectional Studies, Cross-Sectional Studies, Female, Finger Joint – Metabolism, Finger Joint – Physiopathology, Finger Joint – Radiography, Finger Joint/diagnostic imaging/metabolism/physiopathology, Golightly Yvonne M, HAND JOINTS, Hand Joints – Metabolism, Hand Joints – Physiopathology, Hand Joints – Radiography, Hand Joints/*diagnostic imaging/*metabolism/physiopathology, Human, Humans, Jordan Joanne M, Kraus Virginia B, Male, Metacarpophalangeal Joint – Metabolism, Metacarpophalangeal Joint – Physiopathology, Metacarpophalangeal Joint – Radiography, Metacarpophalangeal Joint/diagnostic imaging/metabolism/physiopathology, Middle Age, Middle Aged, Nelson Amanda E, Osteoarthritis, Osteoarthritis – Metabolism, Osteoarthritis – Physiopathology, Osteoarthritis – Radiography, Osteoarthritis/*diagnostic imaging/*metabolism/physiopathology, Perjar Irina, Radiography, Renner Jordan B, Severity of Illness Index, Severity of Illness Indices, Shi Xiaoyan A, The Journal of rheumatology
ECM Production of Primary Human and Bovine Chondrocytes in Hybrid PEG Hydrogels Containing Type I Collagen and Hyaluronic Acid
Tags: 2012, Arthritis, articular-cartilage, Becker M L, Biochemistry & Molecular Biology, Biomacromolecules, Callahan L A S, Chemistry, chondral defects, Dilisio M F, Ganios A M, Horton W E, Journal Article or Conference Abstract Publication, Knee, matrix, McBurney D L, microfracture, networks, Osteoarthritis, Polymer Science, Prevalence, stem-cells, Weiner S D
Contributions of symptomatic osteoarthritis and physical function to incident cardiovascular disease.
Patients' reasons for electing to undergo total knee arthroplasty impact post-operative pain severity and range of motion
Tags: 2009, Approach-avoidance goals, Boarts J M, chronic musculoskeletal pain, Cremeans-Smith J K, Delahanty D L, fatigue, Fear, Greene K, Journal Article or Conference Abstract Publication, Journal of Behavioral Medicine, Osteoarthritis, Pain, Post-operative recovery, predictors, Psychology, quality-of-life, Reasoning, Replacement, Surgery, Surgical outcome, Total knee arthroplasty
Sacroiliac joint bridging: Demographical and anatomical aspects
Tags: 2005, ankylosing, bridging, Dar G, Evolution, Hershkovitz I, idiopathic skeletal hyperostosis, Journal Article or Conference Abstract Publication, Masharawi Y, Neurosciences & Neurology, Orthopedics, Osteoarthritis, Peled N, Peleg S, Population, Rothschild B M, Sacroiliac Joint, Spine, spine diseases, Spondylitis, spondyloathropathy, Steinberg N
tRNA-derived fragments (tRFs) regulate post-transcriptional gene expression via
Tags: 2020, Ansari M Y, Ball H C, chondrocyte, Department of Anatomy & Neurobiology, Green J A, Haqqi Tariq M, JAK3, journalArticle, June 2020 Update II, NEOMED College of Medicine, NEOMED College of Medicine Postdoc, NEOMED Postdoc Publications, Noncoding RNA, Osteoarthritis, Osteoarthritis and cartilage, Transfer RNA, tRNA-derived fragments
Modification Of Osteoarthritis In The Guinea Pig With Pulsed Low-intensity Ultrasound Treatment
Tags: 2010, aggrecan, articular-cartilage, Cartilage, Cartilage repair, degeneration, double-blind trial, electromagnetic-fields, gene-expression, Gurkan I, Horton W E, Huckle J, in-vitro, Journal Article or Conference Abstract Publication, knee osteoarthritis, matrix production, Orthopedics, Osteoarthritis, Osteoarthritis and cartilage, placebo-controlled trials, Pleshko N, Ranganathan A, Rheumatology, Spencer R G, therapeutic ultrasound, tissue engineered cartilage, Todman M, Ultrasound, Yang X
Delphinidin Inhibits Il-1 Beta-induced Activation Of Nf-kappa B By Modulating The Phosphorylation Of Irak-1(ser376) In Human Articular Chondrocytes
Tags: 2013, Chen D X, Chondrocytes, COX-2, delphinidin, Down-Regulation, factor-alpha, gene-expression, Haqqi T M, Haseeb A, human osteoarthritis chondrocytes, IL-1 beta, in-vitro, interleukin-1, Journal Article or Conference Abstract Publication, Kinase, nf-kappa-b, Osteoarthritis, Oxidative Stress, PGE(2), rheumatoid-arthritis, Rheumatology, tumor-necrosis-factor
A Polyphenol-rich Pomegranate Fruit Extract Suppresses NF-kappaB and IL-6 Expression by Blocking the Activation of IKKbeta and NIK in Primary Human Chondrocytes.
