1
40
44
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0246954" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0246954</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
e0246954
Issue
2
Volume
16
ISSN
1932-6203
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Update Year & Number
March 2021 List
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Anatomy & Neurobiology
NEOMED Postdoc Publications
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Does birth weight affect neonatal body weight, growth, and physiology in an animal model?
Publisher
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PLOS One
Date
A point or period of time associated with an event in the lifecycle of the resource
2021
1905-07
Subject
The topic of the resource
PREMATURE infants; BIRTH weight; BODY weight; DEGLUTITION; PHYSIOLOGY; UMBILICAL cord clamping; WEIGHT gain; WEIGHT in infancy
Creator
An entity primarily responsible for making the resource
Adjerid K; Mayerl CJ; Gould FDH; Edmonds CE; Stricklen BM; Bond LE; German RZ
Description
An account of the resource
Infant birth weight affects neuromotor and biomechanical swallowing performance in infant pig models. Preterm infants are generally born low birth weight and suffer from delayed development and neuromotor deficits. These deficits include critical life skills such as swallowing and breathing. It is unclear whether these neuromotor and biomechanical deficits are a result of low birth weight or preterm birth. In this study we ask: are preterm infants simply low birth weight infants or do preterm infants differ from term infants in weight gain and swallowing behaviors independent of birth weight? We use a validated infant pig model to show that preterm and term infants gain weight differently and that birth weight is not a strong predictor of functional deficits in preterm infant swallowing. We found that preterm infants gained weight at a faster rate than term infants and with nearly three times the variation. Additionally, we found that the number of sucks per swallow, swallow duration, and the delay of the swallows relative to the suck cycles were not impacted by birth weight. These results suggest that any correlation of developmental or swallowing deficits with reduced birth weight are likely linked to underlying physiological immaturity of the preterm infant.
Identifier
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<a href="http://doi.org/10.1371/journal.pone.0246954" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0246954</a>
Format
The file format, physical medium, or dimensions of the resource
journalArticle
2021
Adjerid K
BIRTH weight
Body Weight
Bond LE
Deglutition
Department of Anatomy & Neurobiology
Edmonds CE
German RZ
Gould FDH
journalArticle
March 2021 List
Mayerl CJ
NEOMED College of Medicine
NEOMED Postdoc Publications
Physiology
PloS one
PREMATURE infants
Stricklen BM
UMBILICAL cord clamping
Weight Gain
WEIGHT in infancy
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0243113" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0243113</a>
Pages
e0243113
Issue
12
Volume
15
ISSN
1932-6203 1932-6203
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Update Year & Number
December 2020 List
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Pathology
Department of Family & Community Medicine
NEOMED Student Publications
Affiliated Hospital
Mercy Health St Elizabeth Youngstown Hospital
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A method for evaluating breast cancer screening strategies using screen-preventable loss of life.
Publisher
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Plos One
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
1905-07
Creator
An entity primarily responsible for making the resource
Carter KJ; Castro F; Morcos RN
Description
An account of the resource
The objective of this study is to describe how screen-preventable loss of life (screen-PLL) can be used to analyze the distribution of life savings with mammographic screening. The determination of screen-PLL with mammography is possible using a natural history model of breast cancer that simulates clinical and pathologic events of this disease. This investigation uses a Monte Carlo Markov model with data from the Surveillance, Epidemiology, and End Results Program; American Cancer Society; and National Vital Statistics System. Populations of one million women per screening strategy are simulated over a lifetime with mammographic screening based on current guidelines of the American Cancer Society (ACS), United States Preventive Services Task Force (USPSTF), triennial screening from age 50-70, and no screening. Screen-PLL curves are generated and show guideline performance over a lifetime. The screen-PLL curve with no screening is determined by tumor discovery through clinical awareness and has the highest values of screen-PLL. The ACS and USPSTF strategies demonstrate screen-PLL curves favoring the elderly. The curve for triennial screening is more uniform than the ACS or USPSTF curves but could be improved by adding screen(s) at either end of the 50-70 age range. This study introduces the use of screen-PLL as a tool to improve the understanding of screening guidelines and allowing a more balanced allocation of life savings across an aging population. The method presented shows how screen-PLL can be used to analyze and potentially improve breast cancer screening guidelines.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0243113" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0243113</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
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The file format, physical medium, or dimensions of the resource
journalArticle
2020
Carter KJ
Castro F
December 2020 List
Department of Family & Community Medicine
Department of Pathology
journalArticle
Mercy Health St Elizabeth Youngstown Hospital
Morcos RN
NEOMED College of Medicine
NEOMED Student Publications
PloS one
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0041923" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0041923</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
9-9
Issue
7
Volume
7
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Mycobacterium Tuberculosis Complex Lipid Virulence Factors Preserved In The 17,000-year-old Skeleton Of An Extinct Bison, Bison Antiquus
Publisher
An entity responsible for making the resource available
Plos One
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-07
Subject
The topic of the resource
acquired genomic islands; dna; evolution; homo-erectus; Science & Technology - Other Topics; trehalose
Creator
An entity primarily responsible for making the resource
Lee O Y C; Wu H H T; Donoghue H D; Spigelman M; Greenblatt C L; Bull I D; Rothschild B M; Martin L D; Minnikin D E; Besra G S
Description
An account of the resource
Tracing the evolution of ancient diseases depends on the availability and accessibility of suitable biomarkers in archaeological specimens. DNA is potentially information-rich but it depends on a favourable environment for preservation. In the case of the major mycobacterial pathogens, Mycobacterium tuberculosis and Mycobacterium leprae, robust lipid biomarkers are established as alternatives or complements to DNA analyses. A DNA report, a decade ago, suggested that a 17,000-year-old skeleton of extinct Bison antiquus, from Natural Trap Cave, Wyoming, was the oldest known case of tuberculosis. In the current study, key mycobacterial lipid virulence factor biomarkers were detected in the same two samples from this bison. Fluorescence high-performance liquid chromatography (HPLC) indicated the presence of mycolic acids of the mycobacterial type, but they were degraded and could not be precisely correlated with tuberculosis. However, pristine profiles of C-29, C-30 and C-32 mycocerosates and C-27 mycolipenates, typical of the Mycobacterium tuberculosis complex, were recorded by negative ion chemical ionization gas chromatography mass spectrometry of pentafluorobenzyl ester derivatives. These findings were supported by the detection of C-34 and C-36 phthiocerols, which are usually esterified to the mycocerosates. The existence of Pleistocene tuberculosis in the Americas is confirmed and there are many even older animal bones with well-characterised tuberculous lesions similar to those on the analysed sample. In the absence of any evidence of tuberculosis in human skeletons older than 9,000 years BP, the hypothesis that this disease evolved as a zoonosis, before transfer to humans, is given detailed consideration and discussion.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0041923" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0041923</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2012
acquired genomic islands
Besra G S
Bull I D
DNA
Donoghue H D
Evolution
Greenblatt C L
homo-erectus
Journal Article or Conference Abstract Publication
Lee O Y C
Martin L D
Minnikin D E
PloS one
Rothschild B M
Science & Technology - Other Topics
Spigelman M
trehalose
Wu H H T
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0071536" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0071536</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
8-8
Issue
8
Volume
8
Search for Full-text
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Title
A name given to the resource
Differential Regulation Of Cysteinyl Leukotriene Receptor Signaling By Protein Kinase C In Human Mast Cells
Publisher
An entity responsible for making the resource available
Plos One
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-08
Subject
The topic of the resource
activation; antagonist; asthmatic subjects; desensitization; expression; hyperresponsiveness; intestinal epithelial-cells; proliferation; pulmonary inflammation; responses; Science & Technology - Other Topics
Creator
An entity primarily responsible for making the resource
Kondeti V; Duah E; Al-Azzam N; Thodeti C K; Boyce J A; Paruchuri S
Description
An account of the resource
Cysteinyl leukotrienes (cys-LTs) are a group of lipid mediators that are potent bronchoconstrictors, powerful inducers of vascular leakage and potentiators of airway hyperresponsiveness. Cys-LTs play an essential role in asthma and are synthesized as well as activated in mast cells (MCs). Cys-LTs relay their effects mainly through two known GPCRs, CysLT(1)R and CysLT(2)R. Although protein kinase C (PKC) isoforms are implicated in the regulation of CysLT(1)R function, neither the role of PKCs in cys-LT-dependent MC inflammatory signaling nor the involvement of specific isoforms in MC function are known. Here, we show that PKC inhibition augmented LTD4 and LTE4-induced calcium influx through CysLT(1)R in MCs. In contrast, inhibition of PKCs suppressed c-fos expression as well MIP1 beta generation by cys-LTs. Interestingly, cys-LTs activated both PKC alpha and PKC epsilon isoforms in MC. However, knockdown of PKC alpha augmented cys-LT mediated calcium flux, while knockdown of PKC epsilon attenuated cys-LT induced c-fos expression and MIP1 beta generation. Taken together, these results demonstrate for the first time that cys-LT signaling downstream of CysLT(1)R in MCs is differentially regulated by two distinct PKCs which modulate inflammatory signals that have significant pathobiologic implications in allergic reactions and asthma pathology.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0071536" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0071536</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2013
activation
Al-Azzam N
Antagonist
asthmatic subjects
Boyce J A
Desensitization
Duah E
expression
hyperresponsiveness
intestinal epithelial-cells
Journal Article or Conference Abstract Publication
Kondeti V
Paruchuri S
PloS one
proliferation
pulmonary inflammation
responses
Science & Technology - Other Topics
Thodeti C K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0065389" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0065389</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
17-17
Issue
6
Volume
8
Search for Full-text
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Title
A name given to the resource
Alpha-lipoic Acid Antioxidant Treatment Limits Glaucoma-related Retinal Ganglion Cell Death And Dysfunction
Publisher
An entity responsible for making the resource available
Plos One
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-06
Subject
The topic of the resource
controlled trial aladin; dba/2j mouse model; glycation end-products; in-vivo; ischemia-reperfusion; nitric-oxide; open-angle glaucoma; optic neuropathy; oxidative stress; Science & Technology - Other Topics; trabecular meshwork
Creator
An entity primarily responsible for making the resource
Inman D M; Lambert W S; Calkins D J; Horner P J
Description
An account of the resource
Oxidative stress has been implicated in neurodegenerative diseases, including glaucoma. However, due to the lack of clinically relevant models and expense of long-term testing, few studies have modeled antioxidant therapy for prevention of neurodegeneration. We investigated the contribution of oxidative stress to the pathogenesis of glaucoma in the DBA/2J mouse model of glaucoma. Similar to other neurodegenerative diseases, we observed lipid peroxidation and upregulation of oxidative stress-related mRNA and protein in DBA/2J retina. To test the role of oxidative stress in disease progression, we chose to deliver the naturally occurring, antioxidant alpha-lipoic acid (ALA) to DBA/2J mice in their diet. We used two paradigms for ALA delivery: an intervention paradigm in which DBA/2J mice at 6 months of age received ALA in order to intervene in glaucoma development, and a prevention paradigm in which DBA/2J mice were raised on a diet supplemented with ALA, with the goal of preventing glaucoma development. At 10 and 12 months of age (after 4 and 11 months of dietary ALA respectively), we measured changes in genes and proteins related to oxidative stress, retinal ganglion cell (RGC) number, axon transport, and axon number and integrity. Both ALA treatment paradigms showed increased antioxidant gene and protein expression, increased protection of RGCs and improved retrograde transport compared to control. Measures of lipid peroxidation, protein nitrosylation, and DNA oxidation in retina verified decreased oxidative stress in the prevention and intervention paradigms. These data demonstrate the utility of dietary therapy for reducing oxidative stress and improving RGC survival in glaucoma.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0065389" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0065389</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2013
Calkins D J
controlled trial aladin
dba/2j mouse model
Department of Pharmaceutical Sciences
glycation end-products
Horner P J
in-vivo
Inman D M
ischemia-reperfusion
Journal Article or Conference Abstract Publication
Lambert W S
NEOMED College of Pharmacy
nitric-oxide
open-angle glaucoma
optic neuropathy
Oxidative Stress
PloS one
Science & Technology - Other Topics
trabecular meshwork
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0080898" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0080898</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
16-16
Issue
11
Volume
8
Search for Full-text
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Dublin Core
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Title
A name given to the resource
Tumor-specific Chromosome Mis-segregation Controls Cancer Plasticity By Maintaining Tumor Heterogeneity
Publisher
An entity responsible for making the resource available
Plos One
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-11
Subject
The topic of the resource
aneuploidy; clonal evolution; expression; glioblastoma-multiforme; glioma-cells; growth-factor; initiating cells; malignant glioma; mitotic errors; Science & Technology - Other Topics; stem-cells
Creator
An entity primarily responsible for making the resource
Hu Y J; Ru N; Xiao H S; Chaturbedi A; Hoa N T; Tian X J; Zhang H; Ke C; Yan F R; Nelson J; Li Z Z; Gramer R; Yu L P; Siegel E; Zhang X N; Jia Z Y; Jadus M R; Limoli C L; Linskey M E; Xing J H; Zhou Y H
Description
An account of the resource
Aneuploidy with chromosome instability is a cancer hallmark. We studied chromosome 7 (Chr7) copy number variation (CNV) in gliomas and in primary cultures derived from them. We found tumor heterogeneity with cells having Chr7-CNV commonly occurs in gliomas, with a higher percentage of cells in high-grade gliomas carrying more than 2 copies of Chr7, as compared to low-grade gliomas. Interestingly, all Chr7-aneuploid cell types in the parental culture of established glioma cell lines reappeared in single-cell-derived subcultures. We then characterized the biology of three syngeneic glioma cultures dominated by different Chr7-aneuploid cell types. We found phenotypic divergence for cells following Chr7 mis-segregation, which benefited overall tumor growth in vitro and in vivo. Mathematical modeling suggested the involvement of chromosome instability and interactions among cell subpopulations in restoring the optimal equilibrium of tumor cell types. Both our experimental data and mathematical modeling demonstrated that the complexity of tumor heterogeneity could be enhanced by the existence of chromosomes with structural abnormality, in addition to their mis-segregations. Overall, our findings show, for the first time, the involvement of chromosome instability in maintaining tumor heterogeneity, which underlies the enhanced growth, persistence and treatment resistance of cancers.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0080898" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0080898</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2013
