1
40
2
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Text
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URL Address
<a href="http://doi.org/10.1002/jcp.30116" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/jcp.30116</a>
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ISSN
1097-4652 0021-9541
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Update Year & Number
October 2020 List
NEOMED College
NEOMED College of Medicine Student
NEOMED College of Medicine
NEOMED College of Pharmacy
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NEOMED Student Publications
Department of Integrative Medical Sciences
NEOMED Postdoc Publications
Department of Pharmaceutical Sciences
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Transient receptor potential vanilloid 4 channel deletion regulates pathological but not developmental retinal angiogenesis.
Publisher
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Journal of Cellular Physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-10-20
Subject
The topic of the resource
neovascularization; TRPV4; mechanotransduction; ECM stiffness; human retinal endothelial cells
Creator
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Cappelli HC;Guarino BD;Kanugula AK;Adapala R K;Perera V;Smith MA;Paruchuri S;Thodeti CK
Description
An account of the resource
Transient receptor potential vanilloid 4 (TRPV4) channels are mechanosensitive ion channels that regulate systemic endothelial cell (EC) functions such as vasodilation, permeability, and angiogenesis. TRPV4 is expressed in retinal ganglion cells, Müller glia, pigment epithelium, microvascular ECs, and modulates cell volume regulation, calcium homeostasis, and survival. TRPV4-mediated physiological or pathological retinal angiogenesis remains poorly understood. Here, we demonstrate that TRPV4 is expressed, functional, and mechanosensitive in retinal ECs. The genetic deletion of TRPV4 did not affect postnatal developmental angiogenesis but increased pathological neovascularization in response to oxygen-induced retinopathy (OIR). Retinal vessels from TRPV4 knockout mice subjected to OIR exhibited neovascular tufts that projected into the vitreous humor and displayed reduced pericyte coverage compared with wild-type mice. These results suggest that TRPV4 is a regulator of retinal angiogenesis, its deletion augments pathological retinal angiogenesis, and that TRPV4 could be a novel target for the development of therapies against neovascular ocular diseases.
Identifier
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<a href="http://doi.org/10.1002/jcp.30116" target="_blank" rel="noreferrer noopener">10.1002/jcp.30116</a>
Format
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journalArticle
2020
Adapala R K
Cappelli HC
Department of Integrative Medical Sciences
Department of Pharmaceutical Sciences
ECM stiffness
Guarino BD
human retinal endothelial cells
Journal of cellular physiology
journalArticle
Kanugula AK
Mechanotransduction
NEOMED College of Medicine
NEOMED College of Medicine Postdoc
NEOMED College of Medicine Student
NEOMED College of Pharmacy
NEOMED Postdoc Publications
NEOMED Student Publications
Neovascularization
October 2020 List
Paruchuri S
Perera V
Smith MA
Thodeti CK
TRPV4
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
2-2
Volume
30
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Catecholamine Induced Takotsubo Cardiomyopathy: The role of coronary metabolic blood flow regulation in apical ballooning
Publisher
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Faseb Journal
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016-04
Subject
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Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Creator
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Ohanyan V; Yin L; Bardakjian R; Khayata M; Kolz C L; Enrick M; Schatmeyer B; Perera V; Janota D; Hakobyan T; Chilian W M
Identifier
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n/a
Format
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Journal Article
2016
Bardakjian R
Biochemistry & Molecular Biology
Cell Biology
Chilian W M
Enrick M
Faseb Journal
Hakobyan T
Janota D
Journal Article
Khayata M
Kolz C L
Life Sciences & Biomedicine - Other
Ohanyan V
Perera V
Schatmeyer B
Topics
Yin L