1
40
10
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
34–39
Issue
1
Volume
277
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Testosterone causes direct relaxation of rat thoracic aorta.
Publisher
An entity responsible for making the resource available
The Journal of pharmacology and experimental therapeutics
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-04
Subject
The topic of the resource
Female; Male; Animals; Rats; In Vitro Techniques; Vasodilation/*drug effects; Testosterone/*pharmacology; Phenylephrine/pharmacology; Calcium Channels/drug effects; Dose-Response Relationship; Drug; Sprague-Dawley; Aorta; Endothelium; Thoracic/*drug effects/physiology; Vascular/physiology
Creator
An entity primarily responsible for making the resource
Costarella C E; Stallone J N; Rutecki G W; Whittier F C
Description
An account of the resource
Several recent studies have provided evidence that gonadal steroid hormones can exert acute (nongenomic) effects on both neural and vascular tissues. This study examines the acute effects of testosterone (T) on vascular reactivity of the rat thoracic aorta. Aortic rings from male Sprague-Dawley (SD) rats with (+ENDO) and without (-ENDO) endothelium were prepared for isometric tension recording. In (+ENDO) male aortae precontracted with phenylephrine (PE), T produced dose-dependent relaxation from 25 microM (30.3 +/- 7.1%) to 300 microM (99.4 +/- 0.4%), whereas T vehicle (\textless or = 0.5% ethanol) had no effect. Pretreatment of (+ENDO) aortae with T (50 microM; 10 min) attenuated subsequent contractile responses to PE. Both maximal contraction and sensitivity to PE were reduced by T. Pretreatment of (+ENDO) aortae with both T and N omega-nitro-L-arginine methyl ester (250 microM) reversed in part the attenuating effects of T alone; however, both maximal response and sensitivity to PE were still reduced compared to control rings (without T or N omega-nitro-L-arginine methyl ester). Pretreatment of (-ENDO) aortae with T reduced sensitivity to PE, but had no effect on maximal contraction. T pretreatment (50 microM; 10 min) of both (+ENDO) female SD aortae and (+ENDO) male testicular-feminized rat aortae reduced maximal contraction and sensitivity to PE in both groups to a similar extent as in (+ENDO) male SD aortae. These data suggest that T has a direct vasodilating effect on the rat aorta, which involves endothelium-dependent (enhanced NO release) and -independent mechanisms and is gender- and intracellular androgen receptor-independent.
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1996
Animals
Aorta
Calcium Channels/drug effects
Costarella C E
Department of Internal Medicine
Dose-Response Relationship
Drug
Endothelium
Female
In Vitro Techniques
Male
NEOMED College of Medicine
Phenylephrine/pharmacology
Rats
Rutecki G W
Sprague-Dawley
Stallone J N
Testosterone/*pharmacology
The Journal of pharmacology and experimental therapeutics
Thoracic/*drug effects/physiology
Vascular/physiology
Vasodilation/*drug effects
Whittier F C
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1161/01.hyp.26.4.676" target="_blank" rel="noreferrer noopener">http://doi.org/10.1161/01.hyp.26.4.676</a>
Pages
676–683
Issue
4
Volume
26
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Acute exercise attenuates cardiac autonomic regulation in hypertensive rats.
