1
40
7
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
1–6
Issue
1
Volume
28
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Tetrahydro-beta-carboline may produce its stimulus effects via 5HT1B receptors.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1987
1987-09
Subject
The topic of the resource
Male; Animals; Rats; Serotonin/*metabolism; Piperazines/pharmacology; Discrimination Learning/drug effects; Serotonin Antagonists/pharmacology; Carbolines/*pharmacology; Metergoline/pharmacology; Inbred Strains; Receptors
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
To further clarify the role of 5-hydroxytryptamine (5HT) in the behavioral effects of tetrahydro-beta-carboline, male rats were trained to discriminate either 20 mg/kg THBC from its vehicle (n = 10) or 2.0 mg/kg fenfluramine from saline (n = 5). THBC was observed to produce fenfluramine-like effects in the fenfluramine-trained rats while fenfluramine produced THBC-like effects in the
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1987
Animals
Carbolines/*pharmacology
Discrimination Learning/drug effects
Inbred Strains
Male
Metergoline/pharmacology
Pharmacology, biochemistry, and behavior
Piperazines/pharmacology
Rats
Receptors
Schechter M D
Serotonin Antagonists/pharmacology
Serotonin/*metabolism
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0306-3623(91)90441-8" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0306-3623(91)90441-8</a>
Pages
247–251
Issue
2
Volume
22
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Analgesic effects of serotonin and receptor-selective serotonin agonists in the rat spinal cord.
Publisher
An entity responsible for making the resource available
General pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1905-06
Subject
The topic of the resource
Male; Animals; Rats; Pain Measurement; Piperazines/pharmacology; Spinal Cord/*physiology; Tetrahydronaphthalenes/pharmacology; Injections; Amphetamines/pharmacology; Biguanides/pharmacology; Serotonin Antagonists/pharmacology; Reaction Time/drug effects; *Analgesics; 8-Hydroxy-2-(di-n-propylamino)tetralin; Serotonin/*pharmacology; Inbred Strains; Receptors; Spinal; Serotonin/*drug effects/physiology
Creator
An entity primarily responsible for making the resource
Crisp T; Stafinsky J L; Spanos L J; Uram M; Perni V C; Donepudi H B
Description
An account of the resource
1. Serotonin (5-HT) and selective 5-HT receptor agonists were administered intrathecally (i.t.) in rats, and the antinociceptive efficacy of these agents was assessed on the tail-flick and hot plate tests. 2. The 5-HT receptor agonists examined in this study included the 5-HT1A agonist
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0306-3623(91)90441-8" target="_blank" rel="noreferrer noopener">10.1016/0306-3623(91)90441-8</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Analgesics
1991
8-Hydroxy-2-(di-n-propylamino)tetralin
Amphetamines/pharmacology
Animals
Biguanides/pharmacology
Crisp T
Donepudi H B
General pharmacology
Inbred Strains
Injections
Male
Pain Measurement
Perni V C
Piperazines/pharmacology
Rats
Reaction Time/drug effects
Receptors
Serotonin Antagonists/pharmacology
Serotonin/*drug effects/physiology
Serotonin/*pharmacology
Spanos L J
Spinal
Spinal Cord/*physiology
Stafinsky J L
Tetrahydronaphthalenes/pharmacology
Uram M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1523/JNEUROSCI.3572-07.2008" target="_blank" rel="noreferrer noopener">http://doi.org/10.1523/JNEUROSCI.3572-07.2008</a>
Pages
80–90
Issue
1
Volume
28
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Glycinergic "inhibition" mediates selective excitatory responses to combinations of sounds.
