Raising concerns about the Sepsis-3 definitions.
*Data Accuracy; *Infections; *Organ dysfunction; *Sepsis; *Septic shock; *Severity of Illness Index; Arterial Pressure; Consensus; Glasgow Coma Scale; Humans; Infection; Organ Dysfunction Scores; Publishing; Sensitivity and Specificity; Sepsis; Sepsis/*classification/mortality; Validation Studies
The Global Alliance for Infections in Surgery appreciates the great effort of the task force who derived and validated the Sepsis-3 definitions and considers the new definitions an important step forward in the evolution of our understanding of sepsis. Nevertheless, more than a year after their publication, we have a few concerns regarding the use of the Sepsis-3 definitions.
Sartelli Massimo; Kluger Yoram; Ansaloni Luca; Hardcastle Timothy C; Rello Jordi; Watkins Richard R; Bassetti Matteo; Giamarellou Eleni; Coccolini Federico; Abu-Zidan Fikri M; Adesunkanmi Abdulrashid K; Augustin Goran; Baiocchi Gian L; Bala Miklosh; Baraket Oussema; Beltran Marcelo A; Jusoh Asri Che; Demetrashvili Zaza; De Simone Belinda; de Souza Hamilton P; Cui Yunfeng; Davies R Justin; Dhingra Sameer; Diaz Jose J; Di Saverio Salomone; Dogjani Agron; Elmangory Mutasim M; Enani Mushira A; Ferrada Paula; Fraga Gustavo P; Frattima Sabrina; Ghnnam Wagih; Gomes Carlos A; Kanj Souha S; Karamarkovic Aleksandar; Kenig Jakub; Khamis Faryal; Khokha Vladimir; Koike Kaoru; Kok Kenneth Y Y; Isik Arda; Labricciosa Francesco M; Latifi Rifat; Lee Jae G; Litvin Andrey; Machain Gustavo M; Manzano-Nunez Ramiro; Major Piotr; Marwah Sanjay; McFarlane Michael; Memish Ziad A; Mesina Cristian; Moore Ernest E; Moore Frederick A; Naidoo Noel; Negoi Ionut; Ofori-Asenso Richard; Olaoye Iyiade; Ordonez Carlos A; Ouadii Mouaqit; Paolillo Ciro; Picetti Edoardo; Pintar Tadeja; Ponce-de-Leon Alfredo; Pupelis Guntars; Reis Tarcisio; Sakakushev Boris; Kafil Hossein Samadi; Sato Norio; Shah Jay N; Siribumrungwong Boonying; Talving Peep; Trana Cristian; Ulrych Jan; Yuan Kuo-Ching; Catena Fausto
World journal of emergency surgery : WJES
2018
1905-07
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1186/s13017-018-0165-6" target="_blank" rel="noreferrer noopener">10.1186/s13017-018-0165-6</a>
Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA).
*International Cooperation; *Intraabdominal Infections/diagnosis/drug therapy/microbiology; Anti-Infective Agents/*pharmacology; Drug Resistance; Humans; Microbial; Microbial Sensitivity Tests; Prognosis
Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs.
Sartelli Massimo; Weber Dieter G; Ruppe Etienne; Bassetti Matteo; Wright Brian J; Ansaloni Luca; Catena Fausto; Coccolini Federico; Abu-Zidan Fikri M; Coimbra Raul; Moore Ernest E; Moore Frederick A; Maier Ronald V; De Waele Jan J; Kirkpatrick Andrew W; Griffiths Ewen A; Eckmann Christian; Brink Adrian J; Mazuski John E; May Addison K; Sawyer Rob G; Mertz Dominik; Montravers Philippe; Kumar Anand; Roberts Jason A; Vincent Jean-Louis; Watkins Richard R; Lowman Warren; Spellberg Brad; Abbott Iain J; Adesunkanmi Abdulrashid Kayode; Al-Dahir Sara; Al-Hasan Majdi N; Agresta Ferdinando; Althani Asma A; Ansari Shamshul; Ansumana Rashid; Augustin Goran; Bala Miklosh; Balogh Zsolt J; Baraket Oussama; Bhangu Aneel; Beltran Marcelo A; Bernhard Michael; Biffl Walter L; Boermeester Marja A; Brecher Stephen M; Cherry-Bukowiec Jill R; Buyne Otmar R; Cainzos Miguel A; Cairns Kelly A; Camacho-Ortiz Adrian; Chandy Sujith J; Jusoh Asri Che; Chichom-Mefire Alain; Colijn Caroline; Corcione Francesco; Cui Yunfeng; Curcio Daniel; Delibegovic Samir; Demetrashvili Zaza; De Simone Belinda; Dhingra Sameer; Diaz Jose J; Di Carlo Isidoro; Dillip Angel; Di Saverio Salomone; Doyle Michael P; Dorj Gereltuya; Dogjani Agron; Dupont Herve; Eachempati Soumitra R; Enani Mushira Abdulaziz; Egiev Valery N; Elmangory Mutasim M; Ferrada Paula; Fitchett Joseph R; Fraga Gustavo P; Guessennd Nathalie; Giamarellou Helen; Ghnnam Wagih; Gkiokas George; Goldberg Staphanie R; Gomes Carlos Augusto; Gomi Harumi; Guzman-Blanco Manuel; Haque Mainul; Hansen Sonja; Hecker Andreas; Heizmann Wolfgang R; Herzog Torsten; Hodonou Adrien Montcho; Hong Suk-Kyung; Kafka-Ritsch Reinhold; Kaplan Lewis J; Kapoor Garima; Karamarkovic Aleksandar; Kees Martin G; Kenig Jakub; Kiguba Ronald; Kim Peter K; Kluger Yoram; Khokha Vladimir; Koike Kaoru; Kok Kenneth Y Y; Kong Victory; Knox Matthew C; Inaba Kenji; Isik Arda; Iskandar Katia; Ivatury Rao R; Labbate Maurizio; Labricciosa Francesco M; Laterre Pierre-Francois; Latifi Rifat; Lee Jae Gil; Lee Young Ran; Leone Marc; Leppaniemi Ari; Li Yousheng; Liang Stephen Y; Loho Tonny; Maegele Marc; Malama Sydney; Marei Hany E; Martin-Loeches Ignacio; Marwah Sanjay; Massele Amos; McFarlane Michael; Melo Renato Bessa; Negoi Ionut; Nicolau David P; Nord Carl Erik; Ofori-Asenso Richard; Omari AbdelKarim H; Ordonez Carlos A; Ouadii Mouaqit; Junior Gerson Alves Pereira; Piazza Diego; Pupelis Guntars; Rawson Timothy Miles; Rems Miran; Rizoli Sandro; Rocha Claudio; Sakakushev Boris; Sanchez-Garcia Miguel; Sato Norio; Segovia Lohse Helmut A; Sganga Gabriele; Siribumrungwong Boonying; Shelat Vishal G; Soreide Kjetil; Soto Rodolfo; Talving Peep; Tilsed Jonathan V; Timsit Jean Francois; Trueba Gabriel; Trung Ngo Tat; Ulrych Jan; van Goor Harry; Vereczkei Andras; Vohra Ravinder S; Wani Imtiaz; Uhl Waldemar; Xiao Yonghong; Yuan Kuo-Ching; Zachariah Sanoop K; Zahar Jean-Ralph; Zakrison Tanya L; Corcione Antonio; Melotti Rita M; Viscoli Claudio; Viale Perluigi
World journal of emergency surgery : WJES
2016
2016
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1186/s13017-016-0089-y" target="_blank" rel="noreferrer noopener">10.1186/s13017-016-0089-y</a>