Publisher
An entity responsible for making the resource available
Hypertension (Dallas, Tex. : 1979)
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-10
Subject
The topic of the resource
*Physical Exertion; Adrenergic Agents/pharmacology; Animals; Autonomic Nervous System/*physiopathology; Blood Pressure/drug effects; Cholinergic Agents/pharmacology; Heart Conduction System/*physiopathology; Heart Rate/drug effects; Hypertension/*physiopathology; Inbred SHR; Male; Nitroglycerin/pharmacology; Parasympathetic Nervous System/physiopathology; Phenylephrine/pharmacology; Rats; Sympathetic Nervous System/physiopathology; Time Factors
Creator
An entity primarily responsible for making the resource
Chen Y; Chandler M P; DiCarlo S E
Description
An account of the resource
Dynamic exercise may be used as a safe, therapeutic approach to reduce sympathetic nerve activity at rest and thus may be beneficial for individuals with hypertension. Therefore, we tested the hypothesis that a single bout of mild to moderate dynamic exercise would decrease cardiac sympathetic tonus at rest. We designed two experimental protocols to test this hypothesis in male spontaneously hypertensive rats. In protocol 1 (n = 6) cardiac sympathetic tonus and parasympathetic tonus were determined before and after a single bout of dynamic exercise. We developed protocol 2 (n = 5) to determine the component of the autonomic nervous system responsible for the postexercise reduction in heart rate. Rats were instrumented with catheters inserted into the descending aorta for measurements of arterial pressure, mean arterial pressure, and heart rate and into the jugular vein for infusion of drugs. A single bout of mild to moderate dynamic treadmill exercise (12 m/min, 10% grade for 42 +/- 1 minutes, representing approximately 74% to 79% of maximal heart rate) resulted in a postexercise reduction in mean arterial pressure (163 +/- 7 to 149 +/- 5 mm Hg; P \textless .05). Associated with the postexercise hypotension was a reduction in sympathetic and parasympathetic tonus (47 +/- 12% and 71 +/- 12%, respectively). The reduction in heart rate during the early recovery phase was due to a withdrawal of sympathetic tonus, because beta 1-adrenergic receptor blockade significantly enhanced the postexercise reduction in heart rate, and muscarinic-cholinergic receptor blockade did not affect the postexercise decrease in heart rate until 20 minutes after exercise.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1161/01.hyp.26.4.676" target="_blank" rel="noreferrer noopener">10.1161/01.hyp.26.4.676</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Physical Exertion
1995
Adrenergic Agents/pharmacology
Animals
Autonomic Nervous System/*physiopathology
Blood Pressure/drug effects
Chandler M P
Chen Y
Cholinergic Agents/pharmacology
DiCarlo S E
Heart Conduction System/*physiopathology
Heart Rate/drug effects
Hypertension (Dallas, Tex. : 1979)
Hypertension/*physiopathology
Inbred SHR
Male
Nitroglycerin/pharmacology
Parasympathetic Nervous System/physiopathology
Phenylephrine/pharmacology
Rats
Sympathetic Nervous System/physiopathology
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jappl.1992.73.6.2662" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jappl.1992.73.6.2662</a>
Pages
2662–2667
Issue
6
Volume
73
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Reduced vascular responsiveness after a single bout of dynamic exercise in the conscious rabbit.
Publisher
An entity responsible for making the resource available
Journal of applied physiology (Bethesda, Md. : 1985)
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-12
Subject
The topic of the resource
Adenosine/pharmacology; Adrenergic/physiology; Animals; Blood Vessels/*physiology; Dose-Response Relationship; Drug; Hindlimb/physiology; In Vitro Techniques; Isoproterenol/pharmacology; Phenylephrine/pharmacology; Physical Exertion/*physiology; Pressoreceptors/physiology; Purinergic/physiology; Rabbits; Receptors; Reflex/physiology; Regional Blood Flow/physiology
Creator
An entity primarily responsible for making the resource
Howard M G; DiCarlo S E
Description
An account of the resource
We measured agonist-induced changes in the iliac artery blood flow velocity (IFV) independent of baroreflex-mediated compensatory mechanisms in chronically instrumented New Zealand White rabbits (n = 8). Animals were instrumented with a Doppler flow probe around the right common iliac artery. A Teflon catheter was inserted into the right iliolumbar artery for local infusion of the vasoactive agonists. Another Teflon catheter was inserted in the left femoral artery for the measurement of pulsatile and mean arterial (MAP) blood pressures and heart rate (HR). The alpha-adrenergic receptor agonist phenylephrine (PE, 1.32-10.0 micrograms), the beta 1- and beta 2-adrenergic receptor agonist isoproterenol (IP, 0.022-0.11 micrograms), and the purinergic receptor agonist adenosine (AD, 10.0-100.0 micrograms) were injected into the functionally isolated hindlimb, and dose-response curves were generated. Changes in IFV were obtained without changes in MAP or HR. Exercise increased HR, MAP, and IFV (65.3 +/- 7.1 beats/min, 11.1 +/- 2.2 mmHg, and 2.2 +/- 0.3 kHz, respectively). The maximum responses to PE, AD, and IP were reduced 29.0 +/- 6.7, 50.7 +/- 8.5, and 61.0 +/- 8.1%, respectively, after exercise. In conclusion, exercise attenuated adrenergic and purinergic receptor-mediated vascular responses in the intact conscious rabbit.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jappl.1992.73.6.2662" target="_blank" rel="noreferrer noopener">10.1152/jappl.1992.73.6.2662</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1992
Adenosine/pharmacology
Adrenergic/physiology
Animals
Blood Vessels/*physiology
DiCarlo S E
Dose-Response Relationship
Drug
Hindlimb/physiology
Howard M G
In Vitro Techniques
Isoproterenol/pharmacology
Journal of applied physiology (Bethesda, Md. : 1985)
Phenylephrine/pharmacology
Physical Exertion/*physiology
Pressoreceptors/physiology
Purinergic/physiology
Rabbits
Receptors
Reflex/physiology
Regional Blood Flow/physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajpheart.1997.273.6.h2613" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajpheart.1997.273.6.h2613</a>
Pages
H2613–2619
Issue
6
Volume
273
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Daily exercise attenuates the sympathetic component of the arterial baroreflex control of heart rate.