aneuploidy
Chaturbedi A
clonal evolution
expression
glioblastoma-multiforme
glioma-cells
Gramer R
growth-factor
Hoa N T
Hu Y J
initiating cells
Jadus M R
Jia Z Y
Journal Article or Conference Abstract Publication
Ke C
Li Z Z
Limoli C L
Linskey M E
malignant glioma
mitotic errors
Nelson J
PloS one
Ru N
Science & Technology - Other Topics
Siegel E
stem-cells
Tian X J
Xiao H S
Xing J H
Yan F R
Yu L P
Zhang H
Zhang X N
Zhou Y H
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0051646" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0051646</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
18-18
Issue
12
Volume
7
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Processing Of Communication Calls In Guinea Pig Auditory Cortex
Publisher
An entity responsible for making the resource available
Plos One
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-12
Subject
The topic of the resource
Acoustic noise; Action potentials; Anesthesia; Auditory cortex; Brain research; Broadband; Communication; conspecific; Auditory cortex; Cortex (temporal); cortical discrimination; Councils; functional specialization; Guinea pigs; Localization; Macaque; Medical research; Monkeys; neural representation; Neurobiology; neurons; Neurosciences; Ohio; purr call; rhesus-monkey; Saimiri; Science & Technology - Other Topics; Sciences: Comprehensive Works; single neurons; social vocalizations; Sound; species-specific vocalizations; squirrel-monkeys; Stimuli; United Kingdom--UK; Urethane; Vocalization; vocalizations
Creator
An entity primarily responsible for making the resource
Grimsley J M S; Shanbhag S J; Palmer A R; Wallace M N
Description
An account of the resource
Vocal communication is an important aspect of guinea pig behaviour and a large contributor to their acoustic environment. We postulated that some cortical areas have distinctive roles in processing conspecific calls. In order to test this hypothesis we presented exemplars from all ten of their main adult vocalizations to urethane anesthetised animals while recording from each of the eight areas of the auditory cortex. We demonstrate that the primary area (AI) and three adjacent auditory belt areas contain many units that give isomorphic responses to vocalizations. These are the ventrorostral belt (VRB), the transitional belt area (T) that is ventral to AI and the small area (area S) that is rostral to AI. Area VRB has a denser representation of cells that are better at discriminating among calls by using either a rate code or a temporal code than any other area. Furthermore, 10% of VRB cells responded to communication calls but did not respond to stimuli such as clicks, broadband noise or pure tones. Area S has a sparse distribution of call responsive cells that showed excellent temporal locking, 31% of which selectively responded to a single call. AI responded well to all vocalizations and was much more responsive to vocalizations than the adjacent dorsocaudal core area. Areas VRB, AI and S contained units with the highest levels of mutual information about call stimuli. Area T also responded well to some calls but seems to be specialized for low sound levels. The two dorsal belt areas are comparatively unresponsive to vocalizations and contain little information about the calls. AI projects to areas S, VRB and T, so there may be both rostral and ventral pathways for processing vocalizations in the guinea pig.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0051646" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0051646</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2012
Acoustic noise
Action Potentials
Anesthesia
auditory cortex
Brain research
Broadband
Communication
conspecific
Cortex (temporal)
cortical discrimination
Councils
functional specialization
Grimsley J M S
Guinea Pigs
Journal Article or Conference Abstract Publication
localization
Macaque
MEDICAL research
monkeys
neural representation
Neurobiology
Neurons
Neurosciences
Ohio
Palmer A R
PloS one
purr call
rhesus-monkey
saimiri
Science & Technology - Other Topics
Sciences: Comprehensive Works
Shanbhag S J
single neurons
social vocalizations
Sound
species-specific vocalizations
squirrel-monkeys
Stimuli
United Kingdom--UK
Urethane
Vocalization
vocalizations
Wallace M N
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0091719" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0091719</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
12-12
Issue
3
Volume
9
Search for Full-text
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<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
To 3d Or Not To 3d, That Is The Question: Do 3d Surface Analyses Improve The Ecomorphological Power Of The Distal Femur In Placental Mammals?
Publisher
An entity responsible for making the resource available
Plos One
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
2014-03
Subject
The topic of the resource
anatomy; behavior; carnivorans; corpus; discriminant function-analysis; evolution; functional-morphology; hindlimb; locomotor; ratios; rodents; Science & Technology - Other Topics
Creator
An entity primarily responsible for making the resource
Gould F D H
Description
An account of the resource
Improvements in three-dimensional imaging technologies have renewed interest in the study of functional and ecological morphology. Quantitative approaches to shape analysis are used increasingly to study form-function relationships. These methods are computationally intensive, technically demanding, and time-consuming, which may limit sampling potential. There have been few side-by-side comparisons of the effectiveness of such approaches relative to more traditional analyses using linear measurements and ratios. Morphological variation in the distal femur of mammals has been shown to reflect differences in locomotor modes across clades. Thus I tested whether a geometric morphometric analysis of surface shape was superior to a multivariate analysis of ratios for describing ecomorphological patterns in distal femoral variation. A sample of 164 mammalian specimens from 44 genera was assembled. Each genus was assigned to one of six locomotor categories. The same hypotheses were tested using two methods. Six linear measurements of the distal femur were taken with calipers, from which four ratios were calculated. A 3D model was generated with a laser scanner, and analyzed using three dimensional geometric morphometrics. Locomotor category significantly predicted variation in distal femoral morphology in both analyses. Effect size was larger in the geometric morphometric analysis than in the analysis of ratios. Ordination reveals a similar pattern with arboreal and cursorial taxa as extremes on a continuum of morphologies in both analyses. Discriminant functions calculated from the geometric morphometric analysis were more accurate than those calculated from ratios. Both analysis of ratios and geometric morphometric surface analysis reveal similar, biologically meaningful relationships between distal femoral shape and locomotor mode. The functional signal from the morphology is slightly higher in the geometric morphometric analysis. The practical costs of conducting these sorts of analyses should be weighed against potentially slight increases in power when designing protocols for ecomorphological studies.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0091719" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0091719</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2014
anatomy
Behavior
carnivorans
corpus
discriminant function-analysis
Evolution
functional-morphology
Gould F D H
hindlimb
Journal Article or Conference Abstract Publication
locomotor
PloS one
ratios
Rodents
Science & Technology - Other Topics
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0068845" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0068845</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
11-11
Issue
7
Volume
8
Search for Full-text
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<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Hepatic Cannabinoid Receptor Type 1 Mediates Alcohol-Induced Regulation of Bile Acid Enzyme Genes Expression Via CREBH
Publisher
An entity responsible for making the resource available
PLOS ONE
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-07
Subject
The topic of the resource
metabolism; Ohio; mice; Signaling; Signal transduction; liver; Homeostasis; transcription factor; Genes; exposure; Acids; er stress; endoplasmic-reticulum stress; Science & Technology - Other Topics; insulin-resistance; cholesterol 7-alpha-hydroxylase; human hepatocytes; Rodents; Bile acids; alcohol; element-binding protein; gene-expression; endocannabinoid system; bound; cb1 receptors; leptin resistance; Liver diseases; Diabetes mellitus; insulin-resistance; insulin; Fatty liver; hepatocytes; Sciences: Comprehensive Works; Alcohols; Bile; activation; Damage prevention; Deregulation; Muridae; Regulatory mechanisms (biology); RNA extraction; Synthesis
Creator
An entity primarily responsible for making the resource
Chanda D; Kim Y H; Li T; Misra J; Kim D K; Kim J R; Kwon J; Jeong W I; Ahn S H; Park T S; Koo S H; Chiang J Y L; Lee C H; Choi H S
Description
An account of the resource
Bile acids concentration in liver is tightly regulated to prevent cell damage. Previous studies have demonstrated that deregulation of bile acid homeostasis can lead to cholestatic liver disease. Recently, we have shown that ER-bound transcription factor Crebh is a downstream effector of hepatic Cb1r signaling pathway. In this study, we have investigated the effect of alcohol exposure on hepatic bile acid homeostasis and elucidated the mediatory roles of Cb1r and Crebh in this process. We found that alcohol exposure or Cb1r-agonist 2-AG treatment increases hepatic bile acid synthesis and serum ALT, AST levels in vivo alongwith significant increase in Crebh gene expression and activation. Alcohol exposure activated Cb1r, Crebh, and perturbed bile acid homeostasis. Overexpression of Crebh increased the expression of key bile acid synthesis enzyme genes via direct binding of Crebh to their promoters, whereas Cb1r knockout and Crebh-knockdown mice were protected against alcohol-induced perturbation of bile acid homeostasis. Interestingly, insulin treatment protected against Cb1r-mediated Crebh-induced disruption of bile acid homeostasis. Furthermore, Crebh expression and activation was found to be markedly increased in insulin resistance conditions and Crebh knockdown in diabetic mice model (db/db) significantly reversed alcohol-induced disruption of bile acid homeostasis. Overall, our study demonstrates a novel regulatory mechanism of hepatic bile acid metabolism by alcohol via Cb1r-mediated activation of Crebh, and suggests that targeting Crebh can be of therapeutic potential in ameliorating alcohol-induced perturbation of bile acid homeostasis.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0068845" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0068845</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2013
Acids
activation
Ahn S H
Alcohol
Alcohols
Bile
BILE acids
bound
cb1 receptors
Chanda D
Chiang J Y L
Choi H S
cholesterol 7-alpha-hydroxylase
Damage prevention
Deregulation
Diabetes Mellitus
element-binding protein
endocannabinoid system
endoplasmic-reticulum stress
er stress
exposure
Fatty Liver
gene-expression
Genes
hepatocytes
Homeostasis
human hepatocytes
insulin
insulin-resistance
Jeong W I
Journal Article or Conference Abstract Publication
Kim D K
Kim J R
Kim Y H
Koo S H
Kwon J
Lee C H
leptin resistance
Li T
Liver
Liver Diseases
Metabolism
Mice
Misra J
Muridae
Ohio
Park T S
PloS one
Regulatory mechanisms (biology)
RNA extraction
Rodents
Science & Technology - Other Topics
Sciences: Comprehensive Works
Signal Transduction
Signaling
Synthesis
transcription factor
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0019177" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0019177</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
10-10
Issue
4
Volume
6
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Comparative Analysis of Cervical Spine Management in a Subset of Severe Traumatic Brain Injury Cases Using Computer Simulation
Publisher
An entity responsible for making the resource available
PLOS ONE
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-04
Subject
The topic of the resource
mortality; stroke; risk-factors; Science & Technology - Other Topics; ventilator-associated pneumonia; blunt trauma; safe; mri; coma; immobilization
Creator
An entity primarily responsible for making the resource
Carter K J; Dunham C M; Castro F; Erickson B
Description
An account of the resource
Background: No randomized control trial to date has studied the use of cervical spine management strategies in cases of severe traumatic brain injury (TBI) at risk for cervical spine instability solely due to damaged ligaments. A computer algorithm is used to decide between four cervical spine management strategies. A model assumption is that the emergency room evaluation shows no spinal deficit and a computerized tomogram of the cervical spine excludes the possibility of fracture of cervical vertebrae. The study's goal is to determine cervical spine management strategies that maximize brain injury functional survival while minimizing quadriplegia. Methods/Findings: The severity of TBI is categorized as unstable, high risk and stable based on intracranial hypertension, hypoxemia, hypotension, early ventilator associated pneumonia, admission Glasgow Coma Scale (GCS) and age. Complications resulting from cervical spine management are simulated using three decision trees. Each case starts with an amount of primary and secondary brain injury and ends as a functional survivor, severely brain injured, quadriplegic or dead. Cervical spine instability is studied with one-way and two-way sensitivity analyses providing rankings of cervical spine management strategies for probabilities of management complications based on QALYs. Early collar removal received more QALYs than the alternative strategies in most arrangements of these comparisons. A limitation of the model is the absence of testing against an independent data set. Conclusions: When clinical logic and components of cervical spine management are systematically altered, changes that improve health outcomes are identified. In the absence of controlled clinical studies, the results of this comparative computer assessment show that early collar removal is preferred over a wide range of realistic inputs for this subset of traumatic brain injury. Future research is needed on identifying factors in projecting awakening from coma and the role of delirium in these cases.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0019177" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0019177</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2011
blunt trauma
Carter K J
Castro F
coma
Dunham C M
Erickson B
immobilization
Journal Article or Conference Abstract Publication
Mortality
MRI
PloS one
risk-factors
safe
Science & Technology - Other Topics
stroke
ventilator-associated pneumonia
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0054277" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0054277</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
11-11
Issue
1
Volume
8
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Leptin in Whales: Validation and Measurement of mRNA Expression by Absolute Quantitative Real-Time PCR
Publisher
An entity responsible for making the resource available
PLOS ONE
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-01
Subject
The topic of the resource
obesity; mammals; Science & Technology - Other Topics; resistance; mass; weight; quantification; housekeeping genes; reference genes; rt-pcr; serum leptin
Creator
An entity primarily responsible for making the resource
Ball H C; Holmes R K; Londraville R L; Thewissen J G M; Duff R J
Description
An account of the resource
Leptin is the primary hormone in mammals that regulates adipose stores. Arctic adapted cetaceans maintain enormous adipose depots, suggesting possible modifications of leptin or receptor function. Determining expression of these genes is the first step to understanding the extreme physiology of these animals, and the uniqueness of these animals presents special challenges in estimating and comparing expression levels of mRNA transcripts. Here, we compare expression of two model genes, leptin and leptin-receptor gene-related product (OB-RGRP), using two quantitative real-time PCR (qPCR) methods: "relative'' and "absolute''. To assess the expression of leptin and OB-RGRP in cetacean tissues, we first examined how relative expression of those genes might differ when normalized to four common endogenous control genes. We performed relative expression qPCR assays measuring the amplification of these two model target genes relative to amplification of 18S ribosomal RNA (18S), ubiquitously expressed transcript (Uxt), ribosomal protein 9 (Rs9) and ribosomal protein 15 (Rs15) endogenous controls. Results demonstrated significant differences in the expression of both genes when different control genes were employed; emphasizing a limitation of relative qPCR assays, especially in studies where differences in physiology and/or a lack of knowledge regarding levels and patterns of expression of common control genes may possibly affect data interpretation. To validate the absolute quantitative qPCR methods, we evaluated the effects of plasmid structure, the purity of the plasmid standard preparation and the influence of type of qPCR "background'' material on qPCR amplification efficiencies and copy number determination of both model genes, in multiple tissues from one male bowhead whale. Results indicate that linear plasmids are more reliable than circular plasmid standards, no significant differences in copy number estimation based upon background material used, and that the use of ethanol precipitated, linearized plasmid preparation produce the most reliable results.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0054277" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0054277</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2013
