Imperatorin suppresses IL-1beta-induced iNOS expression via inhibiting
Creator
Ahmad Nashrah; Ansari Mohammad Y; Bano Shabana; Haqqi Tariq M
Publisher
International immunopharmacology
Date
2020
2020-05-22
Description
Joint inflammation is a key player in the pathogenesis of osteoarthritis (OA). Imperatorin, a plant-derived small molecule has been reported to have anti-inflammatory properties; however, its effect on chondrocytes is not known. Here, we investigated the effects of Imperatorin on interleukin-1beta (IL-1beta) induced expression of inducible nitric oxide synthase (iNOS) and nitric oxide production in primary human OA chondrocytes and cartilage explants culture under pathological conditions and explored the associated signaling pathways. We pretreated chondrocytes or explants with Imperatorin (50 muM) followed by