Publisher
An entity responsible for making the resource available
The American journal of physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1997-12
Subject
The topic of the resource
Animal/*physiology; Animals; Arteries/drug effects/innervation/*physiology; Baroreflex/drug effects/*physiology; Body Weight; Female; Heart Rate/*physiology; Heart/anatomy & histology/*physiology; Nitroprusside/pharmacology; Organ Size; Parasympathetic Nervous System/physiology; Phenylephrine/pharmacology; Physical Conditioning; Pulse; Rats; Sympathetic Nervous System/physiology
Creator
An entity primarily responsible for making the resource
Collins H L; DiCarlo S E
Description
An account of the resource
The influence of daily spontaneous running (DSR) on the sympathetic (SC) and parasympathetic components of the arterial baroreflex control of heart rate (HR) was examined in 16 female Long Evans rats [8 sedentary (SED) and 8 DSR]. After
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajpheart.1997.273.6.h2613" target="_blank" rel="noreferrer noopener">10.1152/ajpheart.1997.273.6.h2613</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1997
Animal/*physiology
Animals
Arteries/drug effects/innervation/*physiology
Baroreflex/drug effects/*physiology
Body Weight
Collins H L
DiCarlo S E
Female
Heart Rate/*physiology
Heart/anatomy & histology/*physiology
Nitroprusside/pharmacology
Organ Size
Parasympathetic Nervous System/physiology
Phenylephrine/pharmacology
Physical Conditioning
Pulse
Rats
Sympathetic Nervous System/physiology
The American journal of physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajpheart.1997.272.3.H1412" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajpheart.1997.272.3.H1412</a>
Pages
H1412–1418
Issue
3
Volume
272
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Daily exercise and gender influence postexercise cardiac autonomic responses in hypertensive rats.
Publisher
An entity responsible for making the resource available
The American journal of physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1997-03
Subject
The topic of the resource
*Physical Conditioning; Animal; Animals; Atropine Derivatives/pharmacology; Autonomic Nervous System/drug effects/*physiopathology; Exercise Test; Female; Heart Rate/*drug effects; Heart/*innervation; Hypertension/genetics/*physiopathology; Inbred SHR; Male; Metoprolol/pharmacology; Nitroglycerin/pharmacology; Phenylephrine/pharmacology; Rats; Running; Sex Characteristics; Sympathetic Nervous System/drug effects/*physiopathology; Weight Loss
Creator
An entity primarily responsible for making the resource
Chen Y; Chandler M P; DiCarlo S E
Description
An account of the resource
The influence of daily spontaneous running (DSR) and gender on postexercise cardiac autonomic responses was examined in spontaneously hypertensive rats. Rats were weaned at 4-5 wk of age and were randomly assigned to a sedentary (7 males and 6 females) or DSR (7 males and 8 females) group. After 8 weeks of DSR or sedentary control, rats were chronically instrumented with arterial and venous catheters. After 5 days of recovery, cardiac sympathetic (ST) and parasympathetic tonus (PT) were determined (by the response of heart rate to receptor antagonists) on alternate days under two experimental conditions: no exercise and postexercise. After a single bout of dynamic treadmill exercise (12 m/min, 10% grade for 40 min) ST was reduced (P \textless 0.05) (male sedentary: no exercise 45 +/- 4 vs. postexercise 28 +/- 3 beats/min; female sedentary: no exercise 69 +/- 10 vs. postexercise 37 +/- 7 beats/ min). PT was also altered after exercise (male sedentary: no exercise -31 +/- 4 vs. postexercise -11 +/- 2 beats/min; female sedentary: no exercise -5 +/- 4 vs. postexercise 7 +/- 4 beats/min). After DSR, ST was reduced (male sedentary 45 +/- 4 vs. DSR 22 +/- 3 beats/min; female sedentary 69 +/- 10 vs. DSR 36 +/- 4 beats/min) (P \textless 0.05). Finally, male rats had a lower ST and higher PT than female rats. These results demonstrate that 1) ST was reduced after a single bout of dynamic exercise; 2) ST was reduced after DSR; 3) the autonomic response to acute exercise was attenuated after DSR; and 4) there was a gender influence on the cardiac autonomic function.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajpheart.1997.272.3.H1412" target="_blank" rel="noreferrer noopener">10.1152/ajpheart.1997.272.3.H1412</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Physical Conditioning
1997
Animal
Animals
Atropine Derivatives/pharmacology
Autonomic Nervous System/drug effects/*physiopathology
Chandler M P
Chen Y
DiCarlo S E
Exercise Test
Female
Heart Rate/*drug effects
Heart/*innervation
Hypertension/genetics/*physiopathology
Inbred SHR
Male
Metoprolol/pharmacology
Nitroglycerin/pharmacology
Phenylephrine/pharmacology
Rats
Running
Sex Characteristics
Sympathetic Nervous System/drug effects/*physiopathology
The American journal of physiology
Weight Loss
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajpheart.1994.267.4.H1537" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajpheart.1994.267.4.H1537</a>
Pages
H1537–1543
Issue
4
Volume
267
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Gender difference in cardiopulmonary reflex inhibition of sympathetic nerve activity.
Publisher
An entity responsible for making the resource available
The American journal of physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-10
Subject
The topic of the resource
*Blood Pressure/drug effects; *Heart Rate/drug effects; *Reflex/drug effects; Analysis of Variance; Animals; Biguanides/pharmacology; Denervation; Female; Laryngeal Nerves/physiology; Male; Phenylephrine/pharmacology; Pulmonary Circulation/drug effects/physiology; Rats; Sex Characteristics; Sinoatrial Node/*physiology; Sympathetic Nervous System/drug effects/*physiology
Creator
An entity primarily responsible for making the resource
Scislo T J; DiCarlo S E
Description
An account of the resource
We tested the hypothesis that reflex responses to mechanical [increase in left atrial pressure (LAP) 0-25 mmHg] and chemical stimulation [left atrial injection of phenylbiguanide (PBG), 0.5-10 mg/kg] of cardiopulmonary receptors are greater in female (n = 9; 335 +/- 9 g) than in male (n = 10; 558 +/- 23 g) age-matched rats. Anesthetized (500 mg/kg urethan and 80 mg/kg alpha-chloralose), tracheotomized, and artificially ventilated (100% oxygen), sinoaortic-denervated animals were instrumented with left atrial, femoral venous, and arterial catheters and a Tygon occluder around the ascending aorta. Reflex inhibition of lumbar sympathetic nerve activity (LSNA) vs. LAP and dose PBG was higher in female rats. A two-way analysis of variance revealed a significant gender effect, males vs. females (P = 0.023), and a significant gender x dose interaction (P \textless 0.001) for LSNA vs. LAP. There was also a significant gender x dose interaction (P \textless 0.001) for LSNA vs. PBG. However, there was no influence of gender on the reflex inhibition of mean arterial pressure (P = 0.751) or heart rate (P = 0.561). These responses were associated with a higher left ventricular weight-to-body weight ratio in females (2.14 +/- 0.06 vs. 1.95 +/- 0.07 g/kg, P = 0.039).
