1
40
3
-
Text
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URL Address
<a href="http://doi.org/10.1016/S1470-2045(13)70556-4" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/S1470-2045(13)70556-4</a>
Pages
164–171
Issue
2
Volume
15
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Single versus multiple fractions of repeat radiation for painful bone metastases: a randomised, controlled, non-inferiority trial.
Publisher
An entity responsible for making the resource available
The Lancet. Oncology
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
2014-02
Subject
The topic of the resource
*Dose Fractionation; *Radiotherapy; Aged; Analgesics – Therapeutic Use; Analgesics/therapeutic use; Australia; Bone Neoplasms; Bone Neoplasms – Complications; Bone Neoplasms – Radiotherapy; Bone Neoplasms/complications/*radiotherapy/*secondary; Brief Pain Inventory; Canada; Cauda Equina; Chi Square Test; Chi-Square Distribution; Clinical Assessment Tools; Clinical Trials; Computer-Assisted; Computer-Assisted – Adverse Effects; Computer-Assisted/adverse effects; Europe; Female; Fractures; Funding Source; Human; Humans; Intention to Treat Analysis; Israel; Logistic Models; Logistic Regression; Male; Middle Age; Middle Aged; New Zealand; Odds Ratio; Pain – Diagnosis; Pain – Drug Therapy; Pain – Etiology; Pain – Radiotherapy; Pain Measurement; Pain/diagnosis/drug therapy/*etiology/*radiotherapy; Questionnaires; Radiation; Radiation Dosage; Radiotherapy; Radiotherapy Planning; Risk Factors; Scales; Spinal Cord Compression – Etiology; Spinal Cord Compression/etiology; Spontaneous – Etiology; Spontaneous/etiology; Surveys and Questionnaires; Time Factors; Treatment Outcome; Treatment Outcomes
Creator
An entity primarily responsible for making the resource
Chow Edward; van der Linden Yvette M; Roos Daniel; Hartsell William F; Hoskin Peter; Wu Jackson S Y; Brundage Michael D; Nabid Abdenour; Tissing-Tan Caroline J A; Oei Bing; Babington Scott; Demas William F; Wilson Carolyn F; Meyer Ralph M; Chen Bingshu E; Wong Rebecca K S
Description
An account of the resource
BACKGROUND: Although repeat radiation treatment has been shown to palliate pain in patients with bone metastases from multiple primary origin sites, data for the best possible dose fractionation schedules are lacking. We aimed to assess two dose fractionation schedules in patients with painful bone metastases needing repeat radiation therapy. METHODS: We did a multicentre, non-blinded, randomised, controlled trial in nine countries worldwide. We enrolled patients 18 years or older who had radiologically confirmed, painful (ie, pain measured as \textgreater/=2 points using the Brief Pain Inventory) bone metastases, had received previous radiation therapy, and were taking a stable dose and schedule of pain-relieving drugs (if prescribed). Patients were randomly assigned (1:1) to receive either 8 Gy in a single fraction or 20 Gy in multiple fractions by a central computer-generated allocation sequence using dynamic minimisation to conceal assignment, stratified by previous radiation fraction schedule, response to initial radiation, and treatment centre. Patients, caregivers, and investigators were not masked to treatment allocation. The primary endpoint was overall pain response at 2 months, which was defined as the sum of complete and partial pain responses to treatment, assessed using both Brief Pain Inventory scores and changes in analgesic consumption. Analysis was done by intention to treat. This study is registered with ClinicalTrials.gov, number NCT00080912. FINDINGS: Between Jan 7, 2004, and May 24, 2012, we randomly assigned 425 patients to each treatment group. 19 (4%) patients in the 8 Gy group and 12 (3%) in the 20 Gy group were found to be ineligible after randomisation, and 140 (33%) and 132 (31%) patients, respectively, were not assessable at 2 months and were counted as missing data in the intention-to-treat analysis. In the intention-to-treat population, 118 (28%) patients allocated to 8 Gy treatment and 135 (32%) allocated to 20 Gy treatment had an overall pain response to treatment (p=0.21; response difference of 4.00% [upper limit of the 95% CI 9.2, less than the prespecified non-inferiority margin of 10%]). In the per-protocol population, 116 (45%) of 258 patients and 134 (51%) of 263 patients, respectively, had an overall pain response to treatment (p=0.17; response difference 6.00% [upper limit of the 95% CI 13.2, greater than the prespecified non-inferiority margin of 10%]). The most frequently reported acute radiation-related toxicities at 14 days were lack of appetite (201 [56%] of 358 assessable patients who received 8 Gy vs 229 [66%] of 349 assessable patients who received 20 Gy; p=0.011) and diarrhoea (81 [23%] of 357 vs 108 [31%] of 349; p=0.018). Pathological fractures occurred in 30 (7%) of 425 patients assigned to 8 Gy and 20 (5%) of 425 assigned to 20 Gy (odds ratio [OR] 1.54, 95% CI 0.85-2.75; p=0.15), and spinal cord or cauda equina compressions were reported in seven (2%) of 425 versus two (\textless1%) of 425, respectively (OR 3.54, 95% CI 0.73-17.15; p=0.094). INTERPRETATION: In patients with painful bone metastases requiring repeat radiation therapy, treatment with 8 Gy in a single fraction seems to be non-inferior and less toxic than 20 Gy in multiple fractions; however, as findings were not robust in a per-protocol analysis, trade-offs between efficacy and toxicity might exist. FUNDING: Canadian Cancer Society Research Institute, US National Cancer Institute, Cancer Council Australia, Royal Adelaide Hospital, Dutch Cancer Society, and Assistance Publique-Hopitaux de Paris.