1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
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n/a
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
101-101
Issue
1
Volume
181
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Rescue of impaired host dopaminergic neurons and the role of overexpressed neural cell adhesion molecule L1 in aged mice grafted with neural stem cells (NSCS)
Publisher
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Experimental Neurology
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
2003-05
Subject
The topic of the resource
Neurosciences & Neurology
Creator
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Ourednik V; Schachner M; Snyder E Y; Lynch W P; Ourednik J
Identifier
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n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2003
Experimental neurology
Journal Article
Lynch W P
Neurosciences & Neurology
Ourednik J
Ourednik V
Schachner M
Snyder E Y
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1038/nbt750" target="_blank" rel="noreferrer noopener">http://doi.org/10.1038/nbt750</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1103-1110
Issue
11
Volume
20
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Title
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Neural stem cells display an inherent mechanism for rescuing dysfunctional neurons
Publisher
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Nature Biotechnology
Date
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2002
2002-11
Subject
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1-methyl-4-phenyl-1; 2; 3; 6-tetrahydropyridine mptp; adult brain; Biotechnology & Applied Microbiology; central-nervous-system; dopaminergic; gene-transfer; growth factor; juvenile neocortex; mouse-brain; neurotoxicity; parkinsons-disease; replacement
Creator
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Ourednik J; Ourednik V; Lynch W P; Schachner M; Snyder E Y
Description
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We investigated the hypothesis that neural stem cells (NSCs) possess an intrinsic capacity to "rescue" dysfunctional neurons in the brains of aged mice. The study focused on a neuronal cell type with stereotypical projections that is commonly compromised in the aged brain-the dopaminergic (DA) neuron. Unilateral implantation of murine NSCs into the midbrains of aged mice, in which the presence of stably impaired but nonapoptotic DA neurons was increased by treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), was associated with bilateral reconstitution of the mesostriatal system. Functional assays paralleled the spatiotemporal recovery of tyrosine hydroxylase (TH) and dopamine transporter (DAT) activity, which, in turn, mirrored the spatiotemporal distribution of donor-derived cells. Although spontaneous conversion of donor NSCs to TH+ cells contributed to nigral reconstitution in DA-depleted areas, the majority of DA neurons in the mesostriatal system were "rescued" host cells. Undifferentiated donor progenitors spontaneously expressing neuroprotective substances provided a plausible molecular basis for this finding. These observations suggest that host structures may benefit not only from NSC-derived replacement of lost neurons but also from the "chaperone" effect of some NSC-derived progeny.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1038/nbt750" target="_blank" rel="noreferrer noopener">10.1038/nbt750</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1-Methyl-4-phenyl-1
2
2002
3
6-tetrahydropyridine mptp
adult brain
Biotechnology & Applied Microbiology
central-nervous-system
dopaminergic
gene-transfer
growth factor
Journal Article
juvenile neocortex
Lynch W P
mouse-brain
Nature Biotechnology
Neurotoxicity
Ourednik J
Ourednik V
parkinsons-disease
Replacement
Schachner M
Snyder E Y
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/stem.227" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/stem.227</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
2846-2856
Issue
11
Volume
27
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Title
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Cross-Talk Between Stem Cells and the Dysfunctional Brain is Facilitated by Manipulating the Niche: Evidence from an Adhesion Molecule
Publisher
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Stem Cells
Date
A point or period of time associated with an event in the lifecycle of the resource
2009
2009-11
Subject
The topic of the resource
adhesion molecule; Aging; aging and age-related diseases; astrocytes; axonal regeneration; Biotechnology & Applied Microbiology; Cell Biology; central-nervous-system; chaperone effect; differentiation; dopamine; extracellular; functional recovery; Hematology; L1; matrix; migration; model; molecules; motor-neurons; mouse; MPTP; neural stem cells; neurodegeneration; neuroprotection; neurotrophic factors; niche; Oncology; oxidative stress; parkinsons-disease; parkinsons-disease; protect neurons; recognition; spinal-cord-injury; transplantation
Creator
An entity primarily responsible for making the resource
Ourednik V; Ourednik J; Xu Y F; Zhang Y; Lynch W P; Snyder E Y; Schachner M
Description
An account of the resource
In the injured brain, the behavior of neural stem/progenitor cells (NSCs) is regulated by multiple converging factors encountered in the niche, which is composed of several neural and non-neural cell types. Signals emanating from the host influence the migration, survival, distribution, and fate of transplanted NSCs, which in turn can create host microenvironments that favor a return to homeostasis. We tested the hypothesis that overexpression of key facilitatory molecules that de. ne the injury niche might enhance this bidirectional stem cell host interaction to therapeutic advantage. As proof of concept, we investigated whether conditioning the niche with the neural cell adhesion molecule L1 might enhance recovery in a prototypical neurodegenerative milieu-the MPTP-induced model of Parkinson's disease in aged mice-where cross-talk between NSCs and imperiled host dopaminergic neurons is known to be pivotal in rescuing the function and connectivity of the latter. In lesioned mice (and in unlesioned controls), we overexpressed L1 in the NSCs to be transplanted into the ventral mesencephalon. Several pairwise experimental combinations were tested based on variations of engrafting L1 overexpressing versus nonoverexpressing NSCs into wild-type (WT) versus L1-overexpressing transgenic mice (specifically L1 transcribed from the GFAP promoter and, hence, overexpressed in host astrocytes). Enrichment for L1-particularly when expressed simultaneously in both donor NSCs and host brain-led to rapid and extensive distribution of exogenous NSCs, which in turn rescued (with an efficacy greater than in nonengineered controls) dysfunctional host dopaminergic nigral neurons, even when grafting was delayed by a month. L1 overexpression by NSCs also enhanced their own differentiation into tyrosine hydroxylase-expressing neurons in both WT and transgenic hosts. Graft-host interactions were thus favored by progressively increasing levels of L1. More broadly, this study supports the view that manipulating components of the niche (such as an adhesion molecule) that facilitate cross-talk between stem cells and the dysfunctional brain may offer new strategies for more efficacious neurotransplantation, particularly when treatment is delayed as in chronic lesions or advanced stages of a neurodegenerative disease. STEM CELLS 2009; 27: 2846-2856
Identifier
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<a href="http://doi.org/10.1002/stem.227" target="_blank" rel="noreferrer noopener">10.1002/stem.227</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2009
adhesion molecule
Aging
aging and age-related diseases
Astrocytes
axonal regeneration
Biotechnology & Applied Microbiology
Cell Biology
central-nervous-system
chaperone effect
differentiation
Dopamine
extracellular
functional recovery
Hematology
Journal Article
L1
Lynch W P
matrix
migration
model
molecules
motor-neurons
mouse
MPTP
Neural stem cells
Neurodegeneration
Neuroprotection
neurotrophic factors
niche
oncology
Ourednik J
Ourednik V
Oxidative Stress
parkinsons-disease
protect neurons
recognition
Schachner M
Snyder E Y
spinal-cord-injury
stem cells
Transplantation
Xu Y F
Zhang Y