Ball H C
Duff R J
Holmes R K
housekeeping genes
Journal Article or Conference Abstract Publication
Londraville R L
Mammals
mass
Obesity
PloS one
quantification
reference genes
resistance
rt-pcr
Science & Technology - Other Topics
serum leptin
Thewissen J G M
weight
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0038359" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0038359</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
13-13
Issue
5
Volume
7
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Performance of Repetitive Tasks Induces Decreased Grip Strength and Increased Fibrogenic Proteins in Skeletal Muscle: Role of Force and Inflammation
Publisher
An entity responsible for making the resource available
PLOS ONE
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-05
Subject
The topic of the resource
carpal-tunnel-syndrome; factor gene-expression; flexor tendon cells; in-vivo; lengthening contractions; necrosis-factor-alpha; rat model; Science & Technology - Other Topics; strain injury; tissue growth-factor; tnf-alpha
Creator
An entity primarily responsible for making the resource
Abdelmagid S M; Barr A E; Rico M; Amin M; Litvin J; Popoff S N; Safadi F; Barbe M F
Description
An account of the resource
Background: This study elucidates exposure-response relationships between performance of repetitive tasks, grip strength declines, and fibrogenic-related protein changes in muscles, and their link to inflammation. Specifically, we examined forearm flexor digitorum muscles for changes in connective tissue growth factor (CTGF; a matrix protein associated with fibrosis), collagen type I (Col1; a matrix component), and transforming growth factor beta 1 (TGFB1; an upstream modulator of CTGF and collagen), in rats performing one of two repetitive tasks, with or without anti-inflammatory drugs. Methodology/Results: To examine the roles of force versus repetition, rats performed either a high repetition negligible force food retrieval task (HRNF), or a high repetition high force handle-pulling task (HRHF), for up to 9 weeks, with results compared to trained only (TR-NF or TR-HF) and normal control rats. Grip strength declined with both tasks, with the greatest declines in 9-week HRHF rats. Quantitative PCR (qPCR) analyses of HRNF muscles showed increased expression of Col1 in weeks 3-9, and CTGF in weeks 6 and 9. Immunohistochemistry confirmed PCR results, and also showed greater increases of CTGF and collagen matrix in 9-week HRHF rats than 9-week HRNF rats. ELISA, and immunohistochemistry revealed greater increases of TGFB1 in TR-HF and 6-week HRHF, compared to 6-week HRNF rats. To examine the role of inflammation, results from 6-week HRHF rats were compared to rats receiving ibuprofen or anti-TNF-alpha treatment in HRHF weeks 4-6. Both treatments attenuated HRHF-induced increases in CTGF and fibrosis by 6 weeks of task performance. Ibuprofen attenuated TGFB1 increases and grip strength declines, matching our prior results with anti-TNF alpha. Conclusions/Significance: Performance of highly repetitive tasks was associated with force-dependent declines in grip strength and increased fibrogenic-related proteins in flexor digitorum muscles. These changes were attenuated, at least short-term, by anti-inflammatory treatments.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0038359" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0038359</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2012
Abdelmagid S M
Amin M
Barbe M F
Barr A E
carpal-tunnel-syndrome
factor gene-expression
flexor tendon cells
in-vivo
Journal Article or Conference Abstract Publication
lengthening contractions
Litvin J
necrosis-factor-alpha
PloS one
Popoff S N
rat model
Rico M
Safadi F
Science & Technology - Other Topics
strain injury
tissue growth-factor
TNF-alpha
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0121826" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0121826</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
13-13
Issue
3
Volume
10
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Identification of Multiple Metabolic Enzymes from Mice Cochleae Tissue Using a Novel Functional Proteomics Technology
Publisher
An entity responsible for making the resource available
PLOS ONE
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
2015-03
Subject
The topic of the resource
Animal tissues; Beef; Biology; cancer; cancer metabolism; cell metabolism; Cochlea; draft; Drug therapy; E coli; Electrophoresis; Elution; Enzymatic activity; Enzyme assays; Enzyme metabolism; Enzymes; Feasibility studies; Functional analysis; Gel electrophoresis; Genes; Genomics; Hearing impairment; Kinases; Mass spectrometry; Mass spectroscopy; medicine; messenger-rna; metabolism; mice; NAD(P)H oxidase; NADH; Neurobiology; Neurosciences; Nicotinamide adenine dinucleotide; Noise; Otolaryngology; Oxidation-reduction reactions; Phosphatase; Protein expression; proteins; Proteomes; Proteomics; Science & Technology - Other Topics; Sciences: Comprehensive Works; Scientific imaging; Studies; Substance abuse treatment; Technology; United States--US
Creator
An entity primarily responsible for making the resource
Wang D L; Li H; Liang R Q; Bao J X
Description
An account of the resource
A new type of technology in proteomics was developed in order to separate a complex protein mixture and analyze protein functions systematically. The technology combines the ability of two-dimensional gel electrophoresis (2-DE) to separate proteins with a protein elution plate (PEP) to recover active proteins for functional analysis and mass spectrometry (MS)-based identification. In order to demonstrate the feasibility of this functional proteomics approach, NADH and NADPH-dependent oxidases, major redox enzyme families, were identified from mice cochlear tissue after a specific drug treatment. By comparing the enzymatic activity between mice that were treated with a drug and a control group significant changes were observed. Using MS, five NADH-dependent oxidases were identified that showed highly altered enzymatic activities due to the drug treatment. In essence, the PEP technology allows for a systematic analysis of a large enzyme family from a complex proteome, providing insights in understanding the mechanism of drug treatment.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0121826" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0121826</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2015
Animal tissues
Bao J X
Beef
Biology
Cancer
cancer metabolism
cell metabolism
Cochlea
draft
Drug Therapy
E coli
Electrophoresis
Elution
Enzymatic activity
Enzyme assays
Enzyme metabolism
Enzymes
Feasibility Studies
Functional analysis
Gel electrophoresis
Genes
Genomics
Hearing impairment
Journal Article
Kinases
Li H
Liang R Q
Mass spectrometry
Mass spectroscopy
Medicine
messenger-rna
Metabolism
Mice
NAD(P)H oxidase
NADH
Neurobiology
Neurosciences
nicotinamide adenine dinucleotide
Noise
otolaryngology
Oxidation-reduction reactions
Phosphatase
PloS one
PROTEIN expression
Proteins
Proteomes
proteomics
Science & Technology - Other Topics
Sciences: Comprehensive Works
Scientific imaging
Studies
Substance abuse treatment
Technology
United States--US
Wang D L
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0054460" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0054460</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
8-8
Issue
1
Volume
8
Search for Full-text
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<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Cholesterol-Peptide Hybrids to Form Liposome-Like Vesicles for Gene Delivery
Publisher
An entity responsible for making the resource available
PLOS ONE
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-01
Subject
The topic of the resource
condensation; dna; histidine; nanoparticles; oligopeptides; polymers; prospects; Science & Technology - Other Topics; systems; therapy; vectors
Creator
An entity primarily responsible for making the resource
Tang Q; Cao B; Wu H Y; Cheng G
Description
An account of the resource
In this paper, four amphiphilic cholesterol-peptide conjugates (Ch-R5H5, Ch-R3H3, Ch-R5 and Ch-R5) were designed and synthesized, and their properties in gene delivery were evaluated in vitro with an aim of developing more efficient gene delivery carriers. These amphiphilic cholesterol-peptide conjugates are composed of hydrophobic cholesterol and positively charged peptides. They were able to self-assemble into micelles at low concentrations and their critical micelle concentrations in phosphate buffered saline (pH 7.4) are <= 85 mu g/mL. Amphiphilic cholesterol-peptide conjugates condensed DNA more efficiently than a hydrophilic cationic oligoarginine (R10) peptide with no hydrophobic segment. Their transfection efficiencies were at least two orders of magnitude greater than that of R10 peptide in HEK-293 cells. Moreover, the introduction of histidine residues in cholesterol-peptide conjugates led to higher gene expression efficiency compared with cholesterol-peptides without histidine (Ch-R5 and Ch-R3), and the luciferase expression level was comparable or even higher than that induced by PEI at its optimal N/P ratio. In particular, Ch-R5H5 condensed DNA into smaller nanoparticles than Ch-R3H3 at higher N/P ratios, and the minimum size of Ch-R5H5/DNA complexes was 180 nm with zeta potential of 23 mV, achieved at the N/P ratio of 30. This liposome-like vesicle may be a promising gene delivery carrier for intravenous therapy.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0054460" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0054460</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2013
Cao B
Cheng G
condensation
DNA
histidine
Journal Article
Nanoparticles
oligopeptides
PloS one
Polymers
prospects
Science & Technology - Other Topics
systems
Tang Q
therapy
vectors
Wu H Y
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0054804" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0054804</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
11-11
Issue
1
Volume
8
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Extracellular ATP and Toll-Like Receptor 2 Agonists Trigger in Human Monocytes an Activation Program That Favors T Helper 17
Publisher
An entity responsible for making the resource available
PLOS ONE
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-01
Subject
The topic of the resource
adaptive immunity; calcium ionophore; cd14(+) monocytes; cells; growth-factor-beta; host-defense; human dendritic cells; il-12 production; in-vivo; Science & Technology - Other Topics; serum-free conditions; th17
Creator
An entity primarily responsible for making the resource
Paustian C; Taylor P; Johnson T; Xu M; Ramirez N; Rosenthal K S; Shu S Y; Cohen P A; Czerniecki B J; Koski G K
Description
An account of the resource
Strategically-paired Toll-like receptor (TLR) ligands induce a unique dendritic cell (DC) phenotype that polarizes Th1 responses. We therefore investigated pairing single TLR ligands with a non TLR-mediated danger signal to cooperatively induce distinct DC properties from cultured human monocytes. Adenosine triphosphate (ATP) and the TLR2 ligand lipoteichoic acid (LTA) selectively and synergistically induced expression of IL-23 and IL-1 beta from cultured monocytes as determined by ELISA assays. Flow cytometric analysis revealed that a sizable sub-population of treated cells acquired DC-like properties including activated surface phenotype with trans-well assays showing enhanced migration towards CCR7 ligands. Such activated cells also preferentially deviated, in an IL-23 and IL-1-dependent manner, CD4(pos) T lymphocyte responses toward the IL-22(hi), IL-17(hi)/IFN-gamma(lo) Th17 phenotype in standard in vitro allogeneic sensitization assays. Although pharmacological activation of either ionotropic or cAMP-dependent pathways acted in synergy with LTA to enhance IL-23, only inhibition of the cAMP-dependent pathway antagonized ATP-enhanced cytokine production. ATP plus atypical lipopolysaccharide from P. gingivalis (signaling through TLR2) was slightly superior to E. coli-derived LPS (TLR4 ligand) for inducing the high IL-23-secreting DC-like phenotype, but greatly inferior for inducing IL-12 p70 production when paired with IFN-gamma, a distinction reflected in activated DCs' ability to deviate lymphocytes toward Th1. Collectively, our data suggest TLR2 ligands encountered by innate immune cells in an environment with physiologically-relevant levels of extracellular ATP can induce a distinct activation state favoring IL-23- and IL-1 beta-dependent Th17 type response.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0054804" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0054804</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2013
Adaptive Immunity
calcium ionophore
cd14(+) monocytes
Cells
Cohen P A
Czerniecki B J
growth-factor-beta
host-defense
human dendritic cells
il-12 production
in-vivo
Johnson T
Journal Article
Koski G K
Paustian C
PloS one
Ramirez N
Rosenthal K S
Science & Technology - Other Topics
serum-free conditions
Shu S Y
Taylor P
th17
Xu M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0022379" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0022379</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
10-10
Issue
7
Volume
6
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Overexpression of the Lung Cancer-Prognostic miR-146b MicroRNAs Has a Minimal and Negative Effect on the Malignant Phenotype of A549 Lung Cancer Cells
Publisher
An entity responsible for making the resource available
PLOS ONE
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-07
Subject
The topic of the resource
breast-cancer; diseases; expression profiles; glioma; inhibition; invasion; migration; Science & Technology - Other Topics; strand selection; target; tumors
Creator
An entity primarily responsible for making the resource
Patnaik S K; Kannisto E; Mallick R; Yendamuri S
Description
An account of the resource
Introduction: Expression levels of miR-146b-5p and -3p microRNAs in human non-small cell lung cancer (NSCLC) are associated with recurrence of the disease after surgery. To understand this, the effect of miR-146b overexpression was studied in A549 human lung cancer cells. Methods: A549 cells, engineered with lentiviruses to overexpress the human pre-miR-146b precursor microRNA, were examined for proliferation, colony formation on plastic surface and in soft agar, migration and invasiveness in cell culture and in vivo in mice, chemosensitivity to cisplatin and doxorubicin, and global gene expression. miR-146b expressions were assessed in microdissected stroma and epithelia of human NSCLC tumors. Association of miR-146b-5p and -3p expression in early stage NSCLC with recurrence was analyzed. Principal Findings: A549 pre-miR-146b-overexpressors had 3-8-fold higher levels of both miR-146b microRNAs than control cells. Overexpression did not alter cellular proliferation, chemosensitivity, migration, or invasiveness; affected only 0.3% of the mRNA transcriptome; and, reduced the ability to form colonies in vitro by 25%. In human NSCLC tumors, expression of both miR-146b microRNAs was 7-10-fold higher in stroma than in cancerous epithelia, and higher miR-146b-5p but lower 3p levels were predictive of recurrence. Conclusions: Only a minimal effect of pre-miR-146b overexpression on the malignant phenotype was seen in A549 cells. This could be because of opposing effects of miR-146b-5p and -3p overexpression as suggested by the conflicting recurrence-predictive values of the two microRNAs, or because miR-146b expression changes in non-cancerous stroma and not cancerous epithelia of tumors are responsible for the prognostic value of miR-146b.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0022379" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0022379</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2011
breast-cancer
DISEASES
expression profiles
Glioma
inhibition
invasion
Journal Article
Kannisto E
Mallick R
migration
Patnaik S K
PloS one
Science & Technology - Other Topics
strand selection
target
tumors
Yendamuri S
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0206314" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0206314</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
e0206314-e0206314
Issue
11
Volume
13
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
First record of the Miocene hominoid Sivapithecus from Kutch, Gujarat state, western India.
