Browse Items · NEOMED Bibliography Database

Development of social vocalizations in mice.

Adult mice are highly vocal animals, with both males and females vocalizing in same sex and cross sex social encounters. Mouse pups are also highly vocal, producing isolation vocalizations when they are cold or removed from the nest. This study…

Development of GPCR modulation of GABAergic transmission in chicken nucleus laminaris neurons.

Neurons in the nucleus laminaris (NL) of birds act as coincidence detectors and encode interaural time difference to localize the sound source in the azimuth plane. GABAergic transmission in a number of CNS nuclei including the NL is subject to a…

Tags: *Synaptic Transmission, 2012, Animals, Brain/*cytology, Chickens/*metabolism, Department of Anatomy & Neurobiology, G-Protein-Coupled/*metabolism, GABA-A/metabolism, GABA-B/metabolism, gamma-Aminobutyric Acid/*metabolism, Lu Yong, Metabotropic Glutamate/metabolism, NEOMED College of Medicine, Neurons/*metabolism, Patch-Clamp Techniques, PloS one, Receptors, Synapses/metabolism, Tang Zheng-Quan

Diminished behavioral and neural sensitivity to sound modulation is associated with moderate developmental hearing loss.

The acoustic rearing environment can alter central auditory coding properties, yet altered neural coding is seldom linked with specific deficits to adult perceptual skills. To test whether developmental hearing loss resulted in comparable changes to…

Tags: *Attention, *Behavior, 2012, Afferent/pathology, Animal, Animals, Conductive/pathology/*physiopathology, Department of Anatomy & Neurobiology, Female, Gerbillinae, Hearing Loss, Kelly Jack B, Male, NEOMED College of Medicine, Neurons, PloS one, Rosen Merri J, Sanes Dan H, Sarro Emma C

Social vocalizations of big brown bats vary with behavioral context.

Bats are among the most gregarious and vocal mammals, with some species demonstrating a diverse repertoire of syllables under a variety of behavioral contexts. Despite extensive characterization of big brown bat (Eptesicus fuscus) biosonar signals,…

Tags: *Animal Communication, *Behavior, 2012, Acoustics, Animal, Animals, Chiroptera/*physiology, College of Anatomy & Neurobiology, Department of Anatomy & Neurobiology, Electrocardiography, Faure Paul A, Gadziola Marie A, Grimsley Jasmine M S, NEOMED College of Medicine, PloS one, Wenstrup Jeffrey J

Bone marrow SSEA1+ cells support the myocardium in cardiac pressure overload.

RATIONALE: Stage specific embryonic antigen 1+ (SSEA1+) cells have been described as the most primitive mesenchymal progenitor cell in the bone marrow. Cardiac injury mobilizes SSEA1+ cells into the peripheral blood but their in vivo function has not…

The power of the claw.

Scratches on bones have routinely been attributed to tooth marks (a predominantly untested speculation), ignoring the effects of claws, perhaps because of the general assumption that claws are too soft to damage bone. However, some pathologies…

Tags: *Hoof and Claw, *Mechanical Phenomena, 2013, Animals, Biomechanical Phenomena, Bryant Bill, Feeding Behavior, Femur/injuries, Hubbard Christopher, Kilgore Ginny Penn, Martin Larry, Naples Virginia, PloS one, Predatory Behavior, Rothschild Bruce M, Ruminants, Tigers, Tuxhorn Kent

Generation of "virtual" control groups for single arm prostate cancer adjuvant trials.

It is difficult to construct a control group for trials of adjuvant therapy (Rx) of prostate cancer after radical prostatectomy (RP) due to ethical issues and patient acceptance. We utilized 8 curve-fitting models to estimate the time to 60%, 65%,…

Human quadrupeds, primate quadrupedalism, and Uner Tan Syndrome.

Since 2005, an extensive literature documents individuals from several families afflicted with "Uner Tan Syndrome (UTS)," a condition that in its most extreme form is characterized by cerebellar hypoplasia, loss of balance and coordination, impaired…

Interleukin-1/toll-like receptor-induced nuclear factor kappa B signaling participates in intima hyperplasia after carotid artery balloon injury in goto-kakizaki rats: a potential target therapy pathway.

The value of restenosis after percutaneous coronary intervention (PCI) is recognized worldwide, especially for diabetic patients. Interleukin-1/Toll-like receptor (IL-1/TLR) signaling is involved in innate and adaptive immune responses, but whether…

Alterations in gene array patterns in dendritic cells from aged humans.

Dendritic cells (DCs) are major antigen-presenting cells that play a key role in initiating and regulating innate and adaptive immune responses. DCs are critical mediators of tolerance and immunity. The functional properties of DCs decline with age.…

Anthracobunids from the middle eocene of India and pakistan are stem perissodactyls.

