L-DOPA modulation of corpus striatal dopamine and dihydroxyphenylacetic acid output from intact and 6-OHDA lesioned rats.
*Sympathectomy; 3; 4-Dihydroxyphenylacetic Acid/*metabolism; Animals; Antiparkinson Agents/*pharmacology; Chemical; Corpus Striatum/drug effects/*metabolism; Dopamine/*metabolism; Levodopa/*pharmacology; Male; Oxidopamine; Rats; Sprague-Dawley; Substantia Nigra/drug effects/metabolism
In the present report we examined the differences in in vitro dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) efflux from the corpus striatum (CS) of intact versus 6-hydroxydopamine (6-OHDA) lesioned (in substantia nigra) male rats in response to different doses of two pulse infusions of L-dihydroxyphenylalanine (L-DOPA). In the first experiment, we tested the effects of two 20-min infusions of 5 uM L-DOPA. In the second experiment we repeated this protocol using 50 uM
Xu K; Dluzen D E
Journal of neural transmission (Vienna, Austria : 1996)
1996
1905-06
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1007/BF01271190" target="_blank" rel="noreferrer noopener">10.1007/BF01271190</a>
Depletion of olfactory bulb norepinephrine by 6-OHDA disrupts chemical cue but not social recognition responses in male rats.
*Cues; *Social Perception; Animals; Choice Behavior/physiology; Female; Habituation; Hypothalamo-Hypophyseal System/physiology; Male; Norepinephrine/*metabolism; Olfactory Bulb/metabolism/*physiology; Ovariectomy; Ovary/physiology; Oxidopamine; Psychophysiologic/*physiology; Rats; Sprague-Dawley; Testis/physiology; Testosterone/blood; Zucker
In the present experiment, 6-OHDA was infused directly into the olfactory bulb (OB) to produce a localized neurotoxic lesion. Habituation/dishabituation behavioral tests were then conducted to measure recognition responses to chemical cues (urine as a stimulus) and to social stimuli (ovariectomized rat as a stimulus). Infusion of 6-OHDA resulted in a near complete depletion of
Guan X; Blank J; Dluzen D
Brain research
1993
1993-09
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1016/0006-8993(93)90800-3" target="_blank" rel="noreferrer noopener">10.1016/0006-8993(93)90800-3</a>