Publisher
An entity responsible for making the resource available
PloS one
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018
Subject
The topic of the resource
Animals; India; Biological Evolution; Geology; *Archaeology; *Hominidae/anatomy & histology
Creator
An entity primarily responsible for making the resource
Bhandari Ansuya; Kay Richard F; Williams Blythe A; Tiwari Brahma Nand; Bajpai Sunil; Hieronymus Tobin L
Description
An account of the resource
Hominoid remains from Miocene deposits in India and Pakistan have played a pivotal role in understanding the evolution of great apes and humans since they were first described in the 19th Century. We describe here a hominoid maxillary fragment preserving the canine and cheek teeth collected in 2011 from the Kutch (= Kachchh) basin in the Kutch district, Gujarat state, western India. A basal Late Miocene age is proposed based on the associated faunal assemblage that includes Hipparion and other age-diagnostic mammalian taxa. Miocene Hominoidea are known previously from several areas of the Siwalik Group in the outer western Himalayas of India, Pakistan, and Nepal. This is the first record of a hominoid from the Neogene of the Kutch Basin and represents a significant southern range extension of Miocene hominoids in the Indian peninsula. The specimen is assigned to the Genus Sivapithecus, species unspecified.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0206314" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0206314</a>
*Archaeology
*Hominidae/anatomy & histology
2018
Animals
Bajpai Sunil
Bhandari Ansuya
Biological Evolution
Geology
Hieronymus Tobin L
India
Kay Richard F
PloS one
Tiwari Brahma Nand
Williams Blythe A
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0206314" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0206314</a>
Pages
e0206314–e0206314
Issue
11
Volume
13
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
First record of the Miocene hominoid Sivapithecus from Kutch, Gujarat state, western India.
Publisher
An entity responsible for making the resource available
PloS one
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
1905-7
Creator
An entity primarily responsible for making the resource
Bhandari Ansuya; Kay Richard F; Williams Blythe A; Tiwari Brahma Nand; Bajpai Sunil; Hieronymus Tobin
Description
An account of the resource
Hominoid remains from Miocene deposits in India and Pakistan have played a pivotal role in understanding the evolution of great apes and humans since they were first described in the 19th Century. We describe here a hominoid maxillary fragment preserving the canine and cheek teeth collected in 2011 from the Kutch (= Kachchh) basin in the Kutch district, Gujarat state, western India. A basal Late Miocene age is proposed based on the associated faunal assemblage that includes Hipparion and other age-diagnostic mammalian taxa. Miocene Hominoidea are known previously from several areas of the Siwalik Group in the outer western Himalayas of India, Pakistan, and Nepal. This is the first record of a hominoid from the Neogene of the Kutch Basin and represents a significant southern range extension of Miocene hominoids in the Indian peninsula. The specimen is assigned to the Genus Sivapithecus, species unspecified.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0206314" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0206314</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Bajpai Sunil
Bhandari Ansuya
Department of Anatomy & Neurobiology
Hieronymus Tobin
Kay Richard F
NEOMED College of Medicine
PloS one
Tiwari Brahma Nand
Williams Blythe A
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0200087" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0200087</a>
Pages
e0200087–e0200087
Issue
7
Volume
13
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Twin-twin transfusion syndrome screening and diagnosis in the United States: A triangulation design of patient experiences.
Publisher
An entity responsible for making the resource available
PloS one
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
1905-7
Subject
The topic of the resource
Adult; Female; Humans; Retrospective Studies; Ultrasonography; Cross-Sectional Studies; Fetofetal Transfusion/*diagnosis/*diagnostic imaging/*epidemiology; Gestational Age; Patient Reported Outcome Measures; Pregnancy; Prenatal Care/methods; Ultrasonography/methods; United States; Prenatal/methods
Creator
An entity primarily responsible for making the resource
Fischbein Rebecca; Nicholas Lauren; Aultman Julie; Baughman Kristin; Falletta Lynn
Description
An account of the resource
OBJECTIVE: Using patient-reported experiences, this study: 1) quantitatively evaluated TTTS screening trends, 2) examined screening and diagnostic experiences using a mixed methods approach, and 3) determined gaps in clinical care experiences. DESIGN: This was a cross-sectional study. Data was collected using a self-report, retrospective survey. A triangulation design was used to validate quantitative survey data with thematically analyzed qualitative data. SETTING: Participants were recruited through social media and national foundations and completed the survey online. PARTICIPANTS: Participants were 312 women who completed a TTTS pregnancy in the United States, representing the largest survey of participants who have experienced TTTS. METHODS: Descriptive statistics and bivariate analyses were conducted. Multivariate logistic regression examined predictors of ultrasound frequency. Qualitative data were initially coded by hand and checked using qualitative software. RESULTS: The percentages of participants reporting guideline recommended screening, including identification of pregnancy type by gestational week 13 and timely receipt of ultrasounds, increased over time. However, 44.6% of participants diagnosed in recent years (2014 and later), reported that prior to TTTS diagnosis, they did not receive biweekly or more frequent ultrasounds. Three patient-reported provider practices were related to receiving ultrasounds at the recommended frequency: (1) determining MCDA status prior to gestational week 14, (2) providing participants with early warnings about the risk of TTTS to their pregnancies after MCDA status had been determined, and (3) referring participants to a Maternal-Fetal Medicine Specialist after MCDA identification, as validated by qualitative data. Our qualitative data revealed gaps in effective clinical care experiences among OB/GYN and specialist providers. CONCLUSION: These findings indicate screening and diagnosis for TTTS, as reported by patients, is improving in the United States; however, further efforts are required to ensure all patients receive appropriate screening, education and a team-based approach to comprehensive and supportive clinical care.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0200087" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0200087</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Adult
Aultman Julie
Baughman Kristin
College of Graduate Studies
College of Medicine
Cross-Sectional Studies
Department of Family & Community Medicine
Falletta Lynn
Female
Fetofetal Transfusion/*diagnosis/*diagnostic imaging/*epidemiology
Fischbein Rebecca
Gestational Age
Humans
NEOMED College of Graduate Studies
NEOMED College of Medicine
Nicholas Lauren
Patient Reported Outcome Measures
PloS one
Pregnancy
Prenatal Care/methods
Prenatal/methods
Retrospective Studies
Ultrasonography
Ultrasonography/methods
United States
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0196154" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0196154</a>
Pages
e0196154–e0196154
Issue
5
Volume
13
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Comparative metabolomics of aging in a long-lived bat: Insights into the physiology of extreme longevity.
Publisher
An entity responsible for making the resource available
PloS one
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
1905-7
Subject
The topic of the resource
Animals; *Metabolomics; Chiroptera/*physiology; Feces/*chemistry; Longevity/*physiology
Creator
An entity primarily responsible for making the resource
Ball Hope C; Levari-Shariati Shiva; Cooper Lisa Noelle; Aliani Michel
Description
An account of the resource
Vespertilionid bats (Mammalia: Order Chiroptera) live 3-10 times longer than other mammals of an equivalent body size. At present, nothing is known of how bat fecal metabolic profiles shift with age in any taxa. This study established the feasibility of using a non-invasive, fecal metabolomics approach to examine age-related differences in the fecal metabolome of young and elderly adult big brown bats (Eptesicus fuscus) as an initial investigation into using metabolomics for age determination. Samples were collected from captive, known-aged big brown bats (Eptesicus fuscus) from 1 to over 14 years of age: these two ages represent age groups separated by approximately 75% of the known natural lifespan of this taxon. Results showed 41 metabolites differentiated young (n = 22) and elderly (n = 6) Eptesicus. Significant differences in metabolites between young and elderly bats were associated with tryptophan metabolism and incomplete protein digestion. Results support further exploration of the physiological mechanisms bats employ to achieve exceptional longevity.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0196154" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0196154</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Metabolomics
2018
Aliani Michel
Animals
Ball Hope C
Chiroptera/*physiology
Cooper Lisa Noelle
Department of Anatomy & Neurobiology
Feces/*chemistry
Levari-Shariati Shiva
Longevity/*physiology
NEOMED College of Medicine
PloS one
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0195536" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0195536</a>
Pages
e0195536–e0195536
Issue
4
Volume
13
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Heparin free dialysis in critically sick children using sustained low efficiency dialysis (SLEDD-f): A new hybrid therapy for dialysis in developing world.
Publisher
An entity responsible for making the resource available
PloS one
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
1905-07
Subject
The topic of the resource
Humans; Adolescent; Retrospective Studies; Child; Infant; *Critical Care/methods; Acute Kidney Injury/blood/mortality/*therapy; Critical Illness/*therapy; Developing Countries; Feasibility Studies; Follow-Up Studies; Length of Stay; Renal Dialysis/adverse effects/instrumentation/*methods; Treatment Outcome; Preschool
Creator
An entity primarily responsible for making the resource
Sethi Sidharth Kumar; Bansal Shyam B; Khare Anshika; Dhaliwal Maninder; Raghunathan Veena; Wadhwani Nikita; Nandwani Ashish; Yadav Dinesh Kumar; Mahapatra Amit Kumar; Raina Rupesh
Description
An account of the resource
BACKGROUND: In critically sick adults, sustained low efficiency dialysis [SLED] appears to be better tolerated hemodynamically and outcomes seem to be comparable to CRRT. However, there is paucity of data in critically sick children. In children, two recent studies from Taiwan (n = 11) and India (n = 68) showed benefits of SLED in critically sick children. AIMS AND OBJECTIVES: The objective of the study was to look at the feasibility and tolerability of sustained low efficiency daily dialysis-filtration [SLEDD-f] in critically sick pediatric patients. MATERIAL AND METHODS: Design: Retrospective study Inclusion criteria: All pediatric patients who had undergone heparin free SLEDD-f from January 2012 to October 2017. Measurements: Data collected included demographic details, vital signs, PRISM III at admission, ventilator parameters (where applicable), number of inotropes, blood gas and electrolytes before, during, and on conclusion of SLED therapy. Technical information was gathered regarding SLEDD-f prescription and complications. RESULTS: Between 2012-2017, a total of 242 sessions of SLEDD-f were performed on 70 patients, out of which 40 children survived. The median age of patients in years was 12 (range 0.8-17 years), and the median weight was 39 kg (range 8.5-66 kg). The mean PRISM score at admission was 8.77+/-7.22. SLEDD-f sessions were well tolerated, with marked improvement in fluid status and acidosis. Premature terminations had to be done in 23 (9.5%) of the sessions. There were 21 sessions (8.6%) terminated due to hypotension and 2 sessions (0.8%) terminated due to circuit clotting. Post- SLEDD-f hypocalcemia occurred in 15 sessions (6.2%), post- SLEDD-f hypophosphatemia occurred in 1 session (0.4%), and post- SLEDD-f hypokalemia occurred in 17 sessions (7.0%). CONCLUSIONS: This study is the largest compiled data on pediatric SLEDD-f use in critically ill patients. Our study confirms the feasibility of heparin free SLEDD-f in a larger pediatric population, and even in children weighing \textless20 kg on inotropic support.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0195536" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0195536</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Critical Care/methods
2018
Acute Kidney Injury/blood/mortality/*therapy
Adolescent
Bansal Shyam B
Child
Critical Illness/*therapy
Department of Internal Medicine
Developing Countries
Dhaliwal Maninder
Feasibility Studies
Follow-Up Studies
Humans
Infant
Khare Anshika
Length of Stay
Mahapatra Amit Kumar
Nandwani Ashish
NEOMED College of Medicine
PloS one
Preschool
Raghunathan Veena
Raina Rupesh
Renal Dialysis/adverse effects/instrumentation/*methods
Retrospective Studies
Sethi Sidharth Kumar
Treatment Outcome
Wadhwani Nikita
Yadav Dinesh Kumar
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0194091" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0194091</a>
Pages
e0194091–e0194091
Issue
3
Volume
13
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Communication calls produced by electrical stimulation of four structures in the guinea pig brain.
