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                <text>Quantification of Liver Fat Content with Ultrasound: A WFUMB Position Paper.</text>
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                <text>Ferraioli G; Berzigotti A; Barr RG; Choi BI; Cui XW; Dong Y; Gilja OH; Lee JY; Lee DH; Moriyasu F; Piscaglia F; Sugimoto K; Wong GL; Wong VW; Dietrich CF</text>
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                <text>New ultrasound methods that can be used to quantitatively assess liver fat content have recently been developed. These quantitative ultrasound (QUS) methods are based on the analysis of radiofrequency echoes detected by the transducer, allowing calculation of parameters for quantifying the fat in the liver. In this position paper, after a section dedicated to the importance of quantifying liver steatosis in patients with non-alcoholic fatty liver disease and another section dedicated to the assessment of liver fat with magnetic resonance, the current clinical studies performed using QUS are summarized. These new methods include spectral-based techniques and techniques based on envelope statistics. The spectral-based techniques that have been used in clinical studies are those estimating the attenuation coefficient and those estimating the backscatter coefficient. Clinical studies that have used tools based on the envelope statistics of the backscattered ultrasound are those performed by using the acoustic structure quantification or other parameters derived from it, such as the normalized local variance, and that performed by estimating the speed of sound. Experts' opinions are reported. (Copyright © 2021 World Federation for Ultrasound in Medicine &amp; Biology. Published by Elsevier Inc. All rights reserved.)</text>
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                <text>The present, updated document describes the fourth iteration of recommendations for  the hepatic use of contrast-enhanced ultrasound, first initiated in 2004 by the  European Federation of Societies for Ultrasound in Medicine and Biology. The  previous updated editions of the guidelines reflected changes in the available  contrast agents and updated the guidelines not only for hepatic but also for  non-hepatic applications. The 2012 guideline requires updating as, previously, the  differences in the contrast agents were not precisely described and the differences  in contrast phases as well as handling were not clearly indicated. In addition, more  evidence has been published for all contrast agents. The update also reflects the  most recent developments in contrast agents, including U.S. Food and Drug  Administration approval and the extensive Asian experience, to produce a truly  international perspective. These guidelines and recommendations provide general  advice on the use of ultrasound contrast agents (UCAs) and are intended to create  standard protocols for the use and administration of UCAs in liver applications on  an international basis to improve the management of patients.</text>
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