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajpheart.1994.267.4.H1537" target="_blank" rel="noreferrer noopener">10.1152/ajpheart.1994.267.4.H1537</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Blood Pressure/drug effects
*Heart Rate/drug effects
*Reflex/drug effects
1994
Analysis of Variance
Animals
Biguanides/pharmacology
Denervation
DiCarlo S E
Female
Laryngeal Nerves/physiology
Male
Phenylephrine/pharmacology
Pulmonary Circulation/drug effects/physiology
Rats
Scislo T J
Sex Characteristics
Sinoatrial Node/*physiology
Sympathetic Nervous System/drug effects/*physiology
The American journal of physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajpheart.1993.265.6.H2073" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajpheart.1993.265.6.H2073</a>
Pages
H2073–2080
Issue
6
Volume
265
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Role of endothelium in sexual dimorphism in vasopressin-induced contraction of rat aorta.
Publisher
An entity responsible for making the resource available
The American journal of physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-12
Subject
The topic of the resource
*Sex Characteristics; *Vasoconstriction; Animals; Aorta/*drug effects; Arginine Vasopressin/*pharmacology; Arginine/analogs & derivatives/pharmacology; Endothelium; Female; Indomethacin/pharmacology; Male; Nitric Oxide/antagonists & inhibitors; omega-N-Methylarginine; Osmolar Concentration; Phenylephrine/pharmacology; Rats; Sprague-Dawley; Vascular/*physiology
Creator
An entity primarily responsible for making the resource
Stallone J N
Description
An account of the resource
In rat thoracic aorta, contractile responses to arginine vasopressin (AVP) are twofold higher in females than in males. To determine the role of the endothelium in this phenomenon, the effects of endothelium removal and inhibition of nitric oxide (NO) synthase and cyclooxygenase were examined in thoracic aortas prepared from male and female Sprague-Dawley rats and mounted for isometric tension recording. Maximal contractile response to AVP was substantially higher in female (4,232 +/- 316 mg/mg ring dry wt) than in male aortas (1,365 +/- 239; P \textless 0.01). Removal of the endothelium markedly potentiated maximal response to AVP in male aortas (4,100 +/- 422 mg/mg ring wt; P \textless 0.01); endothelium removal increased sensitivity but not maximal response in female aortas. Inhibition of NO synthase with NG-monomethyl-L-arginine (L-NMMA, 250 microM) doubled maximal contraction to AVP in male aortas (3,175 +/- 193 mg/mg ring wt; P \textless 0.01); L-NMMA increased sensitivity but not maximal response in female aortas. Inhibition of cyclooxygenase with indomethacin (10 microM) did not alter maximal response to AVP in male aortas but significantly attenuated responses of female aortas (2,816 +/- 306 mg/mg ring wt; P \textless 0.01). In contrast, maximal contractile response to phenylephrine hydrochloride (PE) was 40% higher in males than in females (P \textless 0.01); L-NMMA increased both the sensitivity and maximal response to PE to a greater extent in female (3,061 +/- 121 vs. 4,971 +/- 135 mg/mg ring wt; P \textless 0.01) than in male aortas (4,317 +/- 227 vs. 4,899 +/- 104 mg/mg ring wt; P \textless 0.01). (ABSTRACT TRUNCATED AT 250 WORDS)
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajpheart.1993.265.6.H2073" target="_blank" rel="noreferrer noopener">10.1152/ajpheart.1993.265.6.H2073</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Sex Characteristics
*Vasoconstriction
1993
Animals
Aorta/*drug effects
Arginine Vasopressin/*pharmacology
Arginine/analogs & derivatives/pharmacology
Endothelium
Female
Indomethacin/pharmacology
Male
Nitric Oxide/antagonists & inhibitors
omega-N-Methylarginine
Osmolar Concentration
Phenylephrine/pharmacology
Rats
Sprague-Dawley
Stallone J N
The American journal of physiology
Vascular/*physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajpheart.1991.260.2.H453" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajpheart.1991.260.2.H453</a>
Pages
H453–458
Issue
2
Volume
260
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Sexual dimorphism in vasopressin-induced contraction of rat aorta.