Publisher
An entity responsible for making the resource available
PloS one
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
1905-07
Subject
The topic of the resource
Female; Male; Animals; Acoustic Stimulation/methods; Auditory Perception/physiology; Brain/*physiology; Electric Stimulation/methods; Guinea Pigs; Neurons/physiology; Animal/physiology; Vocalization
Creator
An entity primarily responsible for making the resource
Green David B; Shackleton Trevor M; Grimsley Jasmine M S; Zobay Oliver; Palmer Alan R; Wallace Mark N
Description
An account of the resource
One of the main central processes affecting the cortical representation of conspecific vocalizations is the collateral output from the extended motor system for call generation. Before starting to study this interaction we sought to compare the characteristics of calls produced by stimulating four different parts of the brain in guinea pigs (Cavia porcellus). By using anaesthetised animals we were able to reposition electrodes without distressing the animals. Trains of 100 electrical pulses were used to stimulate the midbrain periaqueductal grey (PAG), hypothalamus, amygdala, and anterior cingulate cortex (ACC). Each structure produced a similar range of calls, but in significantly different proportions. Two of the spontaneous calls (chirrup and purr) were never produced by electrical stimulation and although we identified versions of chutter, durr and tooth chatter, they differed significantly from our natural call templates. However, we were routinely able to elicit seven other identifiable calls. All seven calls were produced both during the 1.6 s period of stimulation and subsequently in a period which could last for more than a minute. A single stimulation site could produce four or five different calls, but the amygdala was much less likely to produce a scream, whistle or rising whistle than any of the other structures. These three high-frequency calls were more likely to be produced by females than males. There were also differences in the timing of the call production with the amygdala primarily producing calls during the electrical stimulation and the hypothalamus mainly producing calls after the electrical stimulation. For all four structures a significantly higher stimulation current was required in males than females. We conclude that all four structures can be stimulated to produce fictive vocalizations that should be useful in studying the relationship between the vocal motor system and cortical sensory representation.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0194091" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0194091</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Acoustic Stimulation/methods
Animal/physiology
Animals
Auditory Perception/physiology
Brain/*physiology
Electric Stimulation/methods
Female
Green David B
Grimsley Jasmine M S
Guinea Pigs
Male
Neurons/physiology
Palmer Alan R
PloS one
Shackleton Trevor M
Vocalization
Wallace Mark N
Zobay Oliver
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0190498" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0190498</a>
Pages
e0190498–e0190498
Issue
1
Volume
13
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Validation of Growth Layer Group (GLG) depositional rate using daily incremental growth lines in the dentin of beluga (Delphinapterus leucas (Pallas, 1776)) teeth.
Publisher
An entity responsible for making the resource available
PloS one
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
1905-07
Subject
The topic of the resource
Animals; *Beluga Whale; Dentin/*growth & development; Tooth/*growth & development
Creator
An entity primarily responsible for making the resource
Waugh David A; Suydam Robert S; Ortiz Joseph D; Thewissen J G M
Description
An account of the resource
Counts of Growth Layer Groups (GLGs) in the dentin of marine mammal teeth are widely used as indicators of age. In most marine mammals, observations document that GLGs are deposited yearly, but in beluga whales, some studies have supported the view that two GLGs are deposited each year. Our understanding of beluga life-history differs substantially depending on assumptions regarding the timing of GLG deposition; therefore, resolving this issue has important considerations for population assessments. In this study, we used incremental lines that represent daily pulses of dentin mineralization to test the hypothesis that GLGs in beluga dentin are deposited on a yearly basis. Our estimate of the number of daily growth lines within one GLG is remarkably close to 365 days within error, supporting the hypothesis that GLGs are deposited annually in beluga. We show that measurement of daily growth increments can be used to validate the time represented by GLGs in beluga. Furthermore, we believe this methodology may have broader applications to age estimation in other taxa.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0190498" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0190498</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Beluga Whale
2018
Animals
Dentin/*growth & development
Department of Anatomy & Neurobiology
NEOMED College of Medicine
Ortiz Joseph D
PloS one
Suydam Robert S
Thewissen J G M
Tooth/*growth & development
Waugh David A
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0180106" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0180106</a>
Pages
e0180106–e0180106
Issue
6
Volume
12
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
TRPA1 and TRPV1 contribute to propofol-mediated antagonism of U46619-induced constriction in murine coronary arteries.
Publisher
An entity responsible for making the resource available
PloS one
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017
Subject
The topic of the resource
Male; Animals; Mice; TRPV Cation Channels/genetics/*metabolism; TRPA1 Cation Channel; Endothelial Cells/drug effects/metabolism; Nitric Oxide Synthase Type III/metabolism; Vasodilator Agents/*pharmacology; Coronary Vessels/*drug effects/metabolism; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits/metabolism; Microvessels/drug effects/metabolism; Propofol/*pharmacology; Transient Receptor Potential Channels/genetics/*metabolism; Vasoconstrictor Agents/antagonists & inhibitors/pharmacology; Vasodilation/drug effects/physiology; Cells; Cultured; Inbred C57BL; Knockout; 15-Hydroxy-11 alpha; 9 alpha-(epoxymethano)prosta-5; 13-dienoic Acid/*antagonists & inhibitors/pharmacology
Creator
An entity primarily responsible for making the resource
Sinharoy Pritam; Bratz Ian N; Sinha Sayantani; Showalter Loral E; Andrei Spencer R; Damron Derek S
Description
An account of the resource
BACKGROUND: Transient receptor potential (TRP) ion channels have emerged as key components contributing to vasoreactivity. Propofol, an anesthetic is associated with adverse side effects including hypotension and acute pain upon infusion. Our objective was to determine the extent to which TRPA1 and/or TRPV1 ion channels are involved in mediating propofol-induced vasorelaxation of mouse coronary arterioles in vitro and elucidate the potential cellular signal transduction pathway by which this occurs. METHODS: Hearts were excised from anesthetized mice and coronary arterioles were dissected from control C57Bl/6J, TRPA1-/-, TRPV1-/- and double-knockout mice (TRPAV-/-). Isolated microvessels were cannulated and secured in a temperature-controlled chamber and allowed to equilibrate for 1 hr. Vasoreactivity studies were performed in microvessels pre-constricted with U46619 to assess the dose-dependent relaxation effects of propofol on coronary microvascular tone. RESULTS: Propofol-induced relaxation was unaffected in vessels obtained from TRPV1-/- mice, markedly attenuated in pre-constricted vessels obtained from TRPA1-/- mice and abolished in vessels obtained from
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0180106" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0180106</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
13-dienoic Acid/*antagonists & inhibitors/pharmacology
15-Hydroxy-11 alpha
2017
9 alpha-(epoxymethano)prosta-5
Andrei Spencer R
Animals
Bratz Ian N
Cells
Coronary Vessels/*drug effects/metabolism
Cultured
Damron Derek S
Endothelial Cells/drug effects/metabolism
Inbred C57BL
Knockout
Large-Conductance Calcium-Activated Potassium Channel alpha Subunits/metabolism
Male
Mice
Microvessels/drug effects/metabolism
Nitric Oxide Synthase Type III/metabolism
PloS one
Propofol/*pharmacology
Showalter Loral E
Sinha Sayantani
Sinharoy Pritam
Transient Receptor Potential Channels/genetics/*metabolism
TRPA1 Cation Channel
TRPV Cation Channels/genetics/*metabolism
Vasoconstrictor Agents/antagonists & inhibitors/pharmacology
Vasodilation/drug effects/physiology
Vasodilator Agents/*pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0178233" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0178233</a>
Pages
e0178233–e0178233
Issue
5
Volume
12
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Treatment of AKI in developing and developed countries: An international survey of pediatric dialysis modalities.
Publisher
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PloS one
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017
Subject
The topic of the resource
Humans; Child; Surveys and Questionnaires; *Developed Countries; *Developing Countries; Acute Kidney Injury/*therapy; Renal Dialysis/*methods
Creator
An entity primarily responsible for making the resource
Raina Rupesh; Chauvin Abigail M; Bunchman Timothy; Askenazi David; Deep Akash; Ensley Michael J; Krishnappa Vinod; Sethi Sidharth Kumar
Description
An account of the resource
HYPOTHESIS: Acute kidney injury (AKI) is a common cause of morbidity and mortality worldwide, with a pediatric incidence ranging from 19.3% to 24.1%. Treatment of pediatric AKI is a source of debate in varying geographical regions. Currently CRRT is the treatment for pediatric AKI, but limitations due to cost and accessibility force use of adult equipment and other therapeutic options such as peritoneal dialysis (PD) and hemodialysis (HD). It was hypothesized that more cost-effective measures would likely be used in developing countries due to lesser resource availability. METHODS: A 26-question internet-based survey was distributed to 650 pediatric Nephrologists. There was a response rate of 34.3% (223 responses). The survey was distributed via pedneph and pcrrt email servers, inquiring about demographics, technology, resources, pediatric-specific supplies, and preference in renal replacement therapy (RRT) in pediatric AKI. The main method of analysis was to compare responses about treatments between nephrologists in developed countries and nephrologists in developing countries using difference-of-proportions tests. RESULTS: PD was available in all centers surveyed, while HD was available in 85.1% and 54.1% (p = 0.00), CRRT was available in 60% and 33.3% (p = 0.001), and SLED was available in 20% and 25% (p = 0.45) centers of developed and developing world respectively. In developing countries, 68.5% (p = 0.000) of physicians preferred PD to costlier therapies, while in developed countries it was found that physicians favored HD (72%, p = 0.00) or CRRT (24%, p = 0.041) in infants. CONCLUSIONS: Lack of availability of resources, trained physicians and funds often preclude standards of care in developing countries, and there is much development needed in terms of meeting higher global standards for treating pediatric AKI patients. PD remains the main modality of choice for treatment of AKI in infants in developing world.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0178233" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0178233</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Developed Countries
*Developing Countries
2017
Acute Kidney Injury/*therapy
Askenazi David
Bunchman Timothy
Chauvin Abigail M
Child
Deep Akash
Department of Internal Medicine
Ensley Michael J
Humans
Krishnappa Vinod
NEOMED College of Graduate Studies Student
NEOMED College of Medicine
PloS one
Raina Rupesh
Renal Dialysis/*methods
Sethi Sidharth Kumar
Surveys and Questionnaires
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0166560" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0166560</a>
Pages
e0166560–e0166560
Issue
11
Volume
11
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Salvianolic Acid B Alleviates Heart Failure by Inactivating ERK1/2/GATA4 Signaling Pathway after Pressure Overload in Mice.
Publisher
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PloS one
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016
Subject
The topic of the resource
Male; Animals; Mice; Phosphorylation/drug effects; Signal Transduction/*drug effects; Rats; Cell Line; Proto-Oncogene Proteins c-akt/metabolism; Benzofurans/chemistry/*pharmacology; Blood Pressure/drug effects; GATA4 Transcription Factor/metabolism; Heart Failure/metabolism/*pathology; Heart Ventricles/diagnostic imaging; Mitogen-Activated Protein Kinase 1/metabolism; Mitogen-Activated Protein Kinase 3/metabolism; Myocardium/metabolism/pathology; Drugs; Inbred C57BL; Animal; Disease Models; Myocytes; Aorta; Brain/blood; Natriuretic Peptide; Cardiac/cytology/drug effects/metabolism; Chinese Herbal/chemistry/pharmacology; Thoracic/surgery
Creator
An entity primarily responsible for making the resource
Yu Juan; Chen Renshan; Tan Yafang; Wu Jiashin; Qi Jianyong; Zhang Minzhou; Gu Weiwang
Description
An account of the resource
BACKGROUND: Heart failure(HF) is a dangerous disease that affects millions of patients. Radix Salvia is widely used in Chinese clinics to treat heart diseases. Salvianolic acid B(SalB) is the major active component of Radix Salvia. This study investigated the mechanisms of action and effects of SalB on HF in an experimental mouse model of HF. METHODS: We created a mouse model of HF by inducing pressure overload with transverse aortic constriction(TAC) surgery for 2 weeks and compared among 4 study groups: SHAM group (n = 10), TAC group (n = 9), TAC+MET group (metprolol, positive drug treatment, n = 9) and TAC+SalB group (SalB, 240 mg*kg-1*day-1, n = 9). Echocardiography was used to evaluate the dynamic changes in cardiac structure and function in vivo. Plasma brain natriuretic peptide (BNP) concentration was detected by Elisa method. In addition, H9C2 rat cardiomyocytes were cultured and Western blot were implemented to evaluate the phosphorylation of ERK1/2, AKT, and protein expression of GATA4. RESULTS: SalB significantly inhibited the phosphorylation of Thr202/Tyr204 sites of ERK1/2, but not Ser473 site of AKT, subsequently inhibited protein expression of GATA4 and plasma BNP(P \textless 0.001), and then inhibited HF at 2 weeks after TAC surgery. CONCLUSIONS: Our data provide a mechanism of inactivating the ERK1/2/GATA4 signaling pathway for SalB inhibition of the TAC-induced HF.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0166560" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0166560</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2016
Animal
Animals
Aorta
Benzofurans/chemistry/*pharmacology
Blood Pressure/drug effects
Brain/blood
Cardiac/cytology/drug effects/metabolism
Cell Line
Chen Renshan
Chinese Herbal/chemistry/pharmacology
Disease Models
Drugs
GATA4 Transcription Factor/metabolism
Gu Weiwang
Heart Failure/metabolism/*pathology
Heart Ventricles/diagnostic imaging
Inbred C57BL
Male
Mice
Mitogen-Activated Protein Kinase 1/metabolism
Mitogen-Activated Protein Kinase 3/metabolism
Myocardium/metabolism/pathology
Myocytes
Natriuretic Peptide
Phosphorylation/drug effects
PloS one
Proto-Oncogene Proteins c-akt/metabolism
Qi Jianyong
Rats
Signal Transduction/*drug effects
Tan Yafang
Thoracic/surgery
Wu Jiashin
Yu Juan
Zhang Minzhou
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0156753" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0156753</a>
Pages
e0156753–e0156753
Issue
6
Volume
11
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Severe Bone Loss as Part of the Life History Strategy of Bowhead Whales.
