Browse Items · NEOMED Bibliography Database

A disease model descriptive of progression between chronic obstructive pulmonary disease exacerbations and community-acquired pneumonia: roles for underlying lung disease and the pharmacokinetics/pharmacodynamics of the antibiotic.

Patients with chronic obstructive pulmonary disease (COPD) may progress to community-acquired pneumonia (CAP), but there has been no formal study of the factors responsible. We studied the influence of severity of underlying lung disease, pathogen…

Tags: *Anti-Bacterial Agents/pharmacokinetics/therapeutic use, *Community-Acquired Infections/drug therapy/microbiology/physiopathology/prevention & control, *Models, *Pneumonia, 2009, Adelman Martin H, Aged, Area Under Curve, Bacterial/drug therapy/microbiology/physiopathology/prevention & control, Biological, Bronchitis, Chronic Obstructive/drug therapy/microbiology/*physiopathology, Chronic/drug therapy/microbiology/physiopathology, Department of Internal Medicine, Disease Progression, Female, File Thomas M Jr, Humans, International journal of antimicrobial agents, Klugman Keith P, Lavin Bruce, Lung Diseases/complications/drug therapy/microbiology, Lung/microbiology, Male, Microbial Sensitivity Tests, Middle Aged, Monte Scott V, NEOMED College of Medicine, Paladino Joseph A, Pneumococcal/drug therapy/microbiology/physiopathology/prevention & control, Pneumonia, Pulmonary Disease, Schentag Jerome J, Severity of Illness Index, Singer Mendel E, Streptococcus pneumoniae/*drug effects, Yu Victor L

A multicenter, randomized study comparing the efficacy and safety of intravenous and/or oral levofloxacin versus ceftriaxone and/or cefuroxime axetil in treatment of adults with community-acquired pneumonia.

Five hundred ninety patients were enrolled in a prospective, multicenter, randomized trial comparing the efficacy and safety of 7 to 14 days of levofloxacin treatment with that of ceftriaxone and/or cefuroxime axetil in the management of…

A new dosing paradigm: high-dose, short-course fluoroquinolone therapy for community-acquired pneumonia.

The goals of optimal antimicrobial therapy are to treat infection effectively, to improve the clinical condition of the patient, and to prevent the emergence of resistant bacterial strains. For ideal drug usage the World Health Organization…

Tags: 2003, Clinical cornerstone, Community-Acquired Infections/*drug therapy, Department of Internal Medicine, File Thomas M Jr, Fluoroquinolones/*administration & dosage/pharmacology/therapeutic use, Humans, NEOMED College of Medicine, Ofloxacin/administration & dosage/pharmacology/therapeutic use, Pneumococcal/*drug therapy, Pneumonia, Safety, Time Factors, Treatment Outcome

A Structured Approach for Safely Reintroducing Bariatric Surgery in a COVID-19 Environment.

Due to the profound effect of novel coronavirus disease 2019 (COVID-19) on healthcare systems, surgical programs across the country have paused surgical operations and have been utilizing virtual visits to help maintain public safety. For those…

Ambulatory management of lower respiratory tract infections.

Clinical manifestations and radiographic findings are unreliable guides to the selection of antimicrobial therapy for lower respiratory infections. Laboratory evaluation is necessary to identify the etiologic agent. Multiple oral antibiotics are…

Tags: 1991, American family physician, Anti-Bacterial Agents/*therapeutic use, Bacterial Infections/drug therapy, Department of Internal Medicine, File T M Jr, Humans, Legionnaires' Disease/diagnosis, Mycoplasma/diagnosis, NEOMED College of Medicine, Pneumonia, Pneumonia/*diagnosis/*drug therapy, Tan J S, Thomson R B Jr

An update on the association of vitamin D deficiency with common infectious diseases.

Vitamin D plays an important role in modulating the immune response to infections. Deficiency of vitamin D is a common condition, affecting both the general population and patients in health care facilities. Over the last decade, an increasing body…

Appropriate use of antimicrobials for drug-resistant pneumonia: focus on the significance of beta-lactam-resistant Streptococcus pneumoniae.

The beta-lactam antibiotics (penicillins and cephalosporins) are commonly prescribed for the treatment of community-acquired pneumonia. However, Streptococcus pneumoniae, the most common etiologic agent of community-acquired pneumonia, has become…

Tags: *beta-Lactam Resistance, 2002, beta-Lactams/economics/*therapeutic use, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Contraindications, Department of Internal Medicine, File Thomas M Jr, Humans, NEOMED College of Medicine, Pneumococcal/*drug therapy/economics/pathology, Pneumonia, Practice Guidelines as Topic, Streptococcus pneumoniae/*drug effects/metabolism

Aspiration pneumonia, necrotizing pneumonia, and lung abscess.