Publisher
An entity responsible for making the resource available
The American journal of physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-02
Subject
The topic of the resource
*Sex Characteristics; *Vasoconstriction; Animals; Aorta/*drug effects; Arginine Vasopressin/*pharmacology; Dose-Response Relationship; Drug; Female; Male; Osmolar Concentration; Phenylephrine/pharmacology; Rats
Creator
An entity primarily responsible for making the resource
Stallone J N; Crofton J T; Share L
Description
An account of the resource
Previously, we reported that, in the rat, pressor responsiveness to vasopressin (VP) is higher in males than in females during most phases of the estrous cycle. To explore the role of the vasculature in this phenomenon, we examined vascular reactivity to VP in thoracic aortas of male rats and female rats during each phase of the estrous cycle. Aortic rings were prepared from age-matched male and female Sprague-Dawley rats and mounted for isometric tension recording. Maximal response of female aortas to VP (4,246 +/- 163 mg/mg ring dry wt) was more than twice (P less than 0.001) that of male aortas (1,877 +/- 215 mg/mg ring wt). Sensitivity of female aortas to VP was substantially higher (P less than 0.001) than that of male aortas (EC50: 10.9 +/- 0.7 vs. 19.0 +/- 1.6 nM, respectively). Maximal rate of tension development (dT/dtmax) during contraction with VP was nearly twofold higher (P less than 0.01) in female aortas (536 +/- 23 mg/min) than in male aortas (300 +/- 19 mg/min). Maximal response, sensitivity, and dT/dtmax of female aortas did not vary significantly during the estrous cycle. Maximal response of female aortas to phenylephrine (PE; 1,251 +/- 93 mg/mg ring wt) was half that (P less than 0.001) of male aortas (2,546 +/- 194 mg/mg ring wt); sensitivity to PE did not differ significantly (EC50: 0.33 +/- 0.02 vs. 0.38 +/- 0.06 microM, respectively).(ABSTRACT TRUNCATED AT 250 WORDS)
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajpheart.1991.260.2.H453" target="_blank" rel="noreferrer noopener">10.1152/ajpheart.1991.260.2.H453</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Sex Characteristics
*Vasoconstriction
1991
Animals
Aorta/*drug effects
Arginine Vasopressin/*pharmacology
Crofton J T
Dose-Response Relationship
Drug
Female
Male
Osmolar Concentration
Phenylephrine/pharmacology
Rats
Share L
Stallone J N
The American journal of physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajpheart.00099.2002" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajpheart.00099.2002</a>
Pages
H2062–2073
Issue
5
Volume
283
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Sexual dimorphism in prostanoid-potentiated vascular contraction: roles of endothelium and ovarian steroids.
Publisher
An entity responsible for making the resource available
American journal of physiology. Heart and circulatory physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002-11
Subject
The topic of the resource
*Sex Characteristics; Animals; Aorta/drug effects/physiology; Bridged Bicyclo Compounds; Cyclooxygenase Inhibitors/pharmacology; Endothelium; Enzyme Inhibitors/pharmacology; Estrogens/*physiology; Fatty Acids; Female; Heterocyclic; Hydrazines/pharmacology; Imidazoles/pharmacology; Indomethacin/pharmacology; Male; Ovariectomy; Phenylephrine/pharmacology; Progesterone/*physiology; Prostaglandins/*metabolism; Rats; Sprague-Dawley; Thromboxanes/metabolism; Unsaturated; Vascular/*metabolism; Vasoconstriction/drug effects/*physiology; Vasoconstrictor Agents/pharmacology; Vasopressins/pharmacology
Creator
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Fulton Clifford T; Stallone John N
Description
An account of the resource
