1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1016/s0091-3057(00)00461-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0091-3057(00)00461-5</a> Pages 99–104 Issue 1 Volume 68 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Gender and the behavioral manifestations of neuropathic pain. Publisher An entity responsible for making the resource available Pharmacology, biochemistry, and behavior Date A point or period of time associated with an event in the lifecycle of the resource 2001 2001-01 Subject The topic of the resource *Peripheral Nerve Injuries; Animal/*physiology; Animals; Behavior; Female; Gonadal Steroid Hormones/pharmacology; Hyperalgesia/psychology; Inbred F344; Male; Orchiectomy; Ovariectomy; Pain Measurement/drug effects; Pain Threshold/drug effects; Pain/etiology/*psychology; Rats; Sex Characteristics Creator An entity primarily responsible for making the resource Tall J M; Stuesse S L; Cruce W L; Crisp T Description An account of the resource A model of peripheral nerve injury was used to study gender differences in the development and progression of chronic constriction injury (CCI)-induced hyperalgesia and allodynia in male and female Fischer 344 FBNF1 hybrid rats. Rats were randomly assigned to one of the following treatment groups: (1) gonadally intact unligated males (male); (2) gonadally intact ligated males (male (CCI)); (3) castrated ligated males (male (CAS/CCI)); (4) gonadally intact unligated females (female); (5) gonadally intact ligated females (female (CCI)); and (6) ovariectomized ligated females (female (OVX/CCI)). A plantar analgesia meter and calibrated von Frey pressure filaments were used as the analgesiometric assays. In the absence of nerve injury, gonadally intact males responded significantly faster than females to a thermal nociceptive stimulus. The onset of the behavioral manifestations of unilateral ligation of the sciatic nerve did not differ as a function of sex or hormonal status (e.g., gonadally intact and gonadectomized male and female rats developed thermal hyperalgesia within 14 days post-CCI). Paw withdrawal latency (PWL) values of gonadally intact males returned to baseline control values after postligation day 14, whereas gonadally intact females, ovariectomized females and castrated males continued to elicit robust thermal hyperalgesic symptoms throughout the 35-day duration of the experiment. Allodynic responses to peripheral nerve injury were less variable across genders. These data suggest that the mechanisms underlying chronic nociceptive processing differ as a function of gender and gonadal hormone status. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1016/s0091-3057(00)00461-5" target="_blank" rel="noreferrer noopener">10.1016/s0091-3057(00)00461-5</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). *Peripheral Nerve Injuries 2001 Animal/*physiology Animals Behavior Crisp T Cruce W L Female Gonadal Steroid Hormones/pharmacology Hyperalgesia/psychology Inbred F344 Male Orchiectomy Ovariectomy Pain Measurement/drug effects Pain Threshold/drug effects Pain/etiology/*psychology Pharmacology, biochemistry, and behavior Rats Sex Characteristics Stuesse S L Tall J M