Suppurative complications to aspiration pneumonia occur if the initial aspiration and subsequent pneumonitis go unrecognized or untreated. Anaerobic cavitary disease is typically an indolent process, whereas necrotizing pneumonia is more fulminant…

Tags: 1989, Aspiration/diagnosis/*pathology/physiopathology/therapy, Combined Modality Therapy, Department of Internal Medicine, Emergency medicine clinics of North America, Humans, Lung Abscess/diagnosis/etiology/*therapy, Necrosis, NEOMED College of Medicine, Pennza P T, Pneumonia

Assessment of time to clinical response, a proxy for discharge readiness, among hospitalized patients with community-acquired pneumonia who received either ceftaroline fosamil or ceftriaxone in two phase III FOCUS trials.

The primary driver of health care costs for patients with community-acquired pneumonia (CAP) is the hospital length of stay (LOS). Unfortunately, hospital LOS comparisons are difficult to make from phase III CAP trials because of their structured…

Bacterial Pneumonia in Older Adults.

Community-acquired pneumonia is common in the elderly person; its presentation in this population is often confounded by multiple comorbid illnesses, including those that result in confusion. Although severity-of-illness scoring systems might aid…

Burden of community-acquired pneumonia in North American adults.

To determine the burden of community-acquired pneumonia (CAP) affecting adults in North America, a comprehensive literature review was conducted to examine the incidence, morbidity and mortality, etiology, antibiotic resistance, and economic impact…

Tags: 2010, Adult, Bacterial – Economics, Bacterial – Epidemiology, Bacterial – Microbiology, Bacterial – Mortality, Bacterial – Prevention and Control, Bacterial/economics/*epidemiology/microbiology/prevention & control, Community-Acquired Infections – Economics, Community-Acquired Infections – Epidemiology, Community-Acquired Infections – Microbiology, Community-Acquired Infections – Prevention and Control, Community-Acquired Infections/economics/epidemiology/microbiology/prevention & control, Cost of Illness, Department of Internal Medicine, Economic Aspects of Illness, File Thomas M Jr, Health Care Costs, Health Status Indicators, Hospitalization – Economics, Hospitalization – Statistics and Numerical Data, Hospitalization/economics/statistics & numerical data, Human, Humans, Incidence, Length of Stay – Statistics and Numerical Data, Length of Stay/statistics & numerical data, Marrie Thomas J, NEOMED College of Medicine, North America, North America/epidemiology, Pneumococcal Vaccine, Pneumococcal Vaccines, Pneumococcal/economics/epidemiology/mortality/prevention & control, Pneumonia, Postgraduate medicine, Risk Factors, Streptococcus, Streptococcus pneumoniae

Ceftaroline fosamil versus ceftriaxone for the treatment of community-acquired pneumonia: individual patient data meta-analysis of randomized controlled trials.

BACKGROUND: We conducted a meta-analysis of clinical trials of adults hospitalized with pneumonia outcomes research team (PORT) risk class 3-4 community-acquired pneumonia (CAP) receiving ceftaroline fosamil versus ceftriaxone. METHODS: Three Phase…

Clinical implications and treatment of multiresistant Streptococcus pneumoniae pneumonia.

Streptococcus pneumoniae is the leading bacterial cause of community-acquired respiratory tract infections. Prior to the 1970s this pathogen was uniformly susceptible to penicillin and most other antimicrobials. However, since the 1990s there has…

Tags: 2006, Anti-Infective Agents/*therapeutic use, Bacterial, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, Community-Acquired Infections/*drug therapy/economics/*microbiology, Department of Internal Medicine, Drug Resistance, File T M Jr, Fluoroquinolones/*therapeutic use, Humans, Ketolides/therapeutic use, Multiple, NEOMED College of Medicine, Pneumococcal/*drug therapy/economics/*microbiology, Pneumonia, Streptococcus pneumoniae/*growth & development

Clinical implications of 750 mg, 5-day levofloxacin for the treatment of community-acquired pneumonia.

OBJECTIVE: To evaluate the time to symptom resolution and i.v.-to-p.o. transition in community-acquired pneumonia (CAP) patients treated with 750 mg or 500 mg levofloxacin. RESEARCH DESIGN: A retrospective, subset analysis of a multicenter,…

Community-acquired pneumonia: highlights of recent guidelines: how new recommendations may affect your practice.