Tags: 2017, Ashruf Omer S, Chondrocytes, Chondrocytes – Drug Effects, Chondrocytes/drug effects, Department of Anatomy & Neurobiology, Fruit, Fruit/chemistry, Gene Expression Regulation/drug effects, Genes – Drug Effects, Haqqi Tariq M, Haseeb Abdul, Humans, I-kappa B Kinase/genetics/*metabolism, IkappaB, IKKbeta, IL-1beta, Interleukin 1 – Metabolism, Interleukin-1beta/metabolism, Interleukin-6/genetics/*metabolism, Interleukins, Interleukins – Metabolism, Khan Nazir M, NEOMED College of Medicine, NF-kappa B, NF-kappa B – Metabolism, NF-kappa B/genetics/*metabolism, NF-kappaB, NIK, Osteoarthritis, Phosphorylation – Drug Effects, Phosphorylation/drug effects, Phytotherapy research : PTR, Plant Extracts, Plant Extracts – Pharmacodynamics, Plant Extracts/chemistry/*pharmacology, Polyphenols – Pharmacodynamics, Polyphenols/pharmacology, Pomegranate, Protein-Serine-Threonine Kinases/genetics/*metabolism, Proteins – Metabolism, Punicaceae/*chemistry, Signal Transduction – Drug Effects, Signal Transduction/drug effects, Transcription Factor RelA/metabolism, Transferases, Transferases – Metabolism
Medical Care Perceptions In Elderly Patients With Musculoskeletal Complaints
Tags: 2001, Arthritis, Chronic Disease, Elderly, General & Internal Medicine, Hershkovitz A, Hornick T, Israel Medical Association Journal, Journal Article or Conference Abstract Publication, Knee, Management, musculoskeletal symptoms, O'Toole E E, Osteoarthritis, outcomes, Pain, patient expectations, patient perception, Patient Satisfaction, physician, Rose J H, Rothschild B M, satisfaction, treatment regimens
Wogonin, a natural flavonoid, intercalates with genomic DNA and exhibits protective effects in IL-1beta stimulated osteoarthritis chondrocytes.
Tags: 2017, Ahmad Imran, Ansari Mohammad Y, Apoptosis/drug effects, Binding Sites, Cells, Chemico-biological interactions, Chondrocytes/cytology/*drug effects/metabolism, Chondroprotective effects, Cultured, Denaturation, Department of Anatomy & Neurobiology, DNA binding, DNA/chemistry/*metabolism, Flavanones/chemistry/metabolism/*pharmacology, Flavonoids/chemistry/pharmacology, Fluorescence Resonance Energy Transfer, Haqqi Tariq M, Humans, Intercalating Agents/chemistry/metabolism/*pharmacology, Interleukin-1beta/*pharmacology, Khan Nazir M, Molecular Docking Simulation, NEOMED College of Medicine, Nucleic Acid Conformation, Osteoarthritis, Osteoarthritis/metabolism/pathology, Protective Agents/chemistry/metabolism/*pharmacology, Reactive Oxygen Species/metabolism, Up-Regulation/drug effects, Wogonin
Dataset of effect of Wogonin, a natural flavonoid, on the viability and activation of NF-kappaB and MAPKs in IL-1beta-stimulated human OA chondrocytes.
Fourier Transform Infrared Imaging Spectroscopic Analysis Of Tissue Engineered Cartilage: Histologic And Biochemical Correlations
Tags: 2005, Bi X H, Biochemistry & Molecular Biology, bioreactor, Camacho N P, Chondrocytes, Collagen, Fourier transform infrared imaging spectroscopy, hollow fiber bioreactor, hollow-fiber, Horton W E, human articular-cartilage, Journal Article or Conference Abstract Publication, Journal of Biomedical Optics, Kim M, magnetic-resonance microscopy, matrix, Medical Imaging, model, mri techniques, Nuclear Medicine &, optics, Osteoarthritis, proteoglycans, Radiology, Spencer R G, tissue engineered cartilage, Tissue Engineering
MicroRNA-9 promotion of interleukin-6 expression by inhibiting monocyte chemoattractant protein-induced protein 1 expression in interleukin-1beta-stimulated human chondrocytes.
