1
40
6
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(90)90402-4" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(90)90402-4</a>
Pages
267–271
Issue
2
Volume
36
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Discriminative stimulus properties of (+)cathine, an alkaloid of the khat plant.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1990-06
Subject
The topic of the resource
Male; Animals; Rats; Drug Administration Schedule; Drug Tolerance; Psychotropic Drugs/*pharmacology; Haloperidol/pharmacology; Alkaloids/*pharmacology; *Discrimination (Psychology)/drug effects; Catha; Domperidone/pharmacology; Phenylpropanolamine/antagonists & inhibitors/*pharmacology; Plant Extracts/analysis; Inbred Strains
Creator
An entity primarily responsible for making the resource
Pehek E A; Schechter M D
Description
An account of the resource
The effects of the psychostimulant (+)cathine (norpseudoephedrine) were examined in a two-choice, food-motivated, drug-discrimination paradigm. Rats were able to discriminate cathine from vehicle and this effect was dose- and time-dependent. Prior administration of cathine resulted in a diminished response (tolerance) to subsequent cathine and this effect developed and dissipated rapidly. Thus, different dose-response curves were generated depending upon whether cathine or vehicle was administered the day before testing. The development of tolerance also shortened cathine's time course of action and enhanced the ability of haloperidol to antagonize the cathine cue. These results suggest caution in interpreting effects produced by intermittent drug injection schedules.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(90)90402-4" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(90)90402-4</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Discrimination (Psychology)/drug effects
1990
Alkaloids/*pharmacology
Animals
Catha
Domperidone/pharmacology
Drug Administration Schedule
Drug Tolerance
Haloperidol/pharmacology
Inbred Strains
Male
Pehek E A
Pharmacology, biochemistry, and behavior
Phenylpropanolamine/antagonists & inhibitors/*pharmacology
Plant Extracts/analysis
Psychotropic Drugs/*pharmacology
Rats
Schechter M D
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0028-3908(90)90041-o" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0028-3908(90)90041-o</a>
Pages
1171–1176
Issue
12
Volume
29
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effects of cathinone and amphetamine on the neurochemistry of dopamine in vivo.
Publisher
An entity responsible for making the resource available
Neuropharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1990-12
Subject
The topic of the resource
Male; Animals; Rats; Molecular Structure; Structure-Activity Relationship; Reference Values; Kinetics; Dopamine/*metabolism; Brain/drug effects/*metabolism; Psychotropic Drugs/*pharmacology; Alkaloids/*pharmacology; Amphetamine/*pharmacology; Caudate Nucleus/metabolism; Homovanillic Acid/metabolism; Nucleus Accumbens/metabolism; Putamen/metabolism; Inbred Strains; 3; 4-Dihydroxyphenylacetic Acid/metabolism
Creator
An entity primarily responsible for making the resource
Pehek E A; Schechter M D; Yamamoto B K
Description
An account of the resource
The effects of (-)cathinone, the primary psychoactive alkaloid of the Khat plant, were compared to those of (+)amphetamine in the anterior caudate-putamen and the nucleus accumbens. In vivo microdialysis was used to measure extracellular levels of dopamine and metabolites in both regions of the brain simultaneously, after intraperitoneal administration of 0.8, 1.6 or 3.2 mg/kg of either drug (doses expressed as the salts). Both drugs increased levels of dopamine but decreased levels of metabolites in a dose-dependent manner. However, the relative magnitude of these effects depended upon the specific drug, the dose and area of the brain examined. At the largest dose used, amphetamine had a relatively greater effect than cathinone on dopamine in both caudate and accumbens. However, among smaller doses, this difference was only observed in the nucleus accumbens after administration of 1.6 mg/kg. The results also demonstrated a differential regional effect of both drugs at 3.2 mg/kg, in that both had a greater effect on dopamine in the caudate, as opposed to the accumbens. These findings demonstrate a functional heterogeneity of the striatum of the rat, that may be relevant to the understanding of both normal brain function and the neural responses to psychoactive drugs.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0028-3908(90)90041-o" target="_blank" rel="noreferrer noopener">10.1016/0028-3908(90)90041-o</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1990
3
4-Dihydroxyphenylacetic Acid/metabolism
Alkaloids/*pharmacology
Amphetamine/*pharmacology
Animals
Brain/drug effects/*metabolism
Caudate Nucleus/metabolism
Dopamine/*metabolism
Homovanillic Acid/metabolism
Inbred Strains
Kinetics
Male
Molecular Structure
Neuropharmacology
Nucleus Accumbens/metabolism
Pehek E A
Psychotropic Drugs/*pharmacology
Putamen/metabolism
Rats
Reference Values
Schechter M D
Structure-Activity Relationship
Yamamoto B K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0006-8993(90)91256-g" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0006-8993(90)91256-g</a>
Pages
236–242
Issue
2
Volume
506
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A neurochemical heterogeneity of the rat striatum as measured by in vivo electrochemistry and microdialysis.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1990-01
Subject
The topic of the resource
Male; Animals; Rats; Dopamine/*metabolism; Corpus Striatum/*metabolism; Amphetamines/*pharmacology; Electrochemistry; Sulpiride/*pharmacology; Inbred Strains; Receptors; 3; 4-Dihydroxyphenylacetic Acid/metabolism; Dopamine/drug effects; Dopamine D2
Creator
An entity primarily responsible for making the resource
Yamamoto B K; Pehek E A
Description
An account of the resource