The Infectious Diseases Society of America (IDSA) recently published updated guidelines for assessing and treating patients with community-acquired pneumonia. In contrast to the common practice of treating patients on the basis of clinical…

Tags: 1999, Community-Acquired Infections, Department of Internal Medicine, File T M Jr, Journal of Respiratory Diseases, NEOMED College of Medicine, Pneumonia, Pneumonia – Diagnosis, Risk Factors

Community-acquired pneumonia.

Community-associated methicillin-resistant Staphylococcus aureas: not only a cause of skin infections, also a new cause of pneumonia.

Tags: *Methicillin Resistance, 2005, Anti-Bacterial Agents/pharmacology, Bacterial/*epidemiology/*microbiology, Community-Acquired Infections, Current opinion in infectious diseases, Department of Internal Medicine, File Thomas M Jr, Humans, NEOMED College of Medicine, Pneumonia, Staphylococcal Infections/*epidemiology, Staphylococcus aureus/*drug effects

Comparison of narrow-versus broad-spectrum antibiotics in elderly patients with acute exacerbations of chronic obstructive pulmonary disease

Background Little evidence is available regarding the choice of empiric antibiotic therapy in elderly patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD). The primary objective of this study is to compare the outcomes…

Disseminated Mycobacterium Haemophilum Infection And Pneumocystis Jirovecii Pneumonia In A Patient Receiving Immunosuppressive Therapy Case Report And Review Of Literature

Efficacy and Safety of Intravenous-to-oral Lefamulin, a Pleuromutilin Antibiotic, for the Treatment of Community-acquired Bacterial Pneumonia: The Phase III Lefamulin Evaluation Against Pneumonia (LEAP 1) Trial.

BACKGROUND: Lefamulin, a pleuromutilin antibiotic, is active against pathogens commonly causing community-acquired bacterial pneumonia (CABP). The Lefamulin Evaluation Against Pneumonia (LEAP 1) study was a global noninferiority trial to evaluate…

Tags: 2019, Administration Intravenous, Adult, Aged, Anti-Bacterial Agents/administration & dosage/adverse effects/therapeutic use, antibiotic, Clinical Infectious Diseases, Das A, Diterpenes/administration & dosage/adverse effects/therapeutic use, Double-Blind Method, Female, File TM, Gasink LB, Gelone SP, Goldberg L, Hospital List, Humans, journalArticle, lefamulin, Linezolid/adverse effects/therapeutic use, Male, Microbial Sensitivity Tests, Middle Aged, Moxifloxacin, Moxifloxacin/administration & dosage/adverse effects/therapeutic use, Paukner S, pleuromutilin, Pneumonia, Pneumonia Bacterial/drug therapy/metabolism, Polycyclic Compounds/administration & dosage/adverse effects/therapeutic use, Randomized Controlled Trials as Topic, Saviski J, Seltzer E, Sweeney C, Talbot GH, Thioglycolates/administration & dosage/adverse effects/therapeutic use, Wicha WW

Epidemiology, microbiology, and treatment considerations for bacterial pneumonia complicating influenza

Post-influenza bacterial pneumonia is a major cause of morbidity and mortality associated with both seasonal and pandemic influenza virus illness. However, despite much interest in influenza and its complications in recent years, good clinical trial…

Expanded Analysis of 20 Pneumococcal Serotypes Associated With Radiographically Confirmed Community-Acquired Pneumonia in Hospitalized US Adults.

Background: Streptococcus pneumoniae is a causative agent of community-acquired pneumonia (CAP). The 13-valent pneumococcal conjugate vaccine (PCV13) has significantly decreased the burden of PCV13-serotype pneumococcal disease; however, disease due…

Expanded Analysis of 20 Pneumococcal Serotypes Associated With Radiographically Confirmed Community-Acquired Pneumonia in Hospitalized US Adults.

Streptococcus pneumoniae is a causative agent of community-acquired pneumonia (CAP). The 13-valent pneumococcal conjugate vaccine (PCV13) has significantly decreased the burden of PCV13-serotype pneumococcal disease; however, disease from nonvaccine…

Tags: 20-valent pneumococcal conjugate vaccine, 2021, Adult, Pneumonia, serotypes, urinary antigen detection

Extracorporeal Membrane Oxygenation in Extreme Obesity: A Case Report and Review of the Literature.

