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Text
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URL Address
<a href="http://doi.org/10.1016/s0166-3542(99)00042-x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0166-3542(99)00042-x</a>
Pages
145–155
Issue
3
Volume
43
Dublin Core
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Title
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Resveratrol inhibition of herpes simplex virus replication.
Publisher
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Antiviral research
Date
A point or period of time associated with an event in the lifecycle of the resource
1999
1999-10
Subject
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Animals; Antiviral Agents/*pharmacology/toxicity; Cell Cycle/drug effects; Cell Line; Cercopithecus aethiops; Herpesvirus 1; Herpesvirus 2; Human/*drug effects/physiology; Humans; Immediate-Early Proteins/antagonists & inhibitors/biosynthesis; Mice; Resveratrol; Stilbenes/*pharmacology/toxicity; Vero Cells; Virus Latency/drug effects/physiology; Virus Replication/*drug effects/physiology
Creator
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Docherty J J; Fu M M; Stiffler B S; Limperos R J; Pokabla C M; DeLucia A L
Description
An account of the resource
Resveratrol, a phytoalexin, was found to inhibit herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) replication in a dose-dependent, reversible manner. The observed reduction in virus yield was not caused by the direct inactivation of HSV by resveratrol nor inhibition of virus attachment to the cell. The chemical did, however, target an early event in the virus replication cycle since it was most effective when added within 1 h of cell infection, less effective if addition was delayed until 6 h post-infection and not effective if added 9 h post-infection. Resveratrol was also found to delay the cell cycle at S-G2-M interphase, inhibit reactivation of virus from latently-infected neurons and reduce the amount of ICP-4, a major immediate early viral regulatory protein, that is produced when compared to controls. These results suggest that a critical early event in the viral replication cycle, that has a compensatory cellular counterpart, is being adversely affected.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0166-3542(99)00042-x" target="_blank" rel="noreferrer noopener">10.1016/s0166-3542(99)00042-x</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1999
Animals
Antiviral Agents/*pharmacology/toxicity
Antiviral research
Cell Cycle/drug effects
Cell Line
Cercopithecus aethiops
DeLucia A L
Department of Integrative Medical Sciences
Docherty J J
Fu M M
Herpesvirus 1
Herpesvirus 2
Human/*drug effects/physiology
Humans
Immediate-Early Proteins/antagonists & inhibitors/biosynthesis
Limperos R J
Mice
NEOMED College of Medicine
Pokabla C M
Resveratrol
Stiffler B S
Stilbenes/*pharmacology/toxicity
Vero Cells
Virus Latency/drug effects/physiology
Virus Replication/*drug effects/physiology