Publisher
An entity responsible for making the resource available
The Journal of neuroscience : the official journal of the Society for Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
2008-01
Subject
The topic of the resource
Animals; Acoustic Stimulation/methods; Neural Inhibition/drug effects/*physiology; *Sound; Excitatory Amino Acid Antagonists/pharmacology; Action Potentials/drug effects/physiology; Auditory Pathways/*physiology; Glycine Agents/pharmacology; Glycine/*physiology; Chiroptera/physiology; Drug Interactions; GABA Agents/pharmacology; Inferior Colliculi/cytology/drug effects/*physiology; Iontophoresis/methods; Neurons/drug effects/physiology/radiation effects; Piperazines/pharmacology; Dose-Response Relationship; Receptors; Radiation; GABA/physiology; N-Methyl-D-Aspartate/antagonists & inhibitors/physiology
Creator
An entity primarily responsible for making the resource
Sanchez Jason Tait; Gans Donald; Wenstrup Jeffrey J
Description
An account of the resource
In the mustached bat's inferior colliculus (IC), combination-sensitive neurons display time-sensitive facilitatory interactions between inputs tuned to distinct spectral elements in sonar or social vocalizations. Here we compare roles of ionotropic receptors to glutamate (iGluRs), glycine (GlyRs), and GABA (GABA(A)Rs) in facilitatory combination-sensitive interactions. Facilitatory responses to 36 single IC neurons were recorded before, during, and after local application of antagonists to these receptors. The NMDA receptor antagonist CPP [(+/-)-3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid], alone (n = 14) or combined with AMPA receptor antagonist NBQX (n = 22), significantly reduced or eliminated responses to best frequency (BF) sounds across a broad range of sound levels, but did not eliminate combination-sensitive facilitation. In a subset of neurons, GABA(A)R blockers bicuculline or gabazine were applied in addition to iGluR blockers. GABA(A)R blockers did not "uncover" residual iGluR-mediated excitation, and only rarely eliminated facilitation. In nearly all neurons for which the GlyR antagonist strychnine was applied in addition to iGluR blockade (22 of 23 neurons, with or without GABA(A)R blockade), facilitatory interactions were eliminated. Thus, neither glutamate nor GABA neurotransmission are required for facilitatory combination-sensitive interactions in IC. Instead, facilitation may depend entirely on glycinergic inputs that are presumed to be inhibitory. We propose that glycinergic inputs tuned to two distinct spectral elements in vocal signals each activate postinhibitory rebound excitation. When rebound excitations from two spectral elements coincide, the neuron discharges. Excitation from glutamatergic inputs, tuned to the BF of the neuron, is superimposed onto this facilitatory interaction, presumably mediating responses to a broader range of acoustic signals.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1523/JNEUROSCI.3572-07.2008" target="_blank" rel="noreferrer noopener">10.1523/JNEUROSCI.3572-07.2008</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Sound
2008
Acoustic Stimulation/methods
Action Potentials/drug effects/physiology
Animals
Auditory Pathways/*physiology
Chiroptera/physiology
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Dose-Response Relationship
Drug Interactions
Excitatory Amino Acid Antagonists/pharmacology
GABA Agents/pharmacology
GABA/physiology
Gans Donald
Glycine Agents/pharmacology
Glycine/*physiology
Inferior Colliculi/cytology/drug effects/*physiology
Iontophoresis/methods
N-Methyl-D-Aspartate/antagonists & inhibitors/physiology
NEOMED College of Medicine
Neural Inhibition/drug effects/*physiology
Neurons/drug effects/physiology/radiation effects
Piperazines/pharmacology
Radiation
Receptors
Sanchez Jason Tait
The Journal of neuroscience : the official journal of the Society for Neuroscience
Wenstrup Jeffrey J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1523/JNEUROSCI.2894-06.2007" target="_blank" rel="noreferrer noopener">http://doi.org/10.1523/JNEUROSCI.2894-06.2007</a>
Pages
1954–1963
Issue
8
Volume
27
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Contribution of NMDA and AMPA receptors to temporal patterning of auditory responses in the inferior colliculus.
