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URL Address
<a href="http://doi.org/10.1002/jnr.20690" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/jnr.20690</a>
Pages
875–889
Issue
6
Volume
82
Dublin Core
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Title
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Activation and circuitry of uterine-cervix-related neurons in the lumbosacral dorsal root ganglia and spinal cord at parturition.
Publisher
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Journal of neuroscience research
Date
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2005
2005-12
Subject
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Analysis of Variance; Animals; Blotting; Cell Count/methods; Cervix Uteri/*cytology; Cyclic AMP Response Element-Binding Protein/metabolism; Estrogen Receptor alpha/metabolism; Female; Ganglia; Gene Expression Regulation/physiology; Immunohistochemistry/methods; Lumbosacral Region; Models; Nerve Net/cytology/*physiology; Neurological; Neurons/classification/*physiology; Oncogene Proteins v-fos/metabolism; Parturition/*physiology; Pregnancy; Rats; Spinal Cord/*cytology; Spinal/*cytology; Sprague-Dawley; Stilbamidines/metabolism; Time Factors; Western/methods
Creator
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Puder B A; Papka R E
Description
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Stimulation of the uterine cervix at parturition activates neural circuits involving primary sensory nerves and supraspinally projecting neurons of the lumbosacral spinal cord, resulting in output of hypothalamic neurohormones. Dorsal root ganglia (DRG) and spinal neurons of these circuits are not well-characterized. The objectives of this study were to detail the activation of DRG and spinal neurons of the L6/S1 levels that are stimulated at late pregnancy, verify hypothalamic projections of activated spinal neurons, and determine whether activated neurons express estrogen receptor-alpha (ERalpha). Expression of phosphorylated cyclic-AMP response element-binding protein (PCREB) and Fos immunohistochemistry were used to "mark" activated DRG and spinal neurons, respectively. Retrograde tracing identified uterine-cervix-related and spinohypothalamic neurons. Baseline PCREB expression in the DRG increased during pregnancy and peaked during the last trimester. Some PCREB-expressing neurons contained retrograde tracer identifying them as cervix-related neurons. Fos-expressing neurons were few in spinal cords of nonpregnant and day 22 pregnant rats but were numerous in parturient animals. Some Fos-expressing neurons located in the dorsal half of the spinal cord contained retrograde tracer identifying them as spinohypothalamic neurons. Some DRG neurons expressing PCREB also expressed ERalpha, and some spinal neurons activated at parturition projected axons to the hypothalamus and expressed ERalpha. These results indicate that DRG and spinal cord neurons are activated at parturition; that those in the spinal cord are present in areas involved in autonomic and sensory processing; that some spinal neurons project axons to the hypothalamus, ostensibly part of a neuroendocrine reflex; and that sensory and spinal neurons can respond to estrogens. Moreover, some activated sensory neurons may be involved in the animal's perception of labor pain.
Identifier
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<a href="http://doi.org/10.1002/jnr.20690" target="_blank" rel="noreferrer noopener">10.1002/jnr.20690</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2005
Analysis of Variance
Animals
Blotting
Cell Count/methods
Cervix Uteri/*cytology
Cyclic AMP Response Element-Binding Protein/metabolism
Estrogen Receptor alpha/metabolism
Female
Ganglia
Gene Expression Regulation/physiology
Immunohistochemistry/methods
Journal of neuroscience research
Lumbosacral Region
Models
Nerve Net/cytology/*physiology
Neurological
Neurons/classification/*physiology
Oncogene Proteins v-fos/metabolism
Papka R E
Parturition/*physiology
Pregnancy
Puder B A
Rats
Spinal Cord/*cytology
Spinal/*cytology
Sprague-Dawley
Stilbamidines/metabolism
Time Factors
Western/methods