1
40
4
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.jnutbio.2010.09.001" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jnutbio.2010.09.001</a>
Pages
1035–1046
Issue
11
Volume
22
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Anthocyanin-rich black currant (Ribes nigrum L.) extract affords chemoprevention against diethylnitrosamine-induced hepatocellular carcinogenesis in rats.
Publisher
An entity responsible for making the resource available
Journal of Nutritional Biochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-11
Subject
The topic of the resource
Male; Animals; Rats; Chemoprevention; Phenobarbital; Plants; Biochemical Phenomena; Nitrosamines; Preventive Cardiovascular Nurses Association; Proteins – Metabolism; Cell Physiology – Drug Effects; Liver Neoplasms – Metabolism; Liver Neoplasms – Pathology; Antineoplastic Agents – Therapeutic Use; Liver Neoplasms – Prevention and Control; Liver – Pathology; Plant Extracts – Therapeutic Use; Apoptosis – Drug Effects; Liver Neoplasms – Chemically Induced
Creator
An entity primarily responsible for making the resource
Bishayee A; Mbimba T; Thoppil R J; Háznagy-Radnai E; Sipos P; Darvesh A S; Folkesson H G; Hohmann J
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.jnutbio.2010.09.001" target="_blank" rel="noreferrer noopener">10.1016/j.jnutbio.2010.09.001</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2011
Animals
Antineoplastic Agents – Therapeutic Use
Apoptosis – Drug Effects
Biochemical Phenomena
Bishayee A
Cell Physiology – Drug Effects
Chemoprevention
Darvesh A S
Department of Pharmaceutical Sciences
Folkesson H G
Háznagy-Radnai E
Hohmann J
Journal of Nutritional Biochemistry
Liver – Pathology
Liver Neoplasms – Chemically Induced
Liver Neoplasms – Metabolism
Liver Neoplasms – Pathology
Liver Neoplasms – Prevention and Control
Male
Mbimba T
NEOMED College of Pharmacy
Nitrosamines
Phenobarbital
Plant Extracts – Therapeutic Use
Plants
Preventive Cardiovascular Nurses Association
Proteins – Metabolism
Rats
Sipos P
Thoppil R J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.2174/138920112798868575" target="_blank" rel="noreferrer noopener">http://doi.org/10.2174/138920112798868575</a>
Pages
229–234
Issue
1
Volume
13
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Alteration of hepatic proinflammatory cytokines is involved in the resveratrol-mediated chemoprevention of chemically-induced hepatocarcinogenesis.
Publisher
An entity responsible for making the resource available
Current pharmaceutical biotechnology
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-01
Subject
The topic of the resource
Female; Animals; Rats; Gene Expression Regulation/drug effects; Liver/drug effects/metabolism; Resveratrol; Diethylnitrosamine; Anticarcinogenic Agents/pharmacology/*therapeutic use; Cytokines/genetics/*metabolism; Phenobarbital; Stilbenes/pharmacology/*therapeutic use; Sprague-Dawley; RNA; Messenger/metabolism; Liver Neoplasms; Experimental/chemically induced/metabolism/*prevention & control
Creator
An entity primarily responsible for making the resource
Mbimba Thomas; Awale Prabha; Bhatia Deepak; Geldenhuys Werner J; Darvesh Altaf S; Carroll Richard T; Bishayee Anupam
Description
An account of the resource
Hepatocellular carcinoma (HCC), one of the most common cancers in the world, is a leading cause of cancerrelated mortality. HCC develops most frequently in the background of oxidative stress and chronic hepatic inflammation due to viral infections, alcohol abuse as well as exposure to environmental and dietary carcinogens. As the prognosis of HCC is extremely poor and mostly unresponsive to current chemotherapeutic treatment regimens, novel preventive approaches like chemoprevention are urgently needed. We have recently found that resveratrol, a dietary polyphenol present in grapes, berries, peanuts as well as red wine, prevents diethylnitrosamine (DENA)-initiated hepatocarcinogenesis in rats through suppression of inflammation and oxidative stress. As cytokines are considered to be important mediators of inflammation, the objective of the present study was to investigate the effects of resveratrol on hepatic cytokines during DENA-initiated hepatocarcinogenesis in rats. Liver samples were harvested from our previous study in which resveratrol (50, 100 and 300 mg/kg) was found to exert a chemopreventive action against rat liver tumorigenesis induced by DENA. The levels of proinflammatory cytokines, namely tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin- 6 (IL-6), were measured using enzyme-linked immunosorbent assays. The mRNA expression of these cytokines was studied by reverse transcriptase-polymerase chain reaction for comparison. Resveratrol treatment reversed the DENAinduced alteration of the level and expression of hepatic TNF-alpha, IL-1beta and IL-6. From the current results in conjunction with our previous findings, it can be concluded that resveratrol-mediated chemoprevention of rat liver carcinogenesis is related to alteration of proinflammatory cytokines.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.2174/138920112798868575" target="_blank" rel="noreferrer noopener">10.2174/138920112798868575</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2012