Publisher
An entity responsible for making the resource available
The Journal of neuroscience : the official journal of the Society for Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
2007-02
Subject
The topic of the resource
Animals; Chiroptera/*physiology; Neurons/physiology; Action Potentials/drug effects; Excitatory Amino Acid Antagonists/pharmacology; Quinoxalines/pharmacology; Inferior Colliculi/cytology/drug effects/*physiology; Piperazines/pharmacology; *Acoustic Stimulation; Reaction Time/drug effects/*physiology; N-Methyl-D-Aspartate/*physiology; Receptors; AMPA/*physiology
Creator
An entity primarily responsible for making the resource
Sanchez Jason Tait; Gans Donald; Wenstrup Jeffrey J
Description
An account of the resource
Although NMDA receptors (NMDARs) are associated with synaptic plasticity, they form an essential part of responses to sensory stimuli. We compared contributions of glutamatergic NMDARs and AMPA receptors (AMPARs) to auditory responses in the inferior colliculus (IC) of awake, adult mustached bats. We examined the magnitude and temporal pattern of responses to tonal signals in single units before, during, and after local micro-iontophoretic application of selective antagonists to AMPARs [NBQX (1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide)] and NMDARs [CPP ((+/-)3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid)]. Combined blockade of AMPARs and NMDARs eliminated excitatory responses in nearly all neurons, whereas separate blockade of each receptor was quantitatively similar, causing substantial (\textgreater 50%) spike reductions in approximately 75% of units. The major result was that effects of receptor blockade were most closely related to the first-spike latency of a unit. Thus, AMPAR blockade substantially reduced spikes in all short-latency units (\textless 12 ms) but never in long-latency units (\textgreater or = 12 ms). NMDAR blockade had variable effects on short-latency units but reduced spikes substantially for all long-latency units. There were no distinct contributions of AMPARs and NMDARs to early and late elements of responses. Thus, AMPAR blockade reduced early (onset) spikes somewhat more effectively than NMDAR blockade in short-latency units, but NMDAR blockade reduced onset spikes more effectively in long-latency units. AMPAR and NMDAR blockade were equally effective in reducing later elements of sustained responses in short-latency units, whereas NMDAR blockade was much more effective in long-latency units. These results indicate that NMDARs play multiple roles for signal processing in adult IC neurons.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1523/JNEUROSCI.2894-06.2007" target="_blank" rel="noreferrer noopener">10.1523/JNEUROSCI.2894-06.2007</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Acoustic Stimulation
2007
Action Potentials/drug effects
AMPA/*physiology
Animals
Chiroptera/*physiology
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Excitatory Amino Acid Antagonists/pharmacology
Gans Donald
Inferior Colliculi/cytology/drug effects/*physiology
N-Methyl-D-Aspartate/*physiology
NEOMED College of Medicine
Neurons/physiology
Piperazines/pharmacology
Quinoxalines/pharmacology
Reaction Time/drug effects/*physiology
Receptors
Sanchez Jason Tait
The Journal of neuroscience : the official journal of the Society for Neuroscience
Wenstrup Jeffrey J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0024-3205(96)00668-6" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0024-3205(96)00668-6</a>
Pages
PL83–90
Issue
6
Volume
60
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Serotonergic mediation of fenfluramine discriminative stimuli in fawn-hooded rats.
Publisher
An entity responsible for making the resource available
Life sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1905-06
Subject
The topic of the resource
*Discrimination Learning; 4-methylenedioxyamphetamine/pharmacology; Animals; Dose-Response Relationship; Drug; Fenfluramine/administration & dosage/*pharmacology; Fluoxetine/pharmacology; Ibogaine/pharmacology; Male; Methoxydimethyltryptamines/pharmacology; N-Methyl-3; Piperazines/pharmacology; Quipazine/pharmacology; Rats; Serotonin Agents/administration & dosage/*pharmacology; Serotonin Receptor Agonists/pharmacology; Serotonin/*metabolism; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
Fenfluramine, a drug that induces increased synaptic serotonin, was used to train Fawn-Hooded rats in a drug discrimination paradigm. This strain of rats is thought to possess a genetic serotonin storage abnormality. The intent of the study was to see if the Fawn-Hooded rat was similar or dissimilar to the more frequently used strain of Sprague-Dawley rat in its ability to learn to discriminate 2.0 mg/kg fenfluramine administered intraperitoneally. In addition, drugs presumed to work upon central serotonergic neurons were given to the fenfluramine-trained Fawn-Hooded rats to investigate if the cueing properties of the training drug generalized to other agents. Results indicate that the Fawn-Hooded rats learn to discriminate fenfluramine from its vehicle at the same rate, and with a similar sensitivity to lower doses, as do the Sprague-Dawley rats. Furthermore, fenfluramine was shown to completely generalize to MDMA (over 90%); TFMPP, m-CPP, quipazine and fluoxetine produced intermediate results (over 70%) and 5-MeODMT and ibogaine were vehicle-like (less than 70%). As these results coincide with those previously found in Sprague-Dawley rats, the conclusion is that the functional capacity to discriminate fenfluramine appears to be like that of other rat lines, and serotonergically-mediated, in the Fawn-Hooded rat. Suggestions to explain these results are offered and discussed.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0024-3205(96)00668-6" target="_blank" rel="noreferrer noopener">10.1016/s0024-3205(96)00668-6</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Discrimination Learning
1997
4-methylenedioxyamphetamine/pharmacology
Animals
Dose-Response Relationship
Drug
Fenfluramine/administration & dosage/*pharmacology
Fluoxetine/pharmacology
Ibogaine/pharmacology
Life sciences
Male
Methoxydimethyltryptamines/pharmacology
N-Methyl-3
Piperazines/pharmacology
Quipazine/pharmacology
Rats
Schechter M D
Serotonin Agents/administration & dosage/*pharmacology
Serotonin Receptor Agonists/pharmacology
Serotonin/*metabolism
Sprague-Dawley
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0741-8329(95)02004-7" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0741-8329(95)02004-7</a>
Pages
569–572
Issue
6
Volume
12
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
MDMA (Ecstasy) substitutes for the ethanol discriminative cue in HAD but not LAD rats.