The use of extracorporeal membrane oxygenation (ECMO) in the treatment of acute respiratory distress syndrome (ARDS) has been described as early as 1972 [Hill 1972]. Though a subsequent randomized trial showed no survival benefit over conventional…

Tags: *Extracorporeal Membrane Oxygenation, 2018, Adult, Adult/*complications/etiology/*therapy, Aspiration/complications, Azouz Vitali, Female, Firstenberg Michael, Hill Sarah, Humans, Morbid/*complications, Obesity, Pneumonia, Respiratory Distress Syndrome, The heart surgery forum

FOCUS 1: a randomized, double-blinded, multicentre, Phase III trial of the efficacy and safety of ceftaroline fosamil versus ceftriaxone in community-acquired pneumonia.

OBJECTIVES: Ceftaroline, the active form of the prodrug ceftaroline fosamil, is a novel cephalosporin with bactericidal activity against important pathogens associated with community-acquired pneumonia (CAP), including Streptococcus pneumoniae and…

Tags: 2011, 80 and over, Aged, Bacteria, Bacteria/isolation & purification, Bacterial – Drug Therapy, Bacterial/*drug therapy, Ceftriaxone – Administration and Dosage, Ceftriaxone – Adverse Effects, Ceftriaxone/administration & dosage/adverse effects, Cephalosporins – Administration and Dosage, Cephalosporins – Adverse Effects, Cephalosporins/*administration & dosage/*adverse effects, Community-Acquired Infections – Drug Therapy, Community-Acquired Infections/*drug therapy, Critchley Ian A, Department of Internal Medicine, Double-Blind Method, Double-Blind Studies, Eckburg Paul B, Female, File Thomas M Jr, Friedland H David, Human, Humans, Infusions, Intravenous, Lee Jon, Llorens Lily, Low Donald E, Male, Middle Age, Middle Aged, NEOMED College of Medicine, Pneumonia, RANDOMIZED controlled trials, Talbot George H, The Journal of antimicrobial chemotherapy, Thye Dirk A, Treatment Outcome, Treatment Outcomes

Gemifloxacin once daily for 5 days versus 7 days for the treatment of community-acquired pneumonia: a randomized, multicentre, double-blind study.

OBJECTIVES: Short-course therapy has been advocated for the treatment of community-acquired pneumonia (CAP). We compared the efficacy and safety of 5 and 7 day courses of gemifloxacin for outpatient treatment of mild-moderate CAP. PATIENTS AND…

Guidelines for empiric antimicrobial prescribing in community-acquired pneumonia.

Empiric antimicrobial prescribing for community-acquired pneumonia remains a challenge, despite the availability of treatment guidelines. A number of key differences exist between North American and European guidelines, mainly in the outpatient…

Guidelines for empiric antimicrobial prescribing in community-acquired pneumonia.

Empiric antimicrobial prescribing for community-acquired pneumonia remains a challenge, despite the availability of treatment guidelines. A number of key differences exist between North American and European guidelines, mainly in the outpatient…

Higher Pneumococcal Disease Vaccination Rates Needed to Protect More At-Risk US Adults

Pneumococcal disease, which includes pneumococcal pneumonia, meningitis, and bacteremia, is associated with substantial morbidity, mortality, and health care costs in adults. Advanced age, chronic lung or cardiovascular disease, immunosuppressive…

Identifying Barriers to Adult Pneumococcal Vaccination: An NFID Task Force Meeting

Pneumococcal infection is common in adults, and invasive disease is associated with a high mortality rate. Pneumococcal polysaccharide vaccine can prevent invasive pneumococcal disease and is recommended for people aged >= 65 years and for younger…

Tags: 2012, adult vaccination, care, Disease, File T M, General & Internal Medicine, Influenza, Journal Article, Metersky M, Natl Fdn Infect Dis Pneumococcal D, Nichol K L, pneumococcal disease, Pneumococcal Vaccine, Pneumonia, Postgraduate medicine, Rehm S J, Schaffner W, Streptococcus pneumoniae, united-states

Integrated analysis of FOCUS 1 and FOCUS 2: randomized, doubled-blinded, multicenter phase 3 trials of the efficacy and safety of ceftaroline fosamil versus ceftriaxone in patients with community-acquired pneumonia.

BACKGROUND: Ceftaroline, the active form of ceftaroline fosamil, is a broad-spectrum cephalosporin with bactericidal activity against pathogens causing community-acquired pneumonia (CAP), including Streptococcus pneumoniae. Ceftaroline was evaluated…

International guidelines for the treatment of community-acquired pneumonia in adults: the role of macrolides.

