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<a href="http://doi.org/10.1113/jphysiol.2012.230136" target="_blank" rel="noreferrer noopener">http://doi.org/10.1113/jphysiol.2012.230136</a>
Pages
3787–3805
Issue
16
Volume
590
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Title
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Two GABAA responses with distinct kinetics in a sound localization circuit.
Publisher
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The Journal of physiology
Date
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2012
2012-08
Subject
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*Sound; Animals; Chick Embryo; Chickens; Female; GABA-A/*physiology; gamma-Aminobutyric Acid/metabolism; Male; Neurons/*metabolism; Pitch Discrimination; Receptors; Sound Localization/*physiology; Synapses/physiology
Creator
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Tang Zheng-Quan; Lu Yong
Description
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The temporal characteristics and functional diversity of GABAergic inhibition are determined by the spatiotemporal neurotransmitter profile, intrinsic properties of GABAA receptors, and other factors. Here, we report two distinct GABAA responses and the underlying mechanisms in neurons of the chicken nucleus laminaris (NL), the first encoder of interaural time difference for sound localization in birds. The time course of the postsynaptic GABAA currents in NL neurons, recorded with whole-cell voltage clamp, differed between different characteristic frequency (CF) regions. Compared to low-CF (LF) neurons, middle/high-CF (MF/HF) neurons had significantly slower IPSCs, with a 2.6-fold difference in the decay time constants of spontaneous IPSCs and a 5.3-fold difference in the decay of IPSCs elicited by single-pulse stimulus. Such differences were especially dramatic when IPSCs were elicited by train stimulations at physiologically relevant frequencies, and at high stimulus intensities. To account for these distinct GABAA responses, we showed that MF/HF neurons exhibited more prominent asynchronous release of GABA. Supporting this observation, replacement of extracellular Ca2+ with Sr2+ increased the decay of IPSCs in LF neurons, and EGTA-AM reduced the decay of IPSCs in MF/HF neurons. Furthermore, pharmacological evidence suggests that GABA spillover plays a greater role in prolonging the IPSCs of MF/HF neurons. Consequently, under whole-cell current clamp, synaptically released GABA produced short- and long-lasting suppression of the neuronal excitability of LF and MF/HF neurons, respectively. Taken together, these results suggest that the GABAergic inputs to NL neurons may exert a dynamic modulation of interaural time difference (ITD) coding in a CF-dependent manner.
Identifier
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<a href="http://doi.org/10.1113/jphysiol.2012.230136" target="_blank" rel="noreferrer noopener">10.1113/jphysiol.2012.230136</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Sound
2012
Animals
Chick Embryo
Chickens
Department of Anatomy & Neurobiology
Female
GABA-A/*physiology
gamma-Aminobutyric Acid/metabolism
Lu Yong
Male
NEOMED College of Medicine
Neurons/*metabolism
Pitch Discrimination
Receptors
Sound Localization/*physiology
Synapses/physiology
Tang Zheng-Quan
The Journal of physiology