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Text
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Pages
1613–1618
Issue
10
Volume
5
Dublin Core
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Title
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Anthocyanin-rich black currant extract suppresses the growth of human hepatocellular carcinoma cells.
Publisher
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Natural product communications
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
2010-10
Subject
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Humans; Cell Proliferation/drug effects; Fruit/chemistry; *Phytotherapy; Plant Extracts/pharmacology/therapeutic use; Hep G2 Cells; Antioxidants/*therapeutic use; *Ribes/chemistry; Liver Neoplasms/*prevention & control; Carcinoma; Drug Evaluation; Preclinical; Antineoplastic Agents; Hepatocellular/*prevention & control; Phytogenic/analysis
Creator
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Bishayee Anupam; Haznagy-Radnai Erzsebet; Mbimba Thomas; Sipos Peter; Morazzoni Paolo; Darvesh Altaf S; Bhatia Deepak; Hohmann Judit
Description
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Dietary antioxidants, such as anthocyanins, are helpful in the prevention and control of various diseases by counteracting the imbalance of oxidative and antioxidative factors in the living systems. Black currant (Ribes nigrum L., Grossulariaceae) is known to contain high amounts of anthocyanins (250 mg/100 g fresh fruit). Black currant fruits have been used in Asian and European traditional medicine for the treatment of a variety of diseases. Black currant extract has recently been found to be the second most effective amongst nine different berry extracts studied for their free radical scavenging activity. Constituents present in black currant juice have been found to exert a number of health-promoting effects, including immunomodulatory, antimicrobial and antiinflammatory actions, inhibition of low-density lipoprotein, and reduction of cardiovascular diseases. Although antioxidant and antiinflammatory effects of black currant juice could be of value in preventing and treating oxidative stress- and inflammation-driven cancers, no experimental evidence is available to now. The objective of the present study was to evaluate the potential antiproliferative effects of black currant fruit skin extract against HepG2 human liver cancer cells. The aqueous extract yielded an anthocyanin-rich fraction with cyanidin-3-O-rutinoside as one of the major anthocyanins. This fraction exhibited a potent cytotoxic effect on HepG2 cells and this effect was more pronounced than that of delphinidin and cyanidin, two major aglycones of anthocyanins present in black currant. Our results indicate, for the first time, that black currant skin containing an anthocyanin-rich fraction inhibits the proliferation of liver cancer cells, possibly due to additive as well as synergistic effects. This product could be useful in the prevention and treatment of human hepatocellular carcinoma.
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Phytotherapy
*Ribes/chemistry
2010
Antineoplastic Agents
Antioxidants/*therapeutic use
Bhatia Deepak
Bishayee Anupam
Carcinoma
Cell Proliferation/drug effects
Darvesh Altaf S
Department of Pharmaceutical Sciences
Drug Evaluation
Fruit/chemistry
Haznagy-Radnai Erzsebet
Hep G2 Cells
Hepatocellular/*prevention & control
Hohmann Judit
Humans
Liver Neoplasms/*prevention & control
Mbimba Thomas
Morazzoni Paolo
Natural product communications
NEOMED College of Pharmacy
Phytogenic/analysis
Plant Extracts/pharmacology/therapeutic use
Preclinical
Sipos Peter