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Text
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URL Address
<a href="http://doi.org/10.1007/s11916-003-0005-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s11916-003-0005-5</a>
Pages
15–23
Issue
1
Volume
7
Dublin Core
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Title
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Opioids: a review.
Publisher
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Current pain and headache reports
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
2003-02
Subject
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Analgesics; Animals; Clinical Trials as Topic; Drug Tolerance; Humans; mu/drug effects/genetics/physiology; Opioid; Opioid/*drug effects/genetics/physiology; Opioid/adverse effects/*therapeutic use; Pain/*drug therapy/physiopathology; Receptors; Trans-Activators/genetics
Creator
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Chevlen Eric
Description
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Recent discoveries in opioid pharmacology help explain the enormous variability in clinical responses to these powerful analgesics. Although there is only one m opioid receptor gene, splice variants of that gene's expression result in a panoply of different functioning receptors. Other sources of variable response include polymorphisms in the m opioid receptor regulatory region, and pharmacokinetic differences because of cytochrome P-450 mono-oxygenase heterogeneity. Analgesic tolerance is likely the key phenomenon limiting the benefit of opioids. A plethora of intracellular pathways affects this. Among them are the N-methyl-D-aspartate receptor, protein kinase C gamma activity, nitric oxide synthase, and GM1 ganglioside content of the neuronal membrane. Clinical studies undercut the routine use of meperidine in most settings. Other studies have shown better ways to diminish opioid side effects.
Identifier
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<a href="http://doi.org/10.1007/s11916-003-0005-5" target="_blank" rel="noreferrer noopener">10.1007/s11916-003-0005-5</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2003
Analgesics
Animals
Chevlen Eric
Clinical Trials as Topic
Current pain and headache reports
Department of Internal Medicine
Drug Tolerance
Humans
mu/drug effects/genetics/physiology
NEOMED College of Medicine
Opioid
Opioid/*drug effects/genetics/physiology
Opioid/adverse effects/*therapeutic use
Pain/*drug therapy/physiopathology
Receptors
Trans-Activators/genetics