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Text
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URL Address
<a href="http://doi.org/10.1097/00007611-200194030-00010" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/00007611-200194030-00010</a>
Pages
329–331
Issue
3
Volume
94
Dublin Core
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Title
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Humoral hypercalcemia of malignancy in squamous cell carcinoma of the skin: parathyroid hormone–related protein as a cause.
Publisher
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Southern medical journal
Date
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2001
2001-03
Subject
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Aged; Carcinoma; Fatal Outcome; Humans; Hypercalcemia/blood/*etiology; Male; Paraneoplastic Syndromes/blood/etiology/therapy; Parathyroid Hormone-Related Protein; Parathyroid Hormone/blood; Prognosis; Proteins/analysis; Skin Neoplasms/*complications; Squamous Cell/*complications; Treatment Refusal
Creator
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Cisneros G; Lara L F; Crock R; Whittier F C
Description
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The second most common cause of hypercalcemia is humoral hypercalcemia of malignancy (HHM), a condition associated with increased mortality. Although hypercalcemia is usually seen in squamous cell cancers, only 13 cases have been described in association with squamous cell skin cancer, and only 5 of these had characteristics of HHM. We report a case of hypercalcemia due to squamous cell skin cancer confined to the chest wall in a 67-year-old semi-comatose patient. Aggressive treatment with intravenous fluid hydration, furosemide, and etidronate corrected the hypercalcemia. A thorough workup ruled out bone metastasis and confirmed increased parathyroid-related protein, the hallmark of HHM. After regaining consciousness, the patient refused further therapy and subsequently died.
Identifier
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<a href="http://doi.org/10.1097/00007611-200194030-00010" target="_blank" rel="noreferrer noopener">10.1097/00007611-200194030-00010</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2001
Aged
Carcinoma
Cisneros G
Crock R
Department of Internal Medicine
Fatal Outcome
Humans
Hypercalcemia/blood/*etiology
Lara L F
Male
NEOMED College of Medicine
Paraneoplastic Syndromes/blood/etiology/therapy
Parathyroid Hormone-Related Protein
Parathyroid Hormone/blood
Prognosis
Proteins/analysis
Skin Neoplasms/*complications
Southern medical journal
Squamous Cell/*complications
Treatment Refusal
Whittier F C