Anthracobunidae is an Eocene family of large mammals from south Asia that is commonly considered to be part of the radiation that gave rise to elephants (proboscideans) and sea cows (sirenians). We describe a new collection of anthracobunid fossils…

Tags: *Fossils, 2014, Animals, Bajpai Sunil, Clementz Mark, Cooper Lisa Noelle, Department of Anatomy & Neurobiology, Dugong, Elephants, Hussain S Taseer, India, Madar Sandra I, NEOMED College of Medicine, Pakistan, PloS one, Seiffert Erik R, Thewissen J G M

Hepatic carboxylesterase 1 is induced by glucose and regulates postprandial glucose levels.

Metabolic syndrome, characterized by obesity, hyperglycemia, dyslipidemia and hypertension, increases the risks for cardiovascular disease, diabetes and stroke. Carboxylesterase 1 (CES1) is an enzyme that hydrolyzes triglycerides and cholesterol…

Integrin mediated adhesion of osteoblasts to connective tissue growth factor (CTGF/CCN2) induces cytoskeleton reorganization and cell differentiation.

Pre-osteoblast adhesion and interaction with extracellular matrix (ECM) proteins through integrin receptors result in activation of signaling pathways regulating osteoblast differentiation. Connective tissue growth factor (CTGF/CCN2) is a…

MiR-21 enhances melanoma invasiveness via inhibition of tissue inhibitor of metalloproteinases 3 expression: in vivo effects of MiR-21 inhibitor.

Metastatic melanoma is the most aggressive form of this cancer. It is important to understand factors that increase or decrease metastatic activity in order to more effectively research and implement treatments for melanoma. Increased cell invasion…

Propofol causes vasodilation in vivo via TRPA1 ion channels: role of nitric oxide and BKCa channels.

BACKGROUND: Transient receptor potential (TRP) ion channels of the A1 (TRPA1) and V1 (TRPV1) subtypes are key regulators of vasomotor tone. Propofol is an intravenous anesthetic known to cause vasorelaxation. Our objectives were to examine the extent…

Muscle Logic: New Knowledge Resource for Anatomy Enables Comprehensive Searches of the Literature on the Feeding Muscles of Mammals.

BACKGROUND: In recent years large bibliographic databases have made much of the published literature of biology available for searches. However, the capabilities of the search engines integrated into these databases for text-based bibliographic…

The Difference in Prognosis between Renal Sinus Fat and Perinephric Fat Invasion for pT3a Renal Cell Carcinoma: A Meta-Analysis.

BACKGROUND: In the current Tumour-Node-Metastasis (TNM) classification system for renal cell carcinoma (RCC), both renal sinus fat invasion (SFI) and perinephric fat invasion (PFI) are defined as T3a, suggesting that the prognosis should be similar…

Severe Bone Loss as Part of the Life History Strategy of Bowhead Whales.

The evolution of baleen constituted a major evolutionary change that made it possible for baleen whales to reach enormous body sizes while filter feeding on tiny organisms and migrating over tremendous distances. Bowhead whales (Balaena mysticetus)…

Salvianolic Acid B Alleviates Heart Failure by Inactivating ERK1/2/GATA4 Signaling Pathway after Pressure Overload in Mice.

BACKGROUND: Heart failure(HF) is a dangerous disease that affects millions of patients. Radix Salvia is widely used in Chinese clinics to treat heart diseases. Salvianolic acid B(SalB) is the major active component of Radix Salvia. This study…

Treatment of AKI in developing and developed countries: An international survey of pediatric dialysis modalities.

HYPOTHESIS: Acute kidney injury (AKI) is a common cause of morbidity and mortality worldwide, with a pediatric incidence ranging from 19.3% to 24.1%. Treatment of pediatric AKI is a source of debate in varying geographical regions. Currently CRRT is…

TRPA1 and TRPV1 contribute to propofol-mediated antagonism of U46619-induced constriction in murine coronary arteries.

BACKGROUND: Transient receptor potential (TRP) ion channels have emerged as key components contributing to vasoreactivity. Propofol, an anesthetic is associated with adverse side effects including hypotension and acute pain upon infusion. Our…

Validation of Growth Layer Group (GLG) depositional rate using daily incremental growth lines in the dentin of beluga (Delphinapterus leucas (Pallas, 1776)) teeth.

Counts of Growth Layer Groups (GLGs) in the dentin of marine mammal teeth are widely used as indicators of age. In most marine mammals, observations document that GLGs are deposited yearly, but in beluga whales, some studies have supported the view…

Tags: *Beluga Whale, 2018, Animals, Dentin/*growth & development, Department of Anatomy & Neurobiology, NEOMED College of Medicine, Ortiz Joseph D, PloS one, Suydam Robert S, Thewissen J G M, Tooth/*growth & development, Waugh David A

Communication calls produced by electrical stimulation of four structures in the guinea pig brain.