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/S1470-2045(13)70556-4" target="_blank" rel="noreferrer noopener">10.1016/S1470-2045(13)70556-4</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Dose Fractionation
*Radiotherapy
2014
Aged
Analgesics – Therapeutic Use
Analgesics/therapeutic use
Australia
Babington Scott
Bone Neoplasms
Bone Neoplasms – Complications
Bone Neoplasms – Radiotherapy
Bone Neoplasms/complications/*radiotherapy/*secondary
Brief pain inventory
Brundage Michael D
Canada
Cauda Equina
Chen Bingshu E
Chi Square Test
Chi-Square Distribution
Chow Edward
Clinical Assessment Tools
Clinical Trials
Computer-Assisted
Computer-Assisted – Adverse Effects
Computer-Assisted/adverse effects
Demas William F
Europe
Female
Fractures
Funding Source
Hartsell William F
Hoskin Peter
Human
Humans
Intention to Treat Analysis
Israel
Logistic Models
Logistic Regression
Male
Meyer Ralph M
Middle Age
Middle Aged
Nabid Abdenour
New Zealand
Odds Ratio
Oei Bing
Pain – Diagnosis
Pain – Drug Therapy
Pain – Etiology
Pain – Radiotherapy
Pain Measurement
Pain/diagnosis/drug therapy/*etiology/*radiotherapy
Questionnaires
Radiation
Radiation Dosage
Radiotherapy
Radiotherapy Planning
Risk Factors
Roos Daniel
Scales
Spinal Cord Compression – Etiology
Spinal Cord Compression/etiology
Spontaneous – Etiology
Spontaneous/etiology
Surveys and Questionnaires
The Lancet. Oncology
Time Factors
Tissing-Tan Caroline J A
Treatment Outcome
Treatment Outcomes
van der Linden Yvette M
Wilson Carolyn F
Wong Rebecca K S
Wu Jackson S Y
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.ajem.2016.10.028" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.ajem.2016.10.028</a>
Pages
524.e3–524.e4
Issue
3
Volume
35
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Acute aortic occlusion with complications from delayed presentation.
Publisher
An entity responsible for making the resource available
The American journal of emergency medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-03
Subject
The topic of the resource
Acidosis – Etiology; Acidosis/*etiology; Acute Disease; Arterial Occlusive Diseases – Complications; Arterial Occlusive Diseases – Diet Therapy; Arterial Occlusive Diseases/*complications/diet therapy; Computed Tomography Angiography; Delayed – Adverse Effects; Delayed Diagnosis/adverse effects; Diagnosis; Doppler; Dyspnea – Etiology; Dyspnea – Therapy; Dyspnea/*etiology/therapy; Fatal Outcome; Humans; Intratracheal; Intubation; Leg; Leg – Pathology; Leg/diagnostic imaging/*pathology; Male; Middle Age; Middle Aged; Multiple Organ Dysfunction Syndrome – Etiology; Multiple Organ Failure/*etiology; Pain; Pain – Etiology; Pain/diagnostic imaging/etiology; Tachycardia – Etiology; Tachycardia/*etiology; Tachypnea – Etiology; Tachypnea/*etiology; Ultrasonography
Creator
An entity primarily responsible for making the resource
Vibhakar Arjun; Beeson Michelle; Kovacs Mitch; Simon Erin L
Identifier
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<a href="http://doi.org/10.1016/j.ajem.2016.10.028" target="_blank" rel="noreferrer noopener">10.1016/j.ajem.2016.10.028</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2017
Acidosis – Etiology
Acidosis/*etiology
Acute Disease
Arterial Occlusive Diseases – Complications
Arterial Occlusive Diseases – Diet Therapy
Arterial Occlusive Diseases/*complications/diet therapy
Beeson Michelle
Computed Tomography Angiography
Delayed – Adverse Effects
Delayed Diagnosis/adverse effects
Department of Emergency Medicine
Diagnosis
Doppler
Dyspnea – Etiology
Dyspnea – Therapy
Dyspnea/*etiology/therapy
Fatal Outcome
Humans
Intratracheal
Intubation
Kovacs Mitch
Leg
Leg – Pathology
Leg/diagnostic imaging/*pathology
Male
Middle Age
Middle Aged
Multiple Organ Dysfunction Syndrome – Etiology
Multiple Organ Failure/*etiology
NEOMED College of Medicine
Pain
Pain – Etiology
Pain/diagnostic imaging/etiology
Simon Erin L
Tachycardia – Etiology
Tachycardia/*etiology
Tachypnea – Etiology
Tachypnea/*etiology
The American journal of emergency medicine
Ultrasonography
Vibhakar Arjun
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s00520-015-2957-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s00520-015-2957-5</a>
Pages
1617–1623
Issue
4
Volume
24
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Revisiting classification of pain from bone metastases as mild, moderate, or severe based on correlation with function and quality of life.