Publisher
An entity responsible for making the resource available
PloS one
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016
Subject
The topic of the resource
Animals; *Life History Traits; Bone and Bones/diagnostic imaging/pathology; Bone Resorption/*pathology; Bowhead Whale/*growth & development; Tomography; X-Ray Computed; Computer-Assisted; Image Processing
Creator
An entity primarily responsible for making the resource
George John C; Stimmelmayr Raphaela; Suydam Robert; Usip Sharon; Givens Geof; Sformo Todd; Thewissen J G M
Description
An account of the resource
The evolution of baleen constituted a major evolutionary change that made it possible for baleen whales to reach enormous body sizes while filter feeding on tiny organisms and migrating over tremendous distances. Bowhead whales (Balaena mysticetus) live in the Arctic where the annual cycle of increasing and decreasing ice cover affects their habitat, prey, and migration. During the nursing period, bowheads grow rapidly; but between weaning and approximately year 5, bowhead whales display sustained baleen and head growth while limiting growth in the rest of their bodies. During this period, they withdraw resources from the skeleton, in particular the ribs, which may lose 40% of bone mass. Such dramatic changes in bones of immature mammals are rare, although fossil cetaceans between 40 and 50 million years ago show an array of rib specializations that include bone loss and are usually interpreted as related to buoyancy control.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0156753" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0156753</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Life History Traits
2016
Animals
Bone and Bones/diagnostic imaging/pathology
Bone Resorption/*pathology
Bowhead Whale/*growth & development
Computer-Assisted
Department of Anatomy & Neurobiology
George John C
Givens Geof
Image Processing
NEOMED College of Medicine
PloS one
Sformo Todd
Stimmelmayr Raphaela
Suydam Robert
Thewissen J G M
Tomography
Usip Sharon
X-Ray Computed
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0149420" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0149420</a>
Pages
e0149420–e0149420
Issue
2
Volume
11
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The Difference in Prognosis between Renal Sinus Fat and Perinephric Fat Invasion for pT3a Renal Cell Carcinoma: A Meta-Analysis.
Publisher
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PloS one
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
1905-07
Subject
The topic of the resource
Female; Humans; Male; Neoplasm Staging; Odds Ratio; Prognosis; Neoplasm Invasiveness; Proportional Hazards Models; Intra-Abdominal Fat/*pathology; Kidney Neoplasms/*mortality/*pathology; Publication Bias; Carcinoma; Renal Cell/*mortality/*pathology
Creator
An entity primarily responsible for making the resource
Zhang Zhi-Ling; Yu Chun-Ping; Velet Liliya; Li Yong-Hong; Jiang Li-Juan; Zhou Fang-Jian
Description
An account of the resource
BACKGROUND: In the current Tumour-Node-Metastasis (TNM) classification system for renal cell carcinoma (RCC), both renal sinus fat invasion (SFI) and perinephric fat invasion (PFI) are defined as T3a, suggesting that the prognosis should be similar for the two pathologic findings. Several studies, however, have reported a worse prognosis for SFI in patients with a T3a tumor. In order to compare the prognosis of these two pathologic findings (SFI versus. PFI) in a more comprehensive way, this meta-analysis was performed. METHODS: To identify relevant studies, Medline, Embase, Cochrane Library, and Scopus database were searched from the inception until October 2014. A meta-analysis was performed using Review Manager 5.2 and STATA 11. Pooled Odds ratio (OR) and/or hazard ratio (HR) with 95% confidence interval (CI) were calculated to examine the risk or hazard association. RESULTS: A total of 6 studies including 1031 patients qualified for analysis. T3a RCC patients with SFI were significantly associated with poor cancer specific survival(CSS) (HR: 1.47, 95% CI: 1.19-1.83; P\textless0.001) compared to those with PFI. In T3aNx/N0M0 subgroup, SFI patients also showed a worse prognosis than those with PFI (CSS, HR: 1.94, 95% CI: 1.21-3.12; P = 0.006). T3a RCC patients with SFI had higher Furhman grade, greater possibility of lymph node metastasis, sarcomatoid differentiation and tumour necrosis. Main limitation is the relatively small number of included studies. CONCLUSION: The present meta-analysis suggested that SFI is associated with worse CSS in patients with pT3a RCC. However, due to the small number of included studies, future studies with a large sample size are required to further verify our findings.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0149420" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0149420</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2016
Carcinoma
Female
Humans
Intra-Abdominal Fat/*pathology
Jiang Li-Juan
Kidney Neoplasms/*mortality/*pathology
Li Yong-Hong
Male
Neoplasm Invasiveness
Neoplasm Staging
Odds Ratio
PloS one
Prognosis
Proportional Hazards Models
Publication Bias
Renal Cell/*mortality/*pathology
Velet Liliya
Yu Chun-Ping
Zhang Zhi-Ling
Zhou Fang-Jian
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0149102" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0149102</a>
Pages
e0149102–e0149102
Issue
2
Volume
11
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Muscle Logic: New Knowledge Resource for Anatomy Enables Comprehensive Searches of the Literature on the Feeding Muscles of Mammals.
Publisher
An entity responsible for making the resource available
PloS one
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
1905-7
Subject
The topic of the resource
Humans; Animals; *Databases as Topic; Oropharynx/anatomy & histology; Pharyngeal Muscles/*anatomy & histology; Search Engine
Creator
An entity primarily responsible for making the resource
Druzinsky Robert E; Balhoff James P; Crompton Alfred W; Done James; German Rebecca Z; Haendel Melissa A; Herrel Anthony; Herring Susan W; Lapp Hilmar; Mabee Paula M; Muller Hans-Michael; Mungall Christopher J; Sternberg Paul W; Van Auken Kimberly; Vinyard Christopher J; Williams Susan H; Wall Christine E
Description
An account of the resource
BACKGROUND: In recent years large bibliographic databases have made much of the published literature of biology available for searches. However, the capabilities of the search engines integrated into these databases for text-based bibliographic searches are limited. To enable searches that deliver the results expected by comparative anatomists, an underlying logical structure known as an ontology is required. DEVELOPMENT AND TESTING OF THE ONTOLOGY: Here we present the Mammalian Feeding Muscle Ontology (MFMO), a multi-species ontology focused on anatomical structures that participate in feeding and other oral/pharyngeal behaviors. A unique feature of the MFMO is that a simple, computable, definition of each muscle, which includes its attachments and innervation, is true across mammals. This construction mirrors the logical foundation of comparative anatomy and permits searches using language familiar to biologists. Further, it provides a template for muscles that will be useful in extending any anatomy ontology. The MFMO is developed to support the Feeding Experiments End-User Database Project (FEED, https://feedexp.org/), a publicly-available, online repository for physiological data collected from in vivo studies of feeding (e.g., mastication, biting, swallowing) in mammals. Currently the MFMO is integrated into FEED and also into two literature-specific implementations of Textpresso, a text-mining system that facilitates powerful searches of a corpus of scientific publications. We evaluate the MFMO by asking questions that test the ability of the ontology to return appropriate answers (competency questions). We compare the results of queries of the MFMO to results from similar searches in PubMed and Google Scholar. RESULTS AND SIGNIFICANCE: Our tests demonstrate that the MFMO is competent to answer queries formed in the common language of comparative anatomy, but PubMed and Google Scholar are not. Overall, our results show that by incorporating anatomical ontologies into searches, an expanded and anatomically comprehensive set of results can be obtained. The broader scientific and publishing communities should consider taking up the challenge of semantically enabled search capabilities.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0149102" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0149102</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Databases as Topic
2016
Animals
Balhoff James P
Crompton Alfred W
Department of Anatomy & Neurobiology
Done James
Druzinsky Robert E
German Rebecca Z
Haendel Melissa A
Herrel Anthony
Herring Susan W
Humans
Lapp Hilmar
Mabee Paula M
Muller Hans-Michael
Mungall Christopher J
NEOMED College of Medicine
Oropharynx/anatomy & histology
Pharyngeal Muscles/*anatomy & histology
PloS one
Search Engine
Sternberg Paul W
Van Auken Kimberly
Vinyard Christopher J
Wall Christine E
Williams Susan H
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0122189" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0122189</a>
Pages
e0122189–e0122189
Issue
4
Volume
10
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Propofol causes vasodilation in vivo via TRPA1 ion channels: role of nitric oxide and BKCa channels.
Publisher
An entity responsible for making the resource available
PloS one
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
1905-07
Subject
The topic of the resource
Female; Male; Animals; Mice; Signal Transduction; TRPA1 Cation Channel; Arterial Pressure/drug effects; Vasodilator Agents/*pharmacology; Propofol/*pharmacology; Transient Receptor Potential Channels/genetics/*metabolism; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits/*physiology; Nitric Oxide/*physiology; TRPV Cation Channels/genetics/metabolism; Inbred C57BL; Knockout; Drug Evaluation; Preclinical
Creator
An entity primarily responsible for making the resource
Sinha Sayantani; Sinharoy Pritam; Bratz Ian N; Damron Derek S
Description
An account of the resource
BACKGROUND: Transient receptor potential (TRP) ion channels of the A1 (TRPA1) and V1 (TRPV1) subtypes are key regulators of vasomotor tone. Propofol is an intravenous anesthetic known to cause vasorelaxation. Our objectives were to examine the extent to which TRPA1 and/or TRPV1 ion channels mediate propofol-induced depressor responses in vivo and to delineate the signaling pathway(s) involved. METHODS: Mice were subjected to surgery under 1.5-2.5% sevoflurane gas with supplemental oxygen. After a stable baseline in mean arterial pressure (MAP) was achieved propofol (2.5, 5.0, 10.0 mg/kg/min) was administered to assess the hemodynamic actions of the intravenous anesthetic. The effect of nitric oxide synthase (NOS) inhibition with L-NAME and/or calcium-gated K+ channel (BKCa) inhibition with Penetrim A (Pen A), alone and in combination, on propofol-induced decreases in mean arterial pressure were assessed in control C57Bl/6J, TRPA1-/-, TRPV1-/- and double-knockout mice (TRPAV-/-). RESULTS: Propofol decreased MAP in control mice and this effect was markedly attenuated in
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0122189" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0122189</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2015
Animals
Arterial Pressure/drug effects
Bratz Ian N
Damron Derek S
Drug Evaluation
Female
Inbred C57BL
Knockout
Large-Conductance Calcium-Activated Potassium Channel alpha Subunits/*physiology
Male
Mice
Nitric Oxide/*physiology
PloS one
Preclinical
Propofol/*pharmacology
Signal Transduction
Sinha Sayantani
Sinharoy Pritam
Transient Receptor Potential Channels/genetics/*metabolism
TRPA1 Cation Channel
TRPV Cation Channels/genetics/metabolism
Vasodilator Agents/*pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0115919" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0115919</a>
Pages
e0115919–e0115919
Issue
1
Volume
10
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
MiR-21 enhances melanoma invasiveness via inhibition of tissue inhibitor of metalloproteinases 3 expression: in vivo effects of MiR-21 inhibitor.