One of the main central processes affecting the cortical representation of conspecific vocalizations is the collateral output from the extended motor system for call generation. Before starting to study this interaction we sought to compare the…

Tags: 2018, Acoustic Stimulation/methods, Animal/physiology, Animals, Auditory Perception/physiology, Brain/*physiology, Electric Stimulation/methods, Female, Green David B, Grimsley Jasmine M S, Guinea Pigs, Male, Neurons/physiology, Palmer Alan R, PloS one, Shackleton Trevor M, Vocalization, Wallace Mark N, Zobay Oliver

Heparin free dialysis in critically sick children using sustained low efficiency dialysis (SLEDD-f): A new hybrid therapy for dialysis in developing world.

BACKGROUND: In critically sick adults, sustained low efficiency dialysis [SLED] appears to be better tolerated hemodynamically and outcomes seem to be comparable to CRRT. However, there is paucity of data in critically sick children. In children, two…

Comparative metabolomics of aging in a long-lived bat: Insights into the physiology of extreme longevity.

Vespertilionid bats (Mammalia: Order Chiroptera) live 3-10 times longer than other mammals of an equivalent body size. At present, nothing is known of how bat fecal metabolic profiles shift with age in any taxa. This study established the feasibility…

Tags: *Metabolomics, 2018, Aliani Michel, Animals, Ball Hope C, Chiroptera/*physiology, Cooper Lisa Noelle, Department of Anatomy & Neurobiology, Feces/*chemistry, Levari-Shariati Shiva, Longevity/*physiology, NEOMED College of Medicine, PloS one

Twin-twin transfusion syndrome screening and diagnosis in the United States: A triangulation design of patient experiences.

OBJECTIVE: Using patient-reported experiences, this study: 1) quantitatively evaluated TTTS screening trends, 2) examined screening and diagnostic experiences using a mixed methods approach, and 3) determined gaps in clinical care experiences.…

First record of the Miocene hominoid Sivapithecus from Kutch, Gujarat state, western India.

Hominoid remains from Miocene deposits in India and Pakistan have played a pivotal role in understanding the evolution of great apes and humans since they were first described in the 19th Century. We describe here a hominoid maxillary fragment…

Tags: 2018, Bajpai Sunil, Bhandari Ansuya, Department of Anatomy & Neurobiology, Hieronymus Tobin, Kay Richard F, NEOMED College of Medicine, PloS one, Tiwari Brahma Nand, Williams Blythe A

First record of the Miocene hominoid Sivapithecus from Kutch, Gujarat state, western India.

Hominoid remains from Miocene deposits in India and Pakistan have played a pivotal role in understanding the evolution of great apes and humans since they were first described in the 19th Century. We describe here a hominoid maxillary fragment…

Tags: *Archaeology, *Hominidae/anatomy & histology, 2018, Animals, Bajpai Sunil, Bhandari Ansuya, Biological Evolution, Geology, Hieronymus Tobin L, India, Kay Richard F, PloS one, Tiwari Brahma Nand, Williams Blythe A

Overexpression of the Lung Cancer-Prognostic miR-146b MicroRNAs Has a Minimal and Negative Effect on the Malignant Phenotype of A549 Lung Cancer Cells

Introduction: Expression levels of miR-146b-5p and -3p microRNAs in human non-small cell lung cancer (NSCLC) are associated with recurrence of the disease after surgery. To understand this, the effect of miR-146b overexpression was studied in A549…

Tags: 2011, breast-cancer, DISEASES, expression profiles, Glioma, inhibition, invasion, Journal Article, Kannisto E, Mallick R, migration, Patnaik S K, PloS one, Science & Technology - Other Topics, strand selection, target, tumors, Yendamuri S

Extracellular ATP and Toll-Like Receptor 2 Agonists Trigger in Human Monocytes an Activation Program That Favors T Helper 17

Strategically-paired Toll-like receptor (TLR) ligands induce a unique dendritic cell (DC) phenotype that polarizes Th1 responses. We therefore investigated pairing single TLR ligands with a non TLR-mediated danger signal to cooperatively induce…

Cholesterol-Peptide Hybrids to Form Liposome-Like Vesicles for Gene Delivery

In this paper, four amphiphilic cholesterol-peptide conjugates (Ch-R5H5, Ch-R3H3, Ch-R5 and Ch-R5) were designed and synthesized, and their properties in gene delivery were evaluated in vitro with an aim of developing more efficient gene delivery…

Tags: 2013, Cao B, Cheng G, condensation, DNA, histidine, Journal Article, Nanoparticles, oligopeptides, PloS one, Polymers, prospects, Science & Technology - Other Topics, systems, Tang Q, therapy, vectors, Wu H Y

Identification of Multiple Metabolic Enzymes from Mice Cochleae Tissue Using a Novel Functional Proteomics Technology