Animals
Anticarcinogenic Agents/pharmacology/*therapeutic use
Awale Prabha
Bhatia Deepak
Bishayee Anupam
Carroll Richard T
Current pharmaceutical biotechnology
Cytokines/genetics/*metabolism
Darvesh Altaf S
Department of Pharmaceutical Sciences
Diethylnitrosamine
Experimental/chemically induced/metabolism/*prevention & control
Female
Geldenhuys Werner J
Gene Expression Regulation/drug effects
Liver Neoplasms
Liver/drug effects/metabolism
Mbimba Thomas
Messenger/metabolism
NEOMED College of Pharmacy
Phenobarbital
Rats
Resveratrol
RNA
Sprague-Dawley
Stilbenes/pharmacology/*therapeutic use
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.jnutbio.2010.09.001" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jnutbio.2010.09.001</a>
Pages
1035–1046
Issue
11
Volume
22
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Anthocyanin-rich black currant (Ribes nigrum L.) extract affords chemoprevention against diethylnitrosamine-induced hepatocellular carcinogenesis in rats.
Publisher
An entity responsible for making the resource available
The Journal of nutritional biochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-11
Subject
The topic of the resource
Animals; Anthocyanins/*therapeutic use; Anticarcinogenic Agents/therapeutic use; Apoptosis/drug effects; bcl-2-Associated X Protein/metabolism; Cell Proliferation/drug effects; Chemoprevention; Diethylnitrosamine; Down-Regulation; Experimental/metabolism/pathology; Liver Neoplasms; Liver Neoplasms/chemically induced/*prevention & control; Liver/pathology; Male; Phenobarbital; Plant Extracts/*therapeutic use; Proliferating Cell Nuclear Antigen/metabolism; Proto-Oncogene Proteins c-bcl-2/metabolism; Rats; Ribes/chemistry; Sprague-Dawley; Up-Regulation
Creator
An entity primarily responsible for making the resource
Bishayee Anupam; Mbimba Thomas; Thoppil Roslin J; Haznagy-Radnai Erzsebet; Sipos Peter; Darvesh Altaf S; Folkesson Hans G; Hohmann Judit
Description
An account of the resource
Anthocyanins are known to possess potent anticarcinogenic properties against several cancers thus demonstrating potential for cancer prevention. Black currant (Ribes nigrum L., Grossulariaceae) fruits have a high anthocyanin content. This "superfruit" is known to possess various pharmacological effects including alleviation of chronic oxidative stress and inflammation. In contrast to a large volume of literature on the health benefits of black currant, limited evidence on antitumor effects of black currant exists with virtually no data on the prevention of experimental carcinogenesis. In the current study, we have investigated the chemopreventive effects of an anthocyanin-rich black currant skin extract (BCSE) utilizing our well-characterized model of rat liver carcinogenesis. Initiation of hepatocarcinogenesis was done by intraperitoneal injection of diethylnitrosamine (DENA) followed by promotion with phenobarbital. The rats were exposed to dietary BCSE for 4 weeks prior to initiation, and the treatment was continued for 22 consecutive weeks. BCSE dose-dependently decreased the incidence, total number, multiplicity, size and volume of preneoplastic hepatic nodules. The antihepatocarcinogenic effect of BCSE was confirmed by histopathological examination of liver sections. Immunohistochemical analysis of proliferating cell nuclear antigen and DNA fragmentation revealed BCSE-mediated inhibition of abnormal cell proliferation and induction of apoptosis in
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.jnutbio.2010.09.001" target="_blank" rel="noreferrer noopener">10.1016/j.jnutbio.2010.09.001</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2011
Animals
Anthocyanins/*therapeutic use
Anticarcinogenic Agents/therapeutic use
Apoptosis/drug effects
bcl-2-Associated X Protein/metabolism
Bishayee Anupam
Cell Proliferation/drug effects
Chemoprevention
Darvesh Altaf S
Department of Pharmaceutical Sciences
Diethylnitrosamine
Down-Regulation
Experimental/metabolism/pathology
Folkesson Hans G
Haznagy-Radnai Erzsebet
Hohmann Judit
Liver Neoplasms
Liver Neoplasms/chemically induced/*prevention & control
Liver/pathology
Male
Mbimba Thomas
NEOMED College of Pharmacy
Phenobarbital
Plant Extracts/*therapeutic use
Proliferating Cell Nuclear Antigen/metabolism
Proto-Oncogene Proteins c-bcl-2/metabolism
Rats
Ribes/chemistry
Sipos Peter
Sprague-Dawley
The Journal of nutritional biochemistry
Thoppil Roslin J
Up-Regulation
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.cbi.2008.11.015" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.cbi.2008.11.015</a>
Pages
131–144
Issue
2
Volume
179
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Resveratrol-mediated chemoprevention of diethylnitrosamine-initiated hepatocarcinogenesis: inhibition of cell proliferation and induction of apoptosis.