Publisher
An entity responsible for making the resource available
PloS one
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
2015
Subject
The topic of the resource
Humans; Gene Expression Regulation; Cell Line; MicroRNAs/*genetics/metabolism; Cell Movement/genetics; Cell Proliferation/genetics; Melanoma/*genetics/metabolism/pathology; Neoplasm Invasiveness/*genetics/pathology; Skin Neoplasms/*genetics/metabolism/pathology; Tissue Inhibitor of Metalloproteinase-3/*genetics/metabolism; RNA; Tumor; Neoplastic; Small Interfering
Creator
An entity primarily responsible for making the resource
Martin del Campo Sara E; Latchana Nicholas; Levine Kala M; Grignol Valerie P; Fairchild Ene T; Jaime-Ramirez Alena Cristina; Dao Thao-Vi; Karpa Volodymyr I; Carson Mary; Ganju Akaansha; Chan Anthony N; Carson William E 3rd
Description
An account of the resource
Metastatic melanoma is the most aggressive form of this cancer. It is important to understand factors that increase or decrease metastatic activity in order to more effectively research and implement treatments for melanoma. Increased cell invasion through the extracellular matrix is required for metastasis and is enhanced by matrix metalloproteinases (MMPs). Tissue inhibitor of metalloproteinases 3 (TIMP3) inhibits MMP activity. It was previously shown by our group that miR-21, a potential regulator of TIMP3, is over-expressed in cutaneous melanoma. It was therefore hypothesized that increased levels of miR-21 expression would lead to decreased expression of TIMP3 and thereby enhance the invasiveness of melanoma cells. miR-21 over-expression in the melanoma cell lines WM1552c, WM793b, A375 and MEL 39 was accomplished via transfection with pre-miR-21. Immunoblot analysis of miR-21-overexpressing cell lines revealed reduced expression of TIMP3 as compared to controls. This in turn led to a significant increase in the invasiveness of the radial growth phase cell line WM1552c and the vertical growth phase cell line WM793b (p \textless 0.05), but not in the metastatic cell lines A375 or MEL 39. The proliferation and migration of miR-21 over-expressing cell lines was not affected. Reduced expression of TIMP3 was achieved by siRNA knockdown and significantly enhanced invasion of melanoma cell lines, mimicking the effects of miR-21 over-expression. Treatment of tumor cells with a linked nucleic acid antagomir to miR-21 inhibited tumor growth and increased tumor expression of TIMP3 in vivo in 01B74 Athymic NCr-nu/nu mice. Intra-tumoral injections of anti-miR-21 produced similar effects. This data shows that increased expression of miR-21 enhanced the invasive potential of melanoma cell lines through TIMP3 inhibition. Therefore, inhibition of miR-21 in melanoma may reduce melanoma invasiveness.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0115919" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0115919</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2015
Carson Mary
Carson William E 3rd
Cell Line
Cell Movement/genetics
Cell Proliferation/genetics
Chan Anthony N
Dao Thao-Vi
Fairchild Ene T
Ganju Akaansha
Gene Expression Regulation
Grignol Valerie P
Humans
Jaime-Ramirez Alena Cristina
Karpa Volodymyr I
Latchana Nicholas
Levine Kala M
Martin del Campo Sara E
Melanoma/*genetics/metabolism/pathology
MicroRNAs/*genetics/metabolism
Neoplasm Invasiveness/*genetics/pathology
Neoplastic
PloS one
RNA
Skin Neoplasms/*genetics/metabolism/pathology
Small Interfering
Tissue Inhibitor of Metalloproteinase-3/*genetics/metabolism
Tumor
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0115325" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0115325</a>
Pages
e0115325–e0115325
Issue
2
Volume
10
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Integrin mediated adhesion of osteoblasts to connective tissue growth factor (CTGF/CCN2) induces cytoskeleton reorganization and cell differentiation.
Publisher
An entity responsible for making the resource available
PloS one
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
2015
Subject
The topic of the resource
Animals; Mice; Signal Transduction; Cell Line; Cell Adhesion; *Cell Differentiation; Connective Tissue Growth Factor/chemistry/*metabolism; Core Binding Factor Alpha 1 Subunit/metabolism; Cytoskeleton/*metabolism; Extracellular Signal-Regulated MAP Kinases/metabolism; Focal Adhesion Protein-Tyrosine Kinases/metabolism; Integrins/*metabolism; Osteoblasts/*cytology/*metabolism; rac GTP-Binding Proteins/metabolism; Transcriptional Activation; Receptors; Vitronectin/metabolism
Creator
An entity primarily responsible for making the resource
Hendesi Honey; Barbe Mary F; Safadi Fayez F; Monroy M Alexandra; Popoff Steven N
Description
An account of the resource
Pre-osteoblast adhesion and interaction with extracellular matrix (ECM) proteins through integrin receptors result in activation of signaling pathways regulating osteoblast differentiation. Connective tissue growth factor (CTGF/CCN2) is a matricellular protein secreted into the ECM. Prior studies in various cell types have shown that cell adhesion to CTGF via integrin receptors results in activation of specific signaling pathways that regulate cell functions, such as differentiation and cytoskeletal reorganization. To date, there are no studies that have examined whether CTGF can serve as an adhesive substrate for osteoblasts. In this study, we used the MC3T3-E1 cell line to demonstrate that CTGF serves as an adhesive matrix for osteoblasts. Anti-integrin blocking experiments and co-immunoprecipitation assays demonstrated that the integrin alphavbeta1 plays a key role in osteoblast adhesion to a CTGF matrix. Immunofluorescence staining of osteoblasts cultured on a CTGF matrix confirmed actin cytoskeletal reorganization, enhanced spreading, formation of focal adhesions, and activation of Rac1. Alkaline phosphatase (ALP) staining and activity assays, as well as Alizarin red staining demonstrated that osteoblast attachment to CTGF matrix enhanced maturation, bone nodule formation and matrix mineralization. To investigate whether the effect of CTGF on osteoblast differentiation involves integrin-mediated activation of specific signaling pathways, we performed Western blot, chromatin immunoprecipitation (ChIP) and qPCR assays. Osteoblasts cultured on a CTGF matrix showed increased total and phosphorylated (activated) forms of focal adhesion kinase (FAK) and extracellular signal-regulated kinase (ERK). Inhibition of ERK blocked osteogenic differentiation in cells cultured on a CTGF matrix. There was an increase in runt-related transcription factor 2 (Runx2) binding to the osteocalcin gene promoter, and in the expression of osteogenic markers regulated by Runx2. Collectively, the results of this study are the first to demonstrate CTGF serves as a suitable matrix protein, enhancing osteoblast adhesion (via alphavbeta1 integrin) and promoting cell spreading via cytoskeletal reorganization and Rac1 activation. Furthermore, integrin-mediated activation of ERK signaling resulted in increased osteoblast differentiation accompanied by an increase in Runx2 binding to the osteocalcin promoter and in the expression of osteogenic markers.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0115325" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0115325</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Cell Differentiation
2015
Animals
Barbe Mary F
Cell Adhesion
Cell Line
Connective Tissue Growth Factor/chemistry/*metabolism
Core Binding Factor Alpha 1 Subunit/metabolism
Cytoskeleton/*metabolism
Department of Anatomy & Neurobiology
Extracellular Signal-Regulated MAP Kinases/metabolism
Focal Adhesion Protein-Tyrosine Kinases/metabolism
Hendesi Honey
Integrins/*metabolism
Mice
Monroy M Alexandra
NEOMED College of Medicine
Osteoblasts/*cytology/*metabolism
PloS one
Popoff Steven N
rac GTP-Binding Proteins/metabolism
Receptors
Safadi Fayez F
Signal Transduction
Transcriptional Activation
Vitronectin/metabolism
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0109663" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0109663</a>
Pages
e109663–e109663
Issue
10
Volume
9
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Hepatic carboxylesterase 1 is induced by glucose and regulates postprandial glucose levels.
Publisher
An entity responsible for making the resource available
PloS one
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
2014
Subject
The topic of the resource
Male; Animals; Mice; Blood Glucose/*metabolism; Histones/metabolism; Gene Expression Regulation; Acetylation/drug effects; Glucose/*pharmacology; Homeostasis; Carboxylic Ester Hydrolases/*metabolism; Nutritional Status; *Postprandial Period; ATP Citrate (pro-S)-Lyase/metabolism; Chromatin/metabolism; Liver/*enzymology; Inbred C57BL; Enzymologic/drug effects
Creator
An entity primarily responsible for making the resource
Xu Jiesi; Yin Liya; Xu Yang; Li Yuanyuan; Zalzala Munaf; Cheng Gang; Zhang Yanqiao
Description
An account of the resource
Metabolic syndrome, characterized by obesity, hyperglycemia, dyslipidemia and hypertension, increases the risks for cardiovascular disease, diabetes and stroke. Carboxylesterase 1 (CES1) is an enzyme that hydrolyzes triglycerides and cholesterol esters, and is important for lipid metabolism. Our previous data show that over-expression of mouse hepatic CES1 lowers plasma glucose levels and improves insulin sensitivity in diabetic ob/ob mice. In the present study, we determined the physiological role of hepatic CES1 in glucose homeostasis. Hepatic CES1 expression was reduced by fasting but increased in diabetic mice. Treatment of mice with glucose induced hepatic CES1 expression. Consistent with the in vivo study, glucose stimulated CES1 promoter activity and increased acetylation of histone 3 and histone 4 in the CES1 chromatin. Knockdown of ATP-citrate lyase (ACL), an enzyme that regulates histone acetylation, abolished glucose-mediated histone acetylation in the CES1 chromatin and glucose-induced hepatic CES1 expression. Finally, knockdown of hepatic CES1 significantly increased postprandial blood glucose levels. In conclusion, the present study uncovers a novel glucose-CES1-glucose pathway which may play an important role in regulating postprandial blood glucose levels.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0109663" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0109663</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Postprandial Period
2014
Acetylation/drug effects
Animals
ATP Citrate (pro-S)-Lyase/metabolism
Blood Glucose/*metabolism
Carboxylic Ester Hydrolases/*metabolism
Cheng Gang
Chromatin/metabolism
Department of Integrative Medical Sciences
Enzymologic/drug effects
Gene Expression Regulation
Glucose/*pharmacology
Histones/metabolism
Homeostasis
Inbred C57BL
Li Yuanyuan
Liver/*enzymology
Male
Mice
NEOMED College of Medicine
Nutritional Status
PloS one
Xu Jiesi
Xu Yang
Yin Liya
Zalzala Munaf
Zhang Yanqiao
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0109232" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0109232</a>
Pages
e109232–e109232
Issue
10
Volume
9
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Anthracobunids from the middle eocene of India and pakistan are stem perissodactyls.
Publisher
An entity responsible for making the resource available
PloS one
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
1905-7
Subject
The topic of the resource
Animals; *Fossils; India; Dugong; Elephants; Pakistan
Creator
An entity primarily responsible for making the resource
Cooper Lisa Noelle; Seiffert Erik R; Clementz Mark; Madar Sandra I; Bajpai Sunil; Hussain S Taseer; Thewissen J G M
Description
An account of the resource
Anthracobunidae is an Eocene family of large mammals from south Asia that is commonly considered to be part of the radiation that gave rise to elephants (proboscideans) and sea cows (sirenians). We describe a new collection of anthracobunid fossils from Middle Eocene rocks of Indo-Pakistan that more than doubles the number of known anthracobunid fossils and challenges their putative relationships, instead implying that they are stem perissodactyls. Cranial, dental, and postcranial elements allow a revision of species and the recognition of a new anthracobunid genus. Analyses of stable isotopes and long bone geometry together suggest that most anthracobunids fed on land, but spent a considerable amount of time near water. This new evidence expands our understanding of stem perissodactyl diversity and sheds new light on perissodactyl origins.
Identifier
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<a href="http://doi.org/10.1371/journal.pone.0109232" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0109232</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Fossils
2014
Animals
Bajpai Sunil
Clementz Mark
Cooper Lisa Noelle
Department of Anatomy & Neurobiology
Dugong
Elephants
Hussain S Taseer
India
Madar Sandra I
NEOMED College of Medicine
Pakistan
PloS one
Seiffert Erik R
Thewissen J G M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0106471" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0106471</a>
Pages
e106471–e106471
Issue
9
Volume
9
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Alterations in gene array patterns in dendritic cells from aged humans.
Publisher
An entity responsible for making the resource available
PloS one
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
1905-7
Subject
The topic of the resource
Adult; Female; Humans; Male; Aged; Young Adult; Immunity; Cluster Analysis; Age Factors; Gene Expression Regulation; *Gene Expression Profiling; *Transcriptome; Adaptive Immunity/genetics; Antigen-Presenting Cells/immunology/metabolism; Dendritic Cells/immunology/*metabolism; G1 Phase; Healthy Volunteers; 80 and over; Innate/genetics
Creator
An entity primarily responsible for making the resource
Cao Jia-ning; Agrawal Anshu; Sharman Edward; Jia Zhenyu; Gupta Sudhir
Description
An account of the resource
Dendritic cells (DCs) are major antigen-presenting cells that play a key role in initiating and regulating innate and adaptive immune responses. DCs are critical mediators of tolerance and immunity. The functional properties of DCs decline with age. The purpose of this study was to define the age-associated molecular changes in DCs by gene array analysis using Affymatrix GeneChips. The expression levels of a total of 260 genes (1.8%) were significantly different (144 down-regulated and 116 upregulated) in monocyte-derived DCs (MoDCs) from aged compared to young human donors. Of the 260 differentially expressed genes, 24% were down-regulated by more than 3-fold, suggesting that a large reduction in expression occurred for a notable number of genes in the aged. Our results suggest that the genes involved in immune response to pathogens, cell migration and T cell priming display significant age-related changes. Furthermore, downregulated genes involved in cell cycle arrest and DNA replication may play a critical role in aging-associated genetic instability. These changes in gene expression provide molecular based evidence for age-associated functional abnormalities in human DCs that may be responsible for the defects in adaptive immunity observed in the elderly.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0106471" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0106471</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Gene Expression Profiling
*Transcriptome
2014
80 and over
Adaptive Immunity/genetics
Adult
Age Factors
Aged
Agrawal Anshu
Antigen-Presenting Cells/immunology/metabolism
Cao Jia-ning
Cluster Analysis
Dendritic Cells/immunology/*metabolism
Female
G1 Phase
Gene Expression Regulation
Gupta Sudhir
Healthy Volunteers
Humans
Immunity
Innate/genetics
Jia Zhenyu
Male
PloS one
Sharman Edward
Young Adult
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0103794" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0103794</a>
Pages
e103794–e103794
Issue
8
Volume
9
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Interleukin-1/toll-like receptor-induced nuclear factor kappa B signaling participates in intima hyperplasia after carotid artery balloon injury in goto-kakizaki rats: a potential target therapy pathway.