A new type of technology in proteomics was developed in order to separate a complex protein mixture and analyze protein functions systematically. The technology combines the ability of two-dimensional gel electrophoresis (2-DE) to separate proteins…

Tags: 2015, Animal tissues, Bao J X, Beef, Biology, Cancer, cancer metabolism, cell metabolism, Cochlea, draft, Drug Therapy, E coli, Electrophoresis, Elution, Enzymatic activity, Enzyme assays, Enzyme metabolism, Enzymes, Feasibility Studies, Functional analysis, Gel electrophoresis, Genes, Genomics, Hearing impairment, Journal Article, Kinases, Li H, Liang R Q, Mass spectrometry, Mass spectroscopy, Medicine, messenger-rna, Metabolism, Mice, NAD(P)H oxidase, NADH, Neurobiology, Neurosciences, nicotinamide adenine dinucleotide, Noise, otolaryngology, Oxidation-reduction reactions, Phosphatase, PloS one, PROTEIN expression, Proteins, Proteomes, proteomics, Science & Technology - Other Topics, Sciences: Comprehensive Works, Scientific imaging, Studies, Substance abuse treatment, Technology, United States--US, Wang D L

Performance of Repetitive Tasks Induces Decreased Grip Strength and Increased Fibrogenic Proteins in Skeletal Muscle: Role of Force and Inflammation

Background: This study elucidates exposure-response relationships between performance of repetitive tasks, grip strength declines, and fibrogenic-related protein changes in muscles, and their link to inflammation. Specifically, we examined forearm…

Leptin in Whales: Validation and Measurement of mRNA Expression by Absolute Quantitative Real-Time PCR

Leptin is the primary hormone in mammals that regulates adipose stores. Arctic adapted cetaceans maintain enormous adipose depots, suggesting possible modifications of leptin or receptor function. Determining expression of these genes is the first…

Tags: 2013, Ball H C, Duff R J, Holmes R K, housekeeping genes, Journal Article or Conference Abstract Publication, Londraville R L, Mammals, mass, Obesity, PloS one, quantification, reference genes, resistance, rt-pcr, Science & Technology - Other Topics, serum leptin, Thewissen J G M, weight

Comparative Analysis of Cervical Spine Management in a Subset of Severe Traumatic Brain Injury Cases Using Computer Simulation

Background: No randomized control trial to date has studied the use of cervical spine management strategies in cases of severe traumatic brain injury (TBI) at risk for cervical spine instability solely due to damaged ligaments. A computer algorithm…

Tags: 2011, blunt trauma, Carter K J, Castro F, coma, Dunham C M, Erickson B, immobilization, Journal Article or Conference Abstract Publication, Mortality, MRI, PloS one, risk-factors, safe, Science & Technology - Other Topics, stroke, ventilator-associated pneumonia

Hepatic Cannabinoid Receptor Type 1 Mediates Alcohol-Induced Regulation of Bile Acid Enzyme Genes Expression Via CREBH

Bile acids concentration in liver is tightly regulated to prevent cell damage. Previous studies have demonstrated that deregulation of bile acid homeostasis can lead to cholestatic liver disease. Recently, we have shown that ER-bound transcription…

Tags: 2013, Acids, activation, Ahn S H, Alcohol, Alcohols, Bile, BILE acids, bound, cb1 receptors, Chanda D, Chiang J Y L, Choi H S, cholesterol 7-alpha-hydroxylase, Damage prevention, Deregulation, Diabetes Mellitus, element-binding protein, endocannabinoid system, endoplasmic-reticulum stress, er stress, exposure, Fatty Liver, gene-expression, Genes, hepatocytes, Homeostasis, human hepatocytes, insulin, insulin-resistance, Jeong W I, Journal Article or Conference Abstract Publication, Kim D K, Kim J R, Kim Y H, Koo S H, Kwon J, Lee C H, leptin resistance, Li T, Liver, Liver Diseases, Metabolism, Mice, Misra J, Muridae, Ohio, Park T S, PloS one, Regulatory mechanisms (biology), RNA extraction, Rodents, Science & Technology - Other Topics, Sciences: Comprehensive Works, Signal Transduction, Signaling, Synthesis, transcription factor

To 3d Or Not To 3d, That Is The Question: Do 3d Surface Analyses Improve The Ecomorphological Power Of The Distal Femur In Placental Mammals?

Improvements in three-dimensional imaging technologies have renewed interest in the study of functional and ecological morphology. Quantitative approaches to shape analysis are used increasingly to study form-function relationships. These methods are…

Tags: 2014, anatomy, Behavior, carnivorans, corpus, discriminant function-analysis, Evolution, functional-morphology, Gould F D H, hindlimb, Journal Article or Conference Abstract Publication, locomotor, PloS one, ratios, Rodents, Science & Technology - Other Topics

Browse Items (44 total)