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Text
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<a href="http://doi.org/10.1016/j.nurt.2008.10.037" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.nurt.2008.10.037</a>
Pages
175–186
Issue
1
Volume
6
Dublin Core
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Title
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Polycyclic compounds: ideal drug scaffolds for the design of multiple mechanism drugs?
Publisher
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Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Date
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2009
2009-01
Subject
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*Drug Design; Adamantane/chemistry/pharmacology; Animals; Central Nervous System Diseases/*drug therapy; Humans; Molecular Structure; Neuroprotective Agents/chemistry/*pharmacology/therapeutic use; Polycyclic Compounds/*chemistry/pharmacology/therapeutic use; Psychotropic Drugs/chemistry/*pharmacology/therapeutic use; Quantitative Structure-Activity Relationship
Creator
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Van der Schyf Cornelis J; Geldenhuys Werner J
Description
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Recently there has been a resurging interest in developing multi-functional drugs to treat diseases with complex pathological mechanisms. Such drug molecules simultaneously target multiple etiologies that have been found to be important modulators in specific diseases. This approach has significant promise and may be more effective than using one compound specific for one drug target or, by a polypharmaceutical approach, using a cocktail of two or more drugs. Polycyclic ring structures are useful as starting scaffolds in medicinal chemistry programs to develop multi-functional drugs, and may also be useful moieties added to existing structures to improve the pharmacokinetic properties of drugs currently used in the clinic or under development. This review attempts to provide a synopsis of current published research to exemplify the use of polycyclic compounds as starting molecules to develop multi-functional drugs.
Identifier
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<a href="http://doi.org/10.1016/j.nurt.2008.10.037" target="_blank" rel="noreferrer noopener">10.1016/j.nurt.2008.10.037</a>
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*Drug Design
2009
Adamantane/chemistry/pharmacology
Animals
Central Nervous System Diseases/*drug therapy
Geldenhuys Werner J
Humans
Molecular Structure
Neuroprotective Agents/chemistry/*pharmacology/therapeutic use
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Polycyclic Compounds/*chemistry/pharmacology/therapeutic use
Psychotropic Drugs/chemistry/*pharmacology/therapeutic use
Quantitative Structure-Activity Relationship
Van der Schyf Cornelis J