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Tags: Oxidative Stress/*drug effects

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Mechanical Ventilation Antioxidant Trial.

BACKGROUND: Many patients each year require prolonged mechanical ventilation. Inflammatory processes may prevent successful weaning, and evidence indicates that mechanical ventilation induces oxidative stress in the diaphragm, resulting in atrophy…

Tags: 2015, 80 and over, Acetylcysteine, Adult, Aged, American journal of critical care : an official publication, American Association of Critical-Care Nurses, Antioxidants, Antioxidants/*therapeutic use, Artificial, Artificial/*adverse effects, Ascorbic Acid – Administration and Dosage, Ascorbic Acid/therapeutic use, Chi Square Test, Clochesy John M, Critical Care/*methods, Critical Illness, Critically Ill Patients, Cystine/analogs & derivatives/therapeutic use, Data Analysis Software, Department of Internal Medicine, Dietary Supplementation, Double-Blind Method, Double-Blind Studies, Female, Funding Source, Goldstein Lawrence S, Howe Kimberly P, Human, Humans, Inflammation/*drug therapy/*etiology, Intensive Care Units, Length of Stay, Log-Rank Test, Male, Mantel-Haenszel Test, Middle Age, Middle Aged, NEOMED College of Medicine, Owen Hugh, Oxidative Stress, Oxidative Stress/*drug effects, Prospective Studies, RANDOMIZED controlled trials, Respiration, T-Tests, Time Factors, Treatment Outcome, Ventilator Weaning, Vitamin E, Vitamin E/therapeutic use, Vitamins/therapeutic use

Black currant anthocyanins abrogate oxidative stress through Nrf2- mediated antioxidant mechanisms in a rat model of hepatocellular carcinoma.

Hepatocellular carcinoma (HCC), considered to be one of the most lethal cancers with almost \textgreater 1 million deaths reported annually worldwide, remains a devastating disease with no known effective cure. Hence, chemopreventive strategies come…

Tags: *Phytotherapy, 2012, Alkylating Agents/toxicity, Animals, Anthocyanins/*therapeutic use, Antioxidants/therapeutic use, Barnes Kendra F, Bhatia Deepak, Bishayee Anupam, Blotting, Carcinoma, Current cancer drug targets, Darvesh Altaf S, Department of Pharmaceutical Sciences, Diet, Diethylnitrosamine/toxicity, Experimental/chemically induced/metabolism/*prevention & control, Glutathione Transferase, Haznagy-Radnai Erzsebet, Hepatocellular/chemically induced/metabolism/*prevention & control, Hohmann Judit, Immunoenzyme Techniques, Lipid Peroxidation/drug effects, Liver Neoplasms, Male, Messenger/genetics, NEOMED College of Pharmacy, NF-E2-Related Factor 2/genetics/*metabolism, Nitric Oxide Synthase Type II/genetics/metabolism, Oxidative Stress/*drug effects, Rats, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction, Ribes/*chemistry, RNA, Signal Transduction, Sprague-Dawley, Thoppil Roslin J, Tyrosine/analogs & derivatives/metabolism, Western

Resveratrol suppresses oxidative stress and inflammatory response in diethylnitrosamine-initiated rat hepatocarcinogenesis.

Hepatocellular carcinoma (HCC), one of the most frequent and deadliest cancers, has been increasing considerably in the United States. In the absence of a proven effective therapy for HCC, novel chemopreventive strategies are urgently needed to lower…

Tags: 2010, Animals, Antioxidants/*pharmacology/therapeutic use, Antitumor, Barnes Kendra F, Bhatia Deepak, Bishayee Anupam, Cancer prevention research (Philadelphia, Pa.), Carcinogens/toxicity, Carroll Richard T, Chemical and Drug Induced Liver Injury/*etiology/metabolism/pathology, Darvesh Altaf S, Department of Pharmaceutical Sciences, Diethylnitrosamine/toxicity, Dose-Response Relationship, Drug, Drug Screening Assays, Enzyme Induction/drug effects, Experimental/chemically induced/metabolism/pathology/*prevention & control, Female, Hyperplasia, Inflammation/*prevention & control, Lipid Peroxidation/drug effects, Liver Neoplasms, Liver/drug effects/metabolism/pathology, Messenger/biosynthesis/genetics, NEOMED College of Pharmacy, NF-E2-Related Factor 2/biosynthesis/genetics, Nitric Oxide Synthase Type II/biosynthesis/genetics, Oxidative Stress/*drug effects, Phenobarbital/toxicity, Precancerous Conditions/*chemically induced/metabolism/pathology, Rats, Resveratrol, RNA, Sprague-Dawley, Stilbenes/*pharmacology/therapeutic use, Tyrosine/analogs & derivatives/analysis

Autoschizis: a novel cell death.

Vitamin C (VC) and vitamin K(3) (VK(3)) administered in a VC:VK(3) ratio of 100:1 exhibit synergistic antitumor activity and preferentially kill tumor cells by autoschizis, a novel type of necrosis characterized by exaggerated membrane damage and…

Tags: 2002, Animals, Antioxidants/chemistry/*pharmacology/therapeutic use, Ascorbic Acid/chemistry/*pharmacology/therapeutic use, Biochemical pharmacology, Calderon Pedro Buc, Cell Death/*physiology, Gilloteaux Jacques, Humans, Jamison James M, Necrosis, Neoplasms/drug therapy/metabolism/*pathology, Oxidative Stress/*drug effects, Summers Jack L, Taper Henryk S, Vitamin K/chemistry/*pharmacology/therapeutic use

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