1
40
1
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s001340050403" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s001340050403</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
743-748
Issue
7
Volume
23
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A controlled study of leukocyte activation in septic patients
Publisher
An entity responsible for making the resource available
Intensive Care Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1997-07
Subject
The topic of the resource
alpha; burst; chemi-luminescence; chemi-luminescence; formyl-methionyl-leucyl-phenyl alanine; General & Internal Medicine; leukocytes; luminol; neutrophils; opsonized zymosan; oxidative burst; phagocytes; phorbol myristate acetate; polymorphonuclear; respiratory burst; sepsis; septic shock; shock; tumor-necrosis-factor
Creator
An entity primarily responsible for making the resource
Pascual C; Karzai W; Meierhellmann A; Bredle D L; Reinhart K
Description
An account of the resource
Objective: Qualitative and quantitative evaluation of leukocyte activation in septic patients in comparison to two control groups. Design: A prospective clinical study in which the leukocyte oxidative output of whole blood was measured in three groups of patients. Two chemiluminescence markers (luminol or lucigenin), indicative of either total oxidant output or superoxide production, and three stimuli (opsonized zymosan, formyl-methionyl-leucyl-phenylalanine (fMLP), phorbol myristate acetate) (PMA), representing different pathways of leukocyte activation, were used. Tumor necrosis factor, interleukin-6 and C-reactive protein (TNF, IL-6, and CRP) were determined to evaluate the severity of the inflammatory process. Setting: Intensive care and surgical units of a university hospital. Patients: Seventy-four healthy patients, ten ICU patients without signs of sepsis or systemic inflammatory response syndrome and 19 septic patients were studied. Measurement and main results: With all three stimuli, whole blood total oxidative output and superoxide production were generally increased in septic patients. This was most likely due to the increased leukocyte numbers in these patients. When the chemiluminescence values were normalized per phagocyte (granulocytes and monocytes), the total oxidative output of septic phagocytes decreased with opsonin and fMLP but increased with PMA, while superoxide output decreased regardless of the stimuli used. TNF, IL-6 and CRP, although increased in septic patients as compared to ICU controls, correlated weakly with oxidant output. Conclusions: The oxidative output of whole blood was increased in septic patients compared to controls because of elevated leukocyte numbers. However, oxidant output normalized for phagocyte numbers generally decreases during sepsis for most stimuli. Cytokines and CRP do not appear to be associated with the extent of oxidant output during sepsis.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s001340050403" target="_blank" rel="noreferrer noopener">10.1007/s001340050403</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1997
alpha
Bredle D L
burst
chemi-luminescence
formyl-methionyl-leucyl-phenyl alanine
General & Internal Medicine
Intensive Care Medicine
Journal Article
Karzai W
LEUKOCYTES
luminol
Meierhellmann A
Neutrophils
opsonized zymosan
oxidative burst
Pascual C
phagocytes
phorbol myristate acetate
polymorphonuclear
Reinhart K
respiratory burst
sepsis
Septic shock
Shock
tumor-necrosis-factor