The significance of community-acquired pneumonia (CAP) has led to the publication of guidelines from numerous international organisations. Because the macrolide class of antimicrobials is active against most of the key pathogens associated with CAP,…

LVC Timing in Infant Pig Swallowing and the Effect of Safe Swallowing.

Recurrent laryngeal nerve (RLN) injury in neonates, a complication of head and neck surgeries, leads to increased aspiration risk and swallowing dysfunction. The severity of resulting sequelae range from morbidity, such as aspiration pneumonia, to…

Macrolide therapy for community-acquired pneumonia due to atypical pathogens: outcome assessment at an early time point.

BACKGROUND: Therapy directed against atypical pathogens in patients with community-acquired pneumonia (CAP) is often recommended. This post-hoc analysis evaluated the effect of addition of a macrolide to ceftaroline fosamil or ceftriaxone treatment…

Tags: 2017, 80 and over, Adult, Aged, Anti-Bacterial Agents/adverse effects/*therapeutic use, Atypical pathogen, Bacterial/*drug therapy, Ceftaroline fosamil, Ceftriaxone/adverse effects/*therapeutic use, Cephalosporins/adverse effects/*therapeutic use, Chlamydial Pneumonia, Chlamydophila pneumoniae, Clinical Trials, Combination/adverse effects/methods, Community-Acquired Infections/*drug therapy, Community-acquired pneumonia, Department of Internal Medicine, Double-Blind Method, Drug Therapy, Eckburg Paul B, Female, File Thomas M Jr, Friedland H David, Humans, International journal of antimicrobial agents, Legionella pneumophila, Llorens Lily, Macrolide, Macrolides/adverse effects/*therapeutic use, Male, Middle Aged, Mycoplasma, Mycoplasma pneumoniae, NEOMED College of Medicine, Phase III as Topic, Pneumonia, Randomized Controlled Trials as Topic, Talbot George H, Time Factors, Treatment Outcome

Management of community-acquired pneumonia: a focus on conversion from hospital to the ambulatory setting.

Patients with community-acquired pneumonia (CAP) are treated in hospital or in the ambulatory care setting depending on the severity of illness. Despite numerous guidelines proposed, there is no agreement on specific criteria for hospitalization…

Tags: *Ambulatory Care, *Hospitalization, 2003, American journal of respiratory medicine : drugs, devices, and other interventions, Anti-Bacterial Agents/*administration & dosage, Bacterial/*therapy, Community-Acquired Infections/therapy, Department of Internal Medicine, File Thomas M Jr, Humans, NEOMED College of Medicine, Pneumonia, Tan James S

Management Of Community-acquired Pneumonia: An Appropriate-use Tool

Managing patients with recurrent acute exacerbations of chronic bronchitis: a common clinical problem

Chronic obstructive pulmonary disease (COPD) affects 15 million people and is the fourth leading cause of death in the United States. It places a considerable burden on the healthcare system, with exacerbations contributing to a significant…

New diagnostic tests for pneumonia: what is their role in clinical practice?

The utility of diagnostic studies to determine the etiologic agents of community-acquired pneumonia has been controversial in part because of the lack of rapid, accurate, easily performed, and cost-effective methods. Advancements in molecular testing…

Tags: 2011, Antigens, Bacterial/*diagnosis/metabolism, Bacterial/urine, Calcitonin/blood, Clinics in chest medicine, Community-Acquired Infections/*diagnosis/metabolism/*microbiology/virology, Department of Internal Medicine, File Thomas M Jr, Humans, NEOMED College of Medicine, Nucleic Acid Amplification Techniques, Pneumonia, Polymerase Chain Reaction, Protein Precursors/blood, Viral/*diagnosis/metabolism

New Diagnostic Tests for Pneumonia: What is Their Role in Clinical Practice?

The utility of diagnostic studies to determine the etiologic agents of community-acquired pneumonia has been controversial in part because of the lack of rapid, accurate, easily performed, and cost-effective methods. Advancements in molecular testing…

Omadacycline: A novel tetracycline derivative with oral and intravenous formulations.

Omadacycline, an aminomethylcycline, is a novel member of the tetracycline class of antibiotics. It has received approval by the U.S. Food and Drug Administration (FDA) for treatment of community-acquired bacterial pneumonia (CABP) and acute…

Tags: 2019, ABSSSI, antibiotic, Antimicrobial resistance, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Department of Internal Medicine, Deresinski Stan, NEOMED College of Medicine, omadacycline, Pneumonia, Watkins Richard R

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