The neurochemical heterogeneity of the rat striatum was assessed in vivo by measuring subregional changes in extracellular dopamine and DOPAC by in vivo electrochemistry and microdialysis in response to amphetamine and the D2 antagonist, (-)-sulpiride. Both in vivo electrochemical and microdialysis experiments indicated a significant rostrocaudal gradient in dopamine release following amphetamine. The increase in dopamine release was highest in the rostral areas (over 800% of baseline values) and lowest in the most caudal subregion (425% of baseline). No lateromedial differences in dopamine release were observed. DOPAC levels decreased in dialysates but were similar for all 6 subregions examined. In contrast, D2 blockade with (-)-sulpiride revealed a lateromedial gradient in the increases seen for dopamine and DOPAC such that greater increases were observed in the lateral subregions. (-)-Sulpiride did not produce any differential effects along the rostrocaudal axis. The regional gradients detected in extracellular fluid changes of dopamine and DOPAC indicate that dopamine release is locally regulated by an interaction between the density of dopaminergic innervation to a particular subregion and the D2 receptor density.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0006-8993(90)91256-g" target="_blank" rel="noreferrer noopener">10.1016/0006-8993(90)91256-g</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1990
3
4-Dihydroxyphenylacetic Acid/metabolism
Amphetamines/*pharmacology
Animals
Brain research
Corpus Striatum/*metabolism
Dopamine D2
Dopamine/*metabolism
Dopamine/drug effects
Electrochemistry
Inbred Strains
Male
Pehek E A
Rats
Receptors
Sulpiride/*pharmacology
Yamamoto B K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0028-3908(90)90041-o" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0028-3908(90)90041-o</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1171-1176
Issue
12
Volume
29
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
EFFECTS OF CATHINONE AND AMPHETAMINE ON THE NEUROCHEMISTRY OF DOPAMINE INVIVO
Publisher
An entity responsible for making the resource available
Neuropharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1990-12
Subject
The topic of the resource
Neurosciences & Neurology; Pharmacology & Pharmacy
Creator
An entity primarily responsible for making the resource
Pehek E A; Schechter M D; Yamamoto B K
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0028-3908(90)90041-o" target="_blank" rel="noreferrer noopener">10.1016/0028-3908(90)90041-o</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1990
Journal Article
Neuropharmacology
Neurosciences & Neurology
Pehek E A
Pharmacology & Pharmacy
Schechter M D
Yamamoto B K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/syn.890100406" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/syn.890100406</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
317-325
Issue
4
Volume
10
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
SELECTIVE SUBREGIONAL DOPAMINE DEPLETIONS IN THE RAT CAUDATE-PUTAMEN FOLLOWING NIGROSTRIATAL LESIONS
Publisher
An entity responsible for making the resource available
Synapse
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-04
Subject
The topic of the resource
heterogeneity; innervation; Neurosciences & Neurology; nucleus-accumbens; projection; striatum; substantia-nigra
Creator
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Pehek E A; Crock R; Yamamoto B K
Description
An account of the resource
Previous work has demonstrated a complex neurochemical and neuroanatomical heterogeneity of the striatum in normal brains. The present research investigated whether the heterogeneous distribution of dopamine would be altered following unilateral injections of the neurotoxin 6-hydroxydopamine into the substantia nigra of the rat. Four weeks following injection, the nucleus accumbens and subregions of the caudate-putamen and substantia nigra were dissected and analyzed by HPLC with electrochemical detection for dopamine, 5-hydroxytryptamine, and their respective metabolites. Levels of dopamine and its metabolites in the anterodorsolateral caudate-putamen were depleted more than medial, posterior, and ventral, striatal areas in partially lesioned animals (< 90% dopamine depletion). This resulted in an alteration of striatal heterogeneity such that a mediolateral gradient of dopamine tissue content was now superimposed on the normal rostrocaudal gradient observed in controls. Paralleling these findings, dopamine was more depleted in the lateral, as opposed to the medial, substantia nigra. These results indicate that the nigrostriatal dopamine system degenerates in a heterogeneous fashion following 6-hydroxydopamine administration. It is speculated that the differential loss of dopamine neurons observed in the nigra of Parkinson's patients may be due to a differential sensitivity to toxins within the nigra.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/syn.890100406" target="_blank" rel="noreferrer noopener">10.1002/syn.890100406</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1992
Crock R
heterogeneity
innervation
Journal Article
Neurosciences & Neurology
nucleus-accumbens
Pehek E A
projection
striatum
substantia-nigra
synapse
Yamamoto B K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0006-8993(90)91256-g" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0006-8993(90)91256-g</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
236-242
Issue
2
Volume
506
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A NEUROCHEMICAL HETEROGENEITY OF THE RAT STRIATUM AS MEASURED BY INVIVO ELECTROCHEMISTRY AND MICRODIALYSIS
Publisher
An entity responsible for making the resource available
Brain Research
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1990-01
Subject
The topic of the resource
Neurosciences & Neurology
Creator
An entity primarily responsible for making the resource
Yamamoto B K; Pehek E A
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0006-8993(90)91256-g" target="_blank" rel="noreferrer noopener">10.1016/0006-8993(90)91256-g</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1990
Brain research
Journal Article
Neurosciences & Neurology
Pehek E A
Yamamoto B K