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Text
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<a href="http://doi.org/10.1016/j.intimp.2020.106612" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.intimp.2020.106612</a>
Pages
106612
Volume
85
ISSN
1878-1705 1567-5769
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Update Year & Number
June 2020 Update II
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Anatomy & Neurobiology
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Title
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Imperatorin suppresses IL-1beta-induced iNOS expression via inhibiting
Publisher
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International immunopharmacology
Date
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2020
2020-05-22
Subject
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Imperatorin; inflammation; iNOS; Osteoarthritis; Oxidative-stress; Plant-derived-polyphenol
Creator
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Ahmad Nashrah; Ansari Mohammad Y; Bano Shabana; Haqqi Tariq M
Description
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Joint inflammation is a key player in the pathogenesis of osteoarthritis (OA). Imperatorin, a plant-derived small molecule has been reported to have anti-inflammatory properties; however, its effect on chondrocytes is not known. Here, we investigated the effects of Imperatorin on interleukin-1beta (IL-1beta) induced expression of inducible nitric oxide synthase (iNOS) and nitric oxide production in primary human OA chondrocytes and cartilage explants culture under pathological conditions and explored the associated signaling pathways. We pretreated chondrocytes or explants with Imperatorin (50 muM) followed by
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<a href="http://doi.org/10.1016/j.intimp.2020.106612" target="_blank" rel="noreferrer noopener">10.1016/j.intimp.2020.106612</a>
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journalArticle
2020
Ahmad Nashrah
Ansari Mohammad Y
Bano Shabana
Department of Anatomy & Neurobiology
Haqqi Tariq M
Imperatorin
Inflammation
iNOS
International Immunopharmacology
journalArticle
June 2020 Update II
NEOMED College of Medicine
Osteoarthritis
Oxidative-stress
Plant-derived-polyphenol