1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
267–273
Issue
2
Volume
24
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Methamphetamine-gonadal steroid hormonal interactions: effects upon acute toxicity and striatal dopamine concentrations.
Publisher
An entity responsible for making the resource available
Neurotoxicology and teratology
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002-04
Subject
The topic of the resource
Female; Male; Animals; Mice; Sex Factors; Body Weight/drug effects; Organ Size/drug effects; Dopamine/*metabolism; Body Temperature/drug effects; Methamphetamine/*toxicity; Corpus Striatum/*metabolism; Orchiectomy; Ovariectomy; Drug Interactions; Estrogens/pharmacology/*physiology; Heart Rate/drug effects; Heart Ventricles/metabolism; Norepinephrine/metabolism; Pituitary Gland/anatomy & histology; Testosterone/pharmacology/*physiology; Inbred Strains
Creator
An entity primarily responsible for making the resource
Dluzen Dean E; Anderson Linda I; Pilati Charles F
Description
An account of the resource
Methamphetamine (MA)-related deaths and nigrostriatal dopaminergic (NSDA) neurotoxicity are greater in males. The exact basis for this gender difference is not known, but data, which show that estrogen (E) can function as a protectant of both the cardiovascular and NSDA systems, suggest an important role for gonadal steroids in modulating toxicity to this psychostimulant. In the present report, we examined the effects of treatment with the gonadal steroid hormones E and testosterone (T) upon MA-induced toxicity within intact and castrated female and male CD-1 mice. Treatment of intact males with E produced a severe acute toxicity to MA, with only 41% (7/17) males surviving at 24-h post-MA. This incidence of mortality was significantly different from that of nonhormonally treated mice receiving an identical regimen of MA [94% survival (16/17)]. None of the other treatment groups showed mortality rates, which differed significantly from the nonhormonally treated mice. Striatal dopamine (DA) concentrations of E-treated female mice (intact or castrated) were significantly greater than that of the nonhormonally treated mice, which failed to differ statistically among each other. In an attempt to understand some of the bases for the mortality rates in
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2002
Anderson Linda I
Animals
Body Temperature/drug effects
Body Weight/drug effects
Corpus Striatum/*metabolism
Dluzen Dean E
Dopamine/*metabolism
Drug Interactions
Estrogens/pharmacology/*physiology
Female
Heart Rate/drug effects
Heart Ventricles/metabolism
Inbred Strains
Male
Methamphetamine/*toxicity
Mice
Neurotoxicology and teratology
Norepinephrine/metabolism
Orchiectomy
Organ Size/drug effects
Ovariectomy
Pilati Charles F
Pituitary Gland/anatomy & histology
Sex Factors
Testosterone/pharmacology/*physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1046/j.1365-2826.2001.00675.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1046/j.1365-2826.2001.00675.x</a>
Pages
618–624
Issue
7
Volume
13
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Tamoxifen diminishes methamphetamine-induced striatal dopamine depletion in intact female and male mice.
