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40
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Text
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<a href="http://doi.org/10.3389/fncir.2020.599600" target="_blank" rel="noreferrer noopener">http://doi.org/10.3389/fncir.2020.599600</a>
Pages
599600
Volume
14
ISSN
1662-5110 1662-5110
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<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.3389/fncir.2020.599600" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.3389/fncir.2020.599600</a>
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Update Year & Number
December 2020 List
NEOMED College
NEOMED College of Medicine
NEOMED Department
NEOMED Student Publications
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Department of Anatomy & Neurobiology
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Neuromodulation by mGluRs in Sound Localization Circuits in the Auditory Brainstem.
Publisher
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Frontiers In Neural Circuits
Date
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2020
1905-07
Subject
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mGluR; neuromodulation; sound localization; ILD; mGluR; ILD; ITD; neuromodulation; sound localization; ILD; ITD; mGluR; neuromodulation; sound localization; ITD
Creator
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Goel N; Peng K; Lu Y
Description
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The ability of humans and animals to localize the source of a sound in a complex acoustic environment facilitates communication and survival. Two cues are used for sound localization at horizontal planes, interaural time and level differences (ITD and ILD), which are analyzed by distinct neural circuits in the brainstem. Here, we review the studies on metabotropic glutamate receptor (mGluR)-mediated neuromodulation of both intrinsic and synaptic properties of brainstem neurons in these circuits. Both mammalian and avian animal models have been used, with each having their advantages that are not present in the other. For the mammalian model, we discuss mGluR neuromodulation in the ILD circuit, with an emphasis on the recent discovery of differential modulation of synaptic transmission of different transmitter release modes. For the avian model, we focus on reviewing mGluR neuromodulation in the ITD pathway, with an emphasis on tonotopic distribution and synaptic plasticity of mGluR modulation in coincidence detector neurons. Future works are proposed to further investigate the functions and mechanisms of mGluRs in the sound localization circuits.
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<a href="http://doi.org/10.3389/fncir.2020.599600" target="_blank" rel="noreferrer noopener">10.3389/fncir.2020.599600</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
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journalArticle
2020
December 2020 List
Department of Anatomy & Neurobiology
Frontiers in neural circuits
Goel N
ILD
ITD
journalArticle
Lu Y
mGluR
NEOMED College of Medicine
NEOMED Postdoc Publications
NEOMED Student Publications
neuromodulation
Peng K
Sound Localization
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1523/JNEUROSCI.2771-19.2020" target="_blank" rel="noreferrer noopener">http://doi.org/10.1523/JNEUROSCI.2771-19.2020</a>
ISSN
1529-2401 0270-6474
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.1523/JNEUROSCI.2771-19.2020" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1523/JNEUROSCI.2771-19.2020</a>
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Update Year & Number
August 2020 List
NEOMED College
NEOMED College of Medicine
NEOMED Department
NEOMED Postdoc Publications
Department of Anatomy & Neurobiology
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Mechanisms underlying enhancement of spontaneous glutamate release by group I mGluRs at a central auditory synapse.
Publisher
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The Journal of Neuroscience : The Official Journal of the Society for Neuroscience
Date
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2020
2020-08-12
Creator
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Peng K; Wang X; Wang Y; Li D; Huang H; Lu Y
Description
An account of the resource
One emerging concept in neuroscience states that synaptic vesicles and the molecular machinery underlying spontaneous transmitter release are different from those underlying action potential-driven synchronized transmitter release. Differential neuromodulation of these two distinct release modes by metabotropic glutamate receptors (mGluRs) constitutes critical supporting evidence. However, the mechanisms underlying such a differential modulation are not understood. Here, we investigated the mechanisms of the modulation by group I mGluRs (mGluR I) on spontaneous glutamate release in the medial nucleus of the trapezoid body (MNTB), an auditory brainstem nucleus critically involved in sound localization. Whole-cell patch recordings from brainstem slices of mice of both sexes were performed. Activation of mGluR I by 3,5-DHPG (200 μM) produced an inward current at -60 mV, and increased spontaneous glutamate release in MNTB neurons. Pharmacological evidence indicated involvement of both mGluR1 and mGluR5, which was further supported for mGluR5 by immunolabeling results. The modulation was eliminated by blocking Na(V) channels (tetrodotoxin, 1 μM), persistent Na(+) current (I(NaP)) (Riluzole, 10 μM), or Ca(V) channels (CdCl(2), 100 µM). Presynaptic calyx recordings revealed that 3,5-DHPG shifted the activation of I(NaP) to more hyperpolarized voltages and increased I(NaP) at resting membrane potential. Our data indicate that mGluR I enhance spontaneous glutamate release via regulation of I(NaP) and subsequent Ca(2+)-dependent processes under rest condition.SIGNIFICANCE STATEMENTFor brain cells to communicate with each other, neurons release chemical messengers, termed neurotransmitters, in response to action potential invasion (evoked release). Neurons also release neurotransmitters spontaneously. Recent works have revealed different release machineries underlying these two release modes, and their different roles in synaptic development and plasticity. Our recent work discovered differential neuromodulation of these two release modes, but the mechanisms are not well understood. The present study showed that activation of group I metabotropic glutamate receptors enhanced spontaneous glutamate release in an auditory brainstem nucleus, while suppressing evoked release. The modulation is dependent on a persistent Na(+) current and involves subsequent Ca(2+) signaling, providing insight into the mechanisms underlying the different release modes in auditory processing.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1523/JNEUROSCI.2771-19.2020" target="_blank" rel="noreferrer noopener">10.1523/JNEUROSCI.2771-19.2020</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
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journalArticle
2020
August 2020 List
Department of Anatomy & Neurobiology
Huang H
journalArticle
Li D
Lu Y
NEOMED College of Medicine
NEOMED College of Medicine Postdoc
NEOMED Postdoc Publications
Peng K
The Journal of neuroscience : the official journal of the Society for Neuroscience
Wang X
Wang Y