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              <text>31–39</text>
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                <text>The development of long-term potentiation in hippocampus and neocortex.</text>
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                <text>Female; Animals; Neurons/physiology; Rats; Electric Stimulation; *Synaptic Transmission; Aging/*physiology; Synapses/physiology; Hippocampus/*physiology; Cerebral Cortex/*physiology; Memory/*physiology; Evoked Potentials; Mental Recall/*physiology; Visual Cortex/physiology; Visual Pathways/physiology; Inbred Strains</text>
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                <text>Teyler T J; Perkins A T 4th; Harris K M</text>
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                <text>The development of long-term potentiation (LTP), an enduring alteration in synaptic efficacy following afferent activation, was examined in CA1 hippocampus and primary visual cortex of rat. Both regions show little LTP prior to postnatal day 5, demonstrate a maximal potentiated response around postnatal day 15, and a subsequent decline to adult levels. These results are discussed with respect to the underlying mechanism of action and behavioral significance of these critical-period phenomena.</text>
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                <text>A critical period for long-term potentiation in the developing rat visual cortex.</text>
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                <text>The in vitro rodent visual cortical slice preparation demonstrates a critical period for long-term potentiation (LTP). Current source density (CSD) analysis reveals peak potentiation of both supra-(layers II-III) and infragranular (layers V) layers of visual cortex during the second postnatal week following stimulation of the subadjacent white matter. By day 30 both the supra- and infragranular CSD sinks show only minimal potentiation. In adults there is no change in supragranular response but infragranular layers reveal 177% potentiation. Therefore, we conclude that rodent visual cortex displays a critical period for maximum plasticity of both supra and infra-granular layers. Supragranular visual cortex plasticity ends by day 30 whereas infragranular layers retain plastic qualities into adulthood.</text>
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