1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
136-156
Volume
965
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Estrogen, Anti-estrogen, And Gender - Differences In Methamphetamine Neurotoxicity
Publisher
An entity responsible for making the resource available
Cellular and Molecular Mechanisms of Drugs of Abuse Ii: Cocaine, Substituted Amphetamines, Ghb, and Opiates
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002
Subject
The topic of the resource
breast cancer; dopamine; environmental-temperature; GFAP; in-vivo; mediated neuroprotection; mptp-induced neurotoxicity; nigrostriatal; nigrostriatal dopaminergic system; PAI-1; parkinsons-disease; parkinsons-disease; rat-brain; sex-differences; sexual differences; striatal dopamine; tamoxifen; testosterone; thermoregulation
Creator
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Dluzen D E; McDermott J L
Identifier
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n/a
Format
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Book Chapter
2002
breast cancer
Cellular and Molecular Mechanisms of Drugs of Abuse Ii: Cocaine, Substituted Amphetamines, Ghb, and Opiates
Dluzen D E
Dopamine
environmental-temperature
GFAP
in-vivo
McDermott J L
mediated neuroprotection
mptp-induced neurotoxicity
nigrostriatal
nigrostriatal dopaminergic system
PAI-1
parkinsons-disease
rat-brain
sex-differences
sexual differences
striatal dopamine
Tamoxifen
Testosterone
thermoregulation
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/hep.23049" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/hep.23049</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
880-892
Issue
3
Volume
50
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Fenofibrate Differentially Regulates Plasminogen Activator Inhibitor-1 Gene Expression via Adenosine Monophosphate-Activated Protein Kinase-Dependent Induction of Orphan Nuclear Receptor Small Heterodimer Partner
Publisher
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Hepatology
Date
A point or period of time associated with an event in the lifecycle of the resource
2009
2009-09
Subject
The topic of the resource
cells; binding; complex; fibrosis; Gastroenterology & Hepatology; promoter; beta; mechanisms; pai-1; shp; smad3
Creator
An entity primarily responsible for making the resource
Chanda D; Lee C H; Kim Y H; Noh J R; Kim D K; Park J H; Hwang J H; Lee M R; Jeong K H; Lee I K; Kweon G R; Shong M; Oh G T; Chiang J Y L; Choi H S
Description
An account of the resource
Plasminogen activator inhibitor type I (PAI-1) is a marker of the fibrinolytic system and serves as a possible predictor for hepatic metabolic syndromes. Fenofibrate, a peroxisome proliferator-activated receptor alpha (PPAR alpha) agonist, is a drug used for treatment of hyperlipidemia. Orphan nuclear receptor small heterodimer partner (SHP) plays a key role in transcriptional repression of crucial genes involved in various metabolic pathways. In this Study, we show that fenofibrate increased SHP gene expression in cultured liver cells and in the normal and diabetic mouse liver by activating the adenosine monophosphate-activated protein kinase (AMPK signaling pathway in a PPAR alpha-independent manner. Administration of transforming growth factor beta (TGF-beta) or a methionine-deficient and choline-deficient (MCD) diet to induce the progressive fibrosing steatohepatitis model in C57BL/6 mice was significantly reversed by fenofibrate via AMPK-mediated induction of SHP gene expression with a dramatic decrease in PAI-1 messenger RNA (mRNA) and protein expression along with other fibrotic marker genes. No reversal was observed in SHP null mice treated with fenofibrate. Treatment with another PPAR alpha agonist, WY14643, showed contrasting effects on these marker gene expressions in wild-type and SHP null mice, demonstrating the specificity of fenofibrate in activating AMPK signaling. Fenofibrate exhibited a differential inhibitory pattern on PAI-1 gene expression depending on the transcription factors inhibited by SHP. Conclusion: By demonstrating that a PPAR alpha-independent fenofibrate-AMPK-SHP regulatory cascade can play a key role in PAI-1 gene down-regulation and reversal of fibrosis, our study suggests that various AMPK activators regulating SHP might provide a novel pharmacologic option in ameliorating hepatic metabolic syndromes. (HEPATOLOGY 2009;50:880-892.)
Identifier
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<a href="http://doi.org/10.1002/hep.23049" target="_blank" rel="noreferrer noopener">10.1002/hep.23049</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2009
beta
Binding
Cells
Chanda D
Chiang J Y L
Choi H S
complex
Fibrosis
Gastroenterology & Hepatology
Hepatology
Hwang J H
Jeong K H
Journal Article or Conference Abstract Publication
Kim D K
Kim Y H
Kweon G R
Lee C H
Lee I K
Lee M R
mechanisms
Noh J R
Oh G T
PAI-1
Park J H
promoter
Shong M
SHP
smad3