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Text
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URL Address
<a href="http://doi.org/10.1093/cid/cix675" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/cid/cix675</a>
Pages
2137–2143
Issue
12
Volume
65
Dublin Core
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Title
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Increasing Evidence of the Nephrotoxicity of Piperacillin/Tazobactam and Vancomycin Combination Therapy-What Is the Clinician to Do?
Publisher
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Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Date
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2017
2017-11
Subject
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Anti-Bacterial Agents/administration & dosage/*adverse effects/therapeutic use/*toxicity; Combination/*adverse effects; Combined Modality Therapy/*adverse effects; Drug Therapy; Humans; Kidney Diseases/*chemically induced; Kidney/*drug effects/pathology; nephrotoxicity; Penicillanic Acid/administration & dosage/adverse effects/analogs & derivatives/therapeutic use/toxicity; Piperacillin; Piperacillin/administration & dosage/adverse effects/therapeutic use/toxicity; piperacillin/tazobactam; Sepsis; Sepsis/drug therapy; Tazobactam Drug Combination; vancomycin; Vancomycin/administration & dosage/adverse effects/therapeutic use/toxicity
Creator
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Watkins Richard R; Deresinski Stan
Description
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Early administration of appropriate empiric antibiotics is essential for achieving the best possible outcomes in sepsis. Yet the choice of antibiotic therapy has become more challenging due to recent reports of nephrotoxicity with the combination of vancomycin and piperacillin/tazobactam, the "workhorse" regimen at many institutions. In this article we assess the evidence for nephrotoxicity and its possible mechanisms, provide recommendations for risk mitigation, address the advantages and disadvantages of alternative antibiotic choices, and suggest areas for future research.
Identifier
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<a href="http://doi.org/10.1093/cid/cix675" target="_blank" rel="noreferrer noopener">10.1093/cid/cix675</a>
Rights
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2017
Anti-Bacterial Agents/administration & dosage/*adverse effects/therapeutic use/*toxicity
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Combination/*adverse effects
Combined Modality Therapy/*adverse effects
Department of Internal Medicine
Deresinski Stan
Drug Therapy
Humans
Kidney Diseases/*chemically induced
Kidney/*drug effects/pathology
NEOMED College of Medicine
nephrotoxicity
Penicillanic Acid/administration & dosage/adverse effects/analogs & derivatives/therapeutic use/toxicity
Piperacillin
Piperacillin/administration & dosage/adverse effects/therapeutic use/toxicity
piperacillin/tazobactam
sepsis
Sepsis/drug therapy
Tazobactam Drug Combination
vancomycin
Vancomycin/administration & dosage/adverse effects/therapeutic use/toxicity
Watkins Richard R