The effects of constrictor prostanoid (CP) pathway inhibitors on vascular reactivity to vasopressin (VP) and phenylephrine (PE) were examined in thoracic aortas of male, female, and ovariectomized (OVX) female Sprague-Dawley rats. Maximal contractile response of control (Cont) aortas to VP was markedly higher in females (3,885 +/- 332 mg/mg ring wt) than in males (810 +/- 148 mg). Indomethacin (Indo; 10 microM) attenuated maximal response to VP in females (3,043 +/- 277 mg) but not in males. SQ-29,548 (SQ; 1 microM) attenuated maximal response to VP in females (3,042 +/- 290 mg) to a similar extent as Indo. Dazoxiben (Daz; 10 microM) alone had no effect, but Daz + SQ attenuated maximal contractile response to VP to a similar extent as SQ alone. Removal of the endothelium in female aortas attenuated contractile responses to VP in Cont aortas. OVX attenuated maximal contractile response to VP in Cont aortas (2,093 +/- 329 mg) and abolished the attenuating effects of Indo. Indo, SQ, and Daz exerted identical effects on contractile responses of male, female, and OVX female aortas to PE. These findings establish the following in the rat aorta: 1) CP, probably thromboxane and/or endoperoxide, is responsible for approximately
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajpheart.00099.2002" target="_blank" rel="noreferrer noopener">10.1152/ajpheart.00099.2002</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Sex Characteristics
2002
American journal of physiology. Heart and circulatory physiology
Animals
Aorta/drug effects/physiology
Bridged Bicyclo Compounds
Cyclooxygenase Inhibitors/pharmacology
Endothelium
Enzyme Inhibitors/pharmacology
Estrogens/*physiology
Fatty Acids
Female
Fulton Clifford T
Heterocyclic
Hydrazines/pharmacology
Imidazoles/pharmacology
Indomethacin/pharmacology
Male
Ovariectomy
Phenylephrine/pharmacology
Progesterone/*physiology
Prostaglandins/*metabolism
Rats
Sprague-Dawley
Stallone John N
Thromboxanes/metabolism
Unsaturated
Vascular/*metabolism
Vasoconstriction/drug effects/*physiology
Vasoconstrictor Agents/pharmacology
Vasopressins/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0014-2999(94)90654-8" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0014-2999(94)90654-8</a>
Pages
273–283
Issue
3
Volume
259
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Sex differences in nitric oxide-mediated attenuation of vascular reactivity to vasopressin are abolished by gonadectomy.
Publisher
An entity responsible for making the resource available
European journal of pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-07
Subject
The topic of the resource
*Orchiectomy; *Ovariectomy; Acetylcholine/pharmacology; Animals; Aorta; Arginine/analogs & derivatives/pharmacology; Female; In Vitro Techniques; Male; Muscle; Muscle Contraction/drug effects; Nitric Oxide/antagonists & inhibitors/*physiology; omega-N-Methylarginine; Phenylephrine/pharmacology; Potassium Chloride/pharmacology; Rats; Sex Characteristics; Smooth; Sprague-Dawley; Thoracic/drug effects/physiology; Vascular/drug effects/*physiology; Vasopressins/*pharmacology
Creator
An entity primarily responsible for making the resource
Stallone J N
Description
An account of the resource
In the rat thoracic aorta, contractile responses to vasopressin are two-fold higher in females than in males, primarily because nitric oxide-mediated attenuation of contraction is greater in males than in females. To determine the role of the gonadal steroids in this phenomenon, the effects of gonadectomy on nitric oxide and vascular reactivity to vasopressin were examined in thoracic aortae of age-matched intact and gonadectomized male and female rats. Maximal response to vasopressin was markedly higher in gonadectomized-male than in intact-male aortae (2729 +/- 421 vs. 1375 +/- 222 mg/mg ring weight; P \textless 0.01). Inhibition of nitric oxide synthase with NG-methyl-L-arginine (L-NMMA, 250 microM) enhanced maximal response of intact-male (2824 +/- 413 mg/mg ring weight; P \textless 0.01) but not gonadectomized-male aortae (3034 +/- 365 mg/mg ring weight; P \textgreater 0.05). Sensitivity of male aortae to vasopressin was unaffected by gonadectomy or
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0014-2999(94)90654-8" target="_blank" rel="noreferrer noopener">10.1016/0014-2999(94)90654-8</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Orchiectomy
*Ovariectomy
1994
Acetylcholine/pharmacology
Animals
Aorta
Arginine/analogs & derivatives/pharmacology
European journal of pharmacology
Female
In Vitro Techniques
Male
Muscle
Muscle Contraction/drug effects
Nitric Oxide/antagonists & inhibitors/*physiology
omega-N-Methylarginine
Phenylephrine/pharmacology
Potassium Chloride/pharmacology
Rats
Sex Characteristics
Smooth
Sprague-Dawley
Stallone J N
Thoracic/drug effects/physiology
Vascular/drug effects/*physiology
Vasopressins/*pharmacology