Publisher
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PloS one
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
2014
Subject
The topic of the resource
Male; Animals; Rats; NF-kappa B/*metabolism; Signal Transduction/genetics/physiology; Carotid Artery Injuries/*metabolism; Hyperplasia/*metabolism; Interleukin-1/*metabolism; Toll-Like Receptors/*metabolism; Tunica Intima/*metabolism/*pathology; Wistar
Creator
An entity primarily responsible for making the resource
Zhang Xiaotian; Wang Yi; Hu Wenjing; Li Dongye; Zhou Zhongmin; Pan Defeng; Wu Wanling; Xu Tongda
Description
An account of the resource
The value of restenosis after percutaneous coronary intervention (PCI) is recognized worldwide, especially for diabetic patients. Interleukin-1/Toll-like receptor (IL-1/TLR) signaling is involved in innate and adaptive immune responses, but whether and how the IL-1/TLR-induced nuclear factor kappa B (NFkappaB) pathway plays key roles in intimal formation is unclear. The underlying mechanism of intima hyperplasia was investigated with a model of carotid balloon injury in Goto-Kakizaki (GK) and Wistar rats and with lipopolysaccharide-stimulated macrophages. Elastic-van Gieson staining showed the medial area peakedon Day 3 post-injury and decreased by Day 7 post-injury in both GK and Wistar rats. The N/M at Day 7 in GK rats was significantly higher than in Wistar rats (p\textless0.001). The percent of 5-ethynyl-2'-deoxyuridine (EdU) staining-positive cells on Day 3 post-injury was greater than seen on Day 7 post-injury in GK and Wistar rats. The percent of EdU-positive cells on Days 3 and 7 post-injury in Wistar rats was less than that found in GK rats (p\textless0.01; p\textless0.05). NFkappaBp65 immunostaining had increased by Day 7 post-injury. Agilent Whole Genome Oligo Microarray verified that the IL-1/TLR-induced NFkappaB pathway was activated by carotid balloon injury. TLR4, IL-1 receptor associated kinase, inhibitors alpha of NFkappaB, human antigen R, c-Myc (Proto-Oncogene Proteins),
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0103794" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0103794</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2014
Animals
Carotid Artery Injuries/*metabolism
Hu Wenjing
Hyperplasia/*metabolism
Interleukin-1/*metabolism
Li Dongye
Male
NF-kappa B/*metabolism
Pan Defeng
PloS one
Rats
Signal Transduction/genetics/physiology
Toll-Like Receptors/*metabolism
Tunica Intima/*metabolism/*pathology
Wang Yi
Wistar
Wu Wanling
Xu Tongda
Zhang Xiaotian
Zhou Zhongmin
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0101758" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0101758</a>
Pages
e101758–e101758
Issue
7
Volume
9
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Human quadrupeds, primate quadrupedalism, and Uner Tan Syndrome.
Publisher
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PloS one
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
2014
Subject
The topic of the resource
Adult; Female; Humans; Male; Animals; Child; Infant; Gait/*physiology; Syndrome; *Primates; Posture/physiology; Walking/*physiology; Molecular; Evolution
Creator
An entity primarily responsible for making the resource
Shapiro Liza J; Cole Whitney G; Young Jesse W; Raichlen David A; Robinson Scott R; Adolph Karen E
Description
An account of the resource
Since 2005, an extensive literature documents individuals from several families afflicted with "Uner Tan Syndrome (UTS)," a condition that in its most extreme form is characterized by cerebellar hypoplasia, loss of balance and coordination, impaired cognitive abilities, and habitual quadrupedal gait on hands and feet. Some researchers have interpreted habitual use of quadrupedalism by these individuals from an evolutionary perspective, suggesting that it represents an atavistic expression of our quadrupedal primate ancestry or "devolution." In support of this idea, individuals with "UTS" are said to use diagonal sequence quadrupedalism, a type of quadrupedal gait that distinguishes primates from most other mammals. Although the use of primate-like quadrupedal gait in humans would not be sufficient to support the conclusion of evolutionary "reversal," no quantitative gait analyses were presented to support this claim. Using standard gait analysis of 518 quadrupedal strides from video sequences of individuals with "UTS", we found that these humans almost exclusively used lateral sequence-not diagonal sequence-quadrupedal gaits. The quadrupedal gait of these individuals has therefore been erroneously described as primate-like, further weakening the "devolution" hypothesis. In fact, the quadrupedalism exhibited by individuals with UTS resembles that of healthy adult humans asked to walk quadrupedally in an experimental setting. We conclude that quadrupedalism in healthy adults or those with a physical disability can be explained using biomechanical principles rather than evolutionary assumptions.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0101758" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0101758</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Primates
2014
Adolph Karen E
Adult
Animals
Child
Cole Whitney G
Department of Anatomy & Neurobiology
Evolution
Female
Gait/*physiology
Humans
Infant
Male
Molecular
NEOMED College of Medicine
PloS one
Posture/physiology
Raichlen David A
Robinson Scott R
Shapiro Liza J
Syndrome
Walking/*physiology
Young Jesse W
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0085010" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0085010</a>
Pages
e85010–e85010
Issue
1
Volume
9
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Generation of "virtual" control groups for single arm prostate cancer adjuvant trials.
Publisher
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PloS one
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
1905-07
Subject
The topic of the resource
Humans; Male; Middle Aged; Aged; Treatment Outcome; Disease-Free Survival; *Nomograms; *Prostatectomy; Antineoplastic Agents/therapeutic use; Control Groups; Controlled Clinical Trials as Topic; Prostate/drug effects/pathology/surgery; Prostatic Neoplasms/*drug therapy/mortality/pathology/surgery; Neoplasm Recurrence; Chemotherapy; Adjuvant/*methods; Local/*drug therapy/mortality/pathology/surgery
Creator
An entity primarily responsible for making the resource
Jia Zhenyu; Lilly Michael B; Koziol James A; Chen Xin; Xia Xiao-Qin; Wang Yipeng; Skarecky Douglas; Sutton Manuel; Sawyers Anne; Ruckle Herbert; Carpenter Philip M; Wang-Rodriguez Jessica; Jiang Jun; Deng Mingsen; Pan Cong; Zhu Jian-Guo; McLaren Christine E; Gurley Michael J; Lee Chung; McClelland Michael; Ahlering Thomas; Kattan Michael W; Mercola Dan
Description
An account of the resource
It is difficult to construct a control group for trials of adjuvant therapy (Rx) of prostate cancer after radical prostatectomy (RP) due to ethical issues and patient acceptance. We utilized 8 curve-fitting models to estimate the time to 60%, 65%, ... 95% chance of progression free survival (PFS) based on the data derived from Kattan post-RP nomogram. The 8 models were systematically applied to a training set of 153 post-RP cases without adjuvant Rx to develop 8 subsets of cases (reference case sets) whose observed PFS times were most accurately predicted by each model. To prepare a virtual control group for a single-arm adjuvant Rx trial, we first select the optimal model for the trial cases based on the minimum weighted Euclidean distance between the trial case set and the reference case set in terms of clinical features, and then compare the virtual PFS times calculated by the optimum model with the observed PFSs of the trial cases by the logrank test. The method was validated using an independent dataset of 155 post-RP patients without adjuvant Rx. We then applied the method to patients on a Phase II trial of adjuvant chemo-hormonal Rx post RP, which indicated that the adjuvant Rx is highly effective in prolonging PFS after RP in patients at high risk for prostate cancer recurrence. The method can accurately generate control groups for single-arm, post-RP adjuvant Rx trials for prostate cancer, facilitating development of new therapeutic strategies.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0085010" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0085010</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Nomograms
*Prostatectomy
2014
Adjuvant/*methods
Aged
Ahlering Thomas
Antineoplastic Agents/therapeutic use
Carpenter Philip M
Chemotherapy
Chen Xin
Control Groups
Controlled Clinical Trials as Topic
Deng Mingsen
Disease-Free Survival
Gurley Michael J
Humans
Jia Zhenyu
Jiang Jun
Kattan Michael W
Koziol James A
Lee Chung
Lilly Michael B
Local/*drug therapy/mortality/pathology/surgery
Male
McClelland Michael
McLaren Christine E
Mercola Dan
Middle Aged
Neoplasm Recurrence
Pan Cong
PloS one
Prostate/drug effects/pathology/surgery
Prostatic Neoplasms/*drug therapy/mortality/pathology/surgery
Ruckle Herbert
Sawyers Anne
Skarecky Douglas
Sutton Manuel
Treatment Outcome
Wang Yipeng
Wang-Rodriguez Jessica
Xia Xiao-Qin
Zhu Jian-Guo
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0073811" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0073811</a>
Pages
e73811–e73811
Issue
9
Volume
8
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The power of the claw.
Publisher
An entity responsible for making the resource available
PloS one
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
1905-07
Subject
The topic of the resource
Animals; Biomechanical Phenomena; Feeding Behavior; *Hoof and Claw; *Mechanical Phenomena; Femur/injuries; Predatory Behavior; Ruminants; Tigers
Creator
An entity primarily responsible for making the resource
Rothschild Bruce M; Bryant Bill; Hubbard Christopher; Tuxhorn Kent; Kilgore Ginny Penn; Martin Larry; Naples Virginia
Description
An account of the resource
Scratches on bones have routinely been attributed to tooth marks (a predominantly untested speculation), ignoring the effects of claws, perhaps because of the general assumption that claws are too soft to damage bone. However, some pathologies appears to be more compatible with claw rather than tooth impacts. Therefore, it is critical to determine if the claws of any animal are capable of scratching into the surface of any bone–a test and proof of concept. A tiger enrichment program was used to document actual bone damage unequivocally caused by claws, by assuring that the tiger had access to bones only by using its paws (claws). The spectrum of mechanisms causing bone damage was expanded by evidentiary analysis of claw-induced pathology. While static studies suggested that nails/claws could not disrupt bone, specific tiger enrichment activities documented that bones were susceptible to damage from the kinetic energy effect of the striking claw. This documents an expanded differential consideration for scratch marks on bone and evidences the power of the claw.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0073811" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0073811</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Hoof and Claw
*Mechanical Phenomena
2013
Animals
Biomechanical Phenomena
Bryant Bill
Feeding Behavior
Femur/injuries
Hubbard Christopher
Kilgore Ginny Penn
Martin Larry
Naples Virginia
PloS one
Predatory Behavior
Rothschild Bruce M
Ruminants
Tigers
Tuxhorn Kent
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0068528" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0068528</a>
Pages
e68528–e68528
Issue
7
Volume
8
Dublin Core
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Title
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Bone marrow SSEA1+ cells support the myocardium in cardiac pressure overload.
Publisher
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PloS one
Date
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2013
1905-07
Subject
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Male; Animals; Mice; Mesenchymal Stem Cells/cytology/metabolism; Ventricular Remodeling; *Bone Marrow Transplantation; Bone Marrow Cells/cytology/*metabolism; Cell Tracking; Lewis X Antigen/*metabolism; Myocardium/cytology/*metabolism/pathology; Myocytes; Cardiac/cytology/metabolism
Creator
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Finan Amanda; Sopko Nikolai; Dong Feng; Turturice Ben; Kiedrowski Matthew; Penn Marc S
Description
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RATIONALE: Stage specific embryonic antigen 1+ (SSEA1+) cells have been described as the most primitive mesenchymal progenitor cell in the bone marrow. Cardiac injury mobilizes SSEA1+ cells into the peripheral blood but their in vivo function has not been characterized. OBJECTIVE: We generated animals with chimeric bone marrow to determine the fate and function of bone marrow SSEA1+ cells in response to acute cardiac pressure overload. METHODS AND RESULTS: Lethally irradiated mice were transplanted with normal bone marrow where the wild-type SSEA1+ cells were replaced with green fluorescent protein (GFP) SSEA1+ cells. Cardiac injury was induced by trans-aortic constriction (TAC). We identified significant GFP+ cell engraftment into the myocardium after TAC. Bone marrow GFP+ SSEA1 derived cells acquired markers of endothelial lineage, but did not express markers of c-kit+ cardiac progenitor cells. The function of bone marrow SSEA1+ cells after TAC was determined by transplanting lethally irradiated mice with bone marrow depleted of SSEA1+ cells (SSEA1-BM). The cardiac function of SSEA1-BM mice declined at a greater rate after TAC compared to their complete bone marrow transplant counterparts and was associated with decreased bone marrow cell engraftment and greater vessel rarefication in the myocardium. CONCLUSIONS: These results provide evidence for the recruitment of endogenous bone marrow SSEA1+ cells to the myocardium after TAC. We demonstrate that, in vivo, bone marrow SSEA1+ cells have the differentiation potential to acquire endothelial lineage markers. We also show that bone marrow SSEA1+ deficiency is associated with a reduced compensatory capacity to cardiac pressure overload, suggesting their importance in cardiac homeostasis. These data demonstrate that bone marrow SSEA1+ cells are critical for sustaining vascular density and cardiac repair to pressure overload.
Identifier
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<a href="http://doi.org/10.1371/journal.pone.0068528" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0068528</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Bone Marrow Transplantation
2013
Animals
Bone Marrow Cells/cytology/*metabolism
Cardiac/cytology/metabolism
Cell Tracking
Department of Integrative Medical Sciences
Dong Feng
Finan Amanda
Kiedrowski Matthew
Lewis X Antigen/*metabolism
Male
Mesenchymal Stem Cells/cytology/metabolism
Mice
Myocardium/cytology/*metabolism/pathology
Myocytes
NEOMED College of Medicine
Penn Marc S
PloS one
Sopko Nikolai
Turturice Ben
Ventricular Remodeling