Tags: 2015, Academic Medical Centers, Aged, Arthritis & rheumatology (Hoboken, N.J.), Articular/drug effects/*metabolism, Cartilage, Cells, Chondrocytes – Physiology, Chondrocytes/drug effects/*metabolism, Cultured, Department of Anatomy & Neurobiology, Enzyme-Linked Immunosorbent Assay, Funding Source, Gene Knockdown Techniques, Haqqi Tariq M, Haseeb Abdul, Hip/*genetics/metabolism, Human, Humans, Immunoblotting – Utilization, Immunoprecipitation, Interleukin-1beta/pharmacology, Interleukin-6/*genetics/metabolism, Interleukins – Physiology, Makki Mohammad S, Messenger/drug effects/*metabolism, MicroRNAs/drug effects/*genetics/metabolism, Middle Aged, NEOMED College of Medicine, Ohio, Osteoarthritis, Osteoarthritis – Complications, Osteoarthritis – Physiopathology, Reverse Transcriptase Polymerase Chain Reaction, Ribonucleases/drug effects/*genetics/metabolism, RNA, T-Tests, Transcription Factors/drug effects/*genetics/metabolism
Comparison of changes in blood pressure measurements and antihypertensive therapy in older, hypertensive, ambulatory care patients prescribed celecoxib or rofecoxib
Tags: 2003, congestive-heart-failure, controlled trial, cox-2 inhibitor, Dickerson L M, elderly-patients, gastrointestinal toxicity, Journal Article, Nietert P J, nonsteroidal antiinflammatory drugs, nsaids, Ornstein S M, Osteoarthritis, Pharmacology & Pharmacy, Pharmacotherapy, renal-function, rheumatoid-arthritis, Rothenberg R J
Degenerative sternoclavicular arthritis and hyperostosis.
Tags: 2003, Adult, Arthritis, Arthritis – Classification, Arthritis – Drug Therapy, Arthritis – Surgery, Arthroplasty, Athletic Injuries – Complications, Clinics in sports medicine, Female, Heterotopic, Male, Middle Age, Noble J S, Ossification, Osteitis, Osteoarthritis, Sternoclavicular Joint – Pathology
Advanced osteoarthritis in humans is associated with altered collagen VI expression and upregulation of ER-stress markers Grp78 and bag-1.
Tags: 2009, Adult, Antigens/biosynthesis, Articular/metabolism, Baraga Anthony, Biomarkers/metabolism, Bone Neoplasms/metabolism, Cartilage, Chondrosarcoma/metabolism, Collagen Type VI/*biosynthesis, Department of Anatomy & Neurobiology, DNA-Binding Proteins/*biosynthesis, Doane Kathleen J, Down-Regulation, Endoplasmic Reticulum/*metabolism, Gradisar Ian, Heat-Shock Proteins/*biosynthesis, Horton Walter E Jr, Humans, Knee/*metabolism/physiopathology, McBurney Denise L, Middle Aged, NEOMED College of Medicine, Nugent Ashleigh E, Osteoarthritis, Osteosarcoma/metabolism, Proteoglycans/biosynthesis, Speicher Danielle M, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Transcription Factors/*biosynthesis, Up-Regulation
Response of engineered cartilage tissue to biochemical agents as studied by proton magnetic resonance microscopy
Nondestructive, Epi-Illumination Surface Microscopic Characterization of Surface Discontinuity in Bone: A New Approach Offers a Descriptive Vocabulary and New Insights
Tags: 2013, Age, Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology, Anatomy & Morphology, Arthritis, classification, defleshed bones, Disease, erosive, Journal Article, morphology, of-rheumatology criteria, Osteoarthritis, Pathology, periosteal reaction, Porosity, Rothschild B M, scanning electron-microscopy, scurvy, Sharpey fibers, taphonomy
PARAVERTEBRALMASSES IN BLUE-TAILED MONITOR, VARANUS DORIANUS, INDICATIVE OF SOFT-TISSUE INFECTION WITH ASSOCIATED OSTEOMYELITIS
Tags: 2014, Bone, Bone disease, Cells, classification, deformans pagets-disease, Journal Article, Journal of Zoo and Wildlife Medicine, lizard, mass, of-rheumatology criteria, Osteoarthritis, Osteomyelitis, Paget's disease, Rothschild B M, Spondyloarthropathy, Varanus dorianus, Vertebrae, Veterinary Sciences, virus
What is this disease we call spondyloarthropathy?
Tags: 2003, Arthritis, Clinical and experimental rheumatology, Collagen induced arthritis, dactylitis, defleshed bones, erosive, ii collagen, immune complex arthritis, inflammatory arthritis, joint fusion, Journal Article, macaca-mulatta, monkeys, Osteoarthritis, rheumatoid, rheumatoid-arthritis, Rheumatology, Rothschild B M, Spondyloarthropathy, subchondral erosions, trophism
Decompression syndrome and diving behavior in Odontochelys, the first turtle
Tags: 2015, 3-degrees-c, Acta Palaeontologica Polonica, adaptations, avascular necrosis, bone pathology, caretta-caretta, China, diving behavior, gas-exchange, Ichthyosaurs, Journal Article, leatherback turtle, Naples V, Odontochelys, Osteoarthritis, Osteomyelitis, Paleontology, Rothschild B M, SEA, Testudines, Triassic, turtle
Osteoarthritis is for the birds
Tags: 2006, Animal models, Birds, classification, Clinical rheumatology, guinea-pigs, inflammatory arthritis, Journal Article, Knee, monkeys, of-rheumatology criteria, Osteoarthritis, Panza R, pyrophosphate deposition disease, rhesus macaques, Rheumatology, Rothschild B M, santiago, Spondyloarthropathy