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<a href="http://doi.org/10.1111/j.1460-9592.2010.03425.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/j.1460-9592.2010.03425.x</a>
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Pages
1046-1051
Issue
11
Volume
20
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Title
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Complications of anesthesia for children with malignant infantile osteopetrosis before and after hematopoietic stem cell transplantation
Publisher
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Pediatric Anesthesia
Date
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2010
2010-11
Subject
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diagnosis; Pediatrics; intubation; osteopetrosis; management; morbidity; Anesthesiology; complication; autosomal recessive osteopetrosis; anaesthesia
Creator
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Burgoyne L L; Kaur A; Billups C A; Parish M E; Kaddoum R N; Bikhazi G B; Pereiras L A
Description
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P>Objectives and aims: The primary aim was to determine the frequency of anesthetic-related complications for patients with malignant infantile osteopetrosis (MIOP) before and after hematopoietic stem cell transplant (HSCT). The secondary aims were to describe the types of complications that occurred, to determine whether the risk of anesthetic complications was altered by HSCT, and to determine the frequency of difficult intubation. Background: Patients with MIOP undergo HSCT, often in infancy, and anesthesia is frequently required for investigations and procedures associated with transplantation. Although MIOP has adverse implications for anesthetic management, the literature describing the anesthetic management of MIOP patients is limited. Methods: A retrospective review of medical and anesthetic records was undertaken between November 2000 and March 2008. Results: Eleven patients underwent 127 anesthetics. The overall complication rate was 11%. Before HSCT, there were 12 complications in 62 anesthetics (19.3%). After HSCT, there were two complications in 65 anesthetics (3.2%). This difference was not statistically significant. All of the complications were airway or respiratory events. Of the 26 intubations associated with anesthesia, 23 (88.5%) were easy, 1 (3.8%) was moderately difficult, and 2 (7.7%) were difficult. Conclusion: Complications associated with anesthesia for infants and children with MIOP having HSCT are fairly common and are usually airway or respiratory related. Difficult endotracheal intubation is also common.
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<a href="http://doi.org/10.1111/j.1460-9592.2010.03425.x" target="_blank" rel="noreferrer noopener">10.1111/j.1460-9592.2010.03425.x</a>
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Journal Article or Conference Abstract Publication
2010
anaesthesia
Anesthesiology
autosomal recessive osteopetrosis
Bikhazi G B
Billups C A
Burgoyne L L
Complication
Diagnosis
Intubation
Journal Article or Conference Abstract Publication
Kaddoum R N
Kaur A
Management
Morbidity
osteopetrosis
Parish M E
Pediatric Anesthesia
Pediatrics
Pereiras L A