Publisher
An entity responsible for making the resource available
Alcohol (Fayetteville, N.Y.)
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-12
Subject
The topic of the resource
4-methylenedioxyamphetamine/*pharmacology; Alcohol Drinking/*genetics/psychology; Animals; Central Nervous System Depressants/*pharmacology; Cues; Discrimination (Psychology)/*drug effects; Discrimination Learning/drug effects; Dose-Response Relationship; Drug; Ethanol/*pharmacology; Generalization; Male; N-Methyl-3; Piperazines/pharmacology; Rats; Serotonin Agents/*pharmacology; Serotonin Receptor Agonists/pharmacology; Stimulus
Creator
An entity primarily responsible for making the resource
Meehan S M; Gordon T L; Schechter M D
Description
An account of the resource
Selectively bred high- and low-alcohol-drinking (HAD/LAD) rats were trained to discriminate the interoceptive stimuli produced by IP-administered 600 mg/kg ethanol (10% w/v in a two-lever, food-motivated operant task. Once criterion discrimination was attained, animals were tested with 3.0, 1.5, 1.0, and 0.5 mg/kg MDMA. Although no differences in alcohol discrimination were observed between the HAD and LAD animals, the HAD line was significantly more sensitive than the LAD line to the effects of MDMA. These results provide additional information to the growing body of evidence suggesting serotonergic mediation of some of the behavioral effects of ethanol.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0741-8329(95)02004-7" target="_blank" rel="noreferrer noopener">10.1016/0741-8329(95)02004-7</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1995
4-methylenedioxyamphetamine/*pharmacology
Alcohol (Fayetteville, N.Y.)
Alcohol Drinking/*genetics/psychology
Animals
Central Nervous System Depressants/*pharmacology
Cues
Discrimination (Psychology)/*drug effects
Discrimination Learning/drug effects
Dose-Response Relationship
Drug
Ethanol/*pharmacology
Generalization
Gordon T L
Male
Meehan S M
N-Methyl-3
Piperazines/pharmacology
Rats
Schechter M D
Serotonin Agents/*pharmacology
Serotonin Receptor Agonists/pharmacology
Stimulus
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0361-9230(95)02041-1" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0361-9230(95)02041-1</a>
Pages
39–42
Issue
1
Volume
39
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The effects of anticonvulsant drugs on long-term potentiation (LTP) in the rat hippocampus.
Publisher
An entity responsible for making the resource available
Brain research bulletin
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996
Subject
The topic of the resource
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anticonvulsants/*pharmacology; Calcium Channel Blockers/pharmacology; Enzyme Inhibitors/pharmacology; Excitatory Amino Acid Agonists/pharmacology; Female; Hippocampus/*drug effects; Isoquinolines/pharmacology; Long-Term Potentiation/*drug effects; Male; Membrane Potentials/drug effects; N-Methylaspartate/pharmacology; Piperazines/pharmacology; Protein Kinase C/antagonists & inhibitors; Rats; Synapses/drug effects
Creator
An entity primarily responsible for making the resource
Lee G Y; Brown L M; Teyler T J
Description
An account of the resource
In hippocampal CA1 area, there are at least two forms of long-term potentiation (LTP): one is N-methyl-D-aspartate (NMDA) receptor-dependent LTP (NMDA LTP), which is induced with a 25 Hz tetanus and blocked by 50 microM
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0361-9230(95)02041-1" target="_blank" rel="noreferrer noopener">10.1016/0361-9230(95)02041-1</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
1996
Animals
Anticonvulsants/*pharmacology
Brain research bulletin
Brown L M
Calcium Channel Blockers/pharmacology
Enzyme Inhibitors/pharmacology
Excitatory Amino Acid Agonists/pharmacology
Female
Hippocampus/*drug effects
Isoquinolines/pharmacology
Lee G Y
Long-Term Potentiation/*drug effects
Male
Membrane Potentials/drug effects
N-Methylaspartate/pharmacology
Piperazines/pharmacology
Protein Kinase C/antagonists & inhibitors
Rats
Synapses/drug effects
Teyler T J