Publisher
An entity responsible for making the resource available
Journal of neuroendocrinology
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
2001-07
Subject
The topic of the resource
Animals; Catecholamines/metabolism; Corpus Striatum/drug effects/*metabolism; Dopamine Uptake Inhibitors/*pharmacology; Dopamine/*metabolism; Estrogen Antagonists/*pharmacology; Female; Humans; Hypothalamus/metabolism; Inbred Strains; Male; Methamphetamine/*pharmacology; Mice; Neurotoxins/*pharmacology; Olfactory Bulb/metabolism; Organ Size/drug effects; Pituitary Gland/anatomy & histology; Tamoxifen/*pharmacology
Creator
An entity primarily responsible for making the resource
Dluzen D E; McDermott J L; Anderson L I
Description
An account of the resource
It has been demonstrated that the nigrostriatal dopaminergic system of male mice is more sensitive to the neurotoxic effects of methamphetamine (MA). The basis for this difference can be related to oestrogen, which has the capacity to function as a neuroprotectant against neurotoxins that target the nigrostriatal dopaminergic system. We examined the effects of the anti-oestrogen, tamoxifen (TMX), upon MA-induced neurotoxicity of the nigrostriatal dopaminergic system in intact female and male CD-1 mice. Striatal dopamine concentrations of TMX-treated female and male mice receiving MA were significantly greater than mice receiving MA alone. In female, but not male, mice, oestrogen treatment also resulted in greater striatal dopamine concentrations compared to mice receiving MA alone. Interestingly, male mice treated with oestrogen were particularly sensitive to the acute toxic effects of MA and displayed no evidence of nigrostriatal neuroprotection. The dihydroxyphenylacetic acid/dopamine ratios following MA for female and male mice treated with TMX or females treated with oestrogen were significantly reduced compared to MA-treated mice and oestrogen + MA-treated male mice. No differences among the treatment groups were obtained for dopamine in the hypothalamus or olfactory bulb. These data demonstrate that TMX treatment of intact female and male mice diminishes striatal dopamine depletions to the nigrostriatal dopaminergic neurotoxin, MA. Oestrogen also displayed this capacity when administered to female, but accentuated acute toxicity in male mice. These effects are relatively specific for the nigrostriatal dopaminergic system. Such data suggest that TMX can function as a nigrostriatal dopaminergic neuroprotectant against MA-induced neurotoxicity in intact female and male mice.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1046/j.1365-2826.2001.00675.x" target="_blank" rel="noreferrer noopener">10.1046/j.1365-2826.2001.00675.x</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2001
Anderson L I
Animals
Catecholamines/metabolism
Corpus Striatum/drug effects/*metabolism
Dluzen D E
Dopamine Uptake Inhibitors/*pharmacology
Dopamine/*metabolism
Estrogen Antagonists/*pharmacology
Female
Humans
Hypothalamus/metabolism
Inbred Strains
Journal of neuroendocrinology
Male
McDermott J L
Methamphetamine/*pharmacology
Mice
Neurotoxins/*pharmacology
Olfactory Bulb/metabolism
Organ Size/drug effects
Pituitary Gland/anatomy & histology
Tamoxifen/*pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0006-8993(93)90910-f" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0006-8993(93)90910-f</a>
Pages
281–284
Issue
2
Volume
613
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Ablation of the hypothalamic arcuate-median eminence region reduces the concentration of vasoactive intestinal peptide in the anterior pituitary gland of male rats.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-06
Subject
The topic of the resource
Adrenal Glands/anatomy & histology; Animals; Anterior/*physiology; Arcuate Nucleus of Hypothalamus/*physiology; Drinking Behavior; Hypothalamo-Hypophyseal System/*physiology; Male; Median Eminence/*physiology; Organ Size; Pituitary Gland; Pituitary Gland/anatomy & histology; Prolactin/blood/metabolism; Rats; Sprague-Dawley; Testis/anatomy & histology; Time Factors; Vasoactive Intestinal Peptide/*metabolism
Creator
An entity primarily responsible for making the resource
Carrillo A J; Dluzen D E
Description
An account of the resource
This study was designed to determine the influence of the hypothalamus on the content of vasoactive intestinal peptide (VIP) in the anterior pituitary. Disruption of the hypothalamic-pituitary connection was performed by ablating the arcuate-median eminence (ARC-ME) region in adult male rats. Fifteen days later, there was a significant reduction in pituitary mass, adrenal and testicular weight and an increase in water consumption and serum prolactin levels indicating the elimination of hypothalamic influence on the pituitary gland in the ARC-ME group when compared to controls. Anterior pituitary VIP content was also significantly reduced in the lesion group. These data suggest that the hypothalamus is involved in the regulation of pituitary VIP.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0006-8993(93)90910-f" target="_blank" rel="noreferrer noopener">10.1016/0006-8993(93)90910-f</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1993
Adrenal Glands/anatomy & histology
Animals
Anterior/*physiology
Arcuate Nucleus of Hypothalamus/*physiology
Brain research
Carrillo A J
Dluzen D E
Drinking Behavior
Hypothalamo-Hypophyseal System/*physiology
Male
Median Eminence/*physiology
Organ Size
Pituitary Gland
Pituitary Gland/anatomy & histology
Prolactin/blood/metabolism
Rats
Sprague-Dawley
Testis/anatomy & histology
Time Factors
Vasoactive Intestinal Peptide/*metabolism