1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
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n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1077-1081
Issue
12
Volume
122
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Locate full-text within NEOMED Library's e-journal collections
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Perianal Paget's disease - Distinguishing primary and secondary lesions using immunohistochemical studies including gross cystic disease fluid protein-15 and cytokeratin 20 expression
Publisher
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Archives of Pathology & Laboratory Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1998-12
Subject
The topic of the resource
internal malignancy; mammary; Medical Laboratory Technology; Pathology; Research & Experimental Medicine
Creator
An entity primarily responsible for making the resource
Nowak M A; Guerriere-Kovach P; Pathan A; Campbell T E; Deppisch L M
Description
An account of the resource
Background.-Extramammary Paget's disease most commonly occurs on the female external genitalia and rarely occurs in the perianal region and male external genitalia. We present the clinical and pathologic features of 5 cases of perianal Paget's disease and review the literature. Methods.-Clinical and pathologic data were recorded for 5 cases of perianal Paget's disease. Cases were studied retrospectively with special stains, including periodic acid-Schiff, mucicarmine, Alcian blue, carcinoembryonic antigen, S100 protein, pan-keratin, gross cystic disease fluid protein-15 (GCDFP-15), lysozyme, CD15 (Leu-M1), cytokeratin 7 (CK7), and cytokeratin 20 (CK20). Results.-Three (60%) of 5 patients had concurrent rectal adenocarcinomas. All cases reacted positively for pankeratin, although the intensity and distribution of staining varied. Both cases not associated with an underlying carcinoma showed strong GCDFP-15 and CK7 expression and an absence of CK20 expression. The 3 cases associated with an underlying malignancy demonstrated CK7 and CK20 expression and an absence of GCDFP-15 expression. All cases were negative for lysozyme and CD15 (Leu-M1). Conclusions.-The 5 cases reported herein demonstrate that perianal Paget's disease is a heterogeneous entity. The high frequency of associated underlying malignancies and resultant poor clinical outcomes highlight the importance of an aggressive search for a second malignancy. In some cases, perianal Paget's disease merely represents a cutaneous manifestation of an underlying rectal adenocarcinoma and demonstrates a CK7(+)/CK20(+)/GCDFP-15(-)/lysozyme/Leu-M1(-) immunophenotype and signet ring Paget's cells. Other cases represent primary adenocarcinomas of the skin, which are associated with a CK7(+)/CK20(-)/GCDFP-15(+)/lysozyme(-)/Leu-M1(-) immunophenotype and an excellent prognosis if adequately resected. Immunohistochemical studies, particularly CK20 and GCDFP-15, are useful adjuncts in distinguishing primary and secondary perianal Paget's disease.
Identifier
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n/a
Format
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Journal Article
1998
Archives of pathology & laboratory medicine
Campbell T E
Deppisch L M
Guerriere-Kovach P
internal malignancy
Journal Article
Mammary
Medical Laboratory Technology
Nowak M A
Pathan A
Pathology
Research & Experimental Medicine
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1097/00000372-199808000-00019" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/00000372-199808000-00019</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
422-424
Issue
4
Volume
20
Search for Full-text
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<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Syringocystadenoma papilliferum of the male breast
Publisher
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American Journal of Dermatopathology
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1998-08
Subject
The topic of the resource
apocrine; Breast; Dermatology; differentiation; eccrine differentiation; GCDFP-15; lysozyme; male; plasma cell infiltrate; syringocystadenoma papilliferum; tumors
Creator
An entity primarily responsible for making the resource
Nowak M; Pathan A; Fatteh S; Lopez J
Description
An account of the resource
A 39-year-old man presented with a 2-cm, mildly tender mass in the right breast of many years' duration. Microscopic examination showed a syringocystadenoma papilliferum. Because of its location in the breast, we studied the lesion for immunohistochemical markers for apocrine differentiation. Gross cystic disease fluid protein-15 (GCDFP-15) staining yielded negative results in the cystic luminal epithelial cells, whereas GCDFP-15 and lysozyme staining yielded strongly positive results in the epithelial cells of adjacent tubular apocrine glands. Focal strong lysozyme positivity was seen in the cystic luminal epithelial cells. These findings do not support apocrine differentiation in this case, despite its location in the breast, an organ rich in specialized apocrine (lactiferous) elands. To our knowledge, this represents the first reported case of syringocystadenoma papilliferum of the male breast. We present the clinical and pathologic features of this unusual case and a review of the literature.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/00000372-199808000-00019" target="_blank" rel="noreferrer noopener">10.1097/00000372-199808000-00019</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1998
American Journal of Dermatopathology
apocrine
breast
Dermatology
differentiation
eccrine differentiation
Fatteh S
GCDFP-15
Journal Article
Lopez J
lysozyme
Male
Nowak M
Pathan A
plasma cell infiltrate
syringocystadenoma papilliferum
tumors