Publisher
An entity responsible for making the resource available
Chemico-biological interactions
Date
A point or period of time associated with an event in the lifecycle of the resource
2009
2009-05
Subject
The topic of the resource
Animal; Animals; Anticarcinogenic Agents/*antagonists & inhibitors/pharmacology; Antitumor; Apoptosis/*drug effects; Body Weight/drug effects; Cell Proliferation/drug effects; Diethylnitrosamine; Disease Models; Dose-Response Relationship; Drinking/drug effects; Drug; Drug Screening Assays; Eating/drug effects; Experimental/chemically induced/pathology/*prevention & control; Female; Immunohistochemistry; Liver Neoplasms; Organ Size/drug effects; Phenobarbital; Proto-Oncogene Proteins c-bcl-2/biosynthesis; Rats; Resveratrol; Sprague-Dawley; Stilbenes/*pharmacology
Creator
An entity primarily responsible for making the resource
Bishayee Anupam; Dhir Neetika
Description
An account of the resource
Hepatocellular carcinoma (HCC) is one of the most common cancers and lethal diseases. In view of the limited treatment and a grave prognosis of liver cancer, preventive control has been emphasized. Resveratrol, a polyphenol found in grape skins, peanuts, berries and red wine, has been shown to possess potent growth inhibitory effects against various human cancer cells. Although resveratrol has been found to exhibit chemopreventive actions in experimentally induced skin, breast, colon and esophagus rodent tumors, chemopreventive potential of this dietary constituent has not been explored well against experimental liver cancer. We evaluated the inhibitory effect of resveratrol using a two-stage model of rat hepatocarcinogenesis in Sprague-Dawley rats. Initiation was performed by a single intraperitoneal injection of diethylnitrosamine (DENA, 200 mg/kg), followed by promotion with phenobarbital (0.05%) in drinking water. The rats had free access to food supplemented with resveratrol equivalent to 50, 100 or 300 mg/kg body weight/day. Resveratrol treatment was started 4 weeks prior to the initiation and continued for 20 weeks. Resveratrol dose-dependently reduced the incidence, total number and multiplicity of visible hepatocyte nodules. Mean nodular volume and nodular volume as percentage of liver volume were also inhibited upon resveratrol treatment. Histopathological examination of liver tissue confirmed the protective effect of resveratrol. Immunohistochemical detection of cell proliferation and assay of apoptosis indicated a decrease in cell proliferation and increase of apoptotic cells in the livers of resveratrol-supplemented rats. Resveratrol also induced the expression of pro-apoptotic protein Bax, reduced anti-apoptotic Bcl-2 expression, with a concurrent increase in Bax/Bcl-2 ratio with respect to DENA control. The present study provides evidence, for the first time, that resveratrol exerts a significant chemopreventive effect on DENA-initiated hepatocarcinogenesis through inhibition of cell proliferation and induction of apoptosis. Resveratrol-induced apoptogenic signal during rat liver carcinogenesis may be mediated through the downregulation of Bcl-2 and upregulation of Bax expression. Due to a favorable toxicity profile, resveratrol can potentially be developed as a chemopreventive drug against human HCC.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.cbi.2008.11.015" target="_blank" rel="noreferrer noopener">10.1016/j.cbi.2008.11.015</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2009
Animal
Animals
Anticarcinogenic Agents/*antagonists & inhibitors/pharmacology
Antitumor
Apoptosis/*drug effects
Bishayee Anupam
Body Weight/drug effects
Cell Proliferation/drug effects
Chemico-biological interactions
Dhir Neetika
Diethylnitrosamine
Disease Models
Dose-Response Relationship
Drinking/drug effects
Drug
Drug Screening Assays
Eating/drug effects
Experimental/chemically induced/pathology/*prevention & control
Female
Immunohistochemistry
Liver Neoplasms
Organ Size/drug effects
Phenobarbital
Proto-Oncogene Proteins c-bcl-2/biosynthesis
Rats
Resveratrol
Sprague-Dawley
Stilbenes/*pharmacology