Publisher
An entity responsible for making the resource available
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016-04
Subject
The topic of the resource
*Quality of Life; *Severity of Illness Index; 80 and over; 80 and Over; Adolescence; Adolescent; Adult; Aged; Bone metastases; Bone Neoplasms; Bone Neoplasms – Complications; Bone Neoplasms/*complications/secondary; Brief Pain Inventory; Female; Functional interference; Funding Source; Human; Humans; Male; Middle Age; Middle Aged; Pain – Classification; Pain – Etiology; Pain Measurement – Methods; Pain Measurement/*methods; Pain severity; Pain/*classification/etiology; Quality of life; Quality of Life; Questionnaires; Re-irradiation; Severity of Illness Indices; Survival; Young Adult
Creator
An entity primarily responsible for making the resource
Chow Edward; Ding Keyue; Parulekar Wendy R; Wong Rebecca K S; van der Linden Yvette M; Roos Daniel; Hartsell William F; Hoskin Peter; Wu Jackson S Y; Nabid Abdenour; Ong Francisca; van Tienhoven Geertjan; Babington Scott; Demas William F; Wilson Carolyn F; Brundage Michael; Zhu Liting; Meyer Ralph M
Description
An account of the resource
PURPOSE: The objective of our study was to determine the optimal cut points for classification of pain scores as mild, moderate, and severe based on interference with function and quality of life (QOL). METHODS: We evaluated 822 patients who completed the Brief Pain Inventory (BPI) and/or the European Organization for Research and Treatment of Cancer (EORTC) QOL Questionnaire Core 30 (QLQ-C30) prior to receiving repeat radiation therapy for previously irradiated painful bone metastases. Optimal cut points for mild, moderate, and severe pain were determined by the MANOVA that yielded the largest F ratio for the between category effect on the seven interference items of BPI and the six functional domains of QOL (physical, role, emotional, cognitive, social functioning, and global QOL) as indicated by Pillai's Trace, Wilk's lambda, and Hostelling's Trace F statistics. RESULTS: For BPI and for QOL domains separately, the two largest F ratios for Wilk's lambda, Pillai's Trace, and Hotelling's Trace F statistics were from the cut points 4, 8 and 6, 8. When combining both, the optimal cut points were 4, 8 with 1-4 (mild), 5-8 (moderate), and 9-10 (severe). With this classification, the mean scores of all the seven interference items in BPI and the six functional domains were all highly statistically different. Patients with severe pain survived significantly shorter than those with mild and moderate pain (p \textless 0.0001). CONCLUSION: Our analysis supports the classification of pain scores as follows: 1-4 as mild pain, 5-8 as moderate pain, and 9-10 as severe pain. This may facilitate conduct of future clinical trials.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s00520-015-2957-5" target="_blank" rel="noreferrer noopener">10.1007/s00520-015-2957-5</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Quality of Life
*Severity of Illness Index
2016
80 and over
Adolescence
Adolescent
Adult
Aged
Babington Scott
Bone metastases
Bone Neoplasms
Bone Neoplasms – Complications
Bone Neoplasms/*complications/secondary
Brief pain inventory
Brundage Michael
Chow Edward
Demas William F
Ding Keyue
Female
Functional interference
Funding Source
Hartsell William F
Hoskin Peter
Human
Humans
Male
Meyer Ralph M
Middle Age
Middle Aged
Nabid Abdenour
Ong Francisca
Pain – Classification
Pain – Etiology
Pain Measurement – Methods
Pain Measurement/*methods
Pain severity
Pain/*classification/etiology
Parulekar Wendy R
Quality of Life
Questionnaires
Re-irradiation
Roos Daniel
Severity of Illness Indices
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
Survival
van der Linden Yvette M
van Tienhoven Geertjan
Wilson Carolyn F
Wong Rebecca K S
Wu Jackson